藤野 明浩 ふじの あきひろ 先生

来歴等

略歴

1996年 慶應義塾大学病院外科学 研修医
1997年 佐野厚生総合病院外科 医員
1998年 国立埼玉病院外科（現・国立病院機構埼玉病院） 医員
1999年 慶應義塾大学病院外科学（小児） 助手
2002年 独立行政法人国立病院機構栃木病院（現・栃木医療センター）小児外科 医員
2005年 マサチューセッツ総合病院小児外科研究室 研究員
2007年 国立成育医療センター（現・国立成育医療研究センター）第二専門診療部外科 医員
2007年 国立成育医療センター（現・国立成育医療研究センター）研究所生殖医療研究部 研究員（外科と兼任）
2012年 慶應義塾大学医学部外科学（小児） 助教
2012年 慶應義塾大学医学部外科学（小児） 専任講師
2016年 国立成育医療研究センター臓器・運動器病態外科部外科 医長
2018年 同　診療部長
2021年 国立成育医療研究センター脈管（血管・リンパ管）疾患 センター長（兼任）
2023年 慶應義塾大学医学部外科学（小児） 教授

論文

• 1. A role of cytokines in OK-432 injection therapy for cystic lymphangioma: an approach to the mechanism. J Pediatr Surg. 2003, 38:1806-9.

  Fujino A, Moriya Y, Morikawa Y, Hoshino K, Watanabe T, Shimojima N, Kitajima M.

• 2. Expression analysis and evolutionary conservation of the mouse germ cell-specific D6Mm5e gene. Dev Dyn. 2006, 235:2613-9.

  Arango NA, Huang TT, Fujino A, Pieretti-Vanmarcke R, Donahoe PK.

• 3. Mullerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in Mullerian duct regression. Development. 2006, 133:2359-69.

  Zhan Y, Fujino A, MacLaughlin DT, Manganaro TF, Szotek PP, Arango NA, Teixeira J, Donahoe PK.

• 4. Sexual dimorphism of g-protein subunit Gng13 expression in the cortical region of the developing mouse ovary. Dev Dyn. 2007, 236:1991-6.

  Fujino A, Pieretti-Vanmarcke R, Wong A, Donahoe PK, Arango NA.

• 5. ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet. 2008, 40:35-42.

  Onouchi Y, Gunji T, Burns JC, Shimizu C, Newburger JW, Yashiro M, Nakamura Y, Yanagawa H, Wakui K, Fukushima Y, Kishi F, Hamamoto K, Terai M, Sato Y, Ouchi K, Saji T, Nariai A, Kaburagi Y, Yoshikawa T, Suzuki K, Tanaka T, Nagai T, Cho H, Fujino A, Sekine A, Nakamichi R, Tsunoda T, Kawasaki T, Nakamura Y, Hata A.

• 6. Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics. Proc Natl Acad Sci U S A. 2008, 105:12469-73.

  Szotek PP, Chang HL, Brennand K, Fujino A, Pieretti-Vanmarcke R, Lo Celso C, Dombkowski D, Preffer F, Cohen KS, Teixeira J, Donahoe PK.

• 7. Cell migration and activated PI3K/AKT-directed elongation in the developing rat Müllerian duct. Dev Biol. 2009, 325:350-361.

  Fujino A, Arango NA, Zhan Y, Manganaro TF, Li X, MacLaughlin DT, Donahoe PK.

• 8. Common variants in CASP3 confer susceptibility to Kawasaki disease. Hum Mol Genet. 2010; 19: 2898-2906.

  Onouchi Y, Ozaki K, Buns JC, Shimizu C, Hamada H, Honda T, Terai M, Honda A, Takeuchi T, Shibuta S, Suenaga T, Suzuki H, Higashi K, Yasukawa K, Suzuki Y, Sasago K, Kemmotsu Y, Takatsuki S, Saji T, Yoshikawa T, Nagai T, Hamamoto K, Kishi F, Ouchi K, Sato Y, Newburger JW, Baker AL, Shulman ST, Rowley AH, Yashiro M, Nakamura Y, Wakui K, Fukushima Y, Fujino A, Tsunoda T, Kawasaki T, Hata A, Nakamura Y, Tanaka T.

• 9. Acoustic radiation force impulse imaging for assessing graft fibrosis after pediatric living donor liver transplantation: a pilot study. Liver Transpl. 2013;19(11):1202-1213.

  Tomita, H., K. Hoshino, Y. Fuchimoto, H. Ebinuma, K. Ohkuma, Y. Tanami, W. Du, Y. Masugi, N. Shimojima, A. Fujino, M. Kano, T. Fujimura, H. Ishihama, T. Shimizu, M. Tanabe, H. Saito, M. Sakamoto, T. Hibi, Y. Kitagawa and T. Kuroda (2013)

• 10. Long-term native liver fibrosis in biliary atresia: development of a novel scoring system using histology and standard liver tests. J Hepatol. 2014;60(6):1242-1248.

  Tomita, H., Y. Masugi, K. Hoshino, Y. Fuchimoto, A. Fujino, N. Shimojima, H. Ebinuma, H. Saito, M. Sakamoto and T. Kuroda (2014)

• 11. Development and Validation of a Novel Fibrosis Marker in Biliary Atresia during Infancy. Clin Transl Gastroenterol. 2015;6(11):e127.

  Tomita, H., Y. Fuchimoto, A. Fujino, K. Hoshino, Y. Yamada, Y. Masugi, M. Sakamoto, M. Kasahara, Y. Kanamori, A. Nakazawa, F. Yoshida, S. Akatsuka, M. Nakano and T. Kuroda (2015)

• 12. Spleen stiffness measurements by acoustic radiation force impulse imaging after living donor liver transplantation in children: a potential quantitative index for venous complications. Pediatr Radiol. 2015;45(5):658-666.

  Tomita, H., Y. Fuchimoto, K. Ohkuma, K. Hoshino, A. Fujino, M. Kato, T. Fujimura, H. Ishihama, N. Takahashi, Y. Tanami, S. Nakatsuka, H. Ebinuma, H. Saito, M. Shinoda, Y. Kitagawa and T. Kuroda (2015 )

• 13. Clinical Features and Prognosis of Generalized Lymphatic Anomaly, Kaposiform Lymphangiomatosis, and Gorham-Stout Disease. Pediatr Blood Cancer. 2016;63(5):832-838.

  Ozeki, M., A. Fujino, K. Matsuoka, S. Nosaka, T. Kuroda and T. Fukao (2016)

• 14. Diagnosing native liver fibrosis and esophageal varices using liver and spleen stiffness measurements in biliary atresia: a pilot study. Pediatr Radiol. 2016;46(10):1409-1417.

  Tomita, H., K. Ohkuma, Y. Masugi, N. Hosoe, K. Hoshino, Y. Fuchimoto, A. Fujino, T. Shimizu, M. Kato, T. Fujimura, H. Ishihama, N. Takahashi, Y. Tanami, H. Ebinuma, H. Saito, M. Sakamoto, M. Nakano and T. Kuroda (2016 )

• 15. Treatment of mediastinal lymphatic malformation in children: an analysis of a nationwide survey in Japan. Surg Today. 2018;48(7):716-725.

  Ueno, S., A. Fujino, Y. Morikawa, T. Iwanaka, Y. Kinoshita, M. Ozeki, S. Nosaka, K. Matsuoka and N. Usui (2018)

• 16. Efficacy and safety of sirolimus treatment for intractable lymphatic anomalies: A study protocol for an open-label, single-arm, multicenter, prospective study (SILA). Regen Ther. 2019;10:84-91.

  Ozeki, M., R. Asada, A. M. Saito, H. Hashimoto, T. Fujimura, T. Kuroda, S. Ueno, S. Watanabe, S. Nosaka, M. Miyasaka, A. Umezawa, K. Matsuoka, T. Maekawa, Y. Yamada, A. Fujino, S. Hirakawa, T. Furukawa, T. Tajiri, Y. Kinoshita, R. Souzaki and T. Fukao (2019)

• 17. Potential biomarkers of kaposiform lymphangiomatosis. Pediatr Blood Cancer. 2019;66(9):e27878.

  Ozeki, M., A. Nozawa, N. Kawamoto, A. Fujino, S. Hirakawa and T. Fukao (2019)

• 18. Indications for tracheostomy in children with head and neck lymphatic malformation: analysis of a nationwide survey in Japan. Surg Today. 2019;49(5):410-419.

  Ueno, S., A. Fujino, Y. Morikawa, T. Iwanaka, Y. Kinoshita, M. Ozeki, S. Nosaka, K. Matsuoka and N. Usui (2019), Ueno S, Fujino A, Morikawa Y, et al.

• 19. Immunologic Effects of Sirolimus in Patients With Vascular Anomalies. J Pediatr Hematol Oncol. 2020;42(5):e355-e360.

  Nozawa, A., M. Ozeki, S. Yasue, S. Endo, N. Kawamoto, H. Ohnishi, S. Fumino, T. Furukawa, T. Tajiri, T. Maekawa, A. Fujino, R. Souzaki and T. Fukao (2020)

• 20. First-in-human autologous oral mucosal epithelial sheet transplantation to prevent anastomotic re-stenosis in congenital esophageal atresia.. Stem Cell Res Ther. 2022;13(1):35

  Fujino, A., Y. Fuchimoto, Y. Baba, N. Isogawa, T. Iwata, K. Arai, M. Abe, N. Kanai, R. Takagi, M. Maeda and A. Umezawa (2022)

• 21. Sirolimus treatment for intractable lymphatic anomalies: an open-label, single-arm, multicenter, prospective trial. Front Med (Lausanne). 2024 Feb 8;11:1335469.

  Ozeki M, Endo S, Yasue S, Nozawa A, Asada R, Saito AM, Hashimoto H, Fujimura T, Yamada Y, Kuroda T, Ueno S, Watanabe S, Nosaka S, Miyasaka M, Umezawa A, Matsuoka K, Maekawa T, Hirakawa S, Furukawa T, Fumino S, Tajiri T, Takemoto J, Souzaki R, Kinoshita Y, Fujino A.

• 22. Sirolimus treatment for intractable vascular anomalies (SIVA): An open-label, single-arm, multicenter, prospective trial. Pediatr Int. 2025 Jan- Dec;67(1):e70002.

  Ozeki M, Endo S, Yasue S, Asada R, Saito AM, Hashimoto H, Ueno S, Watanabe S, Kato M, Deie K, Nosaka S, Miyasaka M, Umezawa A, Matsuoka K, Kato M, Kuroda T, Maekawa T, Hirakawa S, Furukawa T, Fumino S, Tajiri T, Takemoto J, Kawakubo N, Fujino A.

• 23. Comprehensive targeted next-generation sequencing in patients with slow-flow vascular malformations. J Hum Genet. 2022 Dec;67(12):721-728.

  Nozawa A, Fujino A, Yuzuriha S, Suenobu S, Kato A, Shimizu F, Aramaki-Hattori N, Kuniyeda K, Sakaguchi K, Ohnishi H, Aoki Y, Ozeki M.

• 24. A phase 2 randomized, double-blind trial of ART-001, a selective PI3Kα inhibitor, for the treatment of slow-flow vascular malformations. Orphanet J Rare Dis. 2025 Feb 10;20(1):64.

  Ozeki M, Tanaka A, Kuniyeda K, Nozaki T, Fujino A, Nomura T, Uemura N, Suenobu S, Aramaki-Hattori N, Hayashi A, Kato A, Kiyosue H, Imagawa K, Nagao M, Shimizu F, Ochi J, Horiuchi S, Ohyama T, Ando H, Nagabukuro H.

• 25. Historical Cohort Study of Congenital Isolated Hypoganglionosis of the Intestine: Determining the Best Surgical Interventions. Biomolecules. 2023 Oct 23;13(10):1560.

  Yamada Y, Mori T, Takahashi N, Fujimura T, Kano M, Kato M, Takahashi M, Shimojima N, Watanabe T, Yoshioka T, Kanamori Y, Kuroda T, Fujino A.

• 26. First-in-human autologous oral mucosal epithelial sheet transplantation to prevent anastomotic re-stenosis in congenital esophageal atresia. Stem Cell Res Ther. 2022 Jan 28;13(1):35.

  Fujino A, Fuchimoto Y, Baba Y, Isogawa N, Iwata T, Arai K, Abe M, Kanai N, Takagi R, Maeda M, Umezawa A.

• 27. Infantile Kaposiform hemangioendothelioma in a female patient complicated with severe obstructed jaundice: a case report. Surg Case Rep. 2022 Dec 29;8(1):225.

  Watanabe E, Hashizume N, Yoneda A, Kasahara M, Ozeki G, Saito T, Fujiogi M, Kano M, Yamamoto Y, Miyazaki O, Maekawa T, Nakano N, Yoshioka T, Fujino A, Kanamori Y.

• 28. Evaluation of safety and efficacy of autologous oral mucosa-derived epithelial cell sheet transplantation for prevention of anastomotic restenosis in congenital esophageal atresia and congenital esophageal stenosis. Stem Cell Res Ther. 2023 Apr 13;14(1):86.

  Fujino A, Fuchimoto Y, Mori T, Kano M, Yamada Y, Ohno M, Baba Y, Isogawa N, Arai K, Yoshioka T, Abe M, Kanai N, Takagi R, Maeda M, Umezawa A.

• 29. Outcomes of nonrejection in weakly fluorescent intestine detected by indocyanine green fluorescence angiography: a case series of infants. Surg Case Rep. 2024 Apr 24;10(1):97.

  Hashizume N, Yoneda A, Ozeki G, Saito T, Fujiogi M, Kano M, Yamamoto Y, Ishimaru T, Kanamori Y, Fujino A.

• 30. The Prospective Natural History Study of Patients with Intractable Venous Malformation and Klippel-Trenaunay Syndrome to Guide Designing a Proof-of-Concept Clinical Trial for Novel Therapeutic Intervention. Lymphat Res Biol. 2024 Feb;22(1):27-36.

  Fujino A, Kuniyeda K, Nozaki T, Ozeki M, Ohyama T, Sato I, Kamibeppu K, Tanaka A, Uemura N, Kanmuri K, Nakamura K, Kobayashi F, Suenobu S, Nomura T, Hayashi A, Nagao M, Kato A, Aramaki-Hattori N, Imagawa K, Ishikawa K, Ochi J, Horiuchi S, Nagabukuro H.

受賞

• 1. 2008年 第45回日本小児外科学会学術集会 ベストポスター会長賞「ヒトリンパ管腫モデル動物の作成

• 2. 2012年 慶應義塾大学医学部外科同窓会 平成23年度刀林賞「リンパ管腫内リンパ液動態の検討

• 3. 4th World Congress of Pediatric Surgery（WOFAPS）2013 Best Poster Award "The clinical criteria for 'intractable' lymphangioma led by Japanese pediatric surgeons"

SNS・ブログ等

• その他メディア
  • 慶應義塾大学医学部小児外科
  • リンパ管疾患情報ステーション