齋藤 昭彦 さいとう あきひこ 先生

来歴等

略歴

1991年　新潟大学医学部卒業
1991年　聖路加国際病院小児科　レジデント
1994年　同チーフレジデント
1995年　Harbor UCLA メディカルセンター　アレルギー臨床免疫部門　リサーチフェロー
1997年　南カルフォルニア大学（USC）小児科　レジデント
2000年　カルフォルニア大学サンディエゴ校（UCSD）小児感染症科　クリニカルフェロー
2003年　UCSD 講師
2004年　UCSD　助教授　（現在も併任）
2008年　国立成育医療センター　第一専門診療部　感染症科　医長
2008年　学位取得（医学博士）
2009年　東邦大学医学部医学科　客員教授（併任）
2010年　国立成育医療研究センター　感染症科　医長
国立成育医療研究センター　感染防御対策室　室長
2010年　国立成育医療研究センター　ワクチンセンター長
2011年　新潟大学大学院医歯学総合研究科小児科学分野　教授
国立成育医療研究センター　客員診療部長

論文

(*corresponding authors)
Saitoh A, Ohya T, Yoshida S, Hosoya R, Nishimura K. Stevens-Johnson syndrome with Mycoplasma pneumoniae infection. Acta Ped Jpn 1995;37:113-115.
Aizaki H, Saito(h) A, Kusakawa I, Ashiwara H, Nagamori S, Toda G, Matsuura Y, Miyamura T. Mother to child transmission of a hepatitis C virus variant with an insertional mutation in its hypervariable region. J Hepatol 1996;24:603-613.
Guerrero M, Kruger S, Saitoh A, Sorvillo F, Cheng KJ, French C, Beall G. Pneumonia in HIV-infected patients: A case control survey of factors involved in risk and prevention. AIDS 1999;13:1971-1975.
Saitoh A, Homans J, Kovacs A. Fluconazole treatment of coccidioidal meningitis in children: Two case reports and a review of literature. Pediatr Infect Dis J 2000;19:1204-1208.
Saitoh A, Beall B, Nizet V. Fluminant bacterial meningitis complicating sphenoid sinusitis in children. Pediatric Emergency Care 2003;19: 415-7.
Saitoh A, Powell CA, Fenton T, Douglas SD, Starr SE, Spector SA. Longitudinal analysis of lymphocyte ratios and HIV-1 intracellular DNA Levels in children. J Infect Dis 2004;189:1216-20.
Saitoh A, Viani RM, Schrier RD, Spector SA. Treatment of infants co-infected with HIV-1 and cytomegalovirus with combination antiretrovirals and ganciclovir. J Allergy Clin Immunol 2004;114:983-5.
Saitoh A, Sawyer MH, Leake JAD. Acute disseminated encephalomyelitis associated with enteroviral infection. Pediatr Infect Dis J 2004;23:1174-75.
Saitoh A, Singh KK, Fenton T, Powell CA, Fletcher CV, Brundage R, Starr S, Spector SA. An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children. AIDS 2005;19:371-80.
Saitoh A, Pong A, Waecker NW, Jr, Leake JA, Nespeca M, Bradley JS.
Prediction of neurological sequelae in childhood tuberculous meningitis: a review of 20 cases and proposal of a novel scoring system. Pediatr Infect Dis J 2005;24:207-12.
Saitoh A, Hull AD, Franklin P, Spector SA. Myelomeningocele in an infant with intrauterine exposure to efavirenz. J Perinatol 2005;25:555-556.
Saitoh A, Singh KK, Sandall S, Powell CA, Fenton T, Fletcher CV, Spector SA.
Association of CD4+ lymphocyte counts and new thymic emigrants in HIV-1 infected children during successful HAART. J Aller Clin Immunol 2006;117:909-915.
Spector SA, Saitoh A. Mitochondrial dysfunction: prevention of HIV-1 mother-to-infant transmission outweighs fear. AIDS 2006;20:1777-78.
Saitoh A*, Fletcher CV, Brundage R, Alvero C, Fenton T, Hsia K, Spector SA. Efavirenz pharmacokinetics in HIV-1 infected children are associated with CYP2B6-G516T polymorphism. J Acquir Immune Defic Syndr 2007;45:280-285.
Saitoh A*, Sarles E, Capparelli E, Aweeka F, Kovacs A, Burchett SK, Wiznia A, Nachman S, Fenton S, Spector SA. CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1 infected children. AIDS 2007:21:2191-2200.
Lowenhaupt EA, Matson K, Qureishi B, Saitoh A, Pugatch D. Psychosis in a twelve-year old HIV-positive girl with elevated serum levels of efavirenz. Clin Infect Dis 2007; 45:e128-130.
Saitoh A*, Fenton T, Alvero C, Fletcher CV, Spector SA. Impact of nucleoside reverse transcriptase inhibitors on mitochondria in HIV-1 infected children receiving HAART. Antimicrob Agents Chemother 2007;51:4236-42.
Saitoh A*, Foca M, Viani RM, Heffernan-Vacca S, Vaida F, Lujan-Zilbermann J, Emmanuel PJ, Deville JG, Spector SA. Clinical outcome in perinatally acquired HIV-infected children and adolescents after unstructured treatment interruption. Pediatrics 2008; 121:e513-e521.
Saitoh A, Spector SA. Effect of genetic variations on the pharmacokinetics of non-nucleoside reverse transcriptase inhibitors. Future HIV Therapy 2008; 2:69-81.
Torno MS, Witt MD, Saitoh A, Fletcher CV. Successful use of reduced dose efavirenz in an HIV-Infected patient: Case report and review of the literature. Pharmacotherapy 2008;28:782-7.
Saitoh A*, Haas RH, Naviaux RK, Salva NG, Wong JK, Spector SA. Impact of nucleoside reverse transcriptase inhibitors (NRTIs) on mitochondrial DNA and RNA in human skeletal muscle cells. Antimicrob Agents Chemother 2008;52:2825-30.
Kamiyama S, Saitoh A*. Indication of Oseltamivir in Children and Adolescents with Chronic Underling Diseases. [E-letter] Pediatrics (August 31, 2009), http://pediatrics.aappublications.org/cgi/eletters/124/1/170 (accessed August 31, 2009).
Saitoh A*, Sarles E, Capparelli E, Aweeka F, Singh KK, Kovacs A, Burchett SK, Wiznia A, Nachman S, Fenton S, Spector SA. CYP2C19 Genetic Variants Affect Nelfinavir Pharmacokinetics and Virologic Response in HIV-1 Infected Children Receiving HAART. J Acquir Immune Defic Syndr 2010;54:285-9.
Ohishi A, Takahashi S, Ito Y, Ohishi Y, Tsukamoto K, Nanba Y, Ito N, Kakiuchi S, Saitoh A, Morotomi M, Nakamura T. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr 2010;156:679-81.
Shoji K, Ito Y, Inoue N, Adachi S, Fujimaru T, Nakamura T, Nishina S, Azuma N, and Saitoh A*. Is a Six-Week Course of Ganciclovir Therapy Effective for Chorioretinitis in Infants with Congenital Cytomegalovirus Infection? J Pediatr 2010;157:331-3.
Ogimi C, Tanaka R, Saitoh A, Oh-ishi T. Immunogenicity of Influenza Vaccine in Children with Pediatric Rheumatic Diseases Receiving Immunosuppressive Agents. Pediatr Infect Dis J 2011;30:208-11.
Katsuta T, Kato H, Kaneko Y, Kaneko M, Misaki Y, Kimura M, Shoji K, Nakao H, Saitoh A*. Complete Atrioventricular Block without Myocarditis as a Complication of Varicella in Children. Pediatr Infect Dis J 2011;30:445-6.
Shoji K, Saitoh A*. Bacteremia Associated with Intravascular Catheter Colonized Staphylococcus aureus in Children. J Hosp Infect 2011;78:65-6.
Saitoh A*, Dominguez D, Stani TM, Rossi S, Capparelli E, Spector SA. Intracellular Concentrations of Non-Nucleoside Reverse Transcriptase Inhibitors and Its Potential Role on Apoptosis in Peripheral Blood Mononuclear Cells. J Antivir Antiretrovir 2011;3: 14-19.
Saitoh A*, Sakamoto S, Fukuda A, Shigeta T, Kakiuchi T, Kamiyama S, Katsuta T, Shoji K, Ogimi C, Kasahara M. Universal Preemptive Therapy for Cytomegalovirus Infections in Childrenafter Live-Donor Liver Transplantation. Transplantation 2011 27;92:930-5.
Hanaoka M, Saitoh A, Kubo T. Discrepancy between human T-cell lymphotropic virus type I (HTLV-I) screening test and confirmatory tests in non-endemic areas. J Obstetrics and Gynaecology Research 2012;38:793-6.
Saitoh A*, Nagai A, Tenjinbaru K, Li P, Vaughn DW, Roman F, Kato T. Persistence of immunological response six months after vaccination with an AS03-adjuvanted H1N1 2009 influenza vaccine: an open-label, randomised trial in Japanese children aged 6 months to 17 years. Hum Vaccine Immunother 2012;8:749-58.
Saitoh A*, Okabe N. Current Issues with the Immunization Program in Japan: Can we Fill the "Vaccine Gap"? Vaccine 2012 30:4752-6.
Ogimi C, Shoji K, Katsuta T, Watanabe Y, Saitoh A. Utility of Gram Stain of Endotracheal Aspirates on Empiric Therapy in Children with Hospital-Acquired Pneumonia. J Infect 2012;65:368-70.
Shoji K, Komuro H, Miyata I, Miyairi I, Saitoh A*. Dermatologic Manifestations of Human Parechovirus Type 3 Infection in Neonates and Infants. Pediatr Infect Dis J 2013;32:233-6.
Miyata I, Saitoh A. Detection of enteroviral RNA from preserved umbilical cord. J Clin Virol 2013;56:358-9.
Katsuta T, Shoji K, Watanabe Y, Saitoh A*. Treatment of Pyelonephritis Caused by Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Children. Pediatr Infect Dis J 2013;32:417-9.
Saitoh A, Nagata S, Saitoh A, Tsukahara Y, Vaida F, Sonobe T, Kamiya H, Naruse T, Murashima S. Perinatal Immunization Education Improves Immunization Rates and
Knowledge: A randomized controlled trial. Prev Med 2013 56:398-405.
Funaki T, Shoji K, Yotani N, Katsuta T, Miyazaki O, Nosaka M, Masaki H, Sakai K, Saitoh A*. The Value of Radiographic Findings for the Progression of Pandemic 2009 Influenza A/H1N1 Virus Infection. BMC Infect Dis. 2013;13:516.
Shoji K, Komuro H, Kobayashi Y, Shike T, Funaki T, Katsuta T, Miyata I, Saitoh A*. An Infant with Human Parechovirus Type 3 Infection with a Distinctive Rash on the Extremities. Pediatr Dermatol 2014;31:258-9.
Aizawa Y, Oishi T, Tsukano S, Taguchi T, Saitoh A. Clinical Utility of Loop- Mediated Isothermal Amplification for Rapid Diagnosis of Mycoplasma pneumoniae in Children. J Med Microbiol. 2014; 63:248-51.
Miyata M, Hanaoka N, Okabe N, Fujimoto T, Sakamoto S, Kasahara M, Saitoh A*. Echovirus 3 as Another Enterovirus Causing Life-threatening Neonatal Fulminant Hepatitis. J Clin Virol 2014; 59:132-4.
Watanabe T, Takahashi M, Shoji K, Yamada K, Yamada Y, Tanaka H, Ishihama H, Miyata I, Saitoh A, Kanamori Y. Human Parechovirus-3 Infection Mimicking Hirschsprung-Associated Enterocolitis. J Pediatr Surg Case Rep 2014;2:58-60.
Saitoh A*, Okabe N. Recent Progress and Concerns Regarding the Japanese Immunization Program: Addressing the “Vaccine Gap”. Vaccine 2014;32:4253-8.
Miyata I, Kubo T, Miyairi I, Saitoh A, Morimoto N. Successful detection and genotyping of rubella virus from preserved umbilical cord of patients with congenital rubella syndrome. Clin Infect Dis 2015;60:605-7.
Shoji K, Shinjoh M, Horikoshi Y, Watanabe Y, Sugita K, Tame T, Iwata S, Miyairi I, Saitoh A. High Rate of Inducible Clindamycin Resistance in Staphylococcus aureus Isolates - A Multicenter Study in Tokyo, Japan. J Infect Chemother 2015;21:81-3.
Funaki T, Shoji K, Miyata I, Sakamoto S, Kasahara M, Yoshii H, Miyairi I, Saitoh A*. Serostatus Following Live Attenuated Vaccination Given Prior to Pediatric Liver Transplantation. Liver Transplantation 2015;21:774-83.
Saitoh A*, Aizawa Y, Sato I, Hirano H, Sakai H, Mori M. Skin Thickness in Young Infants and Adolescents: Applications for Intradermal Vaccination. Vaccine 2015;33:3384-91.
Aizawa Y, Watanabe K, Oishi T, Hirano H, Hasegawa I, Saitoh A*. A Role of Maternal Antibodies in Human Parechovirus Type 3 Infection in Neonates and Young Infants. Emerg Infect Dis 2015;21:1966-72.
Shoji K, Funaki T, Kasahara M, Sakamoto S, Vaida F, Ito K, Miyairi S, Saitoh A*. Risk Factors for Bloodstream Infection after Living-Donor Liver Transplantation in Children. Pediatr Infect Dis J 2015;34:1063-8.
Suzuki R, Takeuchi K, Gunji T, Murayama M, Ando A, Hasegawa J, Saitoh A. Mycoplasma hominis as a Cause of Septic Hip Arthritis in a Neonate. J Med Microbiol Case Rep 2015 2. doi: 10.1099/jmmcr.0.000078
Aizawa Y, Yamanaka T, Watanabe K, Oishi T, Saitoh A*. Asymptomatic Children Might Transmit Human Parechovirus Type 3 to Neonates and Young Infants. J Clin Virol 2015;70:105-8.
Suga S, Chang B, Asada K, Akeda H, Nishi J, Okada K, Wakiguchi H, Oda M, Ishiwada N, Saitoh A, Oishi T, Hosoya M, Togashi T, Oishi K, Ihara T. Nationwide Population-Based Surveillance on Invasive Pneumococcal Disease in Japanese Children: Effects of the Seven-valent Pneumococcal Conjugate Vaccine. Vaccine 2015;33:6054-60.
Saitoh A, Saitoh A, Sato I, Shinozaki T, Nagata S. Current practices and needs regarding perinatal childhood immunization education for Japanese mothers. Vaccine 2015;33:6128-33.
Nirei J, Aizawa Y, Okazaki M, Kobayashi A, Onozuka J, Numata O, Oishi T, Saitoh A*. Human Parechovirus Type 3 Infection: A Cause of Apnea in Premature Infants. Pediatr Int 2016;58:400-402.
Nakano T, Watanabe M, Saitoh A, Suga S, Oishi K, Nishimura N. Symposium report of the 17th annual meeting of the Japanese Society for Vaccinology, 2013 Bacterial vaccines: Effectiveness and issues. Vaccine 2016;34:1956-7.
Ito K, Kasahara, Saitoh A, Honda H, Miyairi I. High Rate of Vaccine Failure after Administration of Acellular Pertussis Vaccine Pre- and Post-Liver Transplantation in Children at a Children’s Hospital in Japan. Transpl Infect Dis 2016;18:150-4.
Aizawa Y, Suzuki Y, Watanabe K, Oishi T, Saitoh A*. Clinical Utility of Serum Samples for Human Parechovirus Type 3 Infection in Neonates and Young Infants: The 2014 Epidemic in Japan. J Infect 2016;72:223-32.
Saitoh A*, Aizawa Y. Intradermal Vaccination for Infants and Children. Hum Vaccine & Immunother 2016;12:2447-55.
Saitoh A*. Re: Severe Human Parechovirus Infections in Infants and the Role of Older Siblings (Letter). Am J Epidemiol. 2016;184:603-604
Aizawa Y, Koyama A, Ishihara T, Onodera O, Saitoh A*. Performance of a real-time PCR–based approach and droplet digital PCR in detecting human parechovirus type 3 RNA. J Clin Virol. 2016;84:27-31.
Saitoh A, Saitoh A, Sato I, Shinozaki T, Kamiya H, Nagata S. Effect of Stepwise Perinatal Immunization Education: A Cluster-Randomized Controlled Trial. Vaccine 2017 (in press).
Aizawa Y, Izumita R, Saitoh A*. Human parechovirus type 3 infection: An emerging infection in neonates and young infants. J Infect Chemother (accepted).

著書

齋藤昭彦編　ネルソン小児感染症　医学書院　第2版　2016年

その他

• 【主な受賞】 有壬記念若手研究奨励賞　6/2008

• 【主な受賞】International Ambassador Award, Society for Healthcare and Epidemiology of America　3/2009

• 【主な受賞】Outstanding Researcher Award, 5th Asian Congress of Pediatric Infectious Diseases, Taipei, Taiwan　9/2010

• 【主な受賞】新潟大学　学長教育賞　3/2014