田口 明彦 たぐち あきひこ 先生

来歴等

略歴

1989年　大阪大学医学部卒業
1989年　大阪大学医学部附属病院　研修医
1990年　星ヶ丘厚生年金病院　脳卒中内科　医員
1993年　大阪大学大学院医学系研究科　博士課程(神経解剖学)
1996年　米国コロンビア大学　博士研究員
2000年　国立大阪南病院　循環器科　医員
2002年　国立循環器病研究センター　脳循環研究室　室長/脳神経内科　医長
2011年　先端医療振興財団　先端医療センター　再生医療研究部　部長

論文

1. Taguchi A, Sakai C, Soma T, Kasahara Y, Stern DM, Kajimoto K, Ihara M, Daimon T, Yamahara K, Doi K, Kohara N, Nishimura H, Matsuyama T, Naritomi H, Sakai N, Nagatsuka K. Intravenous autologous bone marrow mononuclear cell transplantation for stroke: Phase1/2a clinical trial in a homogeneous group of stroke patients. Stem Cells Dev. 2015
2. Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Matsuoka K, Kosaka J, Kudo T, Iida H, Kishimoto T. Low amyloid-beta deposition correlates with high education in cognitively normal older adults: A pilot study. Int J Geriatr Psychiatry. 2015;30:919-926
3. Yasuno F, Kazui H, Yamamoto A, Morita N, Kajimoto K, Ihara M, Taguchi A, Matsuoka K, Kosaka J, Tanaka T, Kudo T, Takeda M, Nagatsuka K, Iida H, Kishimoto T. Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment. Neurobiol Aging. 2015;36:2145-2152
4. Ohshima M, Taguchi A, Tsuda H, Sato Y, Yamahara K, Harada-Shiba M, Miyazato M, Ikeda T, Iida H, Tsuji M. Intraperitoneal and intravenous deliveries are not comparable in terms of drug efficacy and cell distribution in neonatal mice with hypoxia-ischemia. Brain Dev. 2015;37:376-386
5. Nakagomi T, Kubo S, Nakano-Doi A, Sakuma R, Lu S, Narita A, Kawahara M, Taguchi A, Matsuyama T. Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cells. Stem Cells. 2015;33:1962-1974
6. Matsuoka K, Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Kudo T, Sekiyama A, Kitamura S, Kiuchi K, Kosaka J, Kishimoto T, Iida H, Nagatsuka K. Delayed atrophy in posterior cingulate cortex and apathy after stroke. Int J Geriatr Psychiatry. 2015;30:566-572
7. Makino H, Miyamoto Y, Kikuchi-Taura A, Soma T, Taguchi A, Kishimoto I. Decreased levels of circulating cd34(+) cells are associated with coronary heart disease in japanese patients with type 2 diabetes. J Diabetes Investig. 2015;6:473-478
8. Maki T, Maeda M, Uemura M, Lo EK, Terasaki Y, Liang AC, Shindo A, Choi YK, Taguchi A, Matsuyama T, Takahashi R, Ihara M, Arai K. Potential interactions between pericytes and oligodendrocyte precursor cells in perivascular regions of cerebral white matter. Neurosci Lett. 2015;597:164-169
9. Kasahara Y, Matsuyama T, Taguchi A. Treatment of autologous bone marrow mononuclear cells for acute and subacute stroke. Cell Therapy for Brain Injury. Springer, Switzerland. 2015:37-46
10. Yasuno F, Taguchi A, Kikuchi-Taura A, Yamamoto A, Kazui H, Kudo T, Sekiyama A, Kajimoto K, Soma T, Kishimoto T, Iida H, Nagatsuka K, Matsuoka K, Kitamura S, Kiuchi K, Kosaka J. Possible protective effect of regulatory t cells on white matter microstructural abnormalities in stroke patients. J Clin Cell Immunol. 2014 5:221-228
11. Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Sekiyama A, Matsuoka K, Kitamura S, Kiuchi K, Kosaka J, Kishimoto T, Iida H, Nagatsuka K. Microstructural abnormalities in white matter and their effect on depressive symptoms after stroke. Psychiatry Res. 2014;223:9-14
12. Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Kudo T, Kikuchi-Taura A, Sekiyama A, Kishimoto T, Iida H, Nagatsuka K. Microstructural abnormality in white matter, regulatory t lymphocytes, and depressive symptoms after stroke. Psychogeriatrics. 2014;14:213-221
13. Yamahara K, Harada K, Ohshima M, Ishikane S, Ohnishi S, Tsuda H, Otani K, Taguchi A, Soma T, Ogawa H, Katsuragi S, Yoshimatsu J, Harada-Shiba M, Kangawa K, Ikeda T. Comparison of angiogenic, cytoprotective, and immunosuppressive properties of human amnion- and chorion-derived mesenchymal stem cells. PLoS One. 2014;9:e88319
14. Tsuji M, Taguchi A, Ohshima M, Kasahara Y, Sato Y, Tsuda H, Otani K, Yamahara K, Ihara M, Harada-Shiba M, Ikeda T, Matsuyama T. Effects of intravenous administration of umbilical cord blood cd34(+) cells in a mouse model of neonatal stroke. Neuroscience. 2014;263:148-158
15. Tsuda H, Yamahara K, Otani K, Okumi M, Yazawa K, Kaimori JY, Taguchi A, Kangawa K, Ikeda T, Takahara S, Isaka Y. Transplantation of allogenic fetal membrane-derived mesenchymal stem cells protects against ischemia/reperfusion-induced acute kidney injury. Cell Transplant. 2014;23:889-899
16. Taguchi A, Kasahara Y, Matsuyama T. Letter by taguchi et al regarding article, "granulocyte colony-stimulating factor in patients with acute ischemic stroke: Results of the ax200 for ischemic stroke trial". Stroke. 2014;45:e8
17. Seo JH, Maki T, Maeda M, Miyamoto N, Liang AC, Hayakawa K, Pham LD, Suwa F, Taguchi A, Matsuyama T, Ihara M, Kim KW, Lo EH, Arai K. Oligodendrocyte precursor cells support blood-brain barrier integrity via tgf-beta signaling. PLoS One. 2014;9:e103174
18. Maki T, Okamoto Y, Carare RO, Hase Y, Hattori Y, Hawkes CA, Saito S, Yamamoto Y, Terasaki Y, Ishibashi-Ueda H, Taguchi A, Takahashi R, Miyakawa T, Kalaria RN, Lo EH, Arai K, Ihara M. Phosphodiesterase iii inhibitor promotes drainage of cerebrovascular beta-amyloid. Ann Clin Transl Neurol. 2014;1:519-533
19. Ihara M, Taguchi A, Maki T, Washida K, Tomimoto H. A mouse model of chronic cerebral hypoperfusion characterizing features of vascular cognitive impairment. Methods Mol Biol. 2014;1135:95-102
20. Ihara M, Nishino M, Taguchi A, Yamamoto Y, Hattori Y, Saito S, Takahashi Y, Tsuji M, Kasahara Y, Takata Y, Okada M. Cilostazol add-on therapy in patients with mild dementia receiving donepezil: A retrospective study. PLoS One. 2014;9:e89516
21. Tsuji M, Ohshima M, Taguchi A, Kasahara Y, Ikeda T, Matsuyama T. A novel reproducible model of neonatal stroke in mice: Comparison with a hypoxia-ischemia model. Exp Neurol. 2013;247:218-225
22. Taguchi A, Takata Y, Ihara M, Kasahara Y, Tsuji M, Nishino M, Stern D, Okada M. Cilostazol improves cognitive function in patients with mild cognitive impairment: A retrospective analysis. Psychogeriatrics. 2013;13:164-169
23. Kasahara Y, Ihara M, Taguchi A. Experimental evidence and early translational steps using bone marrow derived stem cells after human stroke. Front Neurol Neurosci. 2013;32:69-75
24. Kasahara Y, Ihara M, Nakagomi T, Momota Y, Stern DM, Matsuyama T, Taguchi A. A highly reproducible model of cerebral ischemia/reperfusion with extended survival in cb-17 mice. Neurosci Res. 2013;76:163-168
25. Uemura M, Kasahara Y, Nagatsuka K, Taguchi A. Cell-based therapy to promote angiogenesis in the brain following ischemic damage. Curr Vasc Pharmacol. 2012;10:285-288
26. Tsuji M, Taguchi A, Ohshima M, Kasahara Y, Ikeda T. Progesterone and allopregnanolone exacerbate hypoxic-ischemic brain injury in immature rats. Exp Neurol. 2012;233:214-220
27. Tanaka H, Takafuji K, Taguchi A, Wiriyasermkul P, Ohgaki R, Nagamori S, Suh PG, Kanai Y. Linkage of n-cadherin to multiple cytoskeletal elements revealed by a proteomic approach in hippocampal neurons. Neurochem Int. 2012;61:240-250
28. Takata M, Nakagomi T, Kashiwamura S, Nakano-Doi A, Saino O, Nakagomi N, Okamura H, Mimura O, Taguchi A, Matsuyama T. Glucocorticoid-induced tnf receptor-triggered t cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke. Cell Death Differ. 2012;19:756-767
29. Ohshima M, Yamahara K, Ishikane S, Harada K, Tsuda H, Otani K, Taguchi A, Miyazato M, Katsuragi S, Yoshimatsu J, Kodama M, Kangawa K, Ikeda T. Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses th1 and th17 t cell responses in experimental autoimmune myocarditis. J Mol Cell Cardiol. 2012;53:420-428
30. Ohshima M, Tsuji M, Taguchi A, Kasahara Y, Ikeda T. Cerebral blood flow during reperfusion predicts later brain damage in a mouse and a rat model of neonatal hypoxic-ischemic encephalopathy. Exp Neurol. 2012;233:481-489
31. Nakagomi T, Molnar Z, Taguchi A, Nakano-Doi A, Lu S, Kasahara Y, Nakagomi N, Matsuyama T. Leptomeningeal-derived doublecortin-expressing cells in poststroke brain. Stem Cells Dev. 2012;21:2350-2354
32. Kikuchi-Taura A, Taguchi A, Kanda T, Inoue T, Kasahara Y, Hirose H, Sato I, Matsuyama T, Nakagomi T, Yamahara K, Stern D, Ogawa H, Soma T. Human umbilical cord provides a significant source of unexpanded mesenchymal stromal cells. Cytotherapy. 2012;14:441-450
33. Kasahara Y, Nakagomi T, Matsuyama T, Taguchi A. Neurogenesis in the cerebral cortex after stroke. . Stem Cells and Cancer Stem Cells. 2012;2:211-217
34. Kasahara Y, Nakagomi T, Matsuyama T, Stern D, Taguchi A. Cilostazol reduces the risk of hemorrhagic infarction after administration of tissue-type plasminogen activator in a murine stroke model. Stroke. 2012;43:499-506
35. Hirose H, Kato H, Kikuchi-Taura A, Soma T, Taguchi A. Mouse es cells maintained in different pluripotency-promoting conditions differ in their neural differentiation propensity. In Vitro Cell Dev Biol Anim. 2012;48:143-148
36. Zeniya T, Watabe H, Hayashi T, Ose T, Myojin K, Taguchi A, Yamamoto A, Teramoto N, Kanagawa M, Yamamichi Y, Iida H. Three-dimensional quantitation of regional cerebral blood flow in mice using a high-resolution pinhole spect system and 123i-iodoamphetamine. Nucl Med Biol. 2011;38:1157-1164
37. Taguchi A, Zhu P, Cao F, Kikuchi-Taura A, Kasahara Y, Stern DM, Soma T, Matsuyama T, Hata R. Reduced ischemic brain injury by partial rejuvenation of bone marrow cells in aged rats. J Cereb Blood Flow Metab. 2011;31:855-867
38. Taguchi A. Cell-based therapy for patients with vascular dementia. Psychogeriatrics. 2011;11:113-115
39. Nakagomi T, Molnar Z, Nakano-Doi A, Taguchi A, Saino O, Kubo S, Clausen M, Yoshikawa H, Nakagomi N, Matsuyama T. Ischemia-induced neural stem/progenitor cells in the pia mater following cortical infarction. Stem Cells Dev. 2011;20:2037-2051
40. Katayama M, Naritomi H, Oomura M, Nukata M, Yamamoto S, Araki K, Kato H, Kinoshita M, Ito T, Shimode A, Takenobu Y, Watanabe M, Fukunaga R, Taguchi A, Hazama A, Inglin M, Krieger DW. Case reports of unexpected suicides in patients within six months after stroke. Kobe J Med Sci. 2011;56:E184-194
41. Kasahara Y, Tsuji M, Taguchi A. Umbilical cord blood and cell-baced therapy for neurological disease. Adv Med Biol. 2011;26:277-283
42. Kasahara Y, Nakagomi T, Nakano-Doi A, Matsuyama T, Taguchi A. The therapeutic potential of neural stem cells in cerebral ischemia. Curr Signal Transduct Ther. 2011;6:347-352
43. Clausen M, Nakagomi T, Nakano-Doi A, Saino O, Takata M, Taguchi A, Luiten P, Matsuyama T. Ischemia-induced neural stem/progenitor cells express pyramidal cell markers. Neuroreport. 2011;22:789-794
44. Tsuda H, Yamahara K, Ishikane S, Otani K, Nakamura A, Sawai K, Ichimaru N, Sada M, Taguchi A, Hosoda H, Tsuji M, Kawachi H, Horio M, Isaka Y, Kangawa K, Takahara S, Ikeda T. Allogenic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritis. Am J Physiol Renal Physiol. 2010;299:F1004-1013
45. Taguchi A, Kasahara Y, Nakagomi T, Stern DM, Fukunaga M, Ishikawa M, Matsuyama T. A reproducible and simple model of permanent cerebral ischemia in cb-17 and scid mice. J Exp Stroke Transl Med. 2010;3:28-33
46. Saino O, Taguchi A, Nakagomi T, Nakano-Doi A, Kashiwamura S, Doe N, Nakagomi N, Soma T, Yoshikawa H, Stern DM, Okamura H, Matsuyama T. Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke. J Neurosci Res. 2010;88:2385-2397
47. Nakayama D, Matsuyama T, Ishibashi-Ueda H, Nakagomi T, Kasahara Y, Hirose H, Kikuchi-Taura A, Stern DM, Mori H, Taguchi A. Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex. Eur J Neurosci. 2010;31:90-98
48. Nakano-Doi A, Nakagomi T, Fujikawa M, Nakagomi N, Kubo S, Lu S, Yoshikawa H, Soma T, Taguchi A, Matsuyama T. Bone marrow mononuclear cells promote proliferation of endogenous neural stem cells through vascular niches after cerebral infarction. Stem Cells. 2010;28:1292-1302
49. Matsumoto N, Taguchi A, Kitayama H, Watanabe Y, Ohta M, Yoshihara T, Itokazu Y, Dezawa M, Suzuki Y, Sugimoto H, Noda M, Ide C. Transplantation of cultured choroid plexus epithelial cells via cerebrospinal fluid shows prominent neuroprotective effects against acute ischemic brain injury in the rat. Neurosci Lett. 2010;469:283-288
50. Kasahara Y, Taguchi A, Uno H, Nakano A, Nakagomi T, Hirose H, Stern DM, Matsuyama T. Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia. Brain Res. 2010;1340:70-80
51. Fadini GP, Maruyama S, Ozaki T, Taguchi A, Meigs J, Dimmeler S, Zeiher AM, de Kreutzenberg S, Avogaro A, Nickenig G, Schmidt-Lucke C, Werner N. Circulating progenitor cell count for cardiovascular risk stratification: A pooled analysis. PLoS One. 2010;5:e11488
52. Taguchi A, Nakagomi N, Matsuyama T, Kikuchi-Taura A, Yoshikawa H, Kasahara Y, Hirose H, Moriwaki H, Nakagomi T, Soma T, Stern DM, Naritomi H. Circulating cd34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction. J Cereb Blood Flow Metab. 2009;29:34-38
53. Taguchi A. Vascular factors in diabetes and alzheimer's disease. J Alzheimers Dis. 2009;16:859-864
54. Nishikawa T, Iwakiri N, Kaneko Y, Taguchi A, Fukushima K, Mori H, Morone N, Kadokawa J. Nitric oxide release in human aortic endothelial cells mediated by delivery of amphiphilic polysiloxane nanoparticles to caveolae. Biomacromolecules. 2009;10:2074-2085
55. Nakagomi T, Taguchi A, Fujimori Y, Saino O, Nakano-Doi A, Kubo S, Gotoh A, Soma T, Yoshikawa H, Nishizaki T, Nakagomi N, Stern DM, Matsuyama T. Isolation and characterization of neural stem/progenitor cells from post-stroke cerebral cortex in mice. Eur J Neurosci. 2009;29:1842-1852
56. Nakagomi N, Nakagomi T, Kubo S, Nakano-Doi A, Saino O, Takata M, Yoshikawa H, Stern DM, Matsuyama T, Taguchi A. Endothelial cells support survival, proliferation, and neuronal differentiation of transplanted adult ischemia-induced neural stem/progenitor cells after cerebral infarction. Stem Cells. 2009;27:2185-2195
57. Makino H, Okada S, Nagumo A, Sugisawa T, Miyamoto Y, Kishimoto I, Kikuchi-Taura A, Soma T, Taguchi A, Yoshimasa Y. Decreased circulating cd34+ cells are associated with progression of diabetic nephropathy. Diabet Med. 2009;26:171-173
58. Yoshihara T, Taguchi A, Matsuyama T, Shimizu Y, Kikuchi-Taura A, Soma T, Stern DM, Yoshikawa H, Kasahara Y, Moriwaki H, Nagatsuka K, Naritomi H. Increase in circulating cd34-positive cells in patients with angiographic evidence of moyamoya-like vessels. J Cereb Blood Flow Metab. 2008;28:1086-1089
59. Uno H, Taguchi A, Oe H, Nagano K, Yamada N, Moriwaki H, Naritomi H. Relationship between detectability of ischemic lesions by diffusion-weighted imaging and embolic sources in transient ischemic attacks. Eur Neurol. 2008;59:38-43
60. Taguchi A, Matsuyama T, Nakagomi T, Shimizu Y, Fukunaga R, Tatsumi Y, Yoshikawa H, Kikuchi-Taura A, Soma T, Moriwaki H, Nagatsuka K, Stern DM, Naritomi H. Circulating cd34-positive cells provide a marker of vascular risk associated with cognitive impairment. J Cereb Blood Flow Metab. 2008;28:445-449
61. Okada S, Makino H, Nagumo A, Sugisawa T, Fujimoto M, Kishimoto I, Miyamoto Y, Kikuchi-Taura A, Soma T, Taguchi A, Yoshimasa Y. Circulating cd34-positive cell number is associated with brain natriuretic peptide level in type 2 diabetic patients. Diabetes Care. 2008;31:157-158
62. Maruyama S, Taguchi A, Iwashima S, Ozaki T, Yasuda K, Kikuchi-Taura A, Soma T, Ishii H, Murohara T, Takahashi H, Kasuga H, Kumada Y, Toriyama T, Ito Y, Kawahara H, Yuzawa Y, Matsuo S. Low circulating cd34+ cell count is associated with poor prognosis in chronic hemodialysis patients. Kidney Int. 2008;74:1603-1609
63. Makino H, Okada S, Nagumo A, Sugisawa T, Miyamoto Y, Kishimoto I, Akie TK, Soma T, Taguchi A, Yoshimasa Y. Pioglitazone treatment stimulates circulating cd34-positive cells in type 2 diabetes patients. Diabetes Res Clin Pract. 2008;81:327-330
64. Yoshihara T, Ohta M, Itokazu Y, Matsumoto N, Dezawa M, Suzuki Y, Taguchi A, Watanabe Y, Adachi Y, Ikehara S, Sugimoto H, Ide C. Neuroprotective effect of bone marrow-derived mononuclear cells promoting functional recovery from spinal cord injury. J Neurotrauma. 2007;24:1026-1036
65. Taguchi A, Wen Z, Myojin K, Yoshihara T, Nakagomi T, Nakayama D, Tanaka H, Soma T, Stern DM, Naritomi H, Matsuyama T. Granulocyte colony-stimulating factor has a negative effect on stroke outcome in a murine model. Eur J Neurosci. 2007;26:126-133
66. Myojin K, Taguchi A, Umetani K, Fukushima K, Nishiura N, Matsuyama T, Kimura H, Stern DM, Imai Y, Mori H. Visualization of intracerebral arteries by synchrotron radiation microangiography. AJNR Am J Neuroradiol. 2007;28:953-957
67. Kikuchi-Taura A, Soma T, Matsuyama T, Stern DM, Taguchi A. A new protocol for quantifying cd34(+) cells in peripheral blood of patients with cardiovascular disease. Tex Heart Inst J. 2006;33:427-429
68. Taguchi A, Soma T, Tanaka H, Kanda T, Nishimura H, Yoshikawa H, Tsukamoto Y, Iso H, Fujimori Y, Stern DM, Naritomi H, Matsuyama T. Administration of cd34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J Clin Invest. 2004;114:330-338
69. Taguchi A, Matsuyama T, Moriwaki H, Hayashi T, Hayashida K, Nagatsuka K, Todo K, Mori K, Stern DM, Soma T, Naritomi H. Circulating cd34-positive cells provide an index of cerebrovascular function. Circulation. 2004;109:2972-2975
70. Okamura K, Tanaka H, Yagita Y, Saeki Y, Taguchi A, Hiraoka Y, Zeng LH, Colman DR, Miki N. Cadherin activity is required for activity-induced spine remodeling. J Cell Biol. 2004;167:961-972
71. Taguchi A, Ohtani M, Soma T, Watanabe M, Kinosita N. Therapeutic angiogenesis by autologous bone-marrow transplantation in a general hospital setting. Eur J Vasc Endovasc Surg. 2003;25:276-278
72. Todo K, Watanabe M, Fukunaga R, Araki K, Yamamoto S, Rai M, Hoshi T, Nukata M, Taguchi A, Kinoshita N. Imaging of distal internal carotid artery by ultrasonography with a 3.5-mhz convex probe. Stroke. 2002;33:1792-1794
73. Sasaki T, Watanabe M, Nagai Y, Hoshi T, Takasawa M, Nukata M, Taguchi A, Kitagawa K, Kinoshita N, Matsumoto M. Association of plasma homocysteine concentration with atherosclerotic carotid plaques and lacunar infarction. Stroke. 2002;33:1493-1496
74. Bucciarelli LG, Wendt T, Rong L, Lalla E, Hofmann MA, Goova MT, Taguchi A, Yan SF, Yan SD, Stern DM, Schmidt AM. Rage is a multiligand receptor of the immunoglobulin superfamily: Implications for homeostasis and chronic disease. Cell Mol Life Sci. 2002;59:1117-1128
75. Kislinger T, Tanji N, Wendt T, Qu W, Lu Y, Ferran LJ, Jr., Taguchi A, Olson K, Bucciarelli L, Goova M, Hofmann MA, Cataldegirmen G, D'Agati V, Pischetsrieder M, Stern DM, Schmidt AM. Receptor for advanced glycation end products mediates inflammation and enhanced expression of tissue factor in vasculature of diabetic apolipoprotein e-null mice. Arterioscler Thromb Vasc Biol. 2001;21:905-910
76. Tanji N, Markowitz GS, Fu C, Kislinger T, Taguchi A, Pischetsrieder M, Stern D, Schmidt AM, D'Agati VD. Expression of advanced glycation end products and their cellular receptor rage in diabetic nephropathy and nondiabetic renal disease. J Am Soc Nephrol. 2000;11:1656-1666
77. Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, Tanji N, Lu Y, Lalla E, Fu C, Hofmann MA, Kislinger T, Ingram M, Lu A, Tanaka H, Hori O, Ogawa S, Stern DM, Schmidt AM. Blockade of rage-amphoterin signalling suppresses tumour growth and metastases. Nature. 2000;405:354-360
78. Schmidt AM, Hofmann M, Taguchi A, Yan SD, Stern DM. Rage: A multiligand receptor contributing to the cellular response in diabetic vasculopathy and inflammation. Semin Thromb Hemost. 2000;26:485-493
79. Yagita Y, Kitagawa K, Taguchi A, Ohtsuki T, Kuwabara K, Mabuchi T, Matsumoto M, Yanagihara T, Hori M. Molecular cloning of a novel member of the hsp110 family of genes, ischemia-responsive protein 94 kda (irp94), expressed in rat brain after transient forebrain ischemia. J Neurochem. 1999;72:1544-1551
80. Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Du Yan S, Hofmann M, Yan SF, Pischetsrieder M, Stern D, Schmidt AM. N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression. J Biol Chem. 1999;274:31740-31749
81. Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, Neurath MF, Slattery T, Beach D, McClary J, Nagashima M, Morser J, Stern D, Schmidt AM. Rage mediates a novel proinflammatory axis: A central cell surface receptor for s100/calgranulin polypeptides. Cell. 1999;97:889-901
82. Yagita Y, Kitagawa K, Matsushita K, Taguchi A, Mabuchi T, Ohtsuki T, Yanagihara T, Matsumoto M. Effect of immunosuppressant fk506 on ischemia-induced degeneration of hippocampal neurons in gerbils. Life Sci. 1996;59:1643-1650
83. Taguchi A, Wanaka A, Mori T, Matsumoto K, Imai Y, Tagaki T, Tohyama M. Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Brain Res Mol Brain Res. 1996;35:31-40
84. Ohtsuki T, Matsumoto M, Taguchi A, Yang GM, Mabuchi T, Matsushita K, Kuwabara K, Kitagawa K, Yanagihara T. Bifemelane hydrochloride enhances 'ischemic tolerance' phenomenon in gerbil hippocampal ca1 neurons. Life Sci. 1996;59:979-985
85. Matsushita K, Kitagawa K, Matsuyama T, Ohtsuki T, Taguchi A, Mandai K, Mabuchi T, Yagita Y, Yanagihara T, Matsumoto M. Effect of systemic zinc administration on delayed neuronal death in the gerbil hippocampus. Brain Res. 1996;743:362-365
86. Mori T, Wanaka A, Taguchi A, Matsumoto K, Tohyama M. Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse. Brain Res Mol Brain Res. 1995;29:325-335
87. Mori T, Wanaka A, Taguchi A, Matsumoto K, Tohyama M. Localization of novel receptor tyrosine kinase genes of the eph family, mdk1 and its splicing variant, in the developing mouse nervous system. Brain Res Mol Brain Res. 1995;34:154-160
88. Matsumoto K, Wanaka A, Mori T, Taguchi A, Ishii N, Muramatsu H, Muramatsu T, Tohyama M. Localization of pleiotrophin and midkine in the postnatal developing cerebellum. Neurosci Lett. 1994;178:216-220
89. Okamoto M, Matsumoto M, Ohtsuki T, Taguchi A, Mikoshiba K, Yanagihara T, Kamada T. Internucleosomal DNA cleavage involved in ischemia-induced neuronal death. Biochem Biophys Res Commun. 1993;196:1356-1362
90. Ohtsuki T, Matsumoto M, Kitagawa K, Taguchi A, Maeda Y, Hata R, Ogawa S, Ueda H, Handa N, Kamada T. Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion. Brain Res. 1993;614:279-284

【和文】
1. 田口 明彦, 長束 一行, 成冨 博章. 【再生医療-新たな医療を求めて-】 再生医療の臨床研究・治験　急性期心原性脳塞栓症患者に対する自己骨髄単核球静脈内投与の臨床試験. 日本臨床. 2015;73:437-441
2. 田口 明彦. 神経疾患患者に対する再生医療の現状　神経科学の最前線とリハビリテーション. 2015:238-241
3. 田口 明彦. 【脳虚血の基礎と病態】 細胞治療による脳梗塞再生医療. Medical Science Digest. 2015;41:111-114
4. 鈴木 育浩, 前田 光代, 田口 明彦. 脳の科学up date　脳梗塞患者に対する機能再生治療法の開発. 脳21. 2014;17:371-374
5. 田口 明彦, 山原 研一. 【脳血管構築の特異性と認知症】 脳血管をターゲットにした再生医療による認知症治療戦略. 血管医学. 2014;15:69-74
6. 田口 明彦, 笠原 由紀子, 前田 光代. 【最新臨床脳卒中学[上]-最新の診断と治療-】 治療戦略を目指した研究　再生・移植基礎研究　骨髄由来単核球細胞を用いた再生医療. 日本臨床. 2014;72:469-472
7. 田口 明彦. 心原性脳塞栓症患者に対する自己骨髄単核球移植治療とその発展. 脳卒中. 2014;36:131-133
8. 田口 明彦. 脳梗塞患者に対する再生医療開発. 脳循環代謝. 2014;25:105-107
9. 田口 明彦. 【age/rageと心血管疾患】 認知症とage/rage. 医学のあゆみ. 2013;244:671-673
10. 田口 明彦. 高齢者のための再生医療　研究の現状と未来への展望 脳梗塞患者に対する再生医療の現状とその未来. 日本老年医学会雑誌. 2013;50:359-361
11. 田口 明彦. 脳梗塞後の修復メカニズムと細胞治療(post-stroke repairing mechanism and cell therapy) 脳卒中患者に対する自己骨髄単核球を用いた細胞治療とその発展. 脳循環代謝. 2013;24:67-70
12. 田口 明彦, 松山 知弘, 長束 一行. 虚血性脳血管障害における神経再生と血管新生 急性期脳梗塞患者に対する自己骨髄単核球細胞投与の臨床試験. 脳循環代謝. 2012;23:100-105
13. 田口 明彦. 医療トレンド　脳卒中に対する再生医療の現状とその未来像　脳卒中に対する再生医療を神戸から世界に! Schneller. 2012:13-15
14. 辻 雅弘, 笠原 由紀子, 田口 明彦. 老年医学の展望　再生医療の現状と将来　脳血管障害患者に対する細胞治療とその将来. 日本老年医学会雑誌. 2012;49:528-533
15. 猪原 匡史, 田口 明彦. 脳梗塞と体性幹細胞. Bio Clinica. 2012;27:36-40
16. 猪原 匡史, 田口 明彦. 【認知症治療へのβアミロイドからのアプローチ】 血管周囲リンパ排液路を介したβアミロイドのクリアランス. Dementia Japan. 2012;26:292-299
17. 猪原 匡史, 田口 明彦. 【アルツハイマー病の根本治療に向けた研究最前線】 β-アミロイドの血管周囲リンパ排液路を介したクリアランス. 細胞工学. 2012;31:1113-1118
18. 猪原 匡史, 笠原 由紀子, 田口 明彦. 【ニューロリハの最前線】 細胞移植療法による神経機能回復. 分子脳血管病. 2012;11:293-299
19. 上村 昌寛, 笠原 由紀子, 猪原 匡史, 田口 明彦. 血管再生を介したアルツハイマー型認知症治療の可能性. Cardiovascular Frontier. 2012;3:233-237
20. 堀内 正嗣, 猪原 匡史, 茂木 正樹, 田口 明彦 テルミサルタンの可能性-脳領域の観点から-. Pharma Medica. 2011;29:95-100
21. 田口 明彦, 斉藤 こずえ, 梶本 勝文, 森脇 博, 笠原 由紀子, 成冨 博章, 宮下 光太郎, 長束 一行. 神経疾患に対する細胞治療の開発　現状と展望 心原性脳塞栓症患者に対する自己骨髄単核球をもちいた細胞治療の臨床試験. 臨床神経学. 2011;51:1081-1082
22. 田口 明彦. 脳卒中患者に対する再生医療. リハニュース. 2011;49:4-5
23. 田口 明彦. 【再生医療　臨床応用へ向けての現状と課題】 脳卒中. 総合リハビリテーション. 2011;39:13-17
24. 田口 明彦. 自己細胞を用いた脳卒中細胞治療臨床試験 心原性脳梗塞患者に対する自己骨髄単核球を用いた細胞治療. 臨床評価. 2011;39:149-157
25. 田口 明彦. 【神経系におけるips細胞　ips細胞の活用も含めた神経機能修復の現状と将来】 脳梗塞患者に対する自己骨髄幹細胞治療を用いた臨床試験. 脳21. 2011;14:244-248
26. 田口 明彦. 脳梗塞に対する幹細胞治療. 老年期認知症研究会誌. 2011;17:70-71
27. 安井 麻里子, 田口 明彦. 【アストロサイト-その驚くべき多彩な機能】 脳梗塞慢性期治療とアストロサイト　神経再生への挑戦. Clinical Neuroscience. 2011;29:1284-1285
28. 田口 明彦, 長束 一行, 成冨 博章. 【厚生労働省ヒト幹細胞指針に従った臨床研究アップデート】 急性期心原性脳塞栓症患者に対する自己骨髄単核球を用いた細胞治療. 再生医療. 2010;9:433-436
29. 田口 明彦, 笠原 由紀子, 長束 一行. 【再生医療の現状と将来】 脳血管障害患者に対する細胞治療とその未来. ICUとCCU. 2010;34:355-359
30. 田口 明彦 Brain attackに対する先進医療の展望－脳血管障害患者に対する再生医療－. . プラクティス. 2010;27:501-503
31. 藤川 昌敏, 中込 隆之, 土居 亜紀子, 斉野 織恵, 田口 明彦, 松山 知弘. 脳梗塞における骨髄単核球投与の脳血流改善効果の検討. 兵庫医科大学医学会雑誌. 2009;34:117-125
32. 田口 明彦, 成冨 博章. 脳梗塞患者に対する細胞治療. Brain Rescue. 2009:12-15
33. 田口 明彦, 森脇 博, 成冨 博章. 知って得する最新情報　脳血管障害に対する幹細胞治療法の開発. Clinical Neuroscience. 2009;27:112-113
34. 田口 明彦. 神経疾患の再生医療. . 神経疾患の最新の治療2009-2011. 2009:13-15
35. 田口 明彦. 循環器疾患における再生医療. 最新循環器診療マニュアル. 2009:756-761
36. 田口 明彦. 【再生医療の現状と将来展望】 再生医療の現状と将来展望　骨髄細胞を用いた脳血管障害に対する治療法の開発. 日本医科大学医学会雑誌. 2009;5:38-40
37. 田口 明彦. 【虚血性脳卒中　診断と治療の進歩】 最近の話題　脳血管障害に対する再生医療. 日本内科学会雑誌. 2009;98:1325-1330
38. 田口 明彦. 【脳卒中の征圧をめざして】　明日の脳卒中　7つの課題と展望 脳卒中の再生医療. Medicina. 2009;46:1860-1862
39. 田口 明彦. 脳血管障害に対する再生医療とその未来. 麻酔. 2009;58:S12-S20
40. 田口 明彦, 成冨 博章. 基礎医学から　脳梗塞に対する再生医療. 日本医事新報. 2008:46-48
41. 田口 明彦. 脳梗塞に対する幹細胞治療. . 老年期痴呆研究会誌. 2008;17:70-71
42. 田口 明彦. 【新時代の糖尿病学　病因・診断・治療研究の進歩】 糖尿病に起因する合併症　慢性合併症　大血管症　脳血管障害　血管新生療法の現況と今後の展望. 日本臨床. 2008;66:345-348
43. 田口 明彦. 脳血管障害に対する新しい細胞治療の開発. 循環器病研究の進歩. 2007;XXVIII:53-58
44. 田口 明彦, 明神 和紀, 松山 知弘, 「脳卒中、脳血管性痴呆症に対する再生医療的技術を用いた治療法の開発に関する研究」斑. 脳卒中に対する再生医療的技術を用いた治療法の開発に関する研究. 脳卒中. 2006;28:433-436
45. 田口 明彦 自己幹細胞移植による血管再生療法. Buerger病治療と看護総覧. 2005:24-31
46. 田口 明彦. 脳の科学up date　虚血性脳血管障害に対する再生医療の臨床応用に向けて. 脳21. 2005;8:210-213
47. 田口 明彦 難治性バージャー病に対する治療法の進歩. Steps. 2004;5:15
48. 知久 正明, 西上 和宏, 林 富貴雄, 荻野 均, 松田 均, 湊谷 謙司, 佐々木 啓明, 中谷 武嗣, 田口 明彦, 宮田 茂樹, 亀井 政孝, 田中 良一, 盛 英三, 宮武 邦夫, 友池 仁暢. バージャー病の難治性潰瘍に対する骨髄細胞移植の治療効果. 脈管学. 2004;44:191-197
49. 田口 明彦. 各種難病の最新治療情報　炭酸浴療法による血流改善　バージャー病患者さんへの血管新生療法. 難病と在宅ケア. 2003;8:78-81
50. 田口 明彦. 【バージャー病治療の最新情報】　自己骨髄細胞移植による血管新生療法　難治性バージャー病に対する第4の治療法. 難病と在宅ケア. 2002;7:7-10
51. 田口 明彦 自己骨髄移植による血管新生療法. Steps. 2001:2
52. 田口 明彦. 脳の科学up date　rageとamphoterin神経発生と癌の浸潤の制御まで. 脳21. 2001;4:87-89
53. 田口 明彦. 【神経相互接着ダイナミックスとその異常】　rageとamphoterin gliomaの細胞運動における役割とその腫瘍抑制への応用. 脳21. 2001;4:135-139
54. 田口 明彦, 松本 昌泰, 堀 正二. Rageとamphoterin　癌細胞の浸潤,転移の抑制. 治療. 2000;82:2584-2586
55. 田口 明彦, Schmidt Ann Marie. Rageとamphoterin　細胞運動阻害による腫瘍細胞浸潤・転移の抑制. 医学のあゆみ. 2000;195:142-143