猿田 雅之 さるた まさゆき 先生

来歴等

略歴

1997年　東京慈恵会医科大学医学部医学科　卒業
1999年　同大学医学部内科学、消化器・肝臓内科　医員　
2002年　同大学医学部　大学助手
2002年　同大学大学院 医学研究科　臨床系内科学専攻　博士課程　入学
2002年 - 2004年　東北大学大学院 医学系研究科　医科学専攻　病理学講座　病理診断学分野　国内留学
2005年　東京慈恵会医科大学大学院 医学研究科 臨床系内科学専攻　博士課程　修了
2005年　米国ロサンゼルス、Cedars-Sinai Medical Center, Inflammatory Bowel Disease Centerへ留学　（Researcher Post Doctor　博士研究員）
2007年　東京慈恵会医科大学　内科学講座　消化器・肝臓内科　診療医員
2012年　東京慈恵会医科大学　内科学講座　消化器・肝臓内科　診療医長
2012年　東京慈恵会医科大学　内科学講座　消化器・肝臓内科　講師
2013年　東京慈恵会医科大学　（学校法人　慈恵大学）　大学評議員　
2016年　東京慈恵会医科大学　内科学講座　消化器・肝臓内科　主任教授　
現在に至る

論文

1. Ito K, Mitsunaga M, Nishimura T, Saruta M, Iwamoto T, Kobayashi H, Tajiri H. Near-Infrared Photochemoimmunotherapy by Photoactivatable Bifunctional Antibody-Drug Conjugates Targeting Human Epidermal Growth Factor Receptor 2 Positive Cancer. Bioconjug Chem. 2017 May 17;28(5):1458-1469. PLoS One. 2017 Apr 4;12(4):e0174985. Bioconjug Chem. 2017 May 17;28(5):1458-1469.

2. Mitsuishi T, Hamatani S, Hirooka S, Fukasawa N, Aizawa D, Hara Y, Dobashi A, Goda K, Fukuda T, Saruta M, Urashima M, Ikegami M. Clinicopathological characteristics of duodenal epithelial neoplasms: Focus on tumors with a gastric mucin phenotype (pyloric gland-type tumors). PLoS One. 2017 Apr 4;12(4):e0174985.

3. Nakagawa R, Muroyama R, Saeki C, Goto K, Kaise Y, Koike K, Nakano M, Matsubara Y, Takano K, Ito S, Saruta M, Kato N, Zeniya M. miR-425 regulates inflammatory cytokine production in CD4+ T cells via N-Ras upregulation in primary biliary cholangitis. J Hepatol. 2017 Jun;66(6):1223-1230.

4. Torisu Y, Nakano M, Takano K, Nakagawa R, Saeki C, Hokari A, Ishikawa T, Saruta M, Zeniya M. Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis. World J Hepatol. 2017 Jan 8;9(1):57-63.

5. Miyazaki R, Arihiro S, Hayashi E, Kitahara T, Oki S, Kamba S, Ide D, Komoike N, Satoh K, Kato T, Saruta M, Tajiri H, Aoki H, Omura N, Mitsumori N, Mitsuishi T, Yanagisawa H, Takahashi H. A Giant Gastrointestinal Stromal Tumor of the Stomach with Extramural Growth. Case Rep Gastroenterol. 2016 Jun 27;10(2):344-351.

6. Ito K, Mitsunaga M, Arihiro S, Saruta M, Matsuoka M, Kobayashi H, Tajiri H. Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms. BMC Cancer. 2016 Jan 25;16:37.

7. Yamaguchi S, Takeuchi Y, Arai K, Fukuda K, Kuroki Y, Asonuma K, Takahashi H, Saruta M, Yoshida H. Fecal calprotectin is a clinically relevant biomarker of mucosal healing in patients with quiescent ulcerative colitis. J Gastroenterol Hepatol. 2015 Jul 25. doi: 10.1111/jgh.13061.

8. Lymphocyte Homing Antagonists in the Treatment of Inflammatory Bowel Diseases.
Saruta M, Papadakis KA.Gastroenterol Clin North Am. 2014 Sep;43(3):581-601.

9. Arai Y, Arihiro S, Matsuura T, Kato T, Matsuoka M, Saruta M, et al. Prostaglandin E-major urinary metabolite as a reliable surrogate marker for mucosal inflammation in ulcerative colitis. Inflamm Bowel Dis. 2014 ; 20 :1208-16.

10. Efficacy of zinc-carnosine chelate compound, Polaprezinc, enemas in patients with ulcerative colitis.
Itagaki M, Saruta M, Saijo H, Mitobe J, Arihiro S, Matsuoka M, Kato T, Ikegami M, Tajiri H.
Scand J Gastroenterol. 2014 Feb;49(2):164-72.

11. TLR8-mediated activation of human monocytes inhibits TL1A expression.
Saruta M, Michelsen KS, Thomas LS, Yu QT, Landers CJ, Targan SR.
Eur J Immunol. 2009 Aug;39(8):2195-202.

12. Capsule endoscopy in the evaluation and management of inflammatory bowel disease: a future perspective.
Saruta M, Papadakis KA.
Expert Rev Mol Diagn. 2009 Jan;9(1):31-6. Review.

13. High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females.
Saruta M, Targan SR, Mei L, Ippoliti AF, Taylor KD, Rotter JI.
Inflamm Bowel Dis. 2009 Mar;15(3):321-7.

14. Why are cytokines targeted for biological therapy in IBD?
Saruta M, Papadakis KA.
Inflamm Bowel Dis. 2008 Oct;14 Suppl 2:S121-2. No abstract available. Erratum in: Inflamm Bowel Dis. 2009 Sep;15(9):1438-47.

15. Expression of peptide YY in human brain and pituitary tissues.
Morimoto R, Satoh F, Murakami O, Totsune K, Saruta M, Suzuki T, Sasano H, Ito S, Takahashi K.
Nutrition. 2008 Sep;24(9):878-84.

16. Visilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways.
Yu QT, Saruta M, Papadakis KA.
Clin Immunol. 2008 Jun;127(3):322-9.

17. Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease.
Saruta M, Yu QT, Fleshner PR, Mantel PY, Schmidt-Weber CB, Banham AH, Papadakis KA.
Clin Immunol. 2007 Dec;125(3):281-90.

18. Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease.
Saruta M, Yu QT, Avanesyan A, Fleshner PR, Targan SR, Papadakis KA.
J Immunol. 2007 Mar 1;178(5):3293-300.
19. Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis.
Yu QT, Saruta M, Avanesyan A, Fleshner PR, Banham AH, Papadakis KA.
Inflamm Bowel Dis. 2007 Feb;13(2):191-9.

20. Expression of urocortin 3/stresscopin in human adrenal glands and adrenal tumors.
Takahashi K, Totsune K, Saruta M, Fukuda T, Suzuki T, Hirose T, Imai Y, Sasano H, Murakami O.
Peptides. 2006 Jan;27(1):178-82.

21. Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions.
Saruta M, Takahashi K, Suzuki T, Fukuda T, Torii A, Sasano H.
Peptides. 2005 Jul;26(7):1196-206.

22. Urocortin 1, urocortin 3/stresscopin, and corticotropin-releasing factor receptors in human adrenal and its disorders.
Fukuda T, Takahashi K, Suzuki T, Saruta M, Watanabe M, Nakata T, Sasano H.
J Clin Endocrinol Metab. 2005 Aug;90(8):4671-8.

23. E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis.
Nakamura Y, Igarashi K, Suzuki T, Kanno J, Inoue T, Tazawa C, Saruta M, Ando T, Moriyama N, Furukawa T, Ono M, Moriya T, Ito K, Saito H, Ishibashi T, Takahashi S, Yamada S, Sasano H.
Am J Pathol. 2004 Dec;165(6):2019-31.

24. Urocortin 1 in colonic mucosa in patients with ulcerative colitis.
Saruta M, Takahashi K, Suzuki T, Torii A, Kawakami M, Sasano H.
J Clin Endocrinol Metab. 2004 Nov;89(11):5352-61.

25. Expression of urocortin III/stresscopin in human heart and kidney.
Takahashi K, Totsune K, Murakami O, Saruta M, Nakabayashi M, Suzuki T, Sasano H, Shibahara S.
J Clin Endocrinol Metab. 2004 Apr;89(4):1897-903.

その他

• 【受賞】 2008年　武田科学振興財団　一般研究奨励賞　受賞

• 【受賞】2008年　Digestive Disease Week 2008 and the 109th Annual Meeting of the American Gastroenterological Association優秀演題賞　受賞

• 【受賞】2008年　慈恵医師会研究奨励賞　受賞

• 【受賞】2008年　Japan & US Collaboration Conference in Gastroenterology： Award　for JUCC Young Researchers　受賞

• 【受賞】2014年　APAGE Clinical Forum On Inflammatory Bowel Disease 2014 : Certificate of appreciation　受賞