武田 憲文 たけだ のりふみ 先生

来歴等

略歴

1998年　東京大学医学部卒業
2003年　日本学術振興会特別研究員DC1
2006年　東京大学大学院卒業 医学博士取得
2007年　東京大学循環器内科助教
2010年　米国ペンシルバニア大学医学部客員研究員
2013年　東京大学循環器内科助教
2016年　東京大学循環器内科特任講師

論文

【論文】(和文も可)
1. 武田憲文. マルファン症候群と類縁疾患の診断と管理（オーバービュー）. 特集号「Marfan症候群の診断と治療」. 医学のあゆみ（印刷中, 2018年）（医歯薬出版）
2. 原弘典, 武田憲文. 大動脈解離・大動脈瘤. 特集号「血管の炎症を俯瞰する」. 診断と治療（印刷中, 2018年）（診断と治療社）
3. 武田憲文, 前村園子, 八木宏樹, 小室一成. 遺伝性大動脈瘤・解離のprecision medicine. 循環器内科 82:37-43, 2017（科学評論社）
4. 藤原隆行, 武田憲文, 小室一成. 血管再生のメカニズム. 血管医学 17(1):9-15, 2016（メディカルビュー社）
5. 武田憲文, 小室一成. 成体心筋細胞の増殖に重要な役割を担うHippo-YAP経路. 日本再生医療学会雑誌14(2):57, 2015（メディカルビュー社）
6. 武田憲文, 藤田大司, 犬塚亮, 谷口優樹, 縄田寛, 山内治雄, 加藤昌義, 西村敬史, 永原幸, 中島淳, 小野稔, 小室一成. マルファン症候群と類縁疾患. 呼吸と循環 63(6):561-568, 2015（医学書院）
7. 藤田大司, 武田憲文, 今井靖, 平田恭信. マルファン症候群の現状と展望. 綜説シリーズ-現代医学の焦点(380). 日本臨床72(6):1163-1171, 2014（日本臨床社）
8. 武田憲文, 小室一成. 再生医療がもたらす心筋梗塞の治療の将来性についておしえてください. 治療 96(3):272-274, 2014（南山堂）
9. 武田憲文. 心筋リモデリングと心臓線維芽細胞. 心臓43(12):1492-95,2011
10. 武田憲文. 心臓の炎症・線維化とmatricellular蛋白. 呼吸と循環 59(11):1077-1082,2011
11. 今井靖, 小川直美, 西村敬史, 加藤昌義, 武田憲文, 平田恭信, 縄田寛, 竹谷剛, 師田哲郎, 高本眞一. 東京大学医学部附属病院におけるマルファン症候群専門外来：包括的な診療体制の実践. 呼吸と循環 57(11):1099-1103, 2009
12. 武田憲文, 平田恭信. 心房性ナトリウム利尿ペプチド：主要薬剤各論―特徴, 作用機序, 薬物動態, 適応・禁忌, 臨床成績, 副作用―心不全（下）最新の基礎・臨床研究の進歩, 日本臨床 65増刊(5):110-114,2007.
13. 武田憲文, 平田恭信, 永井良三. 後腹膜線維症の心血管病変の見方. 呼吸と循環55:441-447,2007
14. 小野祥太郎, 武田憲文, 川端仁人, 山下尋史. 大動脈基部拡大と潰瘍性大腸炎を合併した大動脈炎症候群の心不全例. メディチーナ43:2094-2099,2006
15. 武田憲文, 平田恭信. 心房性ナトリウム利尿ペプチド. 日本内科学会雑誌 94:270-75,2005.
16. 武田憲文, 寺本信嗣, 尹　浩信, 荒尾敏弘, 松瀬　健, 鳥羽研二, 玉置邦彦, 大内尉義. 高齢にて発症した全身性硬化症と全身性ループスエリテマトーデスのオーバーラップ症候群の一例. 日本老年医学会雑誌37:74-79,2000
17. Hara H, Takeda N#, Komuro I. Pathophysiology and therapeutic potential of cardiac fibrosis. Inflammation and Regeneration, 2017 in press. (#Corresponding Author).
18. Takeda N*, Sayama S*, Iriyama T, Inuzuka R, Maemura S, Fujita D, Yamauchi H, Nawata K, Bougaki M, Hyodo H, Shitara R, Nakayama T, Komatsu A, Nagamatsu T, Osuga Y, Fujii T. Authors’ reply Re: Peripartum type B aortic dissection in patients with Marfan syndrome who underwent aortic root replacement. BJOG, 2017 in press. (*equally first authors)
19. Oshima Y, Hara H, Takeda N#, Hasumi E, Kuroda Y, Tanguchi G, Inuzuka R, Nawata K, Morita H, Komuro I. A novel mutation of NFIX causes Sotos-like syndrome (Malan syndrome) complicated with thoracic aortic aneurysm and dissection. Hum Genome Var 4:17022, 2017 (#Corresponding Author).
20. Takeda N*, Sayama S*, Iriyama T, Inuzuka R, Maemura S, Fujita D, Yamauchi H, Nawata K, Bougaki M, Hyodo H, Shitara R, Nakayama T, Komatsu A, Nagamatsu T, Osuga Y, Fujii T. Peripartum type B aortic dissection in patients with Marfan syndrome who underwent aortic root replacement. BJOG, 2017 in press. (*equally first authors)
21. Takeda N*#, Hara H, Morita H, Hatano M, Amiya E, Maki H, Minatsuki S, Taki M, Shiraishi Y, Fujiwara T, Maemura S, Komuro I. Three novel BMPR2 mutations associated with advanced pulmonary arterial hypertension. Hum Genome Var. 4:17010, 2017 (*equally first authors) (#Corresponding Author).
22. Kamo T, Akazawa H, Suda W, Saga-Kamo A, Shimizu Y, Yagi H, Liu Q, Nomura S, Naito AT, Takeda N, Harada M, Toko H, Kumagai H, Ikeda Y, Takimoto E, Suzuki JI, Honda K, Morita H, Hattori M, Komuro I. Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure. PLoS One 12(3):e0174099, 2017.
23. Harada M, Takeda N, Toko H. Prostaglandin E2 signaling as a target of anti-cardiac fibrosis in heart failure treatment. Int Heart J. 58;3-4, 2017.
24. Amiya E, Morita H, Hatano M, Nitta D, Hosoya Y, Maki H, Motozawa Y, Sato N, Ishiura H, Numakura S, Shintani Y, Kinugawa K, Takeda N, Shimizu J, Tsuji S, Komuro I. Fukutin gene mutations that cause left ventricular noncompaction. Int J Cardiol. 222:727-9, 2016.
25. Takeda N#, Yagi H, Hara H, Fujiwara T, Fujita D, Nawata K, Inuzuka R, Taniguchi Y, Harada M, Toko H, Akazawa H, Komuro I. Pathophysiology and management of cardiovascular manifestations in Marfan and Loeys-Dietz syndrome. Int Heart J. 57:271-7, 2016 (#Corresponding Author)
26. Suzuki JI, Imai Y, Aoki M, Fujita D, Takeda N, Aoyama N, Wakayama K, Ikeda Y, Kumagai H, Akazawa H, Izumi Y, Isobe M, Komuro I, Hirata Y. Periodontitis may deteriorate sinus of Valsalva dilatation in Marfan syndrome patients. Int Heart J. 57:456-60,2016
27. Li D, Takeda N, Jain R, Manderfield LJ, Liu F, Li L, Anderson SA, Epstein JA. Hopx distinguishes hippocampal from lateral ventricle neural stem cells. Stem Cell Res 15:522-529, 2015
28. Takeda N#, Morita H, Fujita D, Inuzuka R, Taniguchi Y, Nawata K, Komuro I. A deleterious MYH11 mutation causing familial thoracic aortic dissection. Hum Genome Var. 2:15028, 2015 (#Corresponding Author)
29. Takeda N*#, Fujita N*, Morita H, Kato M, Nishimura H, Inuzuka R, Taniguchi Y, Nawata K, Hyodo H, Imai Y, Hirata Y, Komuro I. A novel mutation of TGFBR2 causing Loeys-Dietz syndrome complicated with pregnancy-related fatal cervical arterial dissections. Int J Cardiol 201:288-290, 2015 (*equally first authors) (#Corresponding Author)
30. Takeda N*, Imai Y*, Morita H*, Miya F, Hyodo H, Fujita D, Tajima T, Tsunoda T, Nagai R, Kubo M, Komuor I. A deletion mutation in myosin heavy chain 11 causing familial thoracic aortic dissection in two Japanese pedigrees. Int J Cardiol 195:290-292, 2015 (*equally first authors)
31. Kumagai H, Ikeda Y, Motozawa Y, Fujishiro M, Okamura T, Fujio K, Okazaki H, Nomura S, Takeda N, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Yamamoto K, Komuro I, Yanagisawa. Quantitative measurement of GPCR endocytosis via pulse-chase covalent labeling. PLoS One 10:e0129394, 2015
32. Takeda N, Morita H, Fujita D, Inuzuka R, Taniguchi Y, Imai Y, Hirata Y, Komuro I. Congenital contractural arachnodactyly complicated with aortic dilatation and dissection: Case Report and review of literature. Am J Med Genet A 167:2382-2387, 2015
33. Ikeda Y, Kumagai H, Okazaki H, Fujishiro M, Motozawa Y, Nomura S, Takeda N, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Komuro I, Yanagisawa M. Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors. PLoS One 10:e0127445, 2015
34. Jain R, Barkauskas C.E, Takeda N, Bowie E.J, Aghajanian H, Wang Q, Padmanabhan A, Manderfield L.J, Gupta M, Li D, Li L, Trivedi C.M, Hoan L.M, Epstein J.A. Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Nat Commun 6:6727, 2015
35. Yagi H, Hatano M, Takeda N#, Harada S, Suzuki Y, Taniguchi Y, Shintani Y, Morita H, Kanamori N, Aoyama T, Watanabe M, Manabe I, Akazawa H, Kinugawa K, Komuro I. A case of congenital contractural arachnodactyly without FBN1 or FBN2 gene mutation, complicated with dilated cardiomyopathy. Intern Med. 54:1237-1241, 2015. (#Corresponding Author)
36. Fujita D, Takeda N#, Imai Y, Inuzuka R, Komuro I, Hirata Y. Pathophysiology and Japanese clinical characteristics in Marfan syndrome. Pediatr Int 56:484-91,2014 (#Corresponding Author)
37. Takeda N#, Jain R, Li Deqiang, Li L, Lu MM, Epstein JA. Lgr5 identifies progenitor cells capable of taste bud regeneration after injury. PLoS One 8(6):e66314,2013 (#Corresponding Author)
38. Takeda N, Jain R, LeBoeuf MR, Padmanabhan A, Wnag Q, Li L, Lu MM, Millar SE, Epstein JA. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Development 140:1655-1664,2013
39. Ogawa N, Imai Y, Nishimura H, Kato M, Takeda N, Nawata K, Taketani T, Morota T, Takamoto S, Nagai R, Hirata Y. Circulating transforming growth factor beta-1 level in Japanese patients with Marfan syndrome. Int Heart J 54:23-26,2013
40. Sakamoto A, Nagai R, Saito K, Imai Y, Takahashi M, Hosoya Y, Takeda N, Hirano K, Koike K, Enomoto Y, Kume H, Homma Y, Maeda D, Yamada H, Fukayama M, Hirata Y, Ishizaka N. Idiopathic retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pericarditis - Retrospective analysis of 11 case histories. J Cardiol 59:139-146,2012
41. Takeda N, Jain R, Leboeuf MR, Wang Q, Lu MM, Epstein JA. Interconversion between intestinal stem cell populations in distinct niches. Science 334:1420-1424,2011
42. Ogawa M, Imai Y, Takahashi Y, Nawata K, Hara K, Nishimura H, Kato M, Takeda N, Kohro T, Morita H, Taketani T, Yamazaki T, Goto J, Tsuji S, Takamoto S, Nagai R, Hirata Y. Evaluating Japanese patients with the Marfan syndrome using high-throughput microarray-based mutational analysis of Fibrillin-1 gene. Am J Cardiol 108:1801-1807,2011
43. McConnell BB, Kim SS, Yu K, Ghaleb AM, Takeda N, Manabe I, Nusrat A, Nagai R, Yang VW. Kruppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine. Gastroenterology 141:1302-1313,2011
44. Takeda N, Manabe I. Cellular interplay between cardiomyocytes and non-myocytes in cardiac remodeling. Int J Inflam. 2011:535241,2011
45. Takahashi M, Shimizu T, Inajima T, Hosoya Y, Takeda N, Ishizaka N, Yamashita H, Hirata Y, Nagai R. A case of localized IgG4-related thoracic periarteritis and recurrent nerve palse. Am J Med Sci. 341:166-9,2011
46. Iwata H, Manabe I, Fujiu K, Yamamoto T, Takeda N, Eguchi K, Furuya A, Kuro-O M, Sata M, Nagai R. Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages. Circulation 122:2048-57,2010
47. Takeda N, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, Shindo T, Sano M, Otsu K, Snider P, Conway SJ, Nagai R. Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest 120:254-265,2010
48. Takeda N#, Seko Y, Oriuchi Y, Nagai R. Gamma-delta T-cell-mediated dilated cardiomyopathy. Int J Cardiol 125:130-132,2008 (#Corresponding Author)
49. Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H. Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9. J Biol Chem 283;24682-24689,2008
50. Kato H, Ishida J, Nagano K, Sugaya T, Takeda N, Sugiyama F, Yagami KI, Fujita T, Nangaku M, Fukamizu A. Deterioration of atherosclerosis in mice lacking angiotensin II type 1A receptor in bone marrow-derived cells. Lab Invest 88:731-739,2008
51. Kada N, Suzuki T, Aizawa K, Matsumura T, Ishibashi N, Suzuki N, Takeda N, Munemasa Y, Sawaki D, Ishikawa T, Nagai R. Acyclic retinoid inhibits neointima formation through retinoic acid receptor beta-induced apoptosis. Arterioscler Thromb Vasc Biol 27:1535-1541,2007
52. Takeda N#, Nakajima J, Yamada N, Hiroi Y, Hirata Y, Nagai R. Rupture of bronchogenic cyst in the pericardium with high carbohydrate antigen 19-9 production. Respiratory Medicine Extra 3:76-78,2007 (#Corresponding Author)
53. Shimizu T, Takeda N#, Takahashi M, Imai Y, Ishizaka N, Hirata Y, Nagai R. Subarachnoid Hemorrhage from Mycotic Aneurysms. Intern Med 45:1189-1190,2006 (#Corresponding Author)
54. Takeda N, Manabe I, Iwata H, Iimuro S, Kagechika H, Shudo K, Nagai R. Synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6. Arterioscler Thromb Vasc Biol 26:1177-1183,2006
55. Takeda N#, Takahashi T, Seko Y, Maemura K, Nakasone H, Sakamoto K, Hirata Y, Nagai R. Takayasu myocarditis mediated by cytotoxic T lymphocytes. Intern Med 44:256-260,2005 (#Corresponding Author)
56. Takeda N#, Ohtaki E, Kitahara K, Nagayama M, Nagasaki M. Pulmonary thromboembolism in a patient with an anomalous right coronary artery as a cause of unusual biventricular myocardial infarction. Circ J 68:883-886,2004 (#Corresponding Author)
57. Iimuro S, Shindo T, Moriyama N, Amaki T, Niu P, Takeda N, Iwata H, Zhang Y, Ebihara A, Nagai R. Angiogenic effects of adrenomedullin in ischemia and tumor growth. Circ Res 95:415-423,2004
58. Niu P, Shindo T, Iwata H, Iimuro S, Takeda N, Zhang Y, Ebihara A, Suematsu Y, Kangawa K, Hirata Y, Nagai R. Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis, and renal damage. Ciuculation 109:1789-1794,2004
59. Niu P, Shindo T, Iwata H, Ebihara A, Suematsu Y, Zhang Y, Takeda N, Iimuro S, Hirata Y, Nagai R. Accelerated cardiac hypertrophy and renal damage induced by angiotensin II in adrenomedullin knockout mice. Hypertens Res 26:731-736,2003
60. Takeda N, Ohtaki E, Kasegawa H, Tobaru T, Nagayama M, Misu K, Asano R, Kitahara K, Umemura J, Sumiyoshi T, Hosoda S. Infective Endocarditis Associated With Quadricuspid Aortic Valve: A Case Report. Jpn Heart J 44:441-445,2003
61. Takeda N, Ohtaki E, Misu K, Asano R, Tobaru T, Nagayama M, Kitahara K, Umemura J, Sumiyoshi T, Hosoda S. Normalization of left ventricular parameters following carvedilol treatment in a case of unclassified cardiomyopathy with longstanding refractory status. Intern Med 41:1147-1152,2002
62. Takeda N#, Kitahara K, Sumiyoshi T. Chronic Advanced Pulmonary Hypertension. Intern Med 41:675,2002 (#Corresponding Author)
63. Takeda N, Ihn H, Teramoto S. Markedly increased levels of IL-6 and CA125 in pleural fluid of an elderly person with overlap syndrome of systemic sclerosis and systemic lupus erythematosus. Age Ageing. 30:17,2001
64. Machida U, Kami M, Kanda Y, Takeuchi K, Akahane M, Yamaguchi I, Kakiuchi C, Takeda N, Tanaka Y, Chiba S, Honda H, Hirai H. Aspergillus tracheobronchitis after allogeneic bone marrow transplantation. Bone Marrow Transplant 24:1145-1149,1999
65. Takeda N, Shibuya M, Maru Y. The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein. Proc Natl Acad Sci US

著書

【著書】
1. 武田憲文. マルファン症候群. 研修医・若手Dr.にエキスパートが伝授する循環器内科のロジック. pp.307-312小室一成監修, 赤澤宏, 波多野将, 渡辺昌文編集.（南山堂）2017
2. 武田憲文, 原弘典, 小室一成. 生体心筋細胞は分裂するのか？ Annual Review 2015. 小室一成、佐地勉、坂田隆造、赤阪隆史編集（中外医学社）p1-7, 2015　
3. 真鍋一郎, 武田憲文, 永井良三. 心臓線維芽細胞による心筋の増殖・肥大制御. Annual Review 循環器. P23-36. 山口徹, 小室一成, 佐地勉, 高本眞一編, 中外医学社, 2011
4. 武田憲文, 永井良三. 血管生物学から考える. 新・心臓病診療プラクティスシリーズ 15, 血管疾患を診る・治す. P12-18. 小室一成編, 文光堂 2010
5. 武田憲文, 永井良三. 動脈硬化. 循環器疾患治療スタンダード「今月の治療」第11巻臨時増刊号S310-314（総合医学社）, 2003
6. 武田憲文, 丸　義郎. BCR-ABLと慢性骨髄性白血病. がん遺伝子・がん抑制遺伝子254-260,1998
7. 武田憲文, 丸　義朗. abl.ノックアウトマウス・データブック. Molecular Medicine 34(臨時増刊号):1-2,1998

その他

• 【受賞】 2009年度　東京大学医師会医学賞

• 【受賞】2009年（第19回）東京高血圧研究会　研究奨励賞

• 【受賞】 2009年（第26回）国際心臓研究学会(ISHR)日本部会　若手研究奨励賞

• 【受賞】 2009年（第13回）日本心血管内分泌代謝学会学術集会　若手研究奨励賞

• 【受賞】 2009年米国心臓病学会AHA学術集会・Katz賞（優秀賞）

• 【受賞】 2010年（第74回）日本循環器学会学術集会　若手研究奨励賞優秀賞

• 【受賞】 2011年　東京都医師会・グループ研究賞「マルファン症候群患者の総合的診療体制の確立」平田恭信ほか26名