松原 長秀 まつばら ながひで 先生

来歴等

略歴

1983年 愛媛大学医学部 卒業
1983年 岡山大学第一外科 入局
1991年 岡山大学 医学博士取得
1991年 ランケヌー医学研究所勤務 pos doc
1993年 岡山大学病院 医員、助手、講師（病態遺伝子講座）
2008年 姫路赤十字病院 外科部長
2009年 兵庫医科大学外科学講座 講師
2010年 兵庫医科大学外科学講座 准教授
2014年 兵庫医科大学外科学講座 教授
2016年 尼崎中央病院 副院長 消化器センター長

論文

• Genomic landscape of colitis-associated cancer indicates the impact of chronic inflammation and its stratification by mutations in the Wnt signaling. Advanced publication Oncotarget (2017).

  Masashi Fujita, Nagahide Matsubara, Ikuo Matsuda, Kazuhiro Maejima, Ayako Oosawa, Tomoki Yamano, Akihiro Fuhimoto, Mayuko Fruta, Kaoru Nakano, Aya Oku-Sasaki, Hiroko Tanaka, Yuichi Shiraishi, Raul Nicolas Mateos, Kenta Nakai, Satoru Miyano, Naohiro Tomita, Seiichi Hirota, Hiroki Ikeuchi and Hidewaki Nakagawa.

• Feasibility of laparoscopic total proctocolectomy with ileal pouch–anal anastomosis and total colectomy with ileorectal anastomosis for familial adenomatous polyposis: results of a nationwide multicenter study. Int. J. Clin. Oncol. DOI 10.1007/s10147-016-0977-x (2016)

  Tsuyoshi Konishi, Hideyuki Ishida, Hideki Ueno, Hirotoshi Kobayashi, Takao Hinoi, Yasuhiro Inoue, Fumio Ishida, Yukihide Kanemitsu, Tatsuro Yamaguchi, Naohiro Tomita, Nagahide Matsubara, Toshiaki Watanabe, Kenichi Sugihara

• Feasibility of modified short-course radiotherapy combined with a chemoradiosensitizer for T3 rectal cancer. Dis. Colon Rec. 58: 479-487 (2015)

  Naohito Beppu, Nagahide Matsubara, Ayako Kakuno, Hiroshi Doi, Norihiko Kamikonya, Naoki Yamanaka, Hidenori Yanagi, Naohiro Tomita

• Mortality after common rectal surgery in Japan: A study on low anterior resection from a newly established nationwide large-scale clinical database. Dis. Colon Rec. 57: 1075-1081 (2014)

  Nagahide Matsubara, Hiroaki Miyata, Mitsukazu Gotoh, Naohiro Tomita, Hideo Baba, Wataru Kimura, Tohru Nakagoe, Mitsuo Simada, Yuko Kitagawa, Kenichi Sugihara, Masaki Mori.

• Epigenetic regulation and colorectal cancer. Dis. Colon Rec. 55: 96-104 (2012)

  Nagahide Matsubara

• Oncogenic PIK3CA mutations in colorectal cancers and polyps. Int. J. Cancer (2011) 10.1002/ijc.26440

  Whitehall VLJ, Rickman C, Bond CE, Ramsnes I, Greco SA, Umapathy A, McKeone D, Faleiro P, Buttenshaw RL, Worthley DL, Nayler S, Zhao Z, Montgomery GW, Mallitt K, Jass JR, Matsubara N, Notohara K, Ishii T and Leggett BA

• Tubular adenomas with subtle villous change show molecular features characteristic of tubulovillous adenomas. Am. J. Surg. Pathol. 35(2): 212-220 (2011)

  Tatsuhiro Ishii, Kenji Notohara, Aarti Umapathy, Kylie-Ann Mallitt, Hiroshi Chikuba, Yukitoshi Moritani, Noriaki Tanaka, Christophe Rosty, Nagahide Matsubara, Jeremy Jass, Barbara Leggett, Vicki Whitehall

• Analysis of Fecal DNA methylation to detect gastrointestinal neoplasia. J. Natl. Cancer Inst. 101 (18): 1244-1258 (2009)

  Takeshi Nagasaka, Noriaki Tanaka, Harry M. Cullings, Dong-Sheng Sun, Hiromi Sasamoto, Takuyuki Uchida, Minoru Koi, Naoshi Nishida, Yoshio Naomoto, C. Richard Boland, Nagahide Matsubara, Ajay Goel

• Determination of splice-site mutations in Lynch syndrome (hereditary non-polyposis colorectal cancer) patients usingfunctional splicing assay. Familial Cancer 8: 509-517 (2009). DOI 10.1007/s10689-009-9280-6

  Hiromu Naruse, Noriko Ikawa, Kiyoshi Yamaguchi, Yusuke Nakamura, Masami Arai, Chikashi Ishioka, Kokichi Sugano, Kazuo Tamura, Naohiro Tomita, Nagahide Matsubara, Teruhiko Yoshida, Yoshihiro Moriya, Yoichi Furukawa

• Mutations in both KRAS and BRAF contribute to the methylator phenotype in colon cancer. Gastroenterology 134: 1950-1960 (2008)

  Takeshi Nagasaka, Minoru Koi, Matthias Kloor, Johannes Gebert, Alex Vilkin, Naoshi Nishida, Sung Kwan Shin, Hiromi Sasamoto, Noriaki Tanaka, Nagahide Matsubara, C. Richard Boland, and Ajay Goel

• Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. Int. J. Cancer 122: 2429-2436 (2008)

  Takeshi Nagasaka, Ajay Goel, Kenji Notohara, Takaomi Takahata, Hiromi Sasamoto, Takuyuki Uchida, Naoshi Nishida, Noriaki Tanaka, C. Richard Boland, Nagahide Matsubara

• Epigenetic and Genetic Alterations in Netrin-1 Receptors UNC5C and DCC in Human Colon Cancer. Gastroenterology 133:1849–1857 (2007)

  Sung Kwan Shin, Takeshi Nagasaka, Barbara H. Jung, Nagahide Matsubara, Won Ho Kim, John M. Carethers, C. Richard Boland, and Ajay Goel

• Oesophageal squamous cell cancer may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa. Gut 56, 13-19 (2007). [Doi:10.1136/ gut 2005, 089813]

  Ishii, T., Murakami, J., Notohara, K., Cullings, H. M., Sasamoto, H., Kambara, T., Shirakawa, Y., Naomoto, Y., Ouchida, M., Shimizu, K., Tanaka, N., Jass, J. R., Matsubara, N

• Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis. Int. J. Cancer 119 (11), 2513-2519 (2006)

  Ozaki, K., Nagasaka, T., Notohara, K., Kambara, T., Takeda, M., Sasamoto, H., Jass, J. R., Tanaka, N., Matsubara, N.

• Methylatio profiles of genes utilizing newly developed CpG island methylation microarray on colorectal cancer patients. Nucleic Acids Res. 33 (5) e46 (2005)

  Naoki Kimura, Takeshi Nagasaka, Jun Murakami, Hiromi Sasamoto, Masahiro Murakami, Noriaki Tanaka, Nagahide Matsubara

• Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes show different patterns of DNA methylation. J. Clin. Oncol. 22 (22), 4584-4594 (2004).

  Takeshi Nagasaka, Hiromi Sasamoto, Kenji Notohara, Harry M. Cullings, Masanori Takeda, Keigo Kimura, Takeshi Kambara, Donald G. MacPhee, Joanne Young, Barbara A. Leggett, Jeremy R. Jass, Noriaki Tanaka, Nagahide Matsubara

• Allele-specific methylation analysis on upstream promoter region of H19 by methylation-specific PCR with confronting two-pair primers. Int. J. Oncol. 25, 1273-1278 (2004).

  Hiromi Sasamoto, Takeshi Nagasaka, Kenji Notohara, Kazuo Ozaki, Hiroshi Isozaki, Noriaki Tanaka, Nagahide Matsubara

• Diagnostic application of hMLH1 methylation in hereditary non-polyposis colorectal cancer. Disease Markers 20 (4-5), 277-282 (2004).

  Nagahide Matsubara

• Methylation assay by nucleotide incorporation (MANIC): a novel, nonisotopic, quantitative assay for regional CpG methylation density. BioTchniques 36, 846-855 (2004).

  Takeshi Yamamoto, Takeshi Nagasaka, Kenji Notohara, Hiromi Sasamoto, Jun Murakami, Noriaki Tanaka and Nagahide Matsubara

• BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 53: 1137-1144 (2004)

  Takeshi Kambara, Lisa A. Simms, Vicki L. J. Whitehall, Kevin J. Spring, Coral V. A. Wynter, Michael D. Walsh, Melissa A. Barker, Sven Arnold, Andrina McGivern, Nagahide Matsubara, Noriaki Tanaka, Tetsuro Higuchi, Joanne Young, Jeremy R. Jass, and Barbara A. Leggett

• Jass Role of Inherited Defects of MYH in the Development of Sporadic Colorectal Cancer. Gene Chromosome Canc. 40, 1-9 (2004).

  Takeshi Kambara, Vicki L.J. Whitehall, Kevin J. Spring, Melissa A. Barker, Sven Arnold, Coral V.A. Wynter, Nagahide Matsubara, Noriaki Tanaka, Joanne P. Young, Barbara A. Leggett, Jeremy R.

• Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer. Clinical Cancer Res. 10, 1758-1763 (2004).

  Kambara, T., Sharp, G.B., Nagasaka, T., Takeda, M., Sasamoto, H., Nakagawa, H., Isozaki, H., MacPhee, D.G., Jass, J.R., Tanaka, N., Matsubara, N.

• Hypermethylation of O6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases. Clinical Cancer Res. 9, 5306-5312 (2003).

  Nagasaka, T., Sharp, G.B., Notohara, K., Kambara, T., Sasamoto, H., Isozaki, H., MacPhee, D.G., Jass, J.R., Tanaka, N., and Matsubara, N.

• Correspondence re: P. Laiho et al., Low-level microsatellite instability in most colorectal carcinomas. Cancer Res., 62: 1166-1170, 2002. Cancer Res. 62, 5988-5990 (2002).

  Jass, J.R., Whitehall, V.L.J., Young, J., Leggett, B., Meltzer, S.J., Matsubara, N., Fishel, R.

• Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers. Cancer Res. 62, 3641-3645 (2002).

  Mori, Y., Sato, F., Selaru, F. M., Olaru, A., Perry, K., Kimos, M. C., Tamura, G., Matsubara, N., Wang, S., Xu, Y., Yin, J., Zou, T. T., Leggett, B., Young, J., Nukiwa, T., Stine, O. C., Abraham, J. M., Shibata, D., Meltzer, S. J.

• Genetic alterations of the ornithine decarboxylase gene in human colorectal cancers. J. Exp. Clin. Cancer Res., 21 (2), 191-195 (2002).

  Matsubara, N., Yohitaka, T., Hanafusa, H., Tanaka, N., Shimizu, K.

• Effect of naturally occurring E2F-4 alterations on transcriptional activation and proliferation in transfected cells. Lab. Invest. 81, 1565-1573 (2001).

  Takashima, H., Matsubara, N., Matsumoto, Y., Shirakawa, Y., Kawashima, R., Tanino, M., Ito, S., Isozaki, H., Ouchida, M., Meltzer, S.J., Tanaka, N., Shimizu, K.

• High frequency of low level microsatellite instability in early colorectal cancer. Cancer Res. 61, 7743-7746 (2001).

  Takeshi Kambara, Nagahide Matsubara, Hitoshi Nakagawa, Kenji Notohara, Takeshi Nagasaka, Tadashi Yoshino, Hiroshi Isozaki, Gerald B. Sharp, Jeremy Jass, Kenji Shimizu, Noriaki Tanaka

• Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer. Cancer Res. 61, 4345-4349 (2001).

  Chen, L., Matsubara, N. Yoshino, T., Nagasaka, T., Hoshizima, N., Shirakawa, Y., Naomoto, Y., Isozaki, H., Riabowol, K., and Tanaka, N.

• The farthest 3' distal end APC mutation identified in attenuated adenomatous polyposis coli with extracolonic manifestations. Dis. Colon Rectum 43 (5), 720-721 (2000)

  Matsubara, N., Isozaki, H., Tanaka, N.

• Multiple tumors and a novel E2F-4 mutation. Digestion 62, 213-216 (2000)

  Matsubara, N., Yoshitaka, T., Matsuno, T., Ikeda M., Isozaki, H., Tanaka, N., and Shimizu, K.

• Close correlation between mutations of E2F-4 and hMSH3 genes in colorectal cancers with microsatellite instability. Cancer Res. 58, 594-598 (1998)

  Ikeda, M., Orimo, H., Moriyama, H., Nakajima, E., Matsubara, N., Mibu, R., Tanaka, N., Shimada, T., Kimura, A., and Shimizu, K.

• Frequent mutation of the E2F-4 cell cycle gene in primary human gastrointestinal tumors. Cancer Res. 57, 2350-2353 (1997)

  Souza, R. F., Yin, J., Smolinski, K. N., Zou, T-T., Wang, S., Shi, Y-Q., Rhyu, M-G., Cottrell, J., Abraham, J. M., Biden, K., Simms, L., Leggett, B., Bova, G. S., Frank, T., Powell, S. M., Sugimura, H., Young, J., Harpaz, N., Shimizu, K., Matsubara, N., Meltzer, S. J.

• Possible involvement of free radical scavenging properties in the action of tumor necrosis factor-a. Free Rad. Biol. Med. 22, 679-687 (1997)

  Matsubara, N., Hiramats, M., Edamatsu, R., Mizukawa, K., Mori, A., and Orita K.

• Mutation of E2F-4 trinucleotide repeats in colorectal cancer with microsatellite instability. Biochem. Biophys. Res. Commun., 227, 553-557 (1996)

  Yoshitaka, T., Matsubara, N., Ikeda, M., Tanino, M., Hanafusa, H., Tanaka, N., and Shimizu, K.

• Association between high levels of ornithine decarboxylase activity and favorable prognosis in human colorectal carcinoma. Clinical Cancer Research. 1, 665-671 (1995)

  Matsubara, N., Hietala, O.A., Gilmore, S.K., Yum., K.Y., Litwin, S., Watts., P., Brennan, E.F., O'Brien, T.G.

• Electron spin resonance spectrometric and histochemical electron microscopic investigation. Pathophysiology 1, 47-51, (1994)

  Matsubara, N., Mizukawa, K., Iwagaki, K., Fuchimoto, S., Kimura. Y., and Orita, K.: Human tumor cells generate reactive oxygen species

• Tumor necrosis factor-alpha induces translocation of protein kinase C in tumor necrosis factor-sensitive cell lines. Immunology 73, 457-459 (1991)

  Matsubara, N., Fuchimoto, S., Orita, K.

著書

• 【共著】Nagahide Matsubara: Colorectal cancers developed from proximal and distal tumor location belong to the distinct genetic entity and show different oncologic behavior. Chapter 5 81-91, Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy. Current Human Cell Research and Applications. Series Editors: Nariyoshi Shinomiya, Hiroaki Kataoka, Yutaka Shimada. Springer

• 【共著】松原長秀、冨田尚裕：直腸進行癌　消化器疾患最新の治療2011-2012　編集：菅野健太郎、上西紀夫、井廻道夫　南江堂 p232-235 (2011)

• 【共著】松原長秀、冨田尚裕：V.大腸癌　看護学テキスト NiCE 疾病と治療II（消化器系／代謝・内分泌系／血液・造血系／アレルギー／膠原病）総編集：松田輝　萩原俊男　難波光義　鈴木久美　林直子　南江堂　p83-89 (2010)

• 【共著】松原長秀：遺伝性大腸癌　p430-440大腸疾患診療のStrategy　日本メディカルセンター　編集：斉藤裕輔　田中信治　渡邉聡明　2010年

• 【共著】松原長秀、木村直紀：メチレーションチップ−プロモーターのメチル化による遺伝子の不活性化を検出するチップ−　DNAチップ実験まるわかり　p74-79　佐々木博己、青柳一彦編　羊土社2004年12月第1版発行

• 【共著】馬場正三、松原長秀：21世紀の大腸癌診断治療戦略のために　HNPCC in the year 2000 (hereditary nonpolyposis colorectal cancer) 株式会社マイライフ

その他

• 【テレビ出演】2016年　ABC朝日放送　キャスト出演