小林 英介 こばやし えいすけ 先生

来歴等

略歴

2001年 慶應義塾大学医学部 卒業
2005年 国立がんセンター 整形外科
2010年 ハーバード大学マサーチューセッツ総合病院 整形外科 リサーチフェロー
2011年 慶應義塾大学大学院医学博士課程 修了 医学博士取得
2012年 国立がん研究センター中央病院 骨軟部腫瘍科 医員
2018年 慈恵会医科大学 整形外科 非常勤講師
2018年 国立がん研究センター中央病院 骨軟部腫瘍科 医長

論文

• Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas.Sci Rep. 2019 Dec 30;9(1):20360. doi: 10.1038/s41598-019-56883-0.

  Asano N, Takeshima H, Yamashita S, Takamatsu H, Hattori N, Kubo T, Yoshida A, Kobayashi E, Nakayama R, Matsumoto M, Nakamura M, Ichikawa H, Kawai A, Kondo T, Ushijima T.

• Interim results of a real-world observational study of eribulin in soft tissue sarcoma including rare subtypes.Jpn J Clin Oncol. 2019 Oct 1;49(10):938-946.

  Eisuke Kobayashi, Yoichi Naito, Naofumi Asano, Aiko Maejima, Makoto Endo, Shunji Takahashi, Yasunori Megumi, Akira Kawai

• Integrated Exome and RNA Sequencing of Dedifferentiated Liposarcoma.Nat Commun. 2019 Dec 12;10(1):5683. doi: 10.1038/s41467-019-13286-z.

  Makoto Hirata, Naofumi Asano, Kotoe Katayama, Akihiko Yoshida, Yusuke Tsuda, Masaya Sekimizu, Sachiyo Mitani, Eisuke Kobayashi, Motokiyo Komiyama, Hiroyuki Fujimoto, Takahiro Goto, Yukihide Iwamoto, Norifumi Naka, Shintaro Iwata, Yoshihiro Nishida, Toru Hiruma, Hiroaki Hiraga, Hirotaka Kawano, Toru Motoi, Yoshinao Oda, Daisuke Matsubara, Masashi Fujita, Tatsuhiro Shibata, Hidewaki Nakagawa, Robert Nakayama, Tadashi Kondo, Seiya Imoto, Satoru Miyano, Akira Kawai, Rui Yamaguchi, Hitoshi Ichikawa, and Koichi Matsuda

• Expanding the Phenotypic Spectrum of Mesenchymal Tumors Harboring the EWSR1-CREM Fusion.Am J Surg Pathol. 2019 Dec;43(12):1622-1630.

  Yoshida A, Wakai S, Ryo E, Miyata K, Miyazawa M, Yoshida KI, Motoi T, Ogawa C, Iwata S, Kobayashi E, Watanabe SI, Kawai A, Mori T.

• A clinical comparison between dedifferentiated low-grade osteosarcoma and conventional osteosarcoma.Bone Joint J (JBJS British). 2019 Jun;101-B(6):745-752.

  Toki S, Kobayashi E(Corresponding author), Yoshida A, Ogura K, Wakai S, Yoshimoto S, Yonemori K, Kawai A.

• A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes.Nat Commun. 2019 Mar 21;10(1):1299. doi: 10.1038/s41467-019-09143-8.

  Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T.

• Minute Mesenchymal Chondrosarcoma within Osteochondroma: An Unexpected Diagnosis Confirmed by HEY1-NCOA2 Fusion.Hum Pathol. 2018 Mar 26. pii: S0046-8177(18)30091-1. doi: 10.1016/j.humpath.2018.03.014. [Epub ahead of print]

  Toki S, Motoi T, Miyake M, Kobayashi E, Kawai A, Yoshida A.

• Reconstruction of the Shoulder Joint with a Custom-Made Ceramic Implant After a Total Scapulectomy: A Case Report.JBJS Case Connect. 2018 Jan-Mar;8(1):e12. doi: 10.2106/JBJS.CC.17.00061

  Araki Y, Yoshida A, Tanzawa Y, Endo M, Kobayashi E, Kawai A.

• TET2-dependent IL-6 induction mediated by the tumor microenvironment promotes tumor metastasis in osteosarcoma.Oncogene. 2018 Mar 8. doi: 10.1038/s41388-018-0160-0. [Epub ahead of print]

  Tsuyoshi Kadomatsu, Hitoshi Itoh, Hironori Tanoue, Masaki Yugami, Keishi Miyata, Motoyoshi Endo, Jun Morinaga, Ryoma Kurahashi, Kazutoyo Terada, Hiroshi Mizuta, Yuichi Oike, Eisuke Kobayashi, Takeshi Miyamoto

• Unusual subcutaneous invasion of myxoid liposarcoma.J Dermatol. 2018 May;45(5):e130-e131. doi: 10.1111/1346-8138.14136. Epub 2017 Nov 23.

  Minami Y, Kobayashi E (Corresponding author), Kawai A.

• Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma.PLoS One. 2017 Sep 25;12(9):e0185321. doi: 10.1371/journal.pone.0185321. eCollection 2017.

  Mukaihara K, Tanabe Y, Kubota D, Akaike K, Hayashi T, Mogushi K, Hosoya M, Sato S, Kobayashi E, Okubo T, Kim Y, Kohsaka S, Saito T, Kaneko K, Suehara Y.

• Activity of Pazopanib and Trabectedin in Advanced Alveolar Soft Part Sarcoma.Oncologist. 2017 Jul 28. pii: theoncologist.2017-0161. doi: 10.1634/theoncologist.2017-0161.

  Stacchiotti S, Mir O, Le Cesne A, Vincenzi B, Fedenko A, Maki RG, Somaiah N, Patel S, Brahmi M, Blay JY, Boye K, Sundby Hall K, Gelderblom H, Hindi N, Martin-Broto J, Kosela H, Rutkowski P, Italiano A, Duffaud F, Kobayashi E, Casali PG, Provenzano S, Kawai A.

• Histology-Specific Chemotherapy in Soft-Tissue Sarcomas.Gan To Kagaku Ryoho. 2017 Jun;44(6):468-472.

  Kobayashi E, Kawai A.

• Fibroma of Tendon Sheath Presenting Limited Flexion of the Fingers.Case Rep Orthop. 2017;2017:4129714. doi: 10.1155/2017/4129714. Epub 2017 May 16.

  Maeda K, Setsu N, Kato Y, Kawai A, Kobayashi E (Corresponding author)

• Malignant Peripheral Nerve Sheath Tumor of the Femur: A Rare Diagnosis Supported by Complete Immunohistochemical Loss of H3K27me3.Int J Surg Pathol. 2017 Oct;25(7):629-634.

  Sugawara M, Kobayashi E(Corresponding author), Asano N, Yoshida A, Kawai A.

• CIC Break-Apart Fluorescence In Situ Hybridisation Misses a Subset of CIC-DUX4 Sarcomas: A Clinicopathological and Molecular Study.Histopathology. 2017 Sep;71(3):461-469.

  Yoshida A, Arai Y, Kobayashi E, Yonemori K, Ogura K, Hama N, Mukai W, Motoi T, Kawai A, Shibata T, Hiraoka N.

• Angioleiomyoma mimicking pes anserinus bursitis: A case report.J Dermatol. 2017 Aug;44(8):194-195.

  Araki Y, Yoshida A, Chuman H, Tanzawa Y, Endo M, Kawai A, Kobayashi E(Corresponding author).

• Clinical significance of circulating miR-25-3p as a novel diagnostic and prognostic biomarker in osteosarcoma.Oncotarget. 2017 May 16;8(20):33375-33392.

  Fujiwara T, Uotani K, Yoshida A, Morita T, Nezu Y, Kobayashi E, Yoshida A, Uehara T, Omori T, Sugiu K, Komatsubara T, Takeda K, Kunisada T, Kawamura M, Kawai A, Ochiya T, Ozaki T.

• Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities.Mod Pathol. 2017 Jun;30(6):797-809.

  Yoshida A, Kobayashi E, Kubo T, Kodaira M, Motoi T, Motoi N, Yonemori K, Ohe Y, Watanabe SI, Kawai A, Kohno T, Kishimoto H, Ichikawa H, Hiraoka N.

• Angiomatoid fibrous histiocytoma: a series of seven cases including genetically confirmed aggressive cases and a literature review.BMC Musculoskelet Disord. 2017 Jan 23;18(1):31. doi: 10.1186/s12891-017-1390-y.

  Saito K, Kobayashi E(Corresponding author), Yoshida A, Araki Y, Kubota D, Tanzawa Y, Kawai A, Yanagawa T, Takagishi K, Chuman H.

• Reduced argininosuccinate synthetase expression in refractory sarcomas: Impacts on therapeutic potential and drug resistance.Oncotarget. 2016 Oct 25;7(43):70832-70844.

  Kim Y, Kobayashi E(Corresponding author), Kubota D, Suehara Y, Mukaihara K, Akaike K, Ito A, Kaneko K, Chuman H, Kawai A, Kitano S.

• Forty-eight cases of leiomyosarcoma of bone in Japan: A multicenter study from the Japanese musculoskeletal oncology group.J Surg Oncol. 2016 Sep;114(4):495-500.

  Mori T, Nakayama R, Endo M, Hiraga H, Tomita M, Fukase N, Kobayashi E, Kawai A, Ueda T, Morioka H.

• Primary Retroperitoneal Myxoid Liposarcomas.Am J Surg Pathol. 2016 Sep;40(9):1286-90.

  Setsu N, Miyake M, Wakai S, Nakatani F, Kobayashi E, Chuman H, Hiraoka N, Kawai A, Yoshida A.

• Diagnosis and treatment of bone metastasis: comprehensive guideline of the Japanese Society of Medical Oncology, Japanese Orthopedic Association, Japanese Urological Association, and Japanese Society for Radiation Oncology.ESMO Open Mar 2016, 1 (2) DOI: 10.1136/esmoopen-2016-000037

  H Shibata, S Kato, I Sekine, K Abe, N Araki, H Iguchi, T Izumi, Y Inaba, I Osaka, S Kato, A Kawai, S Kinuya, M Kodaira, E Kobayashi, T Kobayashi, J Sato, N Shinohara, S Takahashi, Y Takamatsu, K Takayama, K Takayama, U Tateishi, H Nagakura, M Hosaka, H Morioka, T Moriya, T Yuasa, T Yurikusa, K Yomiya, M Yoshida

• Severe hypercalcemia following denosumab treatment in a juvenile patient.J Bone Miner Metab. 2016 Jan;34(1):118-22.

  Setsu N, Kobayashi E (Corresponding author), Asano N, Yasui N, Kawamoto H, Kawai A, Horiuchi K.

• CIC-rearranged Sarcomas: A Study of 20 Cases and Comparisons With Ewing Sarcomas.Am J Surg Pathol. 2016 Mar;40(3):313-23.

  Yoshida A, Goto K, Kodaira M, Kobayashi E, Kawamoto H, Mori T, Yoshimoto S, Endo O, Kodama N, Kushima R, Hiraoka N, Motoi T, Kawai A.

• Myoepithelioma-like tumors of the vulvar region: a distinctive group of SMARCB1-deficient neoplasms.Am J Surg Pathol. 2015 Aug;39(8):1102-13.

  Yoshida A, Yoshida H, Yoshida M, Mori T, Kobayashi E, Tanzawa Y, Yasugi T, Kawana K, Ishikawa M, Sugiura H, Maeda D, Fukayama M, Kawai A, Hiraoka N, Motoi T.

• Osteosclerosis Induced by Denosumab.Lancet. 2015 Feb 7;385(9967):539.

  Kobayshi E, N Setsu

• Prognostic Value of Relevant Clinicopathologic Variables in Epithelioid Sarcoma: A Multi-institutional Retrospective Study of 44 Patients.Ann Surg Oncol. 2015 Aug;22(8):2624-32.

  Asano N, Yoshida A, Ogura K, Kobayashi E, Susa M, Morioka H, Iwata S, Ishii T, Hiruma T, Chuman H, Kawai A.

• Reversible hair depigmentation in a Japanese female treated with pazopanib.J Dermatol. 2014 Nov;41(11):1021-2.

  Kobayashi E, Koyama T, Kobayashi K, Setsu N, Kawashima M, Kawai A.

• Chronic expanding hematoma with a significantly high fluorodeoxyglucose uptake on 18F-fluorodeoxyglucose positron emission tomography, mimicking a malignant soft tissue tumor: a case report.J Med Case Rep. 2014 Oct 21;8(1):349. doi: 10.1186/1752-1947-8-349.

  Nishida Y, Kobayashi E (Corresponding author), Kubota D, Setsu N, Ogura K, Tanzawa Y, Nakatani F, Kato Y, Chuman H, Kawai A.

• Clinical relevance and therapeutic significance of microRNA-133a expression profiles and functions in malignant osteosarcoma-initiating cells.Stem Cells. 2014 Apr;32(4):959-73

  Fujiwara T, Katsuda T, Hagiwara K, Kosaka N, Yoshioka Y, Takahashi R, Takeshita F, Kubota D, Kondo T, Ichikawa H, Yoshida A, Kobayashi E, Kawai A, Ozaki T, Ochiya T.

• MicroRNA Expression and Functional Profiles of Osteosarcoma.Oncology. 2014 Jan 18;86(2):94-103.

  Kobayashi E, Satow R, Ono M, Masuda M, Honda K, Sakuma T, Kawai A, Morioka H, Toyama Y, Yamada T.

• Lipid-functionalized dextran nanosystems to overcome multidrug resistance in cancer: a pilot study.Clin Orthop Relat Res. 2013 Mar;471(3):915-25.

  Kobayashi E, Iyer AK, Hornicek FJ, Amiji MM, Duan Z.

• MicroRNA Involvement in Osteosarcoma.Sarcoma. 2012;2012:359739.

  Kobayashi E, Hornicek FJ, Duan Z.

• Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma.Mol Cancer Ther. 2010 Mar;9(3):535-44

  Kobayashi E, Masuda M, Nakayama R, Ichikawa H, Satow R, Shitashige M, Honda K, Yamaguchi U, Shoji A, Tochigi N, Morioka H, Toyama Y, Hirohashi S, Kawai A, Yamada T.

• Myxoinflammatory fibroblastic sarcoma.J Orthop Sci. 2008 Nov;13(6):566-71.

  Kobayashi E, Kawai A, Endo M, Suehara Y, Takeda K, Nakatani F, Asano T, Sakuraba M, Chuman H, Seki K, Beppu Y.

• Bilateral adrenal gland metastasis from malignant fibrous histiocytoma: value of [F-18]FDG PET-CT for diagnosis of occult metastases.Ann Nucl Med. 2006 Dec;20(10):695-8.

  Kobayashi E, Kawai A, Seki K, Tateishi U, Beppu Y.

その他

• 【受賞】2013年　整形災害外科学研究助成財団　財団奨励賞

• 【受賞】2014年　武田科学振興財団　医学系研究奨励賞

• 【受賞】2016年　日本整形外科学会香港トラベリングフェロー

• 【受賞】2018年　マンスフィールド-PhRMA研究者プログラムフェロー