藤田 順之 ふじた のぶゆき 先生

来歴等

略歴

2000年 慶應義塾大学医学部 卒業
2007年 慶應義塾大学医学部 博士課程 卒業
2010年 米国Thomas Jefferson大学整形外科 留学
2013年 慶應義塾大学医学部整形外科学教室 助教
2017年 慶應義塾大学医学部整形外科学教室 専任講師
2019年 藤田医科大学整形外科学講座 教授
2022年 藤田医科大学病院 副院長

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論文

• 1. CD24 is expressed specifically in the nucleus pulposus of intervertebral discs. Biochem Biophys Res Commun. 2005, 338, 1890-1896.

  Fujita N, Miyamoto T, Imai J, Hosogane N, Suzuki T, Yagi M, Morita K, Ninomiya K, Miyamoto K, Takaishi H, Matsumoto M, Morioka H, Yabe H, Chiba K, Watanabe S, Toyama Y, Suda T.

• 2. Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc. Biochem Biophys Res Commun. 2008, 372, 362-372.

  Fujita N, Imai J, Suzuki T, Yamada M, Ninomiya K, Miyamoto K, Iwasaki R, Morioka H, Matsumoto M, Chiba K, Watanabe S, Suda T, Toyama Y, Miyamoto T.

• 3. HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc. J Bone Min Res. 2012, 27, 401-412.

  Fujita N, Chiba K, Shapiro IM, Risbud MV.

• 4. Expression of Prolyl Hydroxylases (PHDs) is Selectively Controlled by HIF-1 and HIF-2 in Nucleus Pulposus Cells of the Intervertebral Disc: Distinct Roles of PHD2 and PHD3 in Controlling HIF-1α Activity in Hypoxia. J Biol Chem. 2012, 287, 16975-16986.

  Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV.

• 5. Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of TNF-α on cells of the nucleus pulposus through co-activation of NF-κB/p65 signaling. J Biol Chem. 2012, 287, 39942-39953.

  Fujita N, Gogate SS, Chiba K, Toyama Y, Shapiro IM, Risbud MV.

• 6. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells. FASEB J. 2014, 28, 2455-2465.

  Fujita N, Hirose Y, Tran CM, Chiba K, Miyamoto T, Toyama Y, Shapiro IM, Risbud MV.

• 7. Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration. Arthritis Res Ther. 2015, 17, 316.

  Suzuki S, Fujita N*, Hosogane N, Watanabe R, Hikata T, Iwanami A, Watanabe K, Ishii K, Toyama Y, Takubo K, Horiuchi K, MiyamotoT, Nakamura M, Matsumoto M.

• 8. Potential Involvement of Obesity-associated Chronic Inflammation in the Pathogenesis of Idiopathic Spinal Epidural Lipomatosis. Spine. 2016, 41, E1402-E1407.

  Fujita N, Hosogane N, Hikata T, Iwanami A, Watanabe K, Shiono Y, Okada E, Ishikawa M, Tsuji T, Shimoda M, Horiuchi K, Nakamura M, Matsumoto M, Ishii K.

• 9. A chordoma-derived cell line U-CH1-N recapitulates the biological properties of notochordal nucleus pulposus cells. J Orthop Res. 2016, 34, 1341-1350.

  Fujita N, Suzuki S, Watanabe K, Ishii K, Watanabe R, Shimoda M, Takubo K, Tsuji T, Toyama Y, Miyamoto T, Horiuchi K, Nakamura M, Matsumoto M.

• 10. Potential involvement of the IL-6/JAK/STAT3 pathway in the pathogenesis of intervertebral disc degeneration. Spine. 2017, 42, E817-E824.

  Suzuki S, Fujita N*, Fujii T, Yagi M, Watanabe K, Ishii K, MiyamotoT, Horiuchi K, Nakamura M, Matsumoto M.

• 11. Presence of Modic type 1 change increases risk of postoperative pyogenic discitis following decompression surgery for lumbar canal stenosis. J Orthop Sci. 2017, 22, 988-993.

  Ninomiya K, Fujita N*, Hosogane N, Hikata T, Watanabe K, Tsuji O, Nagoshi N, Yagi M, Kaneko S, Fukui Y, Koyanagi T, Shiraishi T, Tsuji T, Nakamura M, Matsumoto M, Ishii K.

• 12. Idiopathic Spinal epidural fat accumulation is associated with hyperlipidemia. Spine. 2018, 43, E468-E473.

  Ishihara S, Fujita N*, Yagi M, Tsuji T, Michikawa T, Nishiwaki Y, Fukui Y, Horiuchi K, Ishii K, Nakamura M, Matsumoto M, Watanabe K.

• 13. The Unfolded Protein Response Mediated by PERK is casually related to the Pathogenesis of Intervertebral Disc Degeneration. J Orthop Res. 2018, 36, 1334-1345.

  Fujii T, Fujita N*, Suzuki S, Tsuji T, Takaki T, Umezawa K, Watanabe K, Miyamoto T, Horiuchi K, Matsumoto M, Nakamura M.

• 14. Spinal epidural lipomatosis is a previously unrecognized manifestation of metabolic syndrome. Spine J. 2019, 19, 493-500.

  Ishihara S, Fujita N*, Azuma K, Michikawa T, Yagi M, Tsuji T, Takayama M, Matsumoto H, Nakamura M, Matsumoto M, Watanabe K.

• 15. Lumber spinal canal stenosis leads to locomotive syndrome in elderly patients. J Orthop Sci. 2019, 24, 19-23.

  Fujita N, Sakurai A, Miyamoto A, Michikawa T, Tsuji O, Nagoshi N, Okada E, Yagi M, Otaka Y, Tsuji T, Kono H, Ishii K, Nakamura M, Matsumoto M, Watanabe K.

• 16. Impact of lumbar hypolordosis on the incidence of symptomatic postoperative spinal epidural hematoma after decompression surgery for lumbar spinal canal stenosis. Eur Spine J. 2019, 28, 87-93.

  Fujita N, Michikawa T, Yagi M, Suzuki S, Tsuji O, Nagoshi N, Okada E, Tsuji T, Nakamura M, Matsumoto M, Watanabe K.

• 17. Potential involvement of Semaphorin 3A in maintaining intervertebral disc tissue homeostasis. J Orthop Res. 2019, 37, 972-980.

  Mima Y, Suzuki S, Fujii T, Morikawa T, Tamaki S, Takubo K, Shimoda M, Miyamoto T, Watanabe K, Matsumoto M, Nakamura M, Fujita N*.

• 18. Stride length of elderly patients with lumbar spinal stenosis: Multi-center study using the Two-Step test. J Orthop Sci. 2019, 24, 787-792.

  Fujita N, Sakurai A, Miyamoto A, Michikawa T, Otaka Y, Suzuki S, Tsuji O, Nagoshi N, Okada E, Yagi M, Tsuji T, Kono H, Ishii K, Nakamura M, Matsumoto M, Watanabe K.

• 19. Potential association of metabolic and musculoskeletal disorders with lumbar intervertebral disc degeneration: Cross-sectional study using medical checkup data. J Orthop Sci. 2019, 25, 384-388.

  Fujita N, Ishihara S, Michikawa T, Azuma K, Suzuki S, Tsuji O, Nagoshi N, Okada E, Yagi M, Tsuji T, Takayama M, Matsumoto H, Nakamura M, Matsumoto M, Watanabe K.

• 20. Impact of fusion for adolescent idiopathic scoliosis on lung volume measured with computed tomography. Eur Spine J. 2019, 28, 2034-2041.

  Fujita N, Yagi M, Michikawa T, Yamada Y, Suzuki S, Tsuji O, Nagoshi N, Okada E, Tsuji T, Nakamura M, Matsumoto M, Watanabe K.

• 21. Lumbar spinal surgery improves locomotive syndrome in elderly patients with lumbar spinal canal stenosis: A multicenter prospective study. J Orthop Sci. 2020, 25, 213-218.

  Fujita N, Michikawa T, Miyamoto A, Sakurai A, Otaka Y, Suzuki S, Tsuji O, Nagoshi N, Okada E, Yagi M, Tsuji T, Kono H, Ishii K, Nakamura M, Matsumoto M, Watanabe K.

• 22. Negative impact of spinal epidural lipomatosis on the surgical outcome of posterior lumbar spinous-splitting decompression surgery: a multicenter retrospective study. Spine J. 2019, 19, 1977-1985.

  Fujita N, Ishihara S, Michikawa T, Suzuki S, Tsuji O, Nagoshi N, Okada E, Yagi M, Tsuji T, Kono H, Nakamura M, Matsumoto M, Watanabe K.

• 23. Impact of knee osteoarthritis on surgical outcomes of lumbar spinal canal stenosis. J Neurosurg Spine. 2019, in press.

  Ozaki M, Fujita N*, Miyamoto A, Suzuki S, Tsuji O, Nagoshi N, Okada E, Yagi M, Tsuji T, Nakamura M, Matsumoto M, Kono H, Watanabe K.

• 24. Quantitative analysis of intervertebral disc degeneration using Q-space imaging in a rat model. J Orthop Res. 2020, 38, 2220-2229.

  Nakashima D, Fujita N*, Hata J, Komaki Y, Suzuki S, Nagura T, Fujiyoshi K, Watanabe K, Tsuji T, Okano H, Jinzaki M, Matsumoto M, Nakamura M.

• 25. Efficacy of hyaluronic acid on intervertebral disc inflammation: An in vitro study using notochordal cell lines and human disc cells. J Orthop Res. 2020, in press.

  Yamamoto T, Suzuki S, Fujii T, Mima Y, Watanabe K, Matsumoto M, Nakamura M, Fujita N*.

• 26. Collagen profiling of ligamentum flavum in patients with lumbar spinal canal stenosis. J Orthop Sci. 2020, in press.

  Takeda H, Nagai S, Ikeda D, Kaneko S, Tsuji T, Fujita N*.

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著書

• 1. 藤田順之, 千葉一裕. 最新整形外科学大系 10 脊椎・脊髄 脊椎・脊髄の発生と成長，奇形 椎間板. 2008年. 14-16.

• 2. 岡田　英次朗, 藤田順之. MIST手技における側方経路椎体間固定術(LIF)入門―OLF・XLIF®を中心に. 前縦靭帯損傷. 2018年. 215～218.

• 3. 藤田順之. 整形外科専門研修マニュアル. 診断基本手技 (脊椎の身体所見, 神経学的所見, 関節造影, 脊髄造影), 治療基本手技 (清潔操作, 麻酔法, 神経ブロック, 硬膜外ブロック, 薬物療法と医薬品副作用被害救済制度), 運動器疾患各論 (腰部脊柱管狭窄症, 後縦靱帯骨化症). 2018年. ページ多数.

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特許

• (登録特許) 藤田　順之他、特許第6251849号（特願2017-528983） 発明の名称：椎間板変性症、腰痛改善を処置するための医薬組成物、及び治療薬のスクリーニング方法

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受賞

• 1. 2nd International Philadelphia Spine Research Symposium; First Place Podium Award（2013）「HIF-1-PHD2 axis controls syndecan-4 expression in hypoxic nucleus pulposus cells: Syndecan-4 regulates Sox9 level」

• 2. 第4回日本若手脊椎外科研究会（JASA）; Best Presenter Award（2015） 「腰部硬膜外脂肪腫症の病態解明」

• 3. ORS PSRS 3rd International Philadelphia Spine Research Symposium; Second Place Poster Award (2015)「A chordoma-derived cell line U-CH1-N recapitulates the biological properties of notochordal nucleus pulposus cells」

• 4. 日本脊椎脊髄病学会　第12回Asia Traveling Fellowship（2017）

• 5. The International Society for the Study of the Lumbar Spine（ISSLS） best poster presentation award（2017）

• 6. 第7回日本若手脊椎外科研究会 (JASA); Best Presenter Award (2018) 「腰椎椎弓切除後の症候性硬膜外血腫発症の危険因子」

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