原田 和昌 はらだ かずまさ 先生

来歴等

略歴

1985年 東京大学 医学部 卒業
1985年 東京大学医学部附属病院
1990年 Harvard大学 博士研究員
1993年 東京大学大学院医学研究科 医学博士取得
2001年 東京大学医学部 循環器内科 助手
2002年 東京都老人医療センター CCU医長
2005年 東京都老人医療センター 循環器科部長
2009年 東京都健康長寿医療センター 内科総括部長
2012年 東京都健康長寿医療センター 副院長

論文

• 1. Minor ST-T changes on electrocardiograms are associated with reduced constructive myocardial work in hypertensive patients with a preserved ejection fraction. Hypertens Res. 2022 Jun 17. doi: 10.1038/s41440-022-00957-6.

  Nakamura S, Ishikawa J, Sakurayama C, Shimizu R, Toba A, Yamamoto A, Murata T, Harada K.

• 2. Proteome Analysis Demonstrates Involvement of Endoplasmic Reticulum Stress Response in Human Myocardium with Subclinical Left Ventricular Diastolic Dysfunction. Geriatr Gerontol Int. 2021 Jul;21(7):577-583.

  Sato M, Tsumoto H, Toba A, Soejima Y, Arai T, Harada K, Miura Y, Sawabe M.

• 3. Efficacy and Safety of Favipiravir in Moderate COVID-19 Pneumonia Patients without Oxygen Therapy: A Randomized, Phase III Clinical Trial. Infectious Diseases and Therapy. 2021 Dec; 10(4): 2489-2509.

  Shinkai M, Harada K, et al.

• 4. The relationship between blood pressure and cognitive function. Int J Cardiol Cardiovasc Risk Prev. 2021 Aug 8; 10: 200104. doi: 10.1016/j.ijcrp.2021.200104.

  Ishikawa J, Seino S, Kitamura A, Toba A, Toyoshima K, Tamura Y, Watanabe Y, Fujiwara Y, Inagaki H, Awata S, Shinkai S, Araki A, Harada K.

• 5. Delay in seeking treatment before emergent heart failure readmission and its association with clinical phenotype. J Intensive Care. 2020 Aug 26; 8: 65.

  Takei M, Harada K, Shiraishi Y, Matsuda J, Iwasaki Y, Yamamoto Y, Matsushita K, Miyazaki T, Miyamoto T, Iida K, Tanimoto S, Nagatomo Y, Hosoda T, Kohsaka S, Yamamoto T, Nagao K, Takayama M.

• 6. Benefit and harm of intravenous vasodilators across the clinical profile spectrum in acute cardiogenic pulmonary oedema patients. Eur Heart J Acute Cardiovasc Care. 2020 Aug; 9(5): 448-458.

  Shiraishi Y, Kohsaka S, Katsuki T, Harada K, Miyazaki T, Miyamoto T, Matsushita K, Iida K, Takei M, Yamamoto Y, Shindo A, Kitano D, Nagatomo Y, Jimba T, Yamamoto T, Nagao K, Takayama M; for Tokyo CCU Network Scientific Committee.

• 7. Serum growth differentiation factor 15 level is associated with muscle strength and lower extremity function in older patients with cardiometabolic disease. Geriatr Gerontol Int. 2020 Oct; 20(10): 980-987.

  Oba K, Ishikawa J, Tamura Y, Fujita Y, Ito M, Iizuka A, Fujiwara Y, Kodera R, Toba A, Toyoshima K, Chiba Y, Mori S, Tanaka M, Ito H, Harada K, Araki A.

• 8. Effectiveness of a far-infrared low-temperature sauna program on geriatric syndrome and frailty in community-dwelling older people. Geriatr Gerontol Int. 2020 Oct; 20(10): 892-898.

  Sugie M, Harada K, Takahashi T, Nara M, Fujimoto H, Kyo S, Ito H.

• 9. Orthostatic blood pressure rise is associated with frailty in older patients. Geriatr Gerontol Int. 2019 Jun; 19(6): 525-529.

  Toba A, Ishikawa J, Suzuki A, Tamura Y, Araki A, Harada K.

• 10. Ezetimibe Lipid-Lowering Trial on Prevention of Atherosclerotic Cardiovascular Disease in 75 or Older (EWTOPIA 75): A Randomized, Controlled Trial. Circulation. 2019 Sep 17; 140(12): 992-1003.

  Ouchi Y, Sasaki J, Arai H, Yokote K, Harada K, Katayama Y, Urabe T, Uchida Y, Hayashi M, Yokota N, Nishida H, Otonari T, Arai T, Sakuma I, Sakabe K, Yamamoto M, Kobayashi T, Oikawa S, Yamashita S, Rakugi H, Imai T, Tanaka S, Ohashi Y, Kuwabara M, Ito H.

• 11. Younger- vs Older-Old Patients with Heart Failure with Preserved Ejection Fraction. J Am Geriatr Soc. 2019 Oct; 67(10): 2123-2128.

  Matsushita K, Harada K, Miyazaki T, Miyamoto T, Kohsaka S, Iida K, Yamamoto Y, Nagatomo Y, Yoshino H, Yamamoto T, Nagao K, Takayama M.

• 12. Different prognostic associations of beta-blockers and diuretics in heart failure with preserved ejection fraction with versus without high blood pressure. J Hypertens. 2019 Mar; 37(3): 643-649.

  Matsushita K, Harada K, Miyazaki T, Miyamoto T, Kohsaka S, Iida K, Tanimoto S, Takei M, Hosoda T, Yamamoto Y, Shiraishi Y, Yoshino H, Yamamoto T, Nagao K, Takayama M.

• 13. Prevalence of frailty, cognitive impairment, and sarcopenia in outpatients with cardiometabolic disease in a frailty clinic. BMC Geriatr. 2018 Nov 6; 18(1): 264.

  Tamura Y, Ishikawa J, Fujiwara Y, Tanaka M, Kanazawa N, Chiba Y, Iizuka A, Kaito S, Tanaka J, Sugie M, Nishimura T, Kanemaru A, Shimoji K, Hirano H, Furuta K, Kitamura A, Seino S, Shinkai S, Harada K, Kyo S, Ito H, Araki A.

• 14. Peak exercise stroke volume effects on cognitive impairment in community-dwelling people with preserved ejection fraction. ESC Heart Fail. 2018 Oct; 5(5): 876-883.

  Sugie M, Harada K, Takahashi T, Nara M, Kawai H, Fujiwara Y, Ishikawa J, Tanaka J, Koyama T, Kim H, Sengoku R, Fujimoto H, Obuchi S, Kyo S, Ito H.

• 15. Effects of glycemic control on in-hospital mortality among acute heart failure patients with reduced, mid-range, and preserved ejection fraction. Heart Vessels. 2018 Sep; 33(9): 1022-1028.

  Matsushita K, Harada K, Miyazaki T, Miyamoto T, Iida K, Tanimoto S, Yagawa M, Takei M, Nagatomo Y, Hosoda T, Yoshino H, Yamamoto T, Nagao K, Takayama M.

• 16. Japanese version of the Montreal Cognitive Assessment cut-off score to clarify improvement of mild cognitive impairment after exercise training in community-dwelling older adults. Geriatr Gerontol Int. 2018 Jun; 18(6): 833-838.

  Nara M, Sugie M, Takahashi T, Koyama T, Sengoku R, Fujiwara Y, Obuchi S, Harada K, Kyo S, Ito H.

• 17. Impact of Triggering Events on Outcomes of Acute Heart Failure. Am J Med. 2018 Feb; 131(2): 156-164.e2.

  Shiraishi Y, Kohsaka S, Abe T, Harada K, Miyazaki T, Miyamoto T, Iida K, Tanimoto S, Yagawa M, Takei M, Nagatomo Y, Hosoda T, Yamamoto T, Nagao K, Takayama M; Tokyo CCU Network Scientific Committee.

• 18. Impact of age on left ventricular geometry and diastolic function in elderly patients with treated hypertension. Blood Press. 2017 Mar; 22: 1-8.

  Toba A, Kariya T, Aoyama R, Ishiyama T, Tsuboko Y, Takeda K, Fujimoto H, Shimokado K, Harada K.

• 19. Relationship between skeletal muscle mass and cardiac function during exercise in community-dwelling older adults. ESC Heart Fail. 2017 Nov; 4(4): 409-416.

  Sugie M, Harada K, Takahashi T, Nara M, Ishikawa J, Koyama T, Kim H, Tanaka J, Fujimoto H, Obuchi S, von Haehling S, Kyo S, Ito H.

• 20. Femoral muscle mass relates to physical frailty components in community-dwelling older people. Geriatr Gerontol Int. 2017 Oct; 17(10): 1636-1641.

  Takahashi T, Sugie M, Nara M, Koyama T, Obuchi SP, Harada K, Kyo S, Ito H.

• 21. Waon Therapy for Managing Chronic Heart Failure- Results From a Multicenter Prospective Randomized WAON-CHF Study. Circ J. 2016; 80(4): 827-34.

  Tei C, Imamura T, Kinugawa K, Inoue T, Masuyama T, Inoue H, Noike H, Muramatsu T, Takeishi Y, Saku K, Harada K, Daida H, Kobayashi Y, Hagiwara N, Nagayama M, Momomura S, Yonezawa K, Ito H, Gojo S, Akaishi M, Miyata M, Ohishi M; WAON-CHF Study Investigators.

• 22. Nocturnal Blood Pressure Pattern Affects Left Ventricular Remodeling and Late Gadolinium Enhancement in Patients with Hypertension and Left Ventricular Hypertrophy. PLoS One. 2013 Jun 26; 8(6): e67825.

  Yokota H, Imai Y, Tsuboko Y, Tokumaru AM, Fujimoto H, Harada K.

• 23. Association between prehospital time interval and short-term outcome in acute heart failure patients. J Card Fail. 2011 Sep; 17(9): 742-7.

  Takahashi M, Kohsaka S, Miyata H, Yoshikawa T, Takagi A, Harada K, Miyamoto T, Sakai T, Nagao K, Sato N, Takayama M; Tokyo CCU Network Council.

• 24. High lipoprotein(a) level promotes both coronary atherosclerosis and myocardial infarction: a path analysis using a large number of autopsy cases. Heart. 2009; 95: 1997-2002.

  M Sawabe, N Tanaka, K Nakahara, A Hamamatsu, K Chida, T Arai, K Harada, T Inamatsu, T Ozawa, M M Naka, S Matsushita

• 25. Workplace hypertension is associated with obesity and family history of hypertension. Hypertens Res. 2006; 29(12): 969-976.

  Harada K, Karube Y, Saruhara H, Takeda K, Kuwajima I.

• 26. Sustained progression and loss of the gender-related difference in atherosclerosis in the very old: A pathological study of 1074 consecutive autopsy cases. Atherosclerosis. 2006; 186(2): 374-379.

  Sawabe M, Harada K, et al.

• 27. Left ventricular relaxation abnormality is detectable by analysis of the relaxation time constant in patients with atrial fibrillation. Jpn Circ J. 2001; 65(7): 610-616.

  Harada K, et al.

• 28. Vascular endothelial growth factor administration in chronic myocardial ischemia. Am J Physiol. 1996; 270(5 Pt 2): H1791-802.

  Harada K, et al.

• 29. Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis. Nat Med. 1995; 1(10): 1085-1089.

  Pearlman JD, Harada K, et al.

• 30. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts. J Clin Invest. 1994; 94(2):623-630.

  Harada K, et al.

• 31. Acidemia and hypernatremia enhance postischemic recovery of excitation-contraction coupling. Circ Res. 1994; 74(6): 1197-1209.

  Harada K, et al.

著書

• 1. 超高齢者循環器疾患診療の術—先生のお悩みはなんですか？— Heart View, 2020.

• 2. 高血圧でもフレイルは防げる. 小学館クリエイティブ, 2019

• 3. グロスマン・ベイム心臓カテーテル検査・造影・治療法(原書第8版) 南江堂, 2017年

• 4. 高齢心不全患者の治療に関するステートメント2016, 2016

その他

• 1. 【テレビ出演】「名医とつながる！たけしの家庭の医学」2011〜2019年25回

• 2. 【テレビ出演】「林修のレッスン！今でしょ」2022年

• 3. 【テレビ出演】「草野仁の名医が寄りそう！カラダ若返りTV」2022年