真部 淳 まなべ あつし 先生

来歴等

略歴

1985年　北海道大学医学部卒業
1985年　聖路加国際病院研修医
1989年　ローマ・カトリック大学留学
1990年　St. Jude Children’s Research Hospital留学
1993年　聖路加国際病院小児科
1997年　東大医科学研究所小児細胞移植科助手
2004年　聖路加国際病院小児科

論文

（2012年以降の主要研究論文）
1 Kato M, Ishimaru S, Seki M, Yoshida K, Shiraishi Y, Chiba K, Kikuchi N, Sato Y, Ueno H, Tanaka H, Inukai T, Tomizawa D, Hasegawa D, Osumi T, Arakawa Y, Aoki T, Okuya M, Kaizu K, Kato K, Taneyama Y, Goto H, Taki T, Takagi M, Sanada M, Koh K, Takita J, Miyano S, Ogawa S, Ohara A, Tsuchida M, Manabe A.
Long-term outcome of six-month maintenance chemotherapy for acute lymphoblastic leukemia in children. Leukemia 31,580-584(2017)
2 Seki M, Kimura S, Isobe T, Yoshida K, Ueno H, Nakajima-Takagi Y, Wang C, Lin L, Kon A, Suzuki H, Shiozawa Y, Kataoka K, Fujii Y, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Masuda K, Kawamoto H, Ohki K, Kato M, Arakawa Y, Koh K, Hanada R, Moritake H, Akiyama M, Kobayashi R, Deguchi T, Hashii Y, Imamura T, Sato A, Kiyokawa N, Oka A, Hayashi Y, Takagi M, Manabe A, Ohara A, Horibe K, Sanada M, Iwama A, Mano H, Miyano S, Ogawa S, Takita J:
Recurrent PU.1 (SPI1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia. Nat Genet 49,1274-1281(2017)
3 Moriyama T, Nishii R, Perez-Andreu V, Yang W, Klussmann FA, Zhao X, Lin
T-N, Hoshitsuki K, Nersting J, Kihira K, Hofmann sU, Komada Y, Kato M, McCorkle R, Li L, Koh K, Najera CR, Kham S, Isobe T, Chen Z, Chiew E, Bhojwani D, Jeffries C, Lu Y, Schwab M, Inaba H, Pui C-J, Relling MV, Manabe A, Hori H, Schmiegelow K, Yeoh AEJ, Evans WE, Yang JJ.
NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. Nat Genet 48,367-373(2016)
4 Tanaka Y, Kato M, Hasegawa D, Urayama K, Nakadate H, Kondoh K, Nakamura K, Koh K, Komiyama T, Manabe A.
Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukemia. Br J Haematol 171,109-115(2015)
5 Hasegawa D, Chen X, Hirabayashi H, Ishida Y, Watanabe S, Zaike Y, Tsuchida M, Masunaga A, Yoshimi A, Hama A, Kojima S, Ito M, Nakahata T, Manabe A.
Clinical characteristics and treatment outcome in 65 cases with refractory cytopenia of childhood defined according to the WHO 2008 classification. Br J Haematol 166,758-766(2014)
6 Honda Y, Tsuchida M, Zaike Y, Masunaga A, Yoshimi A, Kojima S, Ito M, Kikuchi A, Nakahara T, Manabe A.
Clinical characteristics of 15 children with juvenile myelomonocytic leukemia who developed blast crisis: MDS Committee of Japanese Society of Pediatric Hematology/Oncology. Br J Haematol 165,682-687(2014)
6 Kasai-Yoshida E, Ogihara M, Ozawa M, Nozaki T, Morino M, Manabe A, Hosoya R.
Temporal lobe epilepsy with hippocampal sclerosis in acute lymphoblastic leukemia.Pediatrics 132,e252-256(2013)
7 Ishida Y. Manabe A, Oizumi A, Otani N, Hirata M, Urayama K, Saida Y, Kusakawa I, Fukui T.
Association between parental preference and head computed tomography in children with minor blunt head trauma. JAMA Pediatr 167,491-492(2013)
8 Kikuchi A, Hasegawa D, Ohtsuka Y, Hamamoto K, Kojima S, Okamura J, Nakahata T, Manabe A.
Outcome of children with Refractory Anaemia with Excess of Blast (RAEB) and RAEB in Transformation (RAEB-T) in the Japanese MDS99 study. Br J Haematol 158,657-661(2012)
10 Hasegawa D, Manabe A, Ohara A, Kikuchi A, Koh K, Kiyokawa N, Fukushima T, Ishida Y, Saito T, Hanada R, Tsuchida M.
The Utility of Performing the Initial Lumbar Puncture on Day 8 in Remission Induction Therapy for Childhood Acute Lymphoblastic Leukemia: TCCSG L99-15 Study. Pediatr Blood Cancer 58,23-30(2012)
（それ以前の主要な業績）
1 Manabe A, Ohara A, Hasegawa D, Koh K, Saito T, Kiyokawa N, Kikuchi A, Takahashi H, Ikuta K, Hayashi Y, Hanada R, Tsuchida M.
Significance of the complete clearance of peripheral blasts after 7 days of prednisolone treatment in children with acute lymphoblastic leukemia: The Tokyo Children’s Cancer Study Group (TCCSG) Study L99-15. Haematologica 93,1155-1160(2008)
2 Hasegawa D, Manabe A, Kubota T, Kawasaki H, Hirose I, Ohtsuka Y, Ebihara Y, Tsuruta T, Tsuji K, Goto Y-i, Isomura M, Kojima S, Hoshika A, Nakahata T.
Methylation status of the p15 and p16 genes in pediatric myelodysplastic syndrome and juvenile myelomonocytic leukemia. Br J Haematol 128,805-812(2005)
3 Igarashi S, Manabe A, Ohara A, Kumagai M, Saito T, Okimoto Y, Kamijo T, Isoyama K, Kajiwara M, Sotomatsu M, Sugita K-i, Sugita K-j, Maeada M, Yabe H, Kinoshita T, Kaneko T, Hayashi Y, Ikuta K, Hanada R, Tsuchida M.
No Advantage of Dexamethasone over Prednisolone for the Outcome of Standard and Intermediate Risk Childhood Acute Lymphoblastic Leukemia in the Tokyo Children’s Cancer Study Group L95-14 Protocol. J Clin Oncol 23,6489-6498(2005)
4 Manabe A, Okamura J, Yumura-Yagi K, Akiyama Y, Sako M, Uchiyama H, Kojima S, Koike K, Saito T, Nakahata T.
Allogeneic hematopoietic stem cell transplantation for 27 children with juvenile myelomonocytic leukemia diagnosed based on the International JMML Working Group. Leukemia 16,645-649(2002)
5 Manabe A, Tsuchida M, Hanada R, Ikuta K, Toyoda Y, Okimoto Y, Ishimoto K, Okawa H, Ohara A, Kaneko T, Koike K, Sato T, Sugita K, Bessho F, Hoshi Y, Maeda M, Kinoshita A, Saito T, Tsunematsu Y, Nakazawa S.
Delay of the diagnostic lumbar puncture and intrathecal chemotherapy in children with acute lymphoblastic leukemia who undergo routine corticosteroid testing: Tokyo Children’s Cancer Study Group Study L89-12. J Clin Oncol 19,3182-3187(2001)
6 Toyoda Y, Manabe A, Tsuchida M, Hanada R, Ikuta K, Okimoto Y, Ohara A, Ohkawa Y, Mori T, Ishimoto K, Satoh T, Kaneko T, Maeda M, Koike K-I, Shitara T, Hoshi Y, Hosoya R, Tsunematsu Y, Bessho F, Nakazawa S, Saito T.
Six months of maintenance chemotherapy after intensified treatment for acute lymphoblastic leukemia of childhood. J Clin Oncol 18,1508-1516(2000)
7 Kumagai M, Manabe A, Pui CH, Behm FG, Raimondi SC, Hancock ML, Mahmoud H, Crist WM, Campana D.
Stroma-supported culture of childhood B-lineage acute lymphoblastic leukemia cells predicts treatment outcome. J Clin Invest 97,755-760(1996)
8 Manabe A, Coustan-Smith E, Kumagai M, Behm FG, Raimondi SC, Pui CH, Campana D.
Interleukin-4 induces programmed cell death (apoptosis) in cases of high-risk acute lymphoblastic leukemia. Blood 83,1731-1737(1994)
9 Manabe A, Murti KG, Coustan-Smith E, Kumagai M, Behm FG, Raimondi SC, Campana D.
Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells. Blood 83,758-766(1994)
10 Manabe A, Coustan-Smith E, Behm FG, Raimondi SC, Campana D.
Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia. Blood 79,2370-2377(1992)