銭谷 幹男 ぜにや みきお 先生

来歴等

略歴

1975年3月 東京慈恵会医科大学卒業
1975年5月 第59会医師国家試験合格（医籍登録225894）
1975年4月 東京慈恵会医科大学大学院医学研究科臨床系内科学専攻博士過程入学
1980年8月 東京慈恵会医科大学第一内科学教室 助手
1983年7月 東京慈恵会医科大学学外研究員（米国エール大学）
1992年10月 東京慈恵会医科大学第一内科 講師（現内科学講座 消化器肝臓内科）
1994年4月 同上 助教授
1994年9月 同上 診療科長（1996年3月まで）
1995年11月 東京慈恵会医科大学DNA医学研究所悪性腫瘍治療研究部門助教授（兼任）
1996年4月 付属病院内科消化器・肝臓科 副部長
2004年4月 付属病院消化器・肝臓内科 部長代行
2006年4月 東京慈恵会医科大学 内科学講座 教授
2006年4月 東京慈恵会医科大学 大学院 医学研究科 器官病態・治療学 消化器内 教授
2006年7月 東京慈恵会医科大学 総合健診･予防医学センター センター長
2006年7月 東京慈恵会医科大学 総合健診・予防医学センター 教授
2006年7月 東京慈恵会医科大学 付属病院 総合健診・予防医学センター診療部長
2015年3月 東京慈恵会医科大学 定年退職
2015年4月 国際医療福祉大学 臨床研究センター 山王病院内科教授
2015年4月 藤田保健衛生大学 医学部 客員教授
2016年4月 国際医療福祉大学 大学院教授
2016年4月 医療法人財団順和会 山王メディカルセンター院長
2020年8月 医療法人財団順和会 赤坂山王メディカルセンター院長

論文

【論文】(2012-）
１． Takashi Wada and Mikio Zeniya: Background of the FIB-4 Index in Japanese　Non-Alcoholic Fatty Liver Disease　 Intern Med 54: 127-132, 2015
２． Mikio Zeniya ・Takashi Wada：The therapeutic effect of UDCA is a factor in determining
the prognosis of primary biliary cirrhosis　 J Gastroenterol (2014) 49:1438–1439
３． Mikio Zeniya、Takashi Wada: Immunosuppressive therapy for primary biliary cirrhosis: Do we need in future?　Hepatol Res 44:935-6,2014
４． Shuichi Katoh1, Markku Peltonen,,Takashi Wada, Mikio Zeniya1,Yoichi Sakamoto, Kazunori Utsunomiya
and Jaakko Tuomilehto: Fatty liver and serum cholinesterase are independently correlated with HbA1c
levels: Cross-sectional analysis of 5384 people Journal of International Medical Research 42: 542–553 2014
５． Yamamoto, K.Miyake, Y.Ohira, H.Suzuki, Y.Zeniya, M.Onji, M.Tsubouchi, H.: Intractable, LiverBiliary Diseases Study Group of, Japan Prognosis of autoimmune hepatitis showing acute presentation. Hepatol Res　43：630-638、2013
６． Oikawa, T.Kamiya, A.Zeniya, M.Chikada, H.Hyuck, A. D.Yamazaki, Y.Wauthier, E.Tajiri, H.Miller, L. D.Wang, X. W. Reid, L. M.Nakauchi, H. : Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers. Hepatology 57:1469-1483,2013
７． Harada, K.Hsu, M.Ikeda, H. Zeniya, M.Nakanuma, Y.: Application and validation of a new histologic staging and grading system for primary biliary cirrhosis. J Clin Gastroenterol 47:174-181,2013
８． Zeniya, M.Nakano, M.Saeki, C.Yokoyama, KIshikawa, T.Takaguchi, K.Takahashi, H.:
Usefulness of combined application of double-filtration plasmapheresis and twice-daily injections of interferon-beta in hemodialysis patients with hepatitis C virus genotype 1b infection and a high viral load. Hepatol Res　10.1111/hepr.12207　2013
９． Ohira, H.Abe, K.Takahashi, A. Zeniya, M .Ichida, T. : Clinical features of hepatocellular carcinoma in patients with autoimmune hepatitis in Japan. Hep Res 48:109-114,2013
１０． Nakano, M.Saeki, C.Takahashi, H.Homma, S.Tajiri, H. Zeniya, M. : Activated natural killer T cells producing interferon-gamma elicit promoting activity to murine dendritic cell-based autoimmune hepatic inflammation. Clin Exp Immunol 170:274-282,2012
１１． Nakamura, M.Nishida, N.Kawashima, M.Aiba, Y.Tanaka, A.Yasunami, M.Nakamura, H.Komori, A.Nakamuta, M. Zeniya, M .Hashimoto, E.Ohira, H.Yamamoto, K.Onji, M.Kaneko, S.Honda, M.Yamagiwa, S.Nakao, K.Ichida, T.Takikawa, H.Seike, M.Umemura, T.Ueno, Y.Sakisaka, S.Kikuchi, K.Ebinuma, H.Yamashiki, N.Tamura, S.Sugawara, Y.Mori, A.Yagi, S.Shirabe, K.Taketomi, A.Arai, K.Monoe, K.Ichikawa, T.Taniai, M.Miyake, Y.Kumagi, T.Abe, M. Yoshizawa, K.Joshita,　S.Shimoda, S.Honda,K.Takahashi, H.Hirano, K.Takeyama, Y.Harada, K.Migita, K.Ito, M.Yatsuhashi, H.Fukushima, N.Ota, H.Komatsu, T.Saoshiro, T.Ishida, J.Kouno, H.Kouno, H.Yagura, M.Kobayashi, M.Muro, T.Masaki, N.Hirata, K.Watanabe, Y.Nakamura, Y.Shimada, M.Hirashima, N.Komeda, T.Sugi, K.Koga, M.Ario, K.Takesaki, E.Maehara, Y.Uemoto, S.Kokudo, N.Tsubouchi, H.Mizokami, M.Nakanuma, Y.Tokunaga, K.Ishibashi, H. : Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. Am J Hum Genet 91:721-728,2012
１２． Atsushi Hokari, Tomohisa Ishikawa, Hisao Tajiri, Takahide Matsuda, Osamu Ishii, Nobuyuki Matsumoto, Chiaki Okuse, Hideaki Takahashi, Takeshi Kurihara, Ko-ichi Kawahara, Ikuro Maruyama, Mikio Zeniya: Efficacy of MK615 for the treatment of patients with liver disorders. World J Gastroenterol 2012 18):4118-4126
１３． Mikio Zeniya • Hiroki Takahashi: Characteristics of autoimmune hepatitis in the Asia-Pacific Region: historical review. Hepatol Int (2012) 6:342–349
１４． Hiroki Takahashi and Mikio Zeniya: Acute presentation of autoimmune hepatitis: Does it exist? A published work review. Hepatology Research 2011; 41: 498–504
１５． Abe, M.,Mashiba, T.,Zeniya, M.,Yamamoto, K.,Onji, M.,Tsubouchi, H.: Present status of autoimmune hepatitis in Japan: a nationwide survey. .J Gastroenterol 46:1136-1141,2011
１６． Zeniya,M Takahashi H: Diagnostic Criteria for autoimmune hepatitis: Historical review and present problems. Jikeikai Med J. 58: 89-93,2011
１７． Atsushi Tanaka,Kenichi Harada, Hirotoshi Ebinuma, Atsumasa Komori, Junko Yokokawa, Kaname Yoshizawa,Masanori Abe, Yasuhiro Miyake, Kentaro Kikuchi,Hiromasa Ohira ,Mikio Zeniya ,Kazuhide Yamamoto,Hiromi Ishibashi, Morikazu Onji,Yasuni Nakanuma,Hirohito Tsubouchi and Hajime Takikawa: Primary biliary cirrhosis – Autoimmune hepatitis overlap syndrome: A rationale for corticosteroids use based on anation-wide retrospective study in Japan. Hepatology Research 2011; 41: 877–886
１８． Zeniya M, Yokoyama K, Imamura N Murai S et al.: Siginicance of interferon-βfor the treatment of hepatitis C virus infection in hemodialyzed patients. Hepatol Res. 40:862-869,2010
１９． Satoh K, Takahashi H, Matsuda C, Zeniya M et al.: Natural killer cells target HCV core proteins during the innate immune response in HCV transgenic mice. J Med Virol 82:1545-1553,2010
２０． Saeki C, Nakano M, Takahashi H, Zeniya M et al.: Accumulation of functional regulatory T cells in actively inflamed liver in mouse dendritic cell-based autoimmune hepatic inflammation. Clin Immunol 135:156-166.2010
２１． Oikawa, T.,Kamiya, A.,Kakinuma, S.,Zeniya, M.,.et al.:Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells. Gastroenterology 136: 1000-11,2009
２２． Torisu, Y.,Watanabe A., Nonaka, ,Zeniya, M.et al:,Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF. Cancer Sci 99: 1139-46,2008
２３． Iwasaki, S.,Ohira, H.,Nishiguchi, S.,Zeniya, M.et al: The efficacy of ursodeoxycholic acid and bezafibrate combination therapy for primary biliary cirrhosis: A prospective, multicenter study. Hepatol Res 38: 557-64,2008
２４． Hennes, E. M.,Zeniya, M.,Czaja, A.et al: Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology 48: 169-76,2008
２５． Oikawa, T.,Takahashi, H.,Ishikawa, ,Zeniya, M et al: Intrahepatic expression of the co-stimulatory molecules programmed death-1, and its ligands in autoimmune liver disease. Pathol Int 57: 485-92,2007
２６． Sakauchi, F.,Mori, M.,Zeniya, M.,Toda, G :Antimitochondrial antibody negative primary biliary cirrhosis in Japan: utilization of clinical data when patients applied to receive public financial aid. J Epidemiol 16: 30-4,2006
２７． Komita, H.,Homma, S.,Saotome, H.,Zeniya, M.,et al: Interferon-gamma produced by interleukin-12-activated tumor infiltrating CD8+T cells directly induces apoptosis of mouse hepatocellular carcinoma. J Hepatol 45: 662-72,2006
２８． Hiroki Takahashi, Mikio Zeniya,: Do DCs influence the antiviral effect of interferon/ribavirin by changing their profile during the therapy? J Gastroenterol 2006; 41:816–817
２９． Oikawa, T.,Kamimura, Y. Zeniya, M et al :Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease. J Immunol 177: 4281-7,2006
３０． Zeniya, M. Watanabe, F.Morizane, T.Shibata, M.Maeyama, S.Kage, M.Nakanuma, Y.Toda, G. : Study Group of Intractable Liver Diseases for Research on a Specific Disease, Health Science Research Grant Ministry of Health Labour Welfare of, Japan Diagnosing clinical subsets of autoimmune liver diseases based on a multivariable model. J Gastroenterol 40:1148-1154,2005
３１． Tamaki, S.Homma, S.Enomoto, Y.Komita, H. Zeniya, M. Ohno, T.Toda, G. : Autoimmune hepatic inflammation by vaccination of mice with dendritic cells loaded with well-differentiated hepatocellular carcinoma cells and administration of interleukin-12 Clin Immunol 117: 280-293,2005
３２． Sawada, K.Masaki, N.Hayashi, S .Zeniya, M .Ishikawa, T.Takahashi, H.Ohnishi, K.Fukunaga, K.Hara, N. Yamamoto, T.Hada, T.Toda, G.: Immunomodulatory effects of selective leucocytapheresis as a new adjunct to interferon-alpha2b plus ribavirin combination therapy: a prospective study in patients with high plasma HCV viraemia. J Viral Heoat 12:274-282
３３． Sakauchi, F.Mori, M.Zeniya, M.Toda, G.: A cross-sectional study of primary biliary cirrhosis in Japan: utilization of clinical data when patients applied to receive public financial aid J Epideiol 15:24-28,2005
３４． Czaja, A. J.Bianchi, F. B.Carpenter, H. A.Krawitt, E. L.Lohse, A. W.Manns, M. P.McFarlane, I. G.Mieli-Vergani, G.Toda, G.Vergani, D.Vierling, J.Zeniya, M.: Treatment challenges and investigational opportunities in autoimmune hepatitis. Hepatolo 41:207-215,2005
３５． Amano, K.Leung, P. S.Rieger, R.Quan, C.Wang, X.Marik, J.Suen, Y. F.Kurth, M. J.Nantz, M. H.Ansari, A. A.Lam, K. S. Zeniya, M. Matsuura, E.Coppel, R. L.Gershwin, M. E. : Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol 174:5874-5883,2005
３６． Hokari, A. Zeniya, M .Esumi, H.Ishikawa, T.Kurasima, Y.Toda, G.: Role of nitric oxide (NO) in interferon-alpha therapy for hepatitis C. J Infectt 51:47-53,2005
３７． Iwasa, M. Zeniya, M .Kumagi, T.Hisamochi, A.Yasuda, H.Nishiuchi, M.Akisawa, N.Mantani, N.Watanabe, M.Ito, T.Nakamura, A.Takikawa, H.Adachi, Y. : Modified diagnostic criteria of drug-induced liver injury proposed by the international consensus meeting. Hepatogastroenterology 52:869-874,2005
３８． Atsushi Tanaka, Xiong Ma, Osamu Yokosuka, Martin Weltman, Hong You, Deepak N. Amarapurkar, Yoon Jun Kim, Zaigham Abbas, Diana A. Payawal, Ming-Ling Chang10,, Cumali Efe, Ersan Ozaslan, Masanori Abe, Robert Mitchell-Thain, Mikio Zeniya, Kwang Hyub Han, John M. Vierling, Hajime Takikawa: Autoimmune liver diseases in the Asia–Pacific region: Proceedings of APASL symposium on AIH and PBC 2016 Hepatol Int 10:900-915,2016
３９． David N. Assis, Hiroki Takahashi, Lin Leng, Mikio Zeniya, James L. Boyer, Richard Bucala: A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients Dig Dis Sci DOI 10.1007/s10620-016-4322-z 2016
４０． Katoh S, Peltonen M, Zeniya M, Kaji M, Sakamoto Y, Utsunomiya K, Tuomilehto J: Analysis of the Japanese Diabetes Risk Score and fatty liver markers for incident diabetes in a Japanese cohort. Prim. Care Diab. 10:19-26, 2015
４１． Yuichi Torisu, Masanori Nakano, Keiko Takano, Ryo Nakagawa, Chisato Saeki, Atsushi Hokari, Tomohisa Ishikawa, Masayuki Saruta, Mikio Zeniya: Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis World J Hepatol 2017 January 8; 9(1): 57-63
４２． Nakagawa R, Muroyama R, Saeki C, Goto K, Kaise Y, Koike K, Nakano M, Matsubara Y, Takano K, Ito S, Saruta M, Kato N, Zeniya M.：miR-425 regulates inflammatory cytokine production in CD4+ T cells via N-Ras upregulation in primary biliary cholangitis. J Hepatol 66:1223-1230,2017
４３． Takahashi A, Hino TA, Ohira H, Torimura T, Zeniya M, Abe M, Yoshizawa K, Takaki A, Suzuki Y, Kang JH, Nakamoto N, Fujisawa T, Yonemoto K, Tanaka A, Takiakwa H, Autoimmune Hepatitis Study Group- Subgroup of the Intractable Hepato-Biliary Disease Study Group in Japan: Autoimmune hepatitis in Japan: trends in nationwide survey. J gastroenterol 52:631-640,2017
４４． Minae Kawashima, Yuki Hitomi, Yoshihiro Aiba　Mikio Zeniya, et al: Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population. Human Mol Genet 26:650-659,2017
４５． Satoru Joshita、 Kaname Yoshizawa、 Takeji Umemura、Hiromasa Ohira、Atsushi Takahashi、Kenichi Harada、Nguyen Canh Hiep、Koichi Tsuneyama、Masayoshi Kage、Masayuki Nakano、Jong-Hon Kang、Kazuhiko Koike、Mikio Zeniya、Tetsuya Yasunaka、 Akinobu Takaki、Takuji Torimura、Masanori Abe、Osamu Yokosuka、Atsushi Tanaka、Hajime Takikawa、The Japan Autoimmune Hepatitis Study Group (JAIHSG):　Clinical features of autoimmune hepatitis with acute presentation:a Japanese nationwide survey. J Gastroenterol 53:1079-1088, 2018
４６． Atsushi Takahashi,Teruko Arinaga-Hino, Hiromasa Ohira, Kazumichi Abe,*Takuji Torimura,
Mikio Zeniya, Masanori Abe, Kaname Yoshizawa,Akinobu Takaki,Yoshiyuki Suzuki, Jong-Hon Kang,Nobuhiro Nakamoto, Tomoo Fujisawa, Atsushi Tanaka　 and Hajime Takikawa, Japan AIH Study Group(JAIHSG):Non-alcoholic fatty liver disease in patients with autoimmune hepatitis 2018 HGH 2:54-58
４７． Liberal R, de Boer Y, Andrade R, Bouma G, Dalekos G, Floreani A, Gleeson D, Hirschfield G, Invernizzi P, Lenzi M, Lohse A, Macedo G, Milkiewicz P, Terziroli B, van Hoek B, Vierling J, Heneghan M, Pares A, Montano-Loza A, Granito A, Kremer A, Schramm C, Lammert C, Cancado E, Bjornsson E, Lammert F, Hirschflield G, Hofer H, Mackay I, Neuberger J, Drenth J, van Nieuwkerk C, Muratori L, Swain M, Heneghan M, Zeniya M, Chazouilleres O, Gines P, Chapman R, Berg T, van Buuren H, Ma X : Expert clinical management of autoimmune hepatitis in the real world Alimentary Pharmacology and Therapeutics (2017) 45(5) 723-732
４８． Ryo Nakagawa,Ryosuke Muroyama,Chisato Saeki,Tsunekazu Oikawa,Yoshimi Kaise,Kazuhiko Koike,Jun Arai,Masanori Nakano,Yasuo Matsub ara,Keiko Takano,Yoshihiro Hirata,Masayuki Saruta,Mikio Zeniya
and Naoya Kato　CD4　T cells from patients with primary biliary cholangitis show T cell activation and differentially expressed T-cell receptor repertoires
Hepatology Research 2019; 49: 653–662
４９． Atsushi Takahashi,* Teruko Arinaga-Hino,† Hiromasa Ohira,* Kazumichi Abe,* Takuji Torimura
Mikio Zeniya,‡et al.: Non-alcoholic fatty liver disease in patients with autoimmune
Hepatitis JGH Open: An open access journal of gastroenterology and hepatology 2 (2018) 54–58
５０． Takano K, Chisato S, Oikawa T Hidaka A, Mizuno Y, Ishida J, Takakura K, Nakano M, Torisu Y, Amano K, Ishikawa T, Zeniya M, Tsubota A, Saruta M: IgM response is a prognostic biomarker of primary biliary cholangitis treated with ursodeoxycholic acid and bezafibrate. JGH 35:663-672, 2019

その他

• 【受賞】大和ヘルス財団奨励賞

• 【受賞】三共生命科学財団奨励賞

• 【受賞】上原記念財団研究奨励賞

• 【受賞】武田医学研究奨励賞