S200x200 352625d9 b890 4c07 9746 3da6ac4ea6bd

昭和大学医学部脳神経外科 准教授

清水 克悦 先生

ストーリー記事を読む

専門分野

脳腫瘍(良性腫瘍、頭蓋底腫瘍)、片側顔面痙攀・三叉神経痛

紹介

片側顔面痙攀、三叉神経痛に対する微小血管減圧術では日本有数の手術実績をもつ。仰臥位で脳ベラ用いずに行うkey hole surgeryは他に類を見ない手術法であり、トップクラスの成績を上げている。また、頭蓋底外科手術手技にも精通しており、髄膜腫や神経鞘腫などの手術経験も豊富である。

略歴

1987年 慶應義塾大学医学部卒業
1990年 慶應義塾大学医学部 外科専修医(脳神経外科)
1993年 独立行政法人国立病院機構埼玉病院 脳神経外科医長
1998年 米国Wake Forest大学生理学教室留学(research associate)
2003年 国家公務員共済組合連合会立川病院 脳神経外科部長
2012年 昭和大学医学部 脳神経外科 准教授

所属学会・資格・役職など

医学博士
日本脳神経外科学会(専門医・評議員)
日本脳卒中学会(専門医)
日本脳卒中の外科学会
日本脳神経外科コングレス
日本神経内視鏡学会(認定医)
日本頭蓋底外科学会
日本脳腫瘍の外科学会

受賞・著書・論文など

【論文】

1. Shimizu, K., Ogino, M., Yamaguchi, N., Mitani, S., Saito, R., Kawase, T., and Toya, S.: Propentofylline (HWA285) inhibits the release of dopamine during transient ischemia and modulates its metabolism in rat striatum. Neurosci Lett. 158: 9-12, 1993

2. Shimizu, K. The neuroprotective ef

【論文】

1. Shimizu, K., Ogino, M., Yamaguchi, N., Mitani, S., Saito, R., Kawase, T., and Toya, S.: Propentofylline (HWA285) inhibits the release of dopamine during transient ischemia and modulates its metabolism in rat striatum. Neurosci Lett. 158: 9-12, 1993

2. Shimizu, K. The neuroprotective effects of adenosine against ischemic insult in rat striatum – A study using in vivo microdialysis - . The Keio Journal of Medicine 72: 353-364, 1995

3. 古旗茂、清水克悦、高宮至昭 意欲障害,知的機能障害のみならず,情緒障害にもプロペントフィリンが著効を示した脳梗塞後遺症患者の1症例
老化と疾患 vol.8 (No. 9), 60-62, 1995

4. Shimizu, K., Yamada, F., Fukuda, S., and Toya, S. Spontaneous disappearance of a cerebral arteriovenous malformation. – Case report - . Neurol Med Chir 36: 26-30, 1996

5. 古旗茂、清水克悦、高宮至昭 クモ膜下出血で発症したAVM症例の検討 東京都医師会雑誌 48: 1499-1500, 1996

6. 古旗茂、清水克悦、高宮至昭 脳幹梗塞による手掌口症候群の一例
東京都医師会雑誌 49: 1190-1191, 1996

7. 古旗茂、成高平治、高宮至昭、清水克悦、亀谷徹 プロラクチン産生腺腫と成長ホルモン産生腺腫の分類検討および、後者と糖蛋白ホルモンαサブユニットの意義 ホルモンと臨床(増)44: 106-110, 1996
 
8. Ishikawa, M., Sekizuka, E., Shimizu, K., Yamaguchi, N., and Kawase, T. Measurement of RBC velocities in the rat pial arteries with an image-intensified high-speed video camera system. Microvascular Research 56: 166-172. 1998

9. Ishikawa, M., Sekizuka, E., Sato, S., Shimizu, K., Yamaguchi, N., and Kawase, T. In vivo rat closed spinal window for spinal microcirculation: observation of pial vessels, leukocyte adhesion, and red blood cell velocity. Neurosurgery 44: 156-161, 1999

10. Shimizu, K., Furuhata, S., Sasai, S., Tominaga, S., and Takamiya, Y. Intracerebral cystic meningioma – case report. Neurol Med Chir 39: 530-533, 1999

11. Shimizu, K., Takamiya, Y., Furuhata, S., Naritaka, H., and Kameya, T. Cystic lesion at the foramen magnum disseminated from a pituitary adenoma – case report. Neurol Med Chir 39: 606-611, 1999

12. Shimizu, K., Veltkamp, R., and Busija, D.W. Characteristics of induced spreading depression after transient focal ischemia in the rat. Brain Res 861: 316-324, 2000

13. Shimizu, K., Bari, F., and Busija, D.W. Glibenclamide enhances cortical spreading depression-associated hyperemia in the rat. Neuroreport 11: 2103-2106, 2000

14. Rajapakse, N., Shimizu, K., Payne, M. and Busija, D. Isolation and characterization of intact mitochondria from neonatal rat brain. Brain Res Brain Res Protoc, 8:176-83, 2001

15. 留学報告「米国留学を終えて」刀林 78: 7, 2001. 12. 17.

16. Shimizu, K., Miller, AW., Erdo-s, B., Bari, F., Busija, D.W. Role of endothelium in hyperemia during cortical spreading depression (CSD) in the rat. Brain Res 928: 40-49, 2002

17. Domoki F, Perciaccante JV, Shimizu K, Puskar M, Busija DW, Bari F. N-methyl-D-aspartate-induced vasodilation is mediated by endothelium-independent nitric oxide release in piglets. Am J Physiol Heart Circ Physiol 282: H1404-9, 2002

18. Rajapakse N., Shimizu K., Snipes J., Lacza Z., Busija D.W.. Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats. Neurosci Lett 327: 208-212, 2002

19. Horiguchi T, Shima H, Suga S, Ogino M, Shimizu K, Toya S, Nagao M, Kawase
T. Transient forebrain ischemia induces expression of serine/threonine protein phosphatase 1 mRNA in the vulnerable regions of gerbil brain. Neurosci Lett 325:115-8, 2002

20. Shimizu, K., Lacza, Z., Rajapakse, N., Horiguchi, T., Snipes, J., Busija, D.W..
MitoKATP opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat. Am J Physiol Heart Circ Physiol 283: H1005-1011, 2002

21. Horiguchi, T., Shimizu, K., Ogino, M., Yamaguchi, N., Suga, S., Inamasu, J., Kawase, T. Neuroprotection role of adenosine under hypothermia in the rat global ischemia involves inhibition of not dopamine release but delayed postischemic hypoperfusion. Brain Res 952: 222-231, 2002

22. Veltkamp R, Rajapakse N, Robins G, Puskar M, Shimizu K, Busija DW. Transient focal ischemia increases endothelial nitric oxide synthase in cerebral blood vessels. Stroke 33: 2704-10, 2002

23. Shimizu, K., Rajapakse, N., Horiguchi, T., Payne, R.M., Busija, D.W. Protective effect of a new nonpeptydil mimetic of SOD, M40401 against focal cerebral ischemia in the rat. Brain Res 963: 8-14, 2003

24. Horiguchi, T., Kis, B., Rajapakse N., Shimizu, K., Busija, D.W. Opening of Mitochondrial ATP-sensitive potassium channels is a trigger of 3-nitropropionic acid-induced tolerance to transient focal cerebral ischemia in rats. Stroke 34: 1015-1020, 2003

25. Shimizu, K., Rajapakse, N., Horiguchi, T., Payne, R.M., Busija, D.W. Neuroprotection against hypoxia-ischemia in neonatal rat by novel superoxide dismutase mimetics. Neurosci Lett 346: 41-44, 2003

26. Horiguchi, T., Shimizu, K., Ogino, M., Suga, S., Inamasu, J., Kawase, T. Postischemic hypothermia inhibits the generation of hydroxyl radical following transient forebrain ischemia in rats. J Neurotrauma 20: 511-520, 2003

27. 私の研究「虚血脳障害のメカニズムの解明」刀林 81: 7, 2003. 5. 9

28. Busija DW, Lacza Z, Rajapakse N, Shimizu K, Kis B, Bari F, Domoki F, Horiguchi T. Targeting mitochondrial ATP-sensitive potassium channels--a novel approach to neuroprotection. Brain Res Rev 46: 282-294, 2004

29. Horiguchi T, Snipes JA, Kis B, Shimizu K, Busija DW. The role of nitric oxide in the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Brain Res 1039: 84-89, 2005

30.  清水克悦 13C-MRSによるサルの脳グルコース代謝 慶應医学 82(2):
75-77, 2005

31. Horiguchi T, Kis B, Rajapakse N, Shimizu K, Busija DW. Cortical spreading depression (CSD)-induced tolerance to transient focal cerebral ischemia in halothane anesthetized rats is affected by anesthetic level but not ATP-sensitive potassium channels. Brain Res. 1062: 127-33, 2005

32. Horiguchi T, Snipes JA, Kis B, Shimizu K, Busija DW. Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Neuroscience 140(2):723-30, 2006

33. Busija DW, Bari F, Domoki F, Horiguchi T, Shimizu K. Mechanisms involved
in the cerebrovascular dilator effects of cortical spreading depression. Prog
Neurobiol. 86(4): 417-33, 2008

34. Shimizu K, Ochiai M. Primary diffuse B-cell lymphoma presenting as a subdural tumor associated with calcified chronic subdural hematoma. Case report and review of the literature. Chirurgia 25(1): 77-81, 2012

35. Fukunaga A, Shimizu K, Ochiai M, Yazaki T. Interhemispheric arachnoid
cyst presenting with dementia treated by direct surgery: a case report and review of the literature. Chirurgia 26(3): 253-258, 2013

36. Fukunaga A, Shimzu K, Yazaki T, Ochiai M. A recommendation of the basis of long-term follow-up results of our microvascular decompression operation for hemifacial spasm. Acta Neurochir 155: 1693-1697, 2013

37. 清水克悦 三叉神経痛・顔面けいれんの外科治療 Dental Medical Research 33(1) : 140, 2013.03

38. Kobayashi Y, Sasaki A, Tsuji M, Udaka Y, Oyamada H, Iwai S, Somei M, Kizaki J, Kondo Y, Shimizu K, Mizutani T. Relationship of Grade of Malignant Brain Tumor to Cancer Stem Cells and Survivin Expression. Showa University Journal of Medical Science 25(4): 255-262, 2013

39. Fukunaga A, Yazaki T, Shimizu K, Ochiai M. A case of pituitary metastasis in a patient with male breast cancer developing anterior lobe dysfunction successfully treated by using hormone replacement therapy. No Shinkei Geka 42(7): 629-633, 2014 Japanese

40 清水克悦 片側顔面痙攣・三叉神経痛の根治術 昭和学士会雑誌 74(5): 513-519, 2014

41 谷岡大輔, 清水克悦, 水谷徹 皮弁トラブルを低減するための閉頭法の工夫 -チタンプレートを用いない閉頭法- 日本整容脳神経外科記録集 6: 11-14, 2014

42 Shimizu K, Matsumoto M, Wada A, Sugiyama T, Tanioka D, Okumura H, Fujishima H, Nakajo T, Nakayama S, Yabuzaki H, Mizutani T. Supine No-Retractor Method in Microvascular Decompression for Hemifacial Spasm: Results of 100 Consecutive Operations. J Neurol Surg B Skull Base 76(3): 202-207, 2015

43 Shimizu K, Matsumoto M, Wada A, Mizutani T. Lateral basal approach with a supine, no-retractor method for microvascular decompression for hemifacial spasm. Acta Neurochir 157(5): 803-806, 2015

44 Shimizu K, Wada A, Kushamae Mika, Irie R, Kawauchi U, Kato Y, Iizuka K, ubo M, Sakamoto Y, Ezure H, Otsuka N, Mizutani T. Lateral basal space and interlaminar fatty compartment of the deep cervical fascia in the posterolateral craniocervical junction - An anatomical basis for the surgery in the lateral skull base. Int J Neurol Neurother 3(1): 038 ISSN 2378-3001, 2016

45 Sugiyama T, Mizutani T, Sumi K, Matsumoto M, Yabuzaki H, Kushamae M, Irie R, Kawauchi Y, Sakamoto Y, Shimizu K, Kubo M., Kato Y, Iizuka K. Trapping of Vertebral Aneurysms Using Mid-lateral Suboccipital Approach, with Emphasis on Securing the Distal End. Surgery for Cerebral Stroke 44(6):461-468, January 2016

続きを見る

所属している医療機関

昭和大学病院

東京都品川区旗の台1丁目5-8
東京急行電鉄大井町線「旗の台」駅 徒歩3分

診療時間

  • 曜日
  • 診察時間
  • 08:00〜11:00
  • 08:00〜11:00
  • 08:00〜11:00
  • 08:00〜11:00
  • 08:00〜11:00
  • 08:00〜11:00
  • 面会時間

※ 8:00~11:00 原則紹介制、一部診療科予約制 診療は8:30~17:00 科により異なる 一部診療科は昭和大学病院附属東病院にて対応(代表TEL共通) 創立記念日(11/15)休診 臨時休診あり