岡野 光博 おかの みつひろ 先生

来歴等

略歴

1989年 香川医科大学医学部　 卒業
1993年 岡山大学大学院　 修了
1993年 医学博士 取得
1995年 ハーバード大学大学院公衆衛生学部　 客員研究員
1998年 岡山大学耳鼻咽喉科　 助手
2003年 岡山大学耳鼻咽喉科　 講師
2004年 岡山大学耳鼻咽喉科　 助教授（2007年より准教授）
2017年 国際医療福祉大学耳鼻咽喉科　 教授
2020年 国際医療福祉大学成田病院 教授

論文

• Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis. Allergology International 2019; 68: 216-224.

  Koyama T, Kariya S, Sato Y, Gion Y, Higaki T, Haruna T, Fujiwara T, Takao S, Orita Y,Kanai K, Taniguchi M, Nishizaki K, Okano M.

• Role of saliva in the efficacy of sublingual immunotherapy in seasonal allergic rhinitis. Allergology International 2019; 68: 82-89.

  Haruna T, Kariya S, Fujiwara T, Yuta A, Higaki T, Zhao P, Ogawa Y, Kanai K, Hitara Y,Oka A, Nishizaki K, Okano M.

• Association between impaired IL-10 production following exposure to Staphylococcus aureus enterotoxin B and disease severity in eosinophilic chronic rhinosinusitis. Allergology International 2019; 67: 392-398.

  Haruna T, Kariya S, Fujiwara T, Higaki T, Makihara S, Kanai K, Fujiwara R, Iwasaki S,Noguchi Y, Nishizaki K, Okano M.

• Evaluation of a new and simple classification for endoscopic sinus surgery. Allergy and Rhinology 2017; 8: 118-125.

  Kanai K, Okano M, Haruna T, Higaki T, Omichi R, Makihara SI, Tsumura M, Kariya S, Hirata Y, Nishizaki K.

• IL-22/IL-22R1 signaling regulates the pathophysiology of chronic rhinosinusitis with nasal polyps via alteration of MUC1 expression. Allergology International 2017; 66: 42-51.

  Noyama Y, Okano M, Fujiwara T, Kariya S, Higaki T, Haruna T, Makihara S, Kanai K, Koyama T, Taniguchi M, Ishitoya J, Kanda A, Kobayashi Y, Asako M, Tomoda K, Nishizaki K.

• Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts.Allergology International 2016; 65: 414-419.

  Kanai K, Okano M, Fujiwara T, Kariya S, Haruna T, Omichi R, Makihara S, Hirata Y, Nishizaki K.

• Effect of intranasal corticosteroid on pre-onset activation of eosinophils and mast cells in experimental Japanese cedar pollinosis. Allergology International 2016;65:269-265.

  Noyama Y, Okano M, Fujiwara T, Kariya S, Makihara S, Haruna T, Kanai K, Higaki T,Nishizaki K.

• Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN- production in chronic rhinosinusitis with nasal polyps. Allergology International 2016; 65: 96-102.

  Okano M, Fujiwara T, Kariya S, Higaki T, Makihara S, Haruna T, Noyama Y, Koyama T, Omichi R, Orita Y, Miki K, Kanai K, Nishizaki K.

• Staphylococcal protein A-formulated immune complexes suppress enterotoxin-induced cellular responses in nasal polyps. Journal of Allergy and Clinical Immunology 2015; 136: 343-350.

  Okano M, Fujiwara T, Kariya S, Haruna T, Higaki T, Noyama Y, Makihara S, Kanai K, Nishizaki K.

• Cellular responses to Staphylococcus aureus alpha-toxin in chronic rhinosinusitis with nasal polyps. Allergology International 2014; 63: 563-573.

  Okano M, Fujiwara T, Kariya S, Higaki T, Haruna T, Matsushita O, Noda Y, Makihara S, Kanai K, Noyama Y, Taniguchi M, Nishizaki K.

• Local expression of IL-17A is correlated with nasal eosinophilia and clinical severity in allergic rhinitis. Allergy and Rhinology 2014; 5: 22-27.

  Makihara S, Okano M, Fujiwara T, Noda Y, Higaki T, Miyatake T, Kanai K, Haruna T, Kariya S, Nishizaki K.

• Determining minimal clinically important differences in Japanese cedar/cypress pollinosis. Allergology International 2013; 62:487-493.

  Higaki T, Okano M, Kariya S, Fujiwara T, Haruna T, Hirai H, Murai A, Gotoh M, Okubo K, Yonekura S, Okamoto Y, Nishizaki K.

• Early interventional treatment with intranasal corticosteroids is superior to post-onset treatment in pollinosis. Annals of Allergy Asthma and Immunology 2012; 109: 458-464.

  Higaki T, Okano M, Makihara S, Fujiwara T, Haruna T, Noda Y, Kariya S, Nishizaki K.

• Characterization of IL-18 expression and release in the pathogenesis of chronic rhinosinusitis. International Archives of Allergy and Immunology 2013; 160:275-286.

  Okano M, Fujiwara T, Makihara S, Fujiwara R, Higaki T, Kariya S, Noda Y, Haruna T, Nishizaki K.

• COX/PGE 2 axis critically regulates effects of LPS on eosinophilia-associated cytokine production in nasal polyps. Clinical and Experimental Allergy 2012; 42: 1217-1226.

  Higaki T, Okano M, Fujiwara T, Makihara S, Kariya S, Noda Y, Haruna T, Nishizaki K.

• Makihara S, Okano M, Fujiwara T, Kimura M, Higaki T, Haruna T, Noda Y, Kanai K, Kariya S, Nishizaki K. Early interventional treatment with intranasal mometasone furoate in Japanese cedar/cypress pollinosis: a randomized placebo-controlled trial. Allergology International 2012; 61; 295-304.

  Makihara S, Okano M, Fujiwara T, Kimura M, Higaki T, Haruna T, Noda Y, Kanai K, Kariya S, Nishizaki K. Makihara S, Okano M, Fujiwara T, Kimura M, Higaki T, Haruna T, Noda Y, Kanai K, Kariya S, Nishizaki K. Early interventional treatment with intranasal mometasone furoate in Japanese cedar/cypress pollinosis: a randomized placebo-controlled trial. Allergology International 2012; 61; 295-304.

• Characterization of pollen antigen-induced IL-31 production by peripheral blood mononuclear cells in allergic rhinitis. Journal of Allergy and Clinical Immunology 2011; 127: 277-279.

  Okano M, Fujiwara T, Higaki T, Makihara S, Haruna T, Noda Y, Kanai K, Kariya S, Yasueda H, Nishizaki K.

• Role of fungal antigens in eosinophilia-associated cellular responses in nasal polyps:comparison with enterotoxin. Clinical and Experimental Allergy 2011; 41: 171-178.

  Okano M, Fujiwara T, Haruna T, Kariya S, Makihara S, Higaki T, Nishizaki K.

• Regulation and characterization of IL-17A expression in chronic rhinosinusitis and its relationship with eosinophilic inflammation. Journal of Allergy and Clinical Immunology 2010; 126:397-400.

  Makihara S, Okano M, Fujiwara T, Kariya S, Noda Y, Higaki T, Nishizaki K.

• PGE 2 suppresses staphylococcal enterotoxin-induced eosinophilia-associated cellular responses dominantly via an EP2-mediated pathway in nasal polyps. Journal of Allergy and Clinical Immunology 2009; 123: 868-874.

  Okano M, Fujiwara T, Haruna T, Kariya S, Makihara S, Higaki T, Nishizaki K.

著書

• 【共著】岡野光博. 鼻副鼻腔炎.今日の治療指針 2019年度版　医学書院　2019年

• 【共著】岡野光博. 本態性鼻炎.今日の耳鼻咽喉科・頭頸部外科治療指針　第4版　医学書院　2018年

• 【共著】岡野光博. 小児アレルギー性鼻炎.小児耳鼻咽喉科.　金原出版　2017年

特許

• インターロイキン１０産生促進剤. 岡野光博、西崎和則、藤原田鶴子.

  2018年9月21日登録. 特許第6404821号

• 口腔細菌叢の簡易予測法. 岡野光博、湯田厚司

  2017年9月21日出願. 特願　2017-181000号

その他

• 【受賞】2000年9月　第７回日本鼻科学会学会賞

• 【受賞】2002年5月　岡山医学会賞（砂田賞）　

• 【受賞】2006年12月　第10回日本ヒスタミン研究会　和田記念賞

• 【受賞】2013年11月　日本医師会医学研究奨励賞

• 【受賞】2015年11月　Auris Nasus Larynx Outstanding Reviewer