相原 一 あいはら まこと 先生

来歴等

略歴

1989年 東京大学医学部医学科 卒業
1989年 東京大学医学部附属病院眼科 研修医
1990年 東京大学医学部附属病院眼科 文部教官助手
1990年 東京逓信病院眼科 郵政技官
1992年 東京大学医学部附属病院眼科 文部教官助手
1994年 東京大学大学院医学系研究科外科学専攻博士課程 入学
1998年 東京大学大学院医学系研究科外科学専攻博士課程 修了
1998年 東京大学医学部附属病院眼科 文部教官助手
2000年 University of California San Diego (UCSD), Dept. of Ophthalmology and Hamilton Glaucoma Center Research fellow and Clinical Instructor 臨床医・州限定免許取得
2002年 University of California San Diego (UCSD), Hamilton Glaucoma Center, Principal Investigator Postgraduate Research Scientist UCSD正式職員
2003年 東京大学医学部眼科学教室 講師
2012年 東京大学大学院医学系研究科外科学専攻眼科学 准教授
2012年 四谷しらと眼科 副院長
2014年 東京医科歯科大学眼科 特命教授
2015年 東京大学大学院医学系研究科外科学専攻眼科学 教授

論文

• Effect on Diurnal Intraocular Pressure Variation of Eliminating the alpha-2 Adrenergic Receptor Subtypes in the Mouse. Investigative Ophthalmology & Visual Science 49(3):929-933, 2008

  Aihara M, Lindsey JD, Weinreb RN.

• Establishment of an experimental ferret ocular hypertension model for the analysis of central visual pathway damage. Scientific Reports in press

  Fujishiro T, Kawasaki H, Aihara M*, Saeki T, Yamagishi R, Atarashi T, Mayama C, Araie M.

• Hyperbaric pressure and increased susceptibility to glutamate toxicity in retinal ganglion cells in vitro. Molecular Vision 20:606-615, 2014

  Aihara M*, Chen YN, Uchida S, Nakayama M, Araie M.

• A model for the easy assessment of pressure-dependent damage to retinal ganglion cells using cyan fluorescent protein-expressing transgenic mice. Molecular Vision 18:2468-78, 2012

  Tsuruga H, Murata H, Araie M, Aihara M*.

• Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress-induced retinal ganglion cell death. Molecular Vision 17:1784-93, 2011

  Nakayama M, Aihara M*, Chen YN, Araie M, Tomita-Yokotani K, Iwashina T.

• Neuroprotective Effects Of Prostaglandin Analogues On Retinal Ganglion Cell Death Independent Of Intraocular Pressure Reduction Experimental Eye Research 93(3):265-70, 2011

  Yamagishi R, Aihara M*, Chen YN, Araie M.

• Brimonidine is neuroprotective against glutamate-induced neurotoxicity, oxidative stress and hypoxia in purified rat retinal ganglion cells Molecular Vision 16:246-51, 2010

  Lee K, Nakayama M, Aihara M*, Chen Y-N, and Araie M.

• Kinesin-1/Hsc70 dependent mechanism of slow axonal transport and its relation to fast axonal transport The EMBO Journal 29(4):843-54, 2010

  Terada S, Kinjo M, Aihara M, Takei Y, Hirokawa N.

• Effects of Prostanoid EP agonists on mouse intraocular pressure. Investigative Ophthalmology & Visual Science 50(5):2201-2208, 2009

  Saeki T, Ota T, Aihara M*, Araie M.

• Imaging Mouse Retinal Ganglion Cells and Their Loss in vivo by a Fundus Camera in the Normal and Ischemia-Reperfusion Model. Investigative Ophthalmology & Visual Science 49:5546-5552, 2008

  Murata H, Aihara M*, Chen YN, Ota T, Numaga J, Araie M.

• Reduction of Intraocular Pressure in Mouse Eyes Treated in Latanoprost. Investigative Ophthalmology & Visual Science 43(1):146-150, 2002

  Aihara M, Lindsey JD, Weinreb RN*

• The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. Journal of Clinical　Investigation 117(7):1763-1770, 2007

  Harada, T., Harada, C., Nakamura, K., Quah, H-M.A., Okumura, A., Namekata, K., Saeki, T., Aihara, M., Yoshida, H., Mitani, A., and Tanaka, K.

• Hypoxia-induced retinal ganglion cell death and the neuroprotective effects of beta-adrenergic antagonists Brain Research 1148:28-37, 2007

  Chen YN, Yamada H, Mao W, Matsuyama S, Aihara M*, Araie M

• The IOP-lowering effects and mechanism of action of tafluprost in prostanoid receptor-deficient mice. British Journal Ophthalmology 91(5):673-6, 2007

  Ota T, Aihara M*, Saeki T, Narumiya S, Araie M.

• The Effects of Prostaglandin Analogues on Prostanoid EP1, EP2, and EP3 Receptor-Deficient Mice. Investigative Ophthalmology & Visual Science 47: 47(8): 3395-3399, 2006

  Ota T, Aihara M*, Narumiya S.Araie M

• The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice. Investigative Ophthalmology & Visual Science　46: 46(11):4159-63,

  Ota T, Aihara M*, Narumiya S.,Araie M

• Araie M Prostaglandin Analogues and Mouse Intraocular Pressure: Effects of Tafluprost, Latanoprost, Travoprost, and Unoprostone, Considering 24-Hour Variation Investigative Ophthalmology & Visual Science 46: 2006-2011, 2005

  Ota T, Murata H, Sugimoto E, Aihara M*

• Aqueous humor dynamics in mouse. Investigative Ophthalmology & Visual Science 44(12):5168-5173, 2003

  Aihara M, Lindsey JD, Weinreb RN*

• Experimental Mouse Ocular Hypertension: Establishment of the Model. Investigative Ophthalmology & Visual Science 44(10):4314-20, 2003

  Aihara M, Lindsey JD, Weinreb RN*

• Ocular hypertension in mice with a targeted type I collagen mutation. Investigative Ophthalmology & Visual Science 44 1581-1585, 2003

  Aihara M, Lindsey JD, Weinreb RN*