山上 裕機 先生のプロフィール

山上 裕機 先生

やまうえ ひろき

山上 裕機 先生

和歌山県立医科大学 医学部長・副学長

専門分野

肝胆膵悪性腫瘍の手術、とくに膵癌の手術
消化器癌の集学的治療、とくに免疫療法、遺伝子治療

紹介

がんの第4の治療法「がんペプチドワクチン療法」の第一人者であり、臨床の場での応用に繋げるため大規模な臨床試験の指揮にあたっている。特に治療が難しいとされる肝胆膵のがんを専門にしており、これら悪性疾患を克服するための研究と患者目線に立った診療に尽力し、患者さん、医療者双方から高い信頼を得ている。また、現和歌山県立医科大学副学長として、地域における最高水準の医療を提供すべく、「地域医療」への貢献にも注力している。

略歴

1981年3月 和歌山県立医科大学卒業
1981年4月 和歌山県立医科大学附属病院診療医研修開始
1983年3月 同           修了
1983年4月 国立田辺病院外科勤務
1985年3月 同 退職
1985年4月 和歌山県立医科大学 消化器外科臨床研究医委嘱
1985年10月 同             解嘱
1985年11月 和歌山県立医科大学 消化器外科助手
1991年8月 和歌山県立医科大学 消化器外科講師
1992年9月 アメリカ国立医学研究所(NIH)の国立がん研究所(NCI)
Visiting Associateとして癌免疫遺伝子治療の基礎研究に従事
(主任:Dr. Jeffrey Schlom,腫瘍免疫研究室)
1994年4月 和歌山県立医科大学 第2外科講師(大学の機構改革で講座名変更)
1999年6月 和歌山県立医科大学附属病院 集学的治療・緩和ケア部助教授
2001年6月 和歌山県立医科大学 第2外科教授
2006年4月 和歌山県立医科大学附属病院 副院長
2010年4月 和歌山県立医科大学 副学長
2014年4月 和歌山県立医科大学 医学部長

所属学会・資格・役職など

医学博士
(所属する主な学会・研究会)
1. 日本外科学会: 代議員,認定医・専門医・指導医
2. 日本消化器外科学会: 理事
評議員,認定医・専門医・指導医
3. 日本臨床外科学会: 評議員
4. 日本肝胆膵外科学会: 理事
評議員
Scientific Committee
プロジェクト研究委員長
高度技能専門医資格認定委員長
英文誌Co-Editor
胆道癌取り扱い規約委員
5. 日本膵臓学会: 理事
評議員
膵癌診療ガイドライン作成委員
財務委員
将来計画委員
IAP2016準備委員
6. 日本胃癌学会: 評議員
7. 日本食道学会: 評議員
8. 日本小児外科学会: 評議員
9. 日本腹部救急医学会: 評議員
10. 近畿外科学会: 評議員
11. 日本小児外科学会近畿地方会:評議員
12. 日本癌学会: 評議員
13. 日本癌治療学会: 評議員,英文誌Editorial Board
14. 日本バイオセラピィ学会: 理事長,評議員
15. 日本外科感染症学会: 評議員
16. 日本外科病理学会:  理事
17. 癌免疫外科研究会:    世話人
18. 制癌剤適応研究会:    世話人
19. 日本癌病態治療研究会:  世話人
20. 日本分子腫瘍マーカー研究会 世話人
21. 阪神膵臓外科研究会:   顧問
22. 近畿膵疾患談話会:    代表世話人
23. 近畿肝臓外科研究会:   世話人
24. 日本がん臨床試験推進機構: 評議員,臨床試験企画委員
25. がん集学的治療研究財団: 評議員
26. 手術手技研究会:  世話人
27. 日本膵切研究会:   運営委員
28. 日本胆膵病態・生理研究会 世話人
29. 大腸癌研究会:  世話人
30. 日本胆膵生理機能研究会: 世話人
31. クリニカルビデオフォーラム:世話人
32. 和歌山医学会: 評議員
33. International Association of Pancreatology:Director, Scientific Committee
34. International Society for Digestive Surgery: Active member
35. International College of Surgeons: Fellow
36. International Society of Surgery : Active member
37. International Hepato-Pancreato-Biliary Association:Research Committee
38. American Society of Clinical Oncology:Active member
39. American Association for Cancer Research: Active member
40. International Gastric Cancer Association: Active member
41. International Association for Surgeons and Gastroenterologists: Active member
42. International Society for the Study of Comparative Oncology: Editorial Board

受賞・著書・論文など

【論文】(英文主要論文のみ抜粋)
(2015)
1. Okada KI, Kawai M, Hirono S, Fujii T, Kodera Y, Sho M, Nakajima Y, Satoi S, Kwon AH, Shimizu Y, Ambo Y, Kondo N, Murakami Y, Ohuchida J, Eguchi H, Nagano H, Oba MS, Morita S, Sakamoto J, Yamaue H; JAPAN-PD Investigators. Evaluation of the efficacy of daikenchuto (TJ -100) for the prevention of paralytic ileus after pancreaticoduodenectomy: A multicenter, double-blind, randomized, placebo-controlled trial. Surgery. 2015 Dec 31. pii: S0039-6060(15)00966-6. doi:10.1016/j.surg.2015.11.019. [Epub ahead of print] PubMed PMID: 26747224.

2. Ojima T, Nakamori M, Nakamura

【論文】(英文主要論文のみ抜粋)
(2015)
1. Okada KI, Kawai M, Hirono S, Fujii T, Kodera Y, Sho M, Nakajima Y, Satoi S, Kwon AH, Shimizu Y, Ambo Y, Kondo N, Murakami Y, Ohuchida J, Eguchi H, Nagano H, Oba MS, Morita S, Sakamoto J, Yamaue H; JAPAN-PD Investigators. Evaluation of the efficacy of daikenchuto (TJ -100) for the prevention of paralytic ileus after pancreaticoduodenectomy: A multicenter, double-blind, randomized, placebo-controlled trial. Surgery. 2015 Dec 31. pii: S0039-6060(15)00966-6. doi:10.1016/j.surg.2015.11.019. [Epub ahead of print] PubMed PMID: 26747224.

2. Ojima T, Nakamori M, Nakamura M, Katsuda M, Hayata K, Matsumura S, Iwahashi M, Yamaue H: Phase I/II study of divided-dose docetaxel, cisplatin and fluorouracil for patients with recurrent or metastatic squamous cell carcinoma of the esophagus. Dis Esophagus. 2016 Jan 3. doi: 10.1111/dote.12450. [Epub ahead of print] PubMed PMID: 26725778.

3. Satoi S, Murakami Y, Motoi F, Sho M, Matsumoto I, Uemura K, Kawai M, Kurata M, Yanagimoto H, Yamamoto T, Mizuma M, Unno M, Kinoshita S, Akahori T, Shinzeki M, Fukumoto T, Hashimoto Y, Hirono S, Yamaue H, Honda G, Kwon M: Reappraisal of Total Pancreatectomy in 45 Patients With Pancreatic Ductal Adenocarcinoma in the Modern Era Using Matched-Pairs Analysis: Multicenter Study Group of Pancreatobiliary Surgery in Japan. Pancreas. 2015 Dec 18. [Epub ahead of print] PubMed PMID: 26692442.

4. Ojima T, Takifuji K, Nakamura M, Nakamori M, Yamaue H: Long-term Survival of Patients With Endoscopic Submucosal Dissection for Remnant Gastric Cancers. Surg Laparosc Endosc Percutan Tech. 2015 Dec 16. [Epub ahead of print] PubMed PMID: 26679685.

5. Kubota A, Yamakawa S, Yamamoto E, Kosugi M, Hirano S, Shiraishi J, Kitajima H, Yoneda A, Taduke Y, Mitani Y, Watanabe T, Takifuji K, Yamaue H: Major neonatal surgery: psychosocial consequence of the patient and mothers. J Pediatr Surg. 2015 Oct 9. pii: S0022-3468(15)00600-4. doi: 10.1016/j.jpedsurg.2015.09.017. [Epub ahead of print] PubMed PMID: 26589187.

6. Kawai M, Hirono S, Okada KI, Sho M, Nakajima Y, Eguchi H, Nagano H, Ikoma H, Morimura R, Takeda Y, Nakahira S, Suzumura K, Fujimoto J, Yamaue H: Randomized Controlled Trial of Pancreaticojejunostomy versus Stapler Closure of the Pancreatic Stump During Distal Pancreatectomy to Reduce Pancreatic Fistula. Ann Surg 2015 Sep 29. [Epub ahead of prnt]

7. Yokoyama S, Ieda J, Yamamoto N, Yamaguchi S, Mitani Y, Takeuchi A, Takifuji K, Hotta T, Matsuda K, Watanabe T, Shively JE, Yamaue H: P4H9-detected molecule expression on spindle-shaped fibroblasts indicates malignant phenotype of colorectal cancer. Br J Cancer. 113(10):1454-9, 2015

8. Matsumoto I, Murakami Y, Shinzeki M, Asari S, Goto T, Tani M, Motoi F, Uemura K, Sho M, Satoi S, Honda G, Yamaue H, Unno M, Akahori T, Kwon AH, Kurata M, Ajiki T, Fukumoto T, Ku Y: Proposed preoperative risk factors for early recurrence in patients with resectable pancreatic ductal adenocarcinoma after surgical resection: A multi-center retrospective study. Pancreatology. 15(6):674-80, 2015

9. Mori Y, Tamai H, Shingaki N, Hayami S, Ueno M, Maeda Y, Moribata K, Deguchi H, Niwa T, Inoue I, Maekita T, Iguchi M, Kato J, Terada M, Yamaue H, Ichinose M: Hypointense hepatocellular carcinomas on apparent diffusion coefficient mapping: Pathologic features and metastatic recurrence after hepatectomy. Hepatol Res. 2015 Sep 25. doi: 10.1111/hepr.12598. [Epub ahead of print]

10. Tanigawa N, Yamaue H, Ohyama S, Sakuramoto S, Inada T, Kodera Y, Kitagawa Y, Omura K, Terashima M, Sakata Y, Nashimoto A, Yamaguchi T, Chin K, Nomura E, Lee SW, Takeuchi M, Fujii M, Nakajima T: Exploratory phase II trial in a multicenter setting to evaluate the clinical value of a chemosensitivity test in patients with gastric cancer (JACCRO-GC 04, Kubota memorial trial). Gastric Cancer. 2015 Sep 18. [Epub ahead of print]

11. Hirono S, Kawai M, Okada KI, Miyazawa M, Shimizu A, Kitahata Y, Ueno M, Yamaue H :Pancreatic neck cancer has specific and oncologic characteristics regarding portal vein invasion and lymph node metastasis. Surgery. 2015 Aug 4. pii: S0039-6060(15)00537-1. doi: 10.1016/j.surg.2015.07.001. [Epub ahead of print]

12. Ueno M, Hayami S, Shigekawa Y, Kawai M, Hirono S, Okada KI, Tamai H, Shingaki N, Mori Y, Ichinose M, Yamaue H: Prognostic impact of surgery and radiofrequency ablation on single nodular HCC ≤ 5 cm: cohort study based on serum HCC markers. J Hepatol. 2015 Jul 23. pii: S0168-8278(15)00476-6

13. Takahara T, Wakabayashi G, Beppu T, Aihara A, Hasegawa K, Gotohda N, Hatano E, Tanahashi Y, Mizuguchi T, Kamiyama T, Ikeda T, Tanaka S, Taniai N, Baba H, Tanabe M, Kokudo N, Konishi M, Uemoto S, Sugioka A, Hirata K, Taketomi A, Maehara Y, Kubo S, Uchida E, Miyata H, Nakamura M, Kaneko H, Yamaue H, Miyazaki M, Takada T: Long-term and perioperative outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma with propensity score matching: a multi-institutional Japanese study. J Hepatobiliary Pancreat Sci. 22(10):721-7, 2015

14. Nakamura M, Wakabayashi G, Miyasaka Y, Tanaka M, Morikawa T, Unno M, Tajima H, Kumamoto Y, Satoi S, Kwon M, Toyama H, Ku Y, Yoshitomi H, Nara S, Shimada K, Yokoyama T, Miyagawa S, Toyama Y, Yanaga K, Fujii T, Kodera Y; Study Group of JHBPS; JSEPS, Tomiyama Y, Miyata H, Takahara T, Beppu T, Yamaue H, Miyazaki M, Takada T: Multicenter comparative study of laparoscopic and open distal pancreatectomy using propensity score-matching. J Hepatobiliary Pancreat Sci. 22(10):731-6, 2015

15. Uemura K, Murakami Y, Satoi S, Sho M, Motoi F, Kawai M, Matsumoto I, Honda G, Kurata M, Yanagimoto H, Nishiwada S, Fukumoto T, Unno M, Yamaue H: Impact of Preoperative Biliary Drainage on Long-Term Survival in Resected Pancreatic Ductal Adenocarcinoma: A Multicenter Observational Study. Ann Surg Oncol. Dec;22 Suppl 3:1238-46、2015

16. Murakami Y, Satoi S, Sho M, Motoi F, Matsumoto I, Kawai M, Honda G, Uemura K, Yanagimoto H, Shinzeki M, Kurata M, Kinoshita S, Yamaue H, Unno M: National Comprehensive Cancer Network Resectability Status for Pancreatic Carcinoma Predicts Overall Survival. World J Surg. 39(9):2306-14, 2015

17. Nakamura M, Yamaue H: Reconstruction after proximal gastrectomy for gastric cancer in the upper third of the stomach: a review of the literature published from 2000 to 2014. Surg Today. 2015 May 19. [Epub ahead of print]

18. Okada K, Kawai M, Hirono S Miyazawa M, Shimizu A, Kitahata Y, Yamaue H: Perioperative Administration of Daikenchuto (TJ-100) Reduces the Postoperative Paralytic Ileus in Patients with Pancreaticoduodenectomy. Hepatogastroenterology 62:466-71,2015

19. Beppu T, Wakabayashi G, Hasegawa K, Gotohda N, Mizuguchi T, Takahashi Y, Hirokawa F, Taniai N, Watanabe M, Katou M, Nagano H, Honda G, Baba H, Kokudo N, Konishi M, Hirata K, Yamamoto M, Uchiyama K, Uchida E, Kusachi S, Kubota K, Mori M, Takahashi K, Kikuchi K, Miyata H, Takahara T, Nakamura M, Kaneko H, Yamaue H, Miyazaki M, Takada T: Long-term and perioperative outcomes of laparoscopic versus open liver resection for colorectal liver metastases with propensity score matching: a multi-institutional Japanese study. J Hepatobiliary Pancreat Sci. 22(10):711-20, 2015

20. Murakami Y, Satoi S, Motoi F, Sho M, Kawai M, Matsumoto I, Honda G; Multicentre Study Group of Pancreatobiliary Surgery (MSG-PBS): Portal or superior mesenteric vein resection in pancreatoduodenectomy for pancreatic head carcinoma. Br J Surg. 2015 Jun;102(7):837-46

21. Yamaue H, Tsunoda T, Tani M, Miyazawa M, Yamao K, Mizuno N, Okusaka T, Ueno H, Boku N, Fukutomi A, Ishii H, Ohkawa S, Furukawa M, Maguchi H, Ikeda M, Togashi Y, Nishio K, Ohashi Y: Randomized phase II/III clinical trial of elpamotide for patients with advanced pancreatic cancer; PEGASUS-PC Study. Cancer Sci. 106(7):883-90, 2015

22. Tamai H, Mori Y, Shingaki N, Shimizu R, Nuta J, Moribata K, Maeda Y, Muraki Y, Deguchi H, Inoue I, Maekita T, Kato J, Takifuji K, Yamaue H, Ichinose M: Prognostic effect of response to interferon therapy after laparoscopic splenectomy among patients with marked thrombocytopenia and hepatitis Cvirus-related cirrhosis. Hepatol Int 9(1):67-75, 2015

23. Matsuda K, Hotta T, Takifuji K, Yokoyama S, Oku Y, Watanabe T, Mitani Y, Ieda J, Mizumoto Y, Yamaue H: Randomized clinical trial of defaecatory function after anterior resection for rectal cancer with high versus low ligation of the inferior mesenteric artery. Br J Surg 102(5):501-8, 2015

24. Fujimoto A, Furuta M, Shiraishi Y, Gotoh K, Kawakami Y, Arihiro K, Nakamura T, Ueno M, Ariizumi SI, Hai Nguyen H, Shigemizu D, Abe T, Boroevich KA, Nakano K, Sasaki A, Kitada R, Maejima K, Yamamoto Y, Tanaka H, Shibuya T, Shibata T, Ojima H, Shimada K, Hayami S, Shigekawa Y, Aikata H, Ohdan H, Marubashi S, Yamada T, Kubo M, Hirano S, Ishikawa O, Yamamoto M, Yamaue H, Chayama K, Miyano S, Tsunoda T, Nakagawa H: Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity. Nat Commun 6:6120, 2015

25. Ojima T, Nakamori M, Nakamura M, Katsuda M, Iida T, Hayata K, Takifuji K, Hotta T, Yokoyama S, Matsuda K, Iwahashi M, Yamaue H: Laparoscopic combined resection of synchronous gastric and colorectal cancer. Surg Laparosc Endosc Percutan Tech 25(1):43-6, 2015

26. Matsuda K, Hotta T, Takifuji K, Yokoyama S, Watanabe T, Mitani Y, Ieda J, Iwamoto H, Mizumoto Y, Yamaue H: Clinical characteristics of anastomotic leakage after an anterior resection for rectal cancer by assessing of the international classification on anastomotic leakage. Langenbecks Arch Surg 400(2):207-12,2015

27. Miyazawa M, Kawai M, Hirono S, Okada K, Shimizu A, Kitahata Y, Yamaue H: Preoperative evaluation of the confluent drainage veins to the gastrocolic trunk of Henle: understanding the surgical vascular anatomy during pancreaticoduodenectomy. J Hepatobiliary Pancreat Sci 22(5):386-91, 2015

28. Yamamoto N, Yokoyama S, Ieda J, Mitani Y, Yamaguchi S, Takifuji K, Hotta T, Matsuda K, Watanabe T, Shively JE, Yamaue H: CEACAM1 and hollow spheroid formation modulate the chemosensitivity of colorectal cancer to 5-fluorouracil. Cancer Chemother Pharmacol 75(2)421-30, 2015

29. Shiomi A, Ito M, Maeda K, Kinugasa Y, Ota M, Yamaue H, Shiozawa M, Horie H, Kuriu Y, Saito N: Effects of a Diverting Stoma on Symptomatic Anastomotic Leakage after Low Anterior Resection for Rectal Cancer: A Propensity Score Matching Analysis of 1,014 Consecutive Patients. J Am Coll Surg. 220 (2) 186–194, 2015

30. Matsuyama M, Ishii H, Furuse J, Ohkawa S, Maguchi H, Mizuno N, Yamaguchi T, Ioka T, Ajiki T, Ikeda M, Hakamada K, Yamamoto M, Yamaue H, Eguchi K, Ichikawa W, Miyazaki M, Ohashi Y, Sasaki Y Phase II trial of combination therapy of gemcitabine plus anti-angiogenic vaccination of elpamotide in patients with advanced or recurrent biliary tract cancer. Invest New Drugs 33(2):490-5, 2015

31. Shimizu Y, Yamaue H, Maguchi H, Yamao K, Hirono S, Osanai M, Hijioka S, Kanemitsu Y, Sano T, Senda Y, Bhatia V, Yanagisawa A:Validation of a Nomogram for Predicting the Probability of Carcinoma in Patients With Intraductal Papillary Mucinous Neoplasm in 180 Pancreatic Resection Patients at 3 High-Volume Centers. Pancreas. 44(3):459-64, 2015

32. Hirono S, Yamaue H: Tips and tricks of the surgical technique for borderline resectable pancreatic cancer: mesenteric approach and modified distal pancreatectomy with en-bloc celiac axis resection. J Hepatobiliary Pancreat Sci 22(2):E4-7, 2015

33. Okada K, Kawai M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y, Tani M, Yamaue H: A replaced right hepatic artery adjacent to pancreatic carcinoma should be divided to obtain R0 resection in pancreaticoduodenectomy. Langenbecks Arch Surg 400:57-65,2015

34. Sho M, Murakami Y, Motoi F, Satoi S, Matsumoto I, Kawai M, Honda G, Uemura K, Yanagimoto H, Kurata M, Fukumoto T, Akahori T, Kinoshita S, Nagai M, Nishiwada S, Unno M, Yamaue H, Nakajima Y: Postoperative prognosis of pancreatic cancer with para-aortic lymph node metastasis: a multicenter study on 822 patients. J Gastroenterol 50(6):694-702, 2015

35. Hirono S, Murakami Y, Tani M, Kawai M, Okada K, Uemura K, Sudo T, Hashimoto Y, Nakagawa N, Kondo N, Yamaue H: Identification of Risk Factors for Pancreatic Exocrine Insufficiency After Pancreaticoduodenectomy Using a 13C-Labeled Mixed Triglyceride Breath Test. World J Surg 39(2)516-25,2015

36. Tani M, Kawai M, Okada K, Hirono S, Hotta T, Takifuji K, Yamaue H.: Evaluation of the health-related quality of life for patients following laparoscopic cholecystectomy. Surg Today. 45(5):564-8, 2015

37. Satoi S, Murakami Y, Motoi F, Uemura K, Kawai M, Kurata M, Sho M, Matsumoto I, Yanagimoto H, Yamamoto T, Mizuma M, Unno M, Hashimoto Y, Hirono S, Yamaue H, Honda G, Nagai M, Nakajima Y, Shinzeki M, Fukumoto T, Kwon AH: Reappraisal of Peritoneal Washing Cytology in 984 Patients with Pancreatic Ductal Adenocarcinoma Who Underwent Margin-Negative Resection. J Gastrointest Surg 19(1):6-14, 2015

38. Matsumoto T, Sasako M, Mizusawa J, Hirota S, Ochiai A, Kushima R, Katai H, Tanaka Y, Fukushima N, Nashimoto A, Tsuburaya A; Stomach Cancer Study Group of the Japan Clinical Oncology Group. HER2 expression in locally advanced gastric cancer with extensive lymph node (bulky N2 or paraaortic) metastasis (JCOG1005-A trial). Gastric Cancer. 18(3):467-75. doi: 10.1007/s10120-014-0398-3, 2015

(2014)
39. Mitani Y, Kubota A, Ueno M, Takifuji K, Watanabe T, Hayami S, Kounami S, Tsujimoto H, Yamaue H: Real-time identification of hepatoblastoma using a near infrared imaging with indocyanine green. Journal of Pediatric Surgery CASE REPORTS 2(4)180–3,2014

40. Shiraishi Y, Fujimoto A, Furuta M, Tanaka H, Chiba K, Boroevich KA, Abe T, Kawakami Y, Ueno M, Gotoh K, Ariizumi S, Shibuya T, Nakano K, Sasaki A, Maejima K, Kitada R, Hayami S, Shigekawa Y, Marubashi S, Yamada T, Kubo M, Ishikawa O, Aikata H, Arihiro K, Ohdan H, Yamamoto M, Yamaue H, Chayama K, Tsunoda T, Miyano S, Nakagawa H: Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers. PLoS One 9(12):e114263, 2014

41. Okada K, Kawai M, Tani M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H:Preservation of the Left Gastric Artery on the Basis of Anatomical Features in Patients Undergoing Distal Pancreatectomy with Celiac Axis En-bloc Resection (DP-CAR). World J Surg 38(11):2980-5, 2014

42. Yamaguchi Y, Yamaue H, Okusaka T, Okuno K, Suzuki H, Fujioka T, Otsu A, Ohashi Y, Shimazawa R, Nishio K, Furuse J, Minami H, Tsunoda T, Hayashi Y, Nakamura Y, Committee of Guidance for Peptide Vaccines for the Treatment of Cancer, The Japanese Society for Biological Therapy: Guidance for peptide vaccines for the treatment of cancer. Cancer Sci 105(7):924-31, 2014

43. Tani M, Kawai M, Hirono S, Okada K, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H: Randomized clinical trial of isolated Roux-en-Y versus conventional reconstruction after pancreaticoduodenectomy. Br J Surg 101(9):1084-91, 2014

44. Nakamura M, Nakamori M, Ojima T, Katsuda M, Iida T, Hayata K, Matsumura S, Kato T, Kitadani J, Iwahashi M, Yamaue H: Reconstruction after proximal gastrectomy for early gastric cancer in the upper third of the stomach: An analysis of our 13-year experience. Surgery 156(1)57-63, 2014

45. Ojima T, Takifuji K, Nakamura M, Nakamori M, Katsuda M, Iida T, Hayata K, Iwahashi M, Yamaue H: Endoscopic submucosal dissection for gastric tumors in various types of remnant stomach. Endoscopy 46(8):645-9, 2014

46. Ueda H, Shimono C, Nishimura T, Shimamoto M, Yamaue H: Palonosetron exhibits higher total control rate compared to first-generation serotonin antagonists and improves appetite in delayed-phase chemotherapy-induced nausea and vomiting. Mol Clin Oncol 2(3):375-379, 2014

47. Okada K, Kawai M, Tani M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H: Predicting factors for unresectability in patients with pancreatic ductal adenocarcinoma. J Hepatobiliary Pancreat Sci 21(9):648-53, 2014

48. Ojima T, Takifuji K, Nakamura M, Iwahashi M, Nakamori M, Katsuda M, Iida T, Hayata K, Yamaue H: Complications of Endoscopic Submucosal Dissection for Gastric Noninvasive Neoplasia: An Analysis of 647 Lesions. Surg Laparosc Endosc Percutan Tech. 24(4):370-374, 2014

49. Hotta T, Takifuji K, Yokoyama S, Matsuda K, Oku Y, Nasu T, Tamura K, Ieda J,Yamamoto N, Iwamoto H, Yamaue H: The Impact of a Pelvic Pillow on Learning How to Perform Laparoscopic Low Anterior Resection for Rectal Cancer. Surg Laparosc Endosc Percutan Tech. 24(3):259-263, 2014

50. Hirono S, Kawai M, Tani M, Okada K, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H: Indication for the use of an interposed graft during portal vein and/or superior mesenteric vein reconstruction in pancreatic resection based on perioperative outcomes. Langenbecks Arch Surg399(4):461-71, 2014

51. Ojima T, Iwahashi M, Nakamori M, Nakamura M, Katsuda M, Iida T, Hayata K, Takifuji K, Yamaguchi S, Yamaue H: Is Preoperative Colonoscopy Necessary for Patients Undergoing Gastric Cancer Surgery? Ann Surg Oncol21:S379-84, 2014

52. Kitahata Y, Kawai M, Tani M, Hirono S, Okada K, Miyazawa M, Shimizu A, Yamaue H:Preoperative cholangitis during biliary drainage increases the incidence of postoperative severe complications after pancreaticoduodenectomy. Am J Surg 208: 1-10, 2014

53. Ojima T, Nakamori M, Nakamura M, Katsuda M, Iida T, Hayata K, Takifuji K, Iwahashi M, Matsumura S, Kato T, Kitadani J, Yamaue H: Successful treatment of esophageal fistulas with endoscopic injection of alpha-cyanoacrylate monomer. Endoscopy 46(S 01):E62-E63, 2014

54. Uenishi T, Ariizumi S, Aoki T, Ebata T, Ohtsuka M, Tanaka E, Yoshida H, Imura S, Ueno M, Kokudo N, Nagino M, Hirano S, Kubo S, Unno M, Shimada M, Yamaue H, Yamamoto M, Miyazaki M, Takada T: Proposal of a new staging system for mass-forming intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci 21(7):499-508, 2014

55. Hotta T, Takifuji K, Yokoyama S, Matsuda K, Oku Y, Nasu T, Ieda J, Yamamoto N, Iwamoto H, Takei Y, Mizumoto Y, Yamaue H: Impact of the post/preoperative serum CEA ratio on the survival of patients with rectal cancer. Surg Today 44(11):2106-15, 2014

56. Yoshimura S, Tsunoda T, Osawa R, Harada M, Watanabe T, Hikichi T, Katsuda M, Miyazawa M, Tani M, Iwahashi M, Takeda K, Katagiri T, Nakamura Y, Yamaue H: Identification of an HLA-A2-Restricted Epitope Peptide Derived from Hypoxia-Inducible Protein 2 (HIG2). PLoS One 9(1):e85267, 2014

57. Kiriyama S, Yokoyama S, Ueno M, Hayami S, Ieda J, Yamamoto N, Yamaguchi S, Mitani Y, Nakamura Y, Tani M, Mishra L, Shively JE, Yamaue H: CEACAM1 Long Cytoplasmic Domain Isoform is Associated with Invasion and Recurrence of Hepatocellular Carcinoma. Ann Surg Oncol 21 S505-14, 2014

58. Yokoyama S, Takifuji K, Hotta T, Matsuda K, Watanabe T, Mitani Y, Ieda J, Yamaue H: Survival benefit of lateral lymph node dissection according to the region of involvement and the number of lateral lymph nodes involved. Surg Today 44:1097-1103, 2014

59. Kawai M, Tani M, Hirono S, Okada K, Miyazawa M, Yamaue H: Pylorus-Resecting Pancreaticoduodenectomy Offers Long-Term Outcomes Similar to Those of Pylorus-Preserving Pancreaticoduodenectomy: Results of a Prospective Study. World J Surg 38:1476-1483, 2014

60. Iida T, Iwahashi M, Katsuda M, Ishida K, Nakamori M, Nakamura M, Naka T, Ojima T, Ueda K, Hayata K, Yasuoka H, Yamaue H: Prognostic significance of IL-17 mRNA expression in peritoneal lavage in gastric cancer patients who underwent curative resection. Oncol Rep31:605-12, 2014

61. Beppu T, Sakamoto Y, Hasegawa K, Honda G, Tanaka K, Kotera Y, Nitta H, Yoshidome H, Hatano E, Ueno M, Takamura H, Baba H, Kosuge T, Kokudo N, Takahashi K, Endo I, Wakabayashi G, Miyazaki M, Uemoto S, Ohta T, Kikuchi K, Takayama T, Yamaue H, Yamamoto M, Takada T: Optimal cut-off value for the number of colorectal liver metastases: a project study for hepatic surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci 21(3):169-75, 2014

62. Iwahashi M, Nakamori M, Nakamura M, Ojima T, Katsuda M, Iida T, Hayata K, Yamaue H: Clinical benefits of thoracoscopic esophagectomy in the prone position for esophageal cancer. Surg Today 44(9):1708-15, 2014

63. Yamaue H, Satoi S, Kanbe T, Miyazawa M, Tani M, Kawai M, Hirono S, Okada K, Yanagimoto H, Kwon AH, Mukouyama T, Tsunoda H, Chijiiwa K, Ohuchida J, Kato J, Ueda K, Yamaguchi T, Egawa S, Hayashi K, Shirasaka T: Phase II clinical study of alternate-day oral therapy with S-1 as first-line chemotherapy for locally advanced and metastatic pancreatic cancer. Cancer Chemother Pharmacol 73(1):97-102, 2014

64. Ueno M, Hayami S, Tani M, Kawai M, Hirono S, Yamaue H.:Recent trends in hepatectomy for elderly patients with hepatocellular carcinoma. Surg Today 44(9):1651-9, 2014

65. Motoi F, Unno M, Takahashi H, Okada T, Wada K, Sho M, Nagano H, Matsumoto I, Satoi S, Murakami Y, Kishiwada M, Honda G, Kinoshita H, Baba H, Hishinuma S, Kitago M, Tajima H, Shinchi H, Takamori H, Kosuge T, Yamaue H, Takada T: Influence of preoperative anti-cancer therapy on resectability and perioperative outcomes in patients with pancreatic cancer: Project study by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci 21:148-58, 2014

66. Okada K, Kawai M, Tani M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H: Isolated Roux-en-Y anastomosis of the pancreatic stump in a duct-to-mucosa fashion in patients with distal pancreatectomy with en-bloc celiac axis resection. J Hepatobiliary Pancreat Sci 21(3):193-8, 2014

67. Iwamoto H, Ojima T, Hayata K, Katsuda M, Miyazawa M, Iida T, Nakamura M, Nakamori M, Iwahashi M, Yamaue H: Antitumor immune response of dendritic cells (DCs) expressing tumor-associated antigens derived from induced pluripotent stem cells: In comparison to bone marrow-derived DCs. Int J Cancer 134(2):332-341, 2014

68. Nakamura M, Iwahashi M, Nakamori M, Ojima T, Katsuda M, Iida T, Hayata K, Kato T, Yamaue H: A new prognostic score for the survival of patients with esophageal squamous cell carcinoma. Surg Today44:875-83, 2014

69. Ojima T, Iwahashi M, Nakamori M, Nakamura M, Katsuda M, Iida T, Hayata K, Yamaue H: Atrial fibrillation after esophageal cancer surgery: an analysis of 207 consecutive patients. Surg Today 44:839-47,2014

(2013)
70. Asahara S, Takeda K, Yamao K, Maguchi H, Yamaue H: Phase I/II clinical trial using HLA-A24-restricted peptide vaccine derived from KIF20A for patients with advanced pancreatic cancer. J Transl Med 11:291, 2013

71. Kawai M, Tani M, Okada K, Hirono S, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H: Stump closure of a thick pancreas using stapler closure increases pancreatic fistula after distal pancreatectomy. Am J Surg 206(3):352-9,2013

72. Nasu T, Oku Y, Takifuji K, Hotta T, Yokoyama S, Matsuda K, Tamura K, Ieda J, Yamamoto N, Takemura S, Nakamura Y, Yamaue H: Predicting lymph node metastasis in early colorectal cancer using the CITED1 expression. J Surg Res 185(1):136-42, 2013

73. Satoi S Yamaue H, Kato K, Takahashi S, Hirono S, Takeda S, Eguchi H, Sho M, Wada K, Shinchi H, Kwon AH, Hirano S, Kinoshita T, Nakao A, Nagano H, Nakajima Y, Sano K, Miyazaki M, Takada T: Role of adjuvant surgery for patients with initially unresectable pancreatic cancer with a long-term favorable response to non-surgical anti-cancer treatments: results of a project study for pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci 20(6):590-600,2013

74. Shimizu Y, Yamaue H, Maguchi H, Yamao K, Hirono S, Osanai M, Hijioka S, Hosoda W, Nakamura Y, Shinohara T, Yanagisawa A: Predictors of Malignancy in Intraductal Papillary Mucinous Neoplasm of the Pancreas: Analysis of 310 Pancreatic Resection Patients at Multiple High-Volume Centers. Pancreas 42(5):883-888, 2013

75. Kishi K, Iida T, Ojima T, Sonomura T, Shirai S, Nakai M, Sato M, Yamaue H: Esophageal gel-shifting technique facilitating eradicative boost or reirradiation to upper mediastinal targets of recurrent nerve lymph node without damaging esophagus. J Radiat Res54(4):748-54,2013

76. Horiguchi A, Miyakawa S, Ishihara S, Miyazaki M, Ohtsuka M, Shimizu H, Sano K, Miura F, Ohta T, Kayahara M, Nagino M, Igami T, Hirano S, Yamaue H, Tani M, Yamamoto M, Ota T, Shimada M, Morine Y, Kinoshita H, Yasunaga M, Takada T:Gallbladder bed resection or hepatectomy of segments 4a and 5 for pT2 gallbladder carcinoma: analysis of Japanese registration cases by the study group for biliary surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci 20(5):518-24, 2013

77. Hayata K, Iwahashi M, Ojima T, Katsuda M, Iida T, Nakamori M, Ueda K, Nakamura M, Miyazawa M, Tsuji T, Yamaue H: Inhibition of IL-17A in Tumor Microenvironment Augments Cytotoxicity of Tumor-Infiltrating Lymphocytes in Tumor-Bearing Mice. PLoS One 8(1):e53131, 2013

78. Okada K, Kawai M, Uesaka K, Kodera Y, Nagano H, Murakami Y, Morita S, Sakamoto J, Yamaue H, The JAPAN-PD Investigators: Effect of Daikenchuto (TJ-100) on Postoperative Bowel Motility and on Prevention of Paralytic Ileus after Pancreaticoduodenectomy: A Multicenter, Randomized, Placebo-controlled Phase II Trial (The JAPAN-PD Study). Jpn J Clin Oncol43(4):436-8, 2013

79. Matsuda K, Takifuji K, Hotta T, Yokoyama S, Ieda J, Arii K, Ichinose M, Nakamura Y, Yasuoka H, Yamaue H. Angiosarcoma involving colon and bone successfully responded to paclitaxel and zoledronate: case report. Clin J Gastroenterol. 6(1):20-4, 2013

80. Matsuda K, Hotta T, Takifuji K, Yokoyama S, Oku Y, Hashimoto T, Iwamoto H, Yamaue H: Clinical outcome of up-front surgery in patients with asymptomatic, incurable synchronous peritoneal carcinomatosis. Surg Today 43(9):984-9, 2013

81. Okada K, Kawai M, Tani M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H: Surgical strategy for patients with pancreatic body/tail carcinoma: Who should undergo distal pancreatectomy with en-bloc celiac axis resection? Surgery 153(3):365-72, 2013

82. Tsuji T, Nakamori M, Iwahashi M, Nakamura M, Ojima T, Iida T, Katsuda M, Hayata K, Ino Y, Todo T, Yamaue H: An armed oncolytic herpes simplex virus expressing thrombospondin-1 has an enhanced in vivo antitumor effect against human gastric cancer. Int J Cancer 132(2):485-94, 2013

(2012)
83. Nakase T, Ueno M,Uchiyama K, Matsuura N, Yamaue H: Expression of Cyclooxygenase-2 and Transforming Growth Factor-Beta 1 in Patients with the Early Recurrence of Hepatocellular Carcinoma Following Hepatectomy. Surgical Science 3:322-31,2012(PubMedに掲載なし)

84. Togo N, Ueno M, Uchiyama K, Ozawa S, Yamaue H: Liver regeneration effect of oncostatin M following hepatectomy for the rat cirrhotic liver model. Surgical Science 3:530-6,2012(PubMedに掲載なし)

85. Tsumura A, Yokoyama S, Takifuji K, Hotta T, Matsuda K, Watanabe T, Mitani Y, Yamaue H: Endoscopically observable white nodule caused by distal intramural lymphatic spread of rectal cancer: a case report. World J Surg Oncol 10:216, 2012

86. Hotta T, Takifuji K, Yokoyama S, Matsuda K, Oku Y, Nasu T, Tamura K, Ieda J, Yamamoto N, Yamaue H: The impact of obesity on learning laparoscopic surgery for colon cancer. J Laparoendosc Adv Surg Tech A 22(7):635-40, 2012

87. Cho HS, Hayami S, Toyokawa G, Maejima K, Yamane Y, Suzuki T, Dohmae N, Kogure M, Kang D, Neal DE, Ponder BA, Yamaue H, Nakamura Y, Hamamoto R: RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation. Neoplasia 14(6):476-86, 2012

88. Osawa R, Tsunoda T, Yoshimura S, Watanabe T, Miyazawa M, Tani M, Takeda K, Nakagawa H, Nakamura Y, Yamaue H: Identification of HLA-A24-restricted novel T Cell epitope peptides derived from P-cadherin and kinesin family member 20A. J Biomed Biotechnol 2012:848042, 2012

89. Fujimoto A, Totoki Y, Abe T, Boroevich KA, Hosoda F, Nguyen HH, Aoki M, Hosono N, Kubo M, Miya F, Arai Y, Takahashi H, Shirakihara T, Nagasaki M, Shibuya T, Nakano K, Watanabe-Makino K, Tanaka H, Nakamura H, Kusuda J, Ojima H, Shimada K, Okusaka T, Ueno M, Shigekawa Y, Kawakami Y, Arihiro K, Ohdan H, Gotoh K, Ishikawa O, Ariizumi S, Yamamoto M, Yamada T, Chayama K, Kosuge T, Yamaue H, Kamatani N, Miyano S, Nakagama H, Nakamura Y, Tsunoda T, Shibata T, Nakagawa H: Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet 44(7):760-4, 2012

90. Hotta T, Takifuji K, Yokoyama S, Matsuda K, Yamaue H: Rectal transaction using a curved cutter stapler with an endo-Satinsky clamp during a laparoscopic low anterior resection. Langenbecks Arch Surg 397(7):1149-55, 2012

91. Nakamura M, Iwahashi M, Nakamori M, Naka T, Ojima T, Iida T, Katsuda M, Tsuji T, Hayata K, Mastumura S, Yamaue H: Lower mediastinal lymph node metastasis is an independent survival factor of Siewert type II and III adenocarcinomas in the gastroesophageal junction. Am Surg 78(5):567-73, 2012

92. Hirono S, Tani M, Kawai M, Okada K, Miyazawa M, Shimizu A, Uchiyama K, Yamaue H: Identification of the lymphatic drainage pathways from the pancreatic head guided by indocyanine green fluorescence imaging during pancreaticoduodenectomy. Dig Surg 29(2):132-9, 2012

93. Hotta T, Takifuji K, Yokoyama S, Matsuda K, Higashiguchi T, Tominaga T, Oku Y, Watanabe T, Nasu T, Hashimoto T, Tamura K, Ieda J, Yamamoto N, Iwamoto H, Yamaue H: Literature review of the energy sources for performing laparoscopic colorectal surgery. World J Gastrointest Surg 4(1):1-8, 2012

94. Shimizu A, Hirono S, Tani M, Kawai M, Okada K, Miyazawa M, Kitahata Y, Nakamura Y, Noda T, Yokoyama S, Yamaue H: Coexpression of MUC16 and mesothelin is related to the invasion process in pancreatic ductal adenocarcinoma. Cancer Sci 103(4):739-46, 2012

95. Hirono S, Tani M, Kawai M, Okada K, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H: The carcinoembryonic antigen level in pancreatic juice and mural nodule size are predictors of malignancy for branch duct type intraductal papillary mucinous neoplasms of the pancreas. Ann Surg 255(3):517-22, 2012

96. Naka T, Iwahashi M, Nakamori M, Nakamura M, Ojima T, Iida T, Katsuda M, Toshiaki T, Keiji H, Yamaue H: The evaluation of surgical treatment for gastric cancer patients with noncurative resection. Langenbecks Arch Surg 397(6):959-66, 2012

97. Kiyotani K, Uno S, Mushiroda T, Takahashi A, Kubo M, Mitsuhata N, Ina S, Kihara C, Kimura Y, Yamaue H, Hirata K, Nakamura Y, Zembutsu H: A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy. Pharmacogenet Genomics 22(4):229-35, 2012

98. Hotta T, Takifuji K, Kobayashi Y, Tabuse K, Shimada K, Maeda T, Nakatani Y, Fukiage O, Yamaue H: Management of obstructive colorectal cancer: evaluation of preoperative bowel decompression using ileus tube drainage. Surg Today 42(12):1154-64, 2012

99. Miura K, Shirasaka T, Yamaue H, Sasaki I: S-1 as a core anticancer fluoropyrimidine agent. ExpertOpin Drug Deliv 9(3):273-86, 2012

100. Wang L, Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H: Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Res 22(2):208-19, 2012

101. Ojima T, Iwahashi M, Nakamori M, Nakamura M, Takifuji K, Katsuda M, Iida T, Tsuji T, Hayata K, Yamaue H: The impact of abdominal shape index of patients on laparoscopy-assisted distal gastrectomy for early gastric cancer. Langenbecks Arch Surg 397(3):437-45, 2012

102. Yamaue H, Tani M, Kawai M, Hirono S, Okada K, Miyazawa M: Pancreatic dissection in the procedure of pancreaticoduodenectomy (with videos). J Hepatobiliary Pancreat Sci 19(2):95-9. 2012

103. Beppu T, Sakamoto Y, Hasegawa K, Honda G, Tanaka K, Kotera Y, Nitta H, Yoshidome H, Hatano E, Ueno M, Takamura H, Baba H, Kosuge T, Kokudo N, Takahashi K, Endo I, Wakabayashi G, Miyazaki M, Uemoto S, Ohta T, Kikuchi K, Yamaue H, Yamamoto M, Takada T: A nomogram predicting disease-free survival in patientswith colorectal liver metastases treated with hepatic resection: multicenter data collection as a Project Study for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci 19(1):72-84, 2012

104. Tani M, Kawai M, Hirono S, Hatori T, Imaizumi T, Nakao A, Egawa S, Asano T, Nagakawa T, Yamaue H: Use of omentum or falciform ligament does not decrease complications after pancreaticoduodenectomy: nationwide survey of the Japanese Society of Pancreatic Surgery. Surgery 151(2):183-91, 2012

105. Matsuda K, Hotta T, Takifuji K, Yamamoto M, Nasu T, Togo N, Oka M, Tabuse K, Yamaue H: Clinical impact of a macroscopically complete resection of colorectal cancer with peritoneal carcinomatosis. Surgery 151(2):238-44, 2012

(2011)
106. Kishi K, Sonomura T, Shirai S, Noda Y, Sato M, Kawai M, Yamaue H: Brachytherapy reirradiation with hyaluronate gel injection of paraaortic lymphnode metastasis of pancreatic cancer: paravertebral approach--a technical report with a case. J Radiat Res 52(6):840-4, 2011

107. Tamura K, Yokoyama S, Ieda J, Takifuji K, Hotta T, Matsuda K, Oku Y, Watanabe T, Nasu T, Kiriyama S, Yamamoto N, Nakamura Y, Shively JE, Yamaue H: Hollow spheroids beyond the invasive margin indicate the malignant potential of colorectal cancer. BMJ Open2011 Aug 11;1(1):e000179. doi:10.1136/bmjopen-2011-000179.

108. Hotta T, Yamaue H: Laparoscopic surgery for rectal cancer: review of published literature 2000-2009. Surg Today 41(12):1583-91, 2011

109. Uchiyama K, Ueno M, Ozawa S, Kiriyama S, Shigekawa Y, Hirono S, Kawai M, Tani M, Yamaue H: Combined intraoperative use of contrast-enhanced ultrasonography imaging using a sonazoid and fluorescence navigation system with indocyanine green during anatomical hepatectomy. Langenbecks Arch Surg 396(7):1101-7, 2011

110. Kawai M, Yamaue H: Pancreaticoduodenectomy versus pylorus-preserving pancreaticoduodenectomy: the clinical impact of a new surgical procedure; pylorus-resecting pancreaticoduodenectomy. J Hepatobiliary Pancreat Sci 18(6)755-761, 2011

111. Shirai K, Inoue I, Kato J, Maeda H, Moribata K, Shingaki N, Ueda K, Deguchi H, Maekita T, Iguchi M, Yanaoka K, Tamai H, Oka M, Kawai M, Yamaue H, Yasuoka H, Nakamura Y, Iso-O N, Ichinose M: A case of a giant glucagonoma with parathyroid hormone-related peptide secretion showing an inconsistent postsurgical endocrine status. Intern Med 50(16):1689-94, 2011.

112. Katsuda M, Iwahashi M, Matsuda K, Miyazawa M, Nakamori M, Nakamura M, Ojima T, Iida T, Hayata K, Yamaue H: Comparison of different classes of CpG-ODN in augmenting the generation of human epitope peptide-specific CTLs. Int J Oncol 39(5):1295-302, 2011

113. Matsuda K, Hotta T, Takifuji K, Kobayashi Y, Tsuji T, Nagai Y, Horiuchi T, Yamaue H: Lymph nodes ratio is associated with the survival of colorectal cancer patients with peritoneal carcinomatosis. Am Surg 77(5):602-7, 2011

114. Yokoyama S, Takifuji K, Tani M, Kawai M, Naka T, Uchiyama K, Yamaue H: Endoscopic resection of duodenal bulb neuroendocrine tumor larger than 10 mm in diameter. BMC Gastroenterol 11:67, 2011

115. Ueno M, Uchiyama K, Ozawa S, Hayami S, Shigekawa Y, Tani M, Yamaue H: Adjuvant chemolipiodolization reduces early recurrence derived from intrahepatic metastasis of hepatocellular carcinoma after hepatectomy. Ann Surg Oncol 18(13):3624-31, 2011

116. Kiriyama S, Uchiyama K, Ueno M, Ozawa S, Hayami S, Tani M, Yamaue H: Triple positive tumor markers for hepatocellular carcinoma are useful predictors of poor survival. Ann Surg 254(6):984-91, 2011

117. Shimizu A, Tani M, Kawai M, Hirono S, Miyazawa M, Uchiyama K, Yamaue H: Influence of visceral obesity for postoperative pulmonary complications after pancreaticoduodenectomy. J Gastrointest Surg 15(8):1401-10, 2011

118. Kawai M, Kondo S, Yamaue H, Wada K, Sano K, Motoi F, Unno M, Satoi S, Kwon AH, Hatori T, Yamamoto M, Matsumoto J, Murakami Y, Doi R, Ito M, Miyakawa S, Shinchi H, Natsugoe S, Nakagawara H, Ohta T, Takada T: Predictive risk factors for clinically relevant pancreatic fistula analyzed in 1,239 patients with pancreaticoduodenectomy: multicenter data collection as a project study of pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci 18(4):601-8, 2011

119. Iwahashi M, Nakamori M, Nakamura M, Ojima T, Naka T, Yamaue H: Optimal period for the prophylactic administration of neutrophil elastase inhibitor for patients with esophageal cancer undergoing esophagectomy. World J Surg 35(7):1573-9, 2011

120. Ieda J, Yokoyama S, Tamura K, Takifuji K, Hotta T, Matsuda K, Oku Y, Nasu T, Kiriyama S, Yamamoto N, Nakamura Y, Shively JE, Yamaue H: Re-expression of CEACAM1 long cytoplasmic domain isoform is associated with invasion and migration of colorectal cancer. Int J Cancer 129(6):1351-61, 2011

121. Miyazawa M, Iwahashi M, Ojima T, Katsuda M, Nakamura M, Nakamori M, Ueda K, Naka T, Hayata K, Iida T, Yamaue H: Dendritic cells adenovirally-transduced with full-length mesothelin cDNA elicit mesothelin-specific cytotoxicity against pancreatic cancer cell lines in vitro. Cancer Lett 305(1):32-9, 2011

122. Hotta T, Takifuji K, Yokoyama S, Matsuda K, Oku Y, Hashimoto T, Yamamoto N, Yamaue H: Rectal transection by the Nelaton catheter pulling method during a laparoscopic low anterior resection. Dis Colon Rectum 54(4):495-500, 2011

123. Iida T, Iwahashi M, Katsuda M, Ishida K, Nakamori M, Nakamura M, Naka T, Ojima T, Ueda K, Hayata K, Nakamura Y, Yamaue H: Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer. Oncol Rep 25(5):1271-7, 2011

124. Shigekawa Y, Uchiyama K, Takifuji K, Ueno M, Hama T, Hayami S, Tamai H, Ichinose M, Yamaue H: A laparoscopic splenectomy allows the induction of antiviral therapy for patients with cirrhosis associated with hepatitis C virus. Am Surg 77(2):174-9, 2011

125. Kawai M, Tani M, Hirono S, Miyazawa M, Shimizu A, Uchiyama K, Yamaue H: Pylorus ring resection reduces delayed gastric emptying in patients undergoing pancreatoduodenectomy: a prospective, randomized, controlled trial of pylorus-resecting versus pylorus-preserving pancreatoduodenectomy. Ann Surg 253(3):495-501, 2011

126. Uchiyama K, Yamamoto M, Yamaue H, Ariizumi S, Aoki T, Kokudo N, Ebata T, Nagino M, Ohtsuka M, Miyazaki M, Tanaka E, Kondo S, Uenishi T, Kubo S, Yoshida H, Unno M, Imura S, Shimada M, Ueno M, Takada T: Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci 18(3):443-52, 2011

127. Uchiyama K, Ueno M, Ozawa S, Kiriyama S, Kawai M, Hirono S, Tani M, Yamaue H: Risk factors for postoperative infectious complications after hepatectomy. J Hepatobiliary Pancreat Sci 18(1):67-73, 2011

128. Hayami S, Kelly JD, Cho HS, Yoshimatsu M, Unoki M, Tsunoda T, Field HI, Neal DE, Yamaue H, Ponder BA, Nakamura Y, Hamamoto R: Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer 128(3):574-86, 2011

(2010)
129. Katai H, Sasako M, Fukuda H, Nakamura K, Hiki N, Saka M, Yamaue H, Yoshikawa T, Kojima K, JCOG Gastric Cancer Surgical Study Group: Safety and feasibility of laparoscopy-assisted distal gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: a multicenter phase II trial (JCOG 0703). Gastric Cancer 13(4):238-44, 2010

130. Kawai M, Yamaue H: Analysis of clinical trials evaluating complications after pancreaticoduodenectomy: a new era of pancreatic surgery. Surg Today 40(11):1011-7, 2010

131. Iwahashi M, Katsuda M, Nakamori M, Nakamura M, Naka T, Ojima T, Iida T, Yamaue H: Vaccination with peptides derived from cancer-testis antigens in combination with CpG-7909 elicits strong specific CD8+ T cell response in patients with metastatic esophageal squamous cell carcinoma. Cancer Sci 101(12):2510-7, 2010

132. Shigekawa Y, Kobayashi Y, Higashiguchi T, Nasu T, Yamamoto M, Ochiai M, Tsuji T, Yamaue H: Rectal obstruction by a giant pharmacobezoar composed of magnesium oxide: report of a case. Surg Today 40(10):972-4, 2010

133. Uchiyama K, Ueno M, Ozawa S, Kiriyama S, Shigekawa Y, Yamaue H: Combined use of contrast-enhanced intraoperative ultrasonography and a fluorescence navigation system for identifying hepatic metastases. World J Surg 34(12):2953-9, 2010

134. Nishioka R, Itoh S, Gui T, Gai Z, Oikawa K, Kawai M, Tani M, Yamaue H, Muragaki Y: SNAIL induces epithelial-to-mesenchymal transition in a human pancreatic cancer cell line (BxPC3) and promotes distant metastasis and invasiveness in vivo. Exp Mol Pathol 89(2):149-57, 2010

135. Yoshikawa T, Omura K, Kobayashi O, Nashimoto A, Takabayashi A, Yamada T, Yamaue H, Fujii M, Yamaguchi T, Nakajima T: A phase II study of preoperative chemotherapy with S-1 plus cisplatin followed by D2/D3 gastrectomy for clinically serosa-positive gastric cancer (JACCRO GC-01 study). Eur J Surg Oncol 36(6):546-51, 2010

136. Shimamoto T, Tani M, Kawai M, Hirono S, Ina S, Miyazawa M, Shimizu A, Uchiyama K, Yokoyama S, Tsutsumi M, Yamaue H: MUC1 is a useful molecular marker for malignant intraductal papillary mucinous neoplasms in pancreatic juice obtained from endoscopic retrograde pancreatography. Pancreas 39(6):879-83, 2010

137. Hayami S, Yoshimatsu M, Veerakumarasivam A, Unoki M, Iwai Y, Tsunoda T, Field HI, Kelly JD, Neal DE, Yamaue H, Ponder BA, Nakamura Y, Hamamoto R: Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer 9:59, 2010

138. Yokoyama S, Takifuji K, Hotta T, Matsuda K, Tominaga T, Oku Y, Nasu T, Tamura K, Ieda J, Yamaue H: Moderately differentiated colorectal adenocarcinoma as a lymph node metastatic phenotype: comparison with well differentiated counterparts. BMC Surg 8;10:8, 2010

139. Kitahata Y, Yokoyama S, Takifuji K, Hotta T, Matsuda K, Tominaga T, Oku Y, Watanabe T, Ieda J, Yamaue H: Hemangiopericytoma in the sacrococcygeal space: a case report. J Med Case Rep 4:8, 2010

140. Tani M, Kawai M, Hirono S, Ina S, Miyazawa M, Shimizu A, Yamaue H: A prospective randomized controlled trial of internal versus external drainage with pancreaticojejunostomy for pancreaticoduodenectomy. Am J Surg 199(6):759-64, 2010

141. Ina S, Hirono S, Noda T, Yamaue H: Identifying molecular markers for chemosensitivity to gemcitabine in pancreatic cancer: increased expression of interferon-stimulated gene 15 kd is associated with intrinsic chemoresistance. Pancreas 39(4):473-85, 2010

142. Miyazawa M, Ohsawa R, Tsunoda T, Hirono S, Kawai M, Tani M, Nakamura Y, Yamaue H: Phase I clinical trial using peptide vaccine for human vascular endothelial growth factor receptor 2 in combination with gemcitabine for patients with advanced pancreatic cancer. Cancer Sci 101(2):433-9, 2010

143. Ojima T, Iwahashi M, Nakamori M, Nakamura M, Naka T, Katsuda M, Iida T, Tsuji T, Hayata K, Takifuji K, Yamaue H: Clinicopathological characteristics of remnant gastric cancer after a distal gastrectomy. J Gastrointest Surg 14(2):277-81, 2010

144. Hirono S, Yamaue H: Middle pancreatectomy for pancreatic neoplasms. J Hepatobiliary Pancreat Sci 17(6):803-7, 2010

145. Hirono S, Yamaue H, Hoshikawa Y, Ina S, Tani M, Kawai M, Ushijima M, Matsuura M, Saiki Y, Saiura A, Yamamoto J, Miki Y, Noda T: Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling. Cancer Sci 101(1):259-66, 2010

146. Tominaga T, Iwahashi M, Takifuji K, Hotta T, Yokoyama S, Matsuda K, Higashiguchi T, Oku Y, Nasu T, Yamaue H: Combination of p53 codon 72 polymorphism and inactive p53 mutation predicts chemosensitivity to 5-fluorouracil in colorectal cancer. Int J Cancer 126(7):1691-701, 2010

147. Kawai M, Tani M, Kobayashi Y, Tsuji T, Tabuse K, Horiuchi T, Oka M, Yamaguchi K, Sakata Y, Shimomura T, Yamaue H: The ratio between metastatic and examined lymph nodes is an independent prognostic factor for patients with resectable middle and distal bile duct carcinoma. Am J Surg 199(4):447-52, 2010

148. Matsuda K, Hotta T, Takifuji K, Yokoyama S, Oku Y, Yamaue H: Clinicopathological features of anastomotic recurrence after an anterior resection for rectal cancer. Langenbecks Arch Surg 395(3):235-9, 2010

(ほか、2010年以前の英文主要論文194本)

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