中川 栄二 なかがわ えいじ 先生

来歴等

略歴

1989年 筑波大学医学専門学群医学科 卒業
1989年 滋賀医科大学小児科 医員
1992年 国立精神・神経センター武蔵病院 小児神経科 レジデント
1998年 カナダ　ブリティッシュ・コロンビア大学 神経科 研究員
2000年 獨協医科大学 小児科 講師
2003年 国立精神・神経センター武蔵病院 小児神経科 医長
2016年 国立精神・神経医療研究センター病院 外来部長
2018年 国立精神・神経医療研究センター病院 特命副院長、てんかんセンター長

論文

• 1. Transient water-electrolyte disturbance after hemispherotomy in young infants with epileptic encephalopathy. Child's Nervous System. 2020 May;36(5):1043-1048. doi: 10.1007/s00381-019-04452-1. Epub 2019 Dec 16.

  Saito T, Sugai K, Takahashi A, Ikegaya N, Nakagawa E, Sasaki M, Iwasaki M, Otsuki T.

• 2. A novel pathogenic NFIX variant in a Malan syndrome patient associated with hindbrain overcrowding. Journal of the Neurological Sciences. 2020 May 15;412:116758. doi: 10.1016/j.jns.2020.116758. Epub 2020 Feb 22.

  Tabata K, Iida A, Takeshita E, Nakagawa E, Sato N, Sasaki M, Inoue K, Goto Y.

• 3. A case of CLCN2-related leukoencephalopathy with bright tree appearance during aseptic meningitis. Brain Dev. 2020 Jun;42(6):462-467. doi: 10.1016/j.braindev.2020.02.008.

  Ozaki A, Sasaki M, Hiraide T, Sumitomo N, Takeshita E, shimizu-Motohashi Y, Ishiyama A, Saito T, Komaki H, Nakagawa E, Sato N, Nakashima M, Saitsu H.

• 4. 13q13.3 Microdeletion Associated With Apparently Balanced Translocation of 46,XX,t(7;13) Suggests NBEA Involvement. Brain Dev. 2020 Jun 4;S0387-7604(20)30147-9. doi: 10.1016/j.braindev.2020.05.006. Online ahead of print.

  Miura M, Ishiyama A, Nakagawa E, Sasaki M, Kurosawa K, Inoue K, Goto Y.

• 5. Association of Inattention With Slow-Spindle Density in Sleep EEG of Children With Attention Deficit-Hyperactivity Disorder. Brain Dev. 2019 Oct;41(9):751-759. doi: 10.1016/j.braindev.2019.05.004. Epub 2019 Jun 14. (表彰論文)

  Saito Y, Kaga Y, Nakagawa E, Okubo M, Kohashi K, Omori M, Fukuda A, Inagaki M.

• 6. Bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts: a case report. BMC Psychiatry.2020　3;20(1):349. doi: 10.1186/s12888-020-02750-6.

  Ishikawa M, Omachi Y, Sato N, Nakagawa E.

• 7. Executive dysfunction in medication-na_ve children with ADHD : A multi-modal fNIRS and EEG study. Brain & Development 2020 Sep;42(8):555-563. doi: 10.1016/j.braindev.2020.05.007. Epub 2020 Jun 10.

  Kaga Y, Ueda R, Tanaka M, Kita Y, Suzuki K, Okumura Y, Egashira Y, Shirakawa Y, Mitsuhashi S, Kitamura Y, Nakagawa E, Yamashita Y, Inagaki M.

• 8. Postoperative improvement of executive function and adaptive behavior in children with intractable epilepsy. Brain Dev. 2020 Aug 29;S0387-7604(20)30218-7. doi: 10.1016/j.braindev.2020.08.005. Online ahead of print.

  Ueda R, Kaga Y, Kita Y , Tanaka M , Iwasaki M , Takeshita E , Shimizu-Motohashi Y , Ishiyama A , Saito T , Nakagawa E , Sugai K , Sasaki M , Okada T , Inagaki M.

• 9. Clonazepam as an Effective Treatment for Epilepsy in a Female Patient with NEXMIF Mutation: Case Report. Molecular Syndromology. 2020 Nov;11(4):232-237. doi: 10.1159/000510172. Epub 2020 Sep 1.

  Ogasawara M, Nakagawa E, Takeshita E, Hamanaka K, Miyatake S, Matsumoto N, Sasaki M.

• 10. Cognitive and developmental outcomes after pediatric insular epilepsy surgery for focal cortical dysplasia. J Neurosurg Pediatr. 2020 Aug 7;1-9. doi: 10.3171/2020.5.PEDS2058. Online ahead of print.

  Ikegaya N, Iwasaki M, Kaneko Y, Kaido T, Kimura Y, Yamamoto T, Sumitomo N, Saito T, Nakagawa E, Sugai K, Sasaki M, Takahashi A, Otsuki T.

• 11. Down Syndrome Cell Adhesion Molecule Like-1 (DSCAML1) links the GABA system and seizure susceptibility. Acta Neuropathologica Communications. 2020 8:206. doi.org/10.1186/s40478-020-01082-6

  Hayase Y, Amano S, Hashizume K, Tominaga T, Miyamoto H, Kanno Y, Ueno-Inoue Y, Inoue T, Yamada M, Ogata S, Balan Shabeesh, Hayashi K, Miura Y, Tokudome K, Ohno Y, Nishijo T, Momiyama T, Yanagawa Y, Takizawa A, Mashimo T, Serikawa T, Sekine A, Nakagawa E, Takeshita E, Yoshikawa T, Waga C, Inoue K, Goto Y, Nabeshima Y, Ihara N, Yamakawa K, Taya S, Hoshino M.

• 12. Adaptive behavior and its related factors in children with focal epilepsy. Epilepsy Behav. 2020 Apr 19;108:107092. doi: 10.1016/j.yebeh.2020.107092. Epub ahead of print. PMID: 32320922.

  Ueda R, Kaga Y, Kita Y, Iwasaki M, Takeshita E, Shimizu-Motohashi Y, Ishiyama A, Saito T, Nakagawa E, Sugai K, Sasaki M, Inagaki M.

• 13. Association of lack of functional connectivity between fronto_parietal pairs in children with frontal lobe epilepsy and poor executive function. Epilepsy & Behavior. 10.1016/j.braindev. 2020.08.005 査読有

  Ueda R, Kaga Y, Takeichi H, Iwasaki M, Takeshita E, Shimizu-Motohashi Y, Ishiyama A, Saito T, Nakagawa E, Sugai K, Sasaki M, Inagaki M.

• 14. Down syndrome cell adhesion molecule like_1 (DSCAML1) links the GABA system and seizure susceptibility. acta neuropathol commun (2020) 8:206 https://doi.org/10.1186/s40478-020-01082-6

  Hayase Y, Amano S, Hashizume K, Tominaga T, Miyamoto H, Kanno Y, Ueno_Inoue Y, Inoue T, Yamada M, Ogata S, Shabeesh Balan, Hayashi K, Miura Y, Tokudome K, Ohno Y, Nishijo T, Momiyama T, Yanagawa Y, Takizawa A, Mashimo T, Serikawa T, Sekine A, Nakagawa E, Takeshita E, Yoshikawa T, Waga C, Inoue K, Goto Y, Nabeshima Y, Ihara N, Yamakawa K, Taya S, Hoshino1 M.

• 15. Identification of de novo CSNK2A1 and CSNK2B variants in cases of global developmental delay with seizures. Journal of Human Genetics. 2019 Apr;64(4):313-322.

  Nakashima M, Tohyama J, Nakagawa E, Watanabe Y, Siew CG, Kwong CS, Yamoto K, Hiraide T, Fukuda T, Kaname T, Nakabayashi K, Hata K, Ogata T, Saitsu H, Matsumoto N.

• 16. Ictal deafness in drug-resistant MRI-negative epilepsy. Electroclinical reasoning report. Epileptic Disord 2019; 21(2): 215-20.

  Ikegaya N, Nakagawa E, Sugai K, Sasaki M, Saito T, Sumitomo N, Iijima K, Kimura Y, Kaneko Y, Iwasaki M.

• 17. Age-related differences in frontal lobe function in children with ADHD. Brain Dev. 2019 Aug;41(7):577-586.

  Yasumura A, Omori M, Fukuda A, Takahashi J, Yasumura Y, Nakagawa E, Koike T, Yamashita Y, Miyajima T, Koeda T, Aihara M, Inagaki M.

• 18. Genetic landscape of Rett syndrome-like phenotypes revealed by whole exome sequencing. J Med Genet. 2019 Jun;56(6):396-407.

  Iwama K, Mizuguchi T, Takeshita E, Nakagawa E, Okazaki T, Nomura Y, Iijima Y, Kajiura I, Sugai K, Saito T, Sasaki M, Yuge K, Saikusa T, Okamoto N, Takahashi S, Amamoto M, Tomita I, Kumada S, Anzai Y, Hoshino K, Fattal-Valevski A, Shiroma N, Ohfu M, Moroto M, Tanda K, Nakagawa T, Sakakibara T, Nabatame S, Matsuo M, Yamamoto A, Yukishita S, Inoue K, Waga C, Nakamura Y, Watanabe S, Ohba C, Sengoku T, Fujita A, Mitsuhashi S, Miyatake S, Takata A, Miyake N, Ogata K, Ito S, Saitsu H, Matsuishi T, Goto YI, Matsumoto N.

• 19. Altered Expression of Astrocyte-Related Receptors and Channels Correlates With Epileptogenesis in Hippocampal Sclerosis. Pediatr Dev Pathol. 2019; 22 (6), 532-539.

  Aoki Y, Hanai S, Sukigara S, Otsuki T, Saito T, Nakagawa E, Kaido T, Kaneko Y, Takahashi A, Ikegaya N, Iwasaki M, Sugai K, Sasaki M, Goto Y, Oka A, Itoh M.

• 20. Static Leukoencephalopathy Associated with 17p13.3 Microdeletion Syndrome: A Case Report. Neuropediatrics. 2019; 50 (6)387-390.

  Hirasawa-Inoue A, Takeshita E, Shimizu-Motohashi Y, Ishiyama A, Saito T, Komaki H, Nakagawa E, Sugai K, Inoue K, Goto YI, Sasaki M.

• 21. Single-fiber electromyography-based diagnosis of CACNA1A mutation in children: A potential role of the electrodiagnosis in the era of whole exome sequencing. Brain Dev. 2019; 41 (10)905-909.

  Hirasawa-Inoue A, Ishiyama A, Takeshita E, Shimizu-Motohashi Y, Saito T, Komaki H, Nakagawa E, Yuasa S, Saitsu H, Hamanaka K, Miyatake S, Matsumoto N, Sasaki M.

• 22. Association of inattention with slow-spindle density in sleep EEG of children with attention deficit-hyperactivity disorder. Brain Dev. 2019;41(9):751-759.

  Saito Y, Kaga Y, Nakagawa E, Okubo M, Kohashi K, Omori M, Fukuda A, Inagaki M.

• 23. Postoperative changes in the brain: Assessment with serial T2WI/FLAIR MR images in non-neoplastic patients. Epilepsy Res.　2019.08;154:149-151.

  Shigemoto Y, Sato N, Kimura Y, Morimoto E, Suzuki F, Ikegaya N, Iwasaki M, Nakagawa E, Matsuda H.

• 24. Alteration of the Anatomical Covariance Network After Corpus Callosotomy in Pediatric Intractable Epilepsy. PLoS One. 14 (12), e0222876 2019 Dec 5 eCollection 2019

  Ueda R, Matsuda H, Sato N, Iwasaki M, Sone D, Takeshita E, Shimizu-Motohashi Y, Ishiyama A, Saito T, Komaki H, Nakagawa E, Sugai K, Sasaki M, Kaga Y, Takeichi H, Inagaki M.

• 25. Atypical gamma functional connectivity pattern during light sleep in children with attention deficit hyperactivity disorder. Brain Dev. 2020;42(2):129-139.

  Ueda R, Takeichi H, Kaga Y, Oguri M, Saito Y, Nakagawa E, Maegaki Y, Inagaki M.

• 26. Ten novel insertion/deletion variants in MECP2 identified in Japanese patients with Rett syndrome. Human Genome Variation,6,48 2019 Oct 18 eCollection 2019

  Takeshita E, Iida A, Abe-Hatano C, Nakagawa E, Sasaki M, Inoue K, Goto Y.

• 27. A novel PAK3 pathogenic variant identified in two siblings from a Japanese family with X-linked intellectual disability : case report and review of the literature. 2019 Cold Spring Harb Mol Case Stud 5 (6), 2019 Dec 13

  Iida A, Takano K, Takeshita E, Abe-Hatano C, Hirabayashi S, Inaba Y, Kosugi S, Kamatani Y, Momozawa Y, Kubo M, Nakagawa E, Inoue K, Goto Y.

• 28. Transient water-electrolyte disturbance after hemispherotomy in young infants with epileptic encephalopathy. Child's Nervous System. 2019 Dec 16[Online ahead of print] ISSN 0256-7040. DOI 10.1007/s00381-019-04452-1

  Saito T, Sugai K, Takahashi A, Ikegaya N, Nakagawa E, Sasaki M, Iwasaki M, Otsuki T.

著書

• 1. 中川栄二　今日の精神疾患治療指針　編集：樋口輝彦、市川宏伸、神庭重信、朝田隆、中込和幸　第２版　医学書院　レンノックス−ガストー症候群　608-610頁、2016

• 2. 中川栄二　Landau-Kleffner症候群『てんかん専門医ガイドブック　てんかんにかかわる医師のための基本知識』　診断と治療社 234-235頁、2014　

• 3. 中川栄二　重症心身障害　『小児のリハビリテーション評価マニュアル』監修：高橋秀寿　編集：問川博之　診断と治療社　144-146頁、2014

• 4. 中川栄二　重症児の行動レベルからみた視覚認知機能評価．小児科臨床ピクシス　19、　ここまでわかった小児の発達、編者　五十嵐　隆、中山書店、213-217頁、2010.　

• 5. 中川栄二　精神遅滞．　ポケットプラクティス　小児神経・発達診断、編者　水口　雅、中山書店、105-109頁、2010.

• 6. 中川栄二　先天性筋線維タイプ不均等症．小児筋疾患診療ハンドブック、編者　埜中　征哉、診断と治療社、151-155頁、2009.

• 7. 中川栄二　MEG（脳磁図）、小児神経科診断・治療マニュアル、編著　加我牧子、佐々木征行、須貝研司　改訂第2版　診断と治療社. 182−188頁、2009.

• 8. 中川栄二　NIRS（光トポグラフィ）、小児神経科診断・治療マニュアル　編著　加我牧子、佐々木征行、須貝研司　改訂第2版　診断と治療社. 188−193頁、2009

• 9. 中川栄二　染色体検査、小児神経科診断・治療マニュアル　編著　加我牧子、佐々木征行、須貝研司　改訂第2版　診断と治療社.　223−233頁、2009.

• 10. 中川栄二　てんかん検査クリニカルパス、小児神経科診断・治療マニュアル　編著　加我牧子、佐々木征行、須貝研司　改訂第2版　診断と治療社. 271-273頁、2009.

• 11. 中川栄二　てんかんなどの発作性疾患　小児神経学　監修　有馬正高．診断と治療社、306‐327頁、2008.

• 12. E. Nakagawa, K. Hatori, A. Nagai, HB. Choi, MA. Lee, JH. Bang, J. Kim, JK. Ryu, A. Ozaki, MC. Lee, EY. Snyder, SU. Kim. Generation, characterisation and brain transplantation of immortalized human neural crest stem cells. In: Zigova T, Snyder EY, Sanberg PR, eds. Neural stem cells for brain and spinal cord repair. Totowa, NJ: Humana Press, 89-106, 2003.

• 13. SU. Kim, E. Nakagawa, K. Hatori, A. Nagai, MA. Lee, JH. Bang. Production of immortalized human neural crest stem cells. In: Zigova T, Sanchez-Ramos J, eds. Neural stem cells: methods and protocols. Totowa, NJ: Humana Press, 55-65, 2002.　

• 14. 【翻訳】中川栄二　てんかん　　精神遅滞と発達の遅れ　モイラスミス著、後藤雄一監訳　診断と治療社　　81-105頁、2007.

• 15. 【翻訳】中川栄二、小林巌　監訳．最重度知的・重複障害児（者）の臨床評価、てんかん：最重度知的・重複障害児（者）との密接なかかわり＊．Profound Intellectual and Multiple Disabilities Nursing Complex Needs　Edited by Jillian Pawlyn and Steven Carnaby WILEY-BLACKWELL 2009.

• 16. 【翻訳】最重度知的障害および重複障害の理解と対応． 診断と治療社、85 - 94頁、113- 122頁＊、2010.

受賞

• 1998年　てんかん治療研究振興財団海外留学助成

• 1998年　文部科学省大学院短期留学派遣助成

• 2000年　日本てんかん学会 JUHN AND MARY WADA賞（基礎部門）

• 2008年　日本てんかん学会　UCB & Otsuka賞

• 2013年　国際てんかん学会Gold Poster賞

• 2014年　てんかん治療研究振興財団てんかん研究褒賞

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