井田 弘明 いだ ひろあき 先生

来歴等

略歴

1987年 長崎大学医学部 卒業
1993年 長崎大学大学院医学研究科 博士課程 修了
1994年 米国ハーバード大学 ダナ・ファーバー癌研究所研究員(日本リウマチ財団米国派遣医)
2003年 長崎大学医学部・歯学部附属病院 第一内科 助手
2006年 長崎大学医学部・歯学部附属病院 第一内科 講師
2010年 久留米大学医学部呼吸器・神経・膠原病内科 准教授
2013年 久留米大学医学部呼吸器・神経・膠原病内科 教授

論文

• 1)CD94 ligation induces apoptosis in a subset of IL-2-stimulated NK cells. J. Immunol. 1997;159:2154-60.

  Ida H, Robertson MJ, Voss S, Ritz J, Anderson P.

• 2)Activation-induced NK cell death triggered by CD2 stimulation. Eur. J. Immunol. 1998;28:1292-300.

  Ida H, Anderson P.

• 3) A novel role for Interleukin-18 in human NK cell death: high serum levels and low NK cell number in systemic autoimmune diseases. Arthritis Rheum. 2001;44: 884-92.

  Shibatomi K, Ida H, Yamasaki S, Nakashima T, Origuchi T, Kawakami A, Migita K, Kawabe Y, Tsujihata M, Anderson P, Eguchi K.

• 4)Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death. Eur J Immunol. 2003;33: 3284-92.

  Ida H, Nakashima T, Kedersha NL, Yamasaki S, Huang M, Izumi Y, Miyashita T, Kawakami A, Migita K, Bird PI, Anderson P, Eguchi K.

• 5)A novel mutation (T61I) in the gene encoding tumour necrosis factor receptor superfamily 1A (TNFRSF1A) in a Japanese patient with tumour necrosis factor receptor-associated periodic syndrome (TRAPS) associated with systemic lupus erythematosus. Rheumatology. 2004;43: 1292-9.

  Ida H, Kawasaki E, Miyashita T, Tanaka F, Kamachi M, Izumi Y, Huang M, Tamai M, Origuchi T, Kawakami A, Migita K, Motomura M, Yoshimura T, Eguchi K.

• 6)Hereditary Periodic Fever Syndromes in Japan. Intern Med. 2005;44:177-8.

  Ida H, Eguchi K.

• 7)Granzyme B and NK cell death. Modern Rheum. 2005;15: 315-22.

  Ida H, Utz PJ, Anderson P, Eguchi K.

• 8) Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjögren's syndrome. Clin Exp Immunol. 2005;142:148-54.

  Huang M, Ida H, Kamachi M, Iwanaga N, Izumi Y, Tanaka F, Aratake K, Arima K, Tamai M, Hida A, Nakamura H, Origuchi T, Kawakami A, Ogawa N, Sugai S, Utz PJ, Eguchi K.

• 9) Characterization of peripheral natural killer cells in primary Sjögren’s syndrome: impaired NK cell activity and low NK cell number. J Lab Clin Med. 2006;147: 242-249. (Translational research)

  Izumi Y, Ida H, Huang M, Iwanaga N, Tanaka F, Aratake K, Arima K, Tamai M, Kamachi M, Nakamura H, Origuchi T, Kawakami A, Anderson P, Eguchi K.

• 10)Successful treatment using Tacrolimus (FK506) in a patient with TNF receptor-associated periodic syndrome (TRAPS) complicated by monocytic fasciitis. Rheumatology. 2006;45: 1171-3.

  Ida H, Aramaki T, Arima K, Origuchi T, Kawakami A, Eguchi K.

• 11)La autoantigen translocates to cytoplasm after cleavage during granzyme B-mediated cytotoxicity. Life Sciences. 2007;81:1461-6.

  Huang M, Ida H, Arima K, Nakamura H, Aramaki T, Fujikawa K, Tamai M, Kamachi M, Kawakami A, Yamasaki H, Origuchi T, Eguchi K.

• 12) A case of periodic-fever-syndrome-like disorder with lipodystrophy, myositis, and autoimmune abnormalities. Mod Rheumatol. 2008;18:203-7.

  Kasagi S, Kawano S, Nakazawa T, Sugino H, Koshiba M, Ichinose K, Ida H, Eguchi K, Kumagai S.

• 13) A significantly impaired natural killer cell activity due to a low activity on a per-cell basis in rheumatoid arthritis. Mod Rheumatol. 2009;19:245-52.

  Aramaki T, Ida H, Izumi Y, Fujikawa K, Huang M, Arima K, Tamai M, Kamachi M, Nakamura H,Kawakami A, Origuchi T, Matsuoka N, Eguchi K.

• 14)Different expression levels of TNF receptors on the rheumatoid synovial macrophages derived from surgery and a synovectomy as detected by a new flow cytometric analysis. Cytotechnology. 2009;60:161-4.

  Ida H, Aramaki T, Nakamura H, Fujikawa K, Arima K, Tamai M, Kamachi M, Satoh K, Origuchi T, Kawakami A, Furuichi I, Kawabe Y, Eguchi K.

• 15)An assembly defect due to a PSMB8 mutation reduces proteasome activities and causes autoinflammation. Proc Natl Acad Sci U S A 2011;108:14914-9.

  Arima K, Kinoshita A, Mishima H, Kanazawa N, Kaneko T, Mizushima T, Ichinose K, Nakamura H, Tsujino A, Kawakami A, Matsunaka M, Kasagi S, Kawano S, Kumagai S, Ohmura K, Mimori T, Hirano M, Ueno S, Tanaka K, Tanaka M, Toyoshima I, Sugino H, Yamakawa A, Tanaka K, Niikawa N, Furukawa F, Murata S, Eguchi K, Ida H, Yoshiura K.

• 16) Clinical and Genetic Features of Patients With TNFRSF1A Variants in Japan: Findings of a Nationwide Survey. Arthritis Rheumatol. 2016;68:2760-71.

  Ueda N, Ida H, Washio M, Miyahara H, Tokunaga S, Tanaka F, Takahashi H, Kusuhara K, Ohmura K, Nakayama M, Ohara O, Nishikomori R, Minota S, Takei S, Fujii T, Ishigatsubo Y, Tsukamoto H, Tahira T, Horiuchi T.

• 17)ISSAID/EMQN Best Practice Guidelines for the Genetic Diagnosis of Monogenic Autoinflammatory Diseases in the Next-Generation Sequencing Era. Clin Chem. 2020;66:525-36.

  Shinar Y, Ceccherini I, Rowczenio D, Aksentijevich I, Arostegui J, Ben-Chétrit E, Boursier G, Gattorno M, Hayrapetyan H, Ida H, Kanazawa N, Lachmann HJ, Mensa-Vilaro A, Nishikomori R, Oberkanins C, Obici L, Ohara O, Ozen S, Sarkisian T, Sheils K, Wolstenholme N, Zonneveld-Huijssoon E, van Gijn ME, Touitou I.

• 18) First case of pyrin-associated autoinflammation with neutrophilic dermatosis complicated by amyloidosis [published online ahead of print, 2020 Jan 30]. Rheumatology (Oxford). 2020;keaa005.

  Kiyota M, Oya M, Ayano M, Niiro H, Iwasaki T, Fujiwara M, Oda Y, Fujimoto K, Ida H.

• 19)Clinical and Genetic Analysis of 22 Japanese Patients with Familial Mediterranean Fever: An Examination of MEFV and 10 Other Genes Related to Autoinflammatory Syndromes. Intern Med. 2020;59(11):1373-8.

  Fujimoto K, Hidaka Y, Koga T, Kaieda S, Yamasaki S, Nakashima M, Hoshino T, Ida H.

• 20)Clinical phenotypes and genetic analyses for diagnosis of systemic autoinflammatory diseases in adult patients with unexplained fever. Mod Rheumatol. In press.

  Hidaka Y, Fujimoto K, Matsuo N, Koga T, Kaieda S, Yamasaki S, Nakashima M, Migita K, Nakayama M, Ohara O, Hoshino T, Nishikomori R, Ida H.

著書

• 自己炎症症候群の臨床／新興医学出版社／2015年

その他

• 【受賞】 2001年　第45回日本リウマチ学会総会若手研究者優秀賞

• 【受賞】2003年　第11回認定内科専門医会研究奨励賞

• 【受賞】2003年　平成14年度三浦記念リウマチ学術研究賞 (日本リウマチ財団)

• 【受賞】2004年　平成16年度日本リウマチ学会賞