石田 晋 いしだ すすむ 先生

来歴等

略歴

1990年 慶應義塾大学医学部眼科 入局
1992年 佐野厚生総合病院眼科 出向
1994年 佐野厚生総合病院眼科 医長
1995年 慶應義塾大学医学部眼科 助手
1999年 慶應義塾大学医学部病理学 研究員
2001年 ハーバード大学医学部眼科 研究員
2003年 慶應義塾大学医学部眼科 助手
2004年 慶應義塾大学医学部眼科 講師
2005年 慶應義塾大学総合医科学研究センター網膜細胞生物学研究室　 主任（眼科学講師と兼任）
2008年 慶應義塾大学医学部稲井田記念抗加齢眼科学講座 准教授（網膜細胞生物学研究室主任と兼任）
2009年 北海道大学大学院医学研究科感覚器病学講座眼科学分野 教授

論文

• VEGF164 is proinflammatory in the diabetic retina.Invest Ophthalmol Vis Sci.44, 2155-2162, 2003.

  Ishida S, Usui T, Yamashiro K, Kaji Y, Ahmed E, Carrasquillo KG, Amano S, Hida T, Oguchi Y,Adamis AP.

• VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization.J Exp Med. 2003; 198: 483-489.

  Ishida S, Usui T, Yamashiro K, Kaji Y, Amano S, Ogura Y, Hida T, Oguchi Y, Ambati J,MillerJW, Gragoudas ES, Ng YS, D’Amore PA, Shima DT, Adamis AP.

• Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease.Nat Med. 9, 781-788, 2003.

  Ishida S, Yamashiro K, Usui T, Kaji Y, Ogura Y, Hida T, Honda Y, Oguchi Y, Adamis AP.

• Suppression of diabetes-induced retinal inflammation by blocking angiotensin II type1receptor or its downstream NF-κB pathway.Invest Ophthalmol Vis Sci: 2007; 48: 4342-4350.

  Nagai N, Izumi-Nagai K, Oike Y, Koto T, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M,Tsubota K, Yamashiro K, Umezawa K,Ishida S.

• Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina.Diabetes. 2008; 57: 2191-2198.

  Kurihara T, Ozawa Y, Nagai N, Shinoda K, Noda K, Imamura Y, Tsubota K, Okano H, Oike Y,Ishida S.

• Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization.Arterioscler Thromb Vasc Biol.2006; 26: 2252-2259.

  Nagai N, Oike Y, Izumi K, Urano T, Kubota Y, Noda K, Ozawa Y, Inoue M, Tsubota K, Suda T,Ishida S.

• (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system.Am J Pathol.2008; 173: 1911-1918.

  Satofuka S, Ichihara A, Nagai N, Ozawa Y, Fukamizu A, Tsubota K, Itoh H, Oike Y,Ishida S.

• Macular pigment lutein is anti-inflammatory in preventing choroidal neovascularization.Arterioscler Thromb Vasc Biol.2007; 27: 2555-2562.

  Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Umezawa K, Ohno S,Oike Y,Ishida S.

• Interleukin-6 receptor-mediated activation of STAT3 promotes choroidal neovascularization.Am J Pathol:2007; 170:2149-2158.

  Izumi-Nagai K, Nagai N, Ozawa Y, Mihara M, Ohsugi Y, Kurihara T, Koto T, Satofuka S,InoueM, Tsubota K, Okano H, Oike Y,Ishida S.

• (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation.Diabetes.2009; 58：1625-1633.

  Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A ,Tsubota K, Itoh H, Oike Y,Ishida S.

• Receptor-associated prorenin system in the pathogenesis of retinal diseases. Front Biosci. 2012; 4: 1449-1460

  Satofuka S, Kanda A, Ishida S.

• Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci. 2012; 53: 4055-4062

  Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S.

• (Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy. Diabetologia. 2012; 55: 3104-3113

  Kanda A, Noda K, Saito W, Ishida S.

• Angiopoietin-like protein 2 mediates endotoxin-induced acute inflammation in the eye. Lab Invest. 2012; 92: 1553-1563

  Kanda A, Noda K, Oike Y, Ishida S.

• Expression of vascular endothelial growth factor (VEGF) and intravitreal anti-VEGF therapy with bevacizumab in vasoproliferative retinal tumors. Retina. 2013; 33: 1959-1967

  Saito W, Kase S, Fujiya A, Dong Z, Noda K, Ishida S.

• Macular choroidal blood flow velocity decreases with regression of acute central serous chorioretinopathy. Br J Ophthalmol. 2013; 97: 775-780

  Saito M, Saito W, Hashimoto Y, Yoshizawa C, Fujiya A, Noda K, Ishida S.

• Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice. J Neurosci. 2013; 33: 19341-19351

  Kanda A, Noda K, Yuki K, Ozawa Y, Furukawa T, Ichihara A, Ishida S.

• Vitreous renin activity correlates with vascular endothelial growth factor in proliferative diabetic retinopathy. Br J Ophthalmol. 2013; 97: 666-668

  Kanda A, Noda K, Saito W, Ishida S.

• Decreased proteasomal activity causes photoreceptor degeneration in mice. Invest Ophthalmol Vis Sci. 2014; 55: 4682-4690

  Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S.

• Clinical features of Japanese patients with anti-α-enolase antibody-positive autoimmune retinopathy: Novel subtype of multiple drusen. Am J Ophthalmol. 2018; 196: 181-196

  Ando R, Saito W, Kanda A, Kase S, Fujinami K, Sugahara M, Nakamura Y, Eguchi S, Mori S, Noda K, Shinoda K, Ishida S.

• Suppression of choroidal neovascularization and fibrosis by a novel RNAi therapeutic agent against (pro)renin receptor. Mol Ther Nucleic Acids. 2019; 17: 113-125

  Liu Y, Kanda A, Wu D, Ishizuka ET, Kase S, Noda K, Ichihara A, Ishida S.