井上 猛 いのうえ たけし 先生

来歴等

略歴

1984年　北海道大学医学部卒業
1993年　北海道大学医学博士取得
1993年　北海道大学精神科 助手
2000年　北海道大学精神科 講師
2012年　北海道大学精神科 准教授
2015年　東京医科大学精神医学分野　主任教授

論文

Inoue T, Tsuchiya K and Koyama T: Regional changes in dopamine and serotonin activation with various intensity of physical and psychological stress in the rat brain. Pharmacol. Biochem. Behav. 49:911-920, 1994.

Inoue T, Tsuchiya K, Miura J, Sakakibara S, Denda K, Kasahara T and Koyama T: Bromocriptine treatment of tricyclic and heterocyclic antidepressant-resistant depression. Biol. Psychiatry 40: 151-153, 1996.

Inoue T, Li XB, Abekawa T, Kitaichi Y, Izumi T, Nakagawa S, Koyama T: Selective serotonin reuptake inhibitor reduces conditioned fear through its effect in the amygdala. Eur. J. Pharmacol. 497: 311-316, 2004.

Inoue T, Nakagawa S, Kitaichi Y, Izumi T, Tanaka T, Masui T, Kusumi I, Denda K, Koyama T: Long-term outcome of antidepressant-refractory depression: The relevance of unrecognized bipolarity. J Affect Disord 95:61-67, 2006.

Boku S, Nakagawa S, Masuda T, Nishikawa H, Kato A, Kitaichi Y, Inoue T, Koyama T: Glucocorticoids and lithium reciprocally regulate the proliferation of adult dentate gyrus-derived neural precursor cells through GSK-3β andβ-catenin/TCF pathway. Neuropsychopharmacology 34:805-815, 2009.

Inoue T, Kitagawa M, Tanaka T, Nakagawa S, Koyama T: Depression and major depressive disorder in patients with Parkinson's disease. Movement Disorders 25 (1): 44–49, 2010.

Inoue T, Kitaichi Y, Masui T, Nakagawa S, Boku S, Tanaka T, Suzuki K, Nakato Y, Usui R, Koyama T: Pramipexole for stage 2 treatment-resistant major depression: an open study. Prog Neuropsychopharmacol Biol Psychiatry 34: 1446–1449, 2010.

Inoue T, Abekawa T, Nakagawa S, Suzuki K, Tanaka T, Kitaichi Y, Boku S, Nakato Y, Toda H, Koyama T: Long-term naturalistic follow-up of lithium augmentation: relevance to bipolarity. J Affect Disord 129:64-67, 2011.

Inoue T, Kitaichi Y, Koyama T: SSRIs and conditioned fear. Prog Neuropsychopharmacol Biol Psychiatry 35: 1810-1819, 2011.

Inoue T, Honda M, Kawamura K, Tsuchiya K, Suzuki T, Ito K, Matsubara R, Shinohara K, Ishikane T, Sasaki K, Boku S, Fujisawa D, Ono Y, Koyama T: Sertraline treatment of patients with major depressive disorder who failed initial treatment with paroxetine or fluvoxamine. Prog Neuropsychopharmacol Biol Psychiatry 38(2):223-227, 2012.

Nakai Y, Inoue T, Toda H, Toyomaki A, Nakato Y, Nakagawa S, Kitaichi Y, Kameyama R, Hayashishita Y, Wakatsuki Y, Oba K, Tanabe H, Kusumi I: The influence of childhood abuse, adult stressful life events and temperaments on depressive symptoms in the non-clinical general adult population. J Affect Disord 158:101-107, 2014.

Boku S, Toda H, Nakagawa S, Kato A, Inoue T, Koyama T, Hiroi N, Kusumi I: Neonatal maternal separation alters the capacity of adult neural precursor cells to differentiate into neurons via methylation of retinoic acid receptor gene promoter. Biol Psychiatry 77:335-344, 2015.

Inoue T, Inagaki Y, Kimura T, Shirakawa O: Prevalence and predictors of bipolar disorders in patients with a major depressive episode: the Japanese epidemiological trial with latest measure of bipolar disorder (JET-LMBP). J Affect Disord 174:535-541, 2015.

Toda H, Inoue T, Tsunoda T, Nakai Y, Tanichi M, Tanaka T, Hashimoto N, Nakato Y, Nakagawa S, Kitaichi Y, Mitsui N, Boku S, Tanabe H, Nibuya M, Yoshino A, Kusumi I: The structural equation analysis of childhood abuse, adult stressful life events and temperaments in major depressive disorders and their influence on refractoriness. Neuropsych. Dis. Treat. 11:2079-2090, 2015.

Nakai Y, Inoue T, Chen C, Toda H, Toyomaki A, Nakato Y, Nakagawa S, Kitaichi Y, Kameyama R, Wakatsuki Y, Kitagawa K, Tanabe H, Kusumi I: The moderator effects of affective temperaments, childhood abuse and adult stressful life events on depressive symptoms in the nonclinical general adult population. J Affect Disord 187:203-210, 2015.

Toda H, Inoue T, Tsunoda T, Nakai Y, Tanichi M, Tanaka T, Hashimoto N, Takaesu Y, Nakagawa S, Kitaichi Y, Boku S, Tanabe H, Nibuya M, Yoshino A, Kusumi I: Affective temperaments play an important role in the relationship between childhood abuse and depressive symptoms in major depressive disorder. Psychiatry Research 236: 142-147, 2016.

Ikeda M, Takahashi A, Kamatani Y, Okahisa Y, Kunugi H, Mori N, Sasaki T, Ohmori T, Okamoto Y, Kawasaki H, Shimodera S, Kato T, Yoneda H, Yoshimura R, Iyo M, Matsuda K, Akiyama M, Ashikawa K, Kashiwase K, Tokunaga K, Kondo K, Saito T, Shimasaki A, Kawase K, Kitajima T, Matsuo K, Itokawa M, Someya T, Inada T, Hashimoto R, Inoue T, Akiyama K, Tanii H, Arai H, Kanba S, Ozaki N, Kusumi I, Yoshikawa T, Kubo M, Iwata N, the advanced Collaborative Study of Mood Disorder (COSMO) team: A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder. Mol Psychiatry 2017. doi: 10.1038/mp.2016.259. [Epub ahead of print]

Ono Y, Takaesu Y, Nakai Y, Ichiki M, Masuya J, Kusumi I, Inoue T: The influence of parental care and overprotection, neuroticism and adult stressful life events on depressive symptoms in the general adult population. J Affect Disord 217:66-72, 2017.

Matsuo K, Harada K, Fujita Y, Okamoto Y, Ota M, Narita H, Mwangi B, Gutierrez CA, Okada G, Takamura M, Yamagata H, Kusumi I, Kunugi H, Inoue T, C. Soares J, Yamawaki S, Watanabe Y: Distinctive neuroanatomical substrates for depression in bipolar disorder versus major depressive disorder. Cerebral Cortex [Epub ahead of print] DOI: 10.1093/cercor/bhx319

Toda H, Inoue T, Tanichi M, Saito T, Nakagawa S, Masuya J, Tanabe H, Yoshino A, Kusumi I: Affective Temperaments Play an Important Role in the Relationship between Child Abuse and the diagnosis of bipolar disorder. Psychiatry Research 262:13-19, 2018.

著書

井上　猛、小山　司：難治性うつ病．「気分障害」（上島国利、樋口輝彦、野村総一郎、大野　裕、神庭重信、尾崎紀夫編集）、医学書院、pp512-533, 2008年