首藤 昭彦 すとう あきひこ 先生

来歴等

略歴

1984年 産業医科大学医学部 卒業
1990年 慶應義塾大学外科 専修医終了 医学博士取得
1990年 米国スローンケタリングキャンサーセンター コーネル大学乳腺外科留学
1993年 神奈川県大和市立病院 外科所属
2010年 神奈川県川崎市立井田病院 外科部長
2011年 聖マリアンナ医科大学 乳腺内分泌外科臨床教授
2019年 国立がん研究センター中央病院 乳腺外科長

論文

• PEM（Positron Emission Mammmography）と乳がん術前MRIの比較検討。　乳がんの臨床　28（1）：128-129，2013.

  印牧義英、嶋本裕、川本久紀、首藤昭彦、福田護、岡田幸法、岡本聡子、中島康雄、津川浩一郎、前田一郎、小澤幸彦、片山敦

• Carcinosarcoma of the ampulla of Vater: a case report with immunohistochemical and ultrastructural studies. Am J Gastroenterol. Oct;94(10):3055-9,1999.

  Kijima H, Takeshita T, Suzuki H, Tanahashi T, Suto A, Izumika H, Miki H, Terasaki Y, Nakamura M, Watanabe H, Tamaoki N, Omiya H.

• In Vitro and In Vivo modulation of growth regulation in the human breast cancer cell line MCF-7 by estradiol metabolites. Breast Cancer. Apr 2;6(2):87-92,1999.

  Suto A, Telang NT, Tanino H, Takeshita T, Ohmiya H, Osborne MP, Kubota T.

• Bcl-2 expression in breast cancer is down-regulated by trans-arterial administration of chemotherapeutic agents. Oncol Rep. Sep-Oct;8(5):1019-22,2001

  Sato T, Kijima H, Suto A, Sato S, Yoshida H, Terasaki-Fukuzawa Y, Shimbori M, Onoda N, Osamura RY, Takeshita T.

• Decreased nm23 expression, but not Ki-67 labeling index, is significantly correlated with lymph node metastasis of breast invasive ductal carcinoma. Int J Mol Med. Jan;9(1):25-9,2002.

  Terasaki-Fukuzawa Y, Kijima H, Suto A, Takeshita T, Iezumi K, Sato S, Yoshida H, Sato T, Shimbori M, Shiina Y.

• Resistant mechanisms of anthracyclines--pirarubicin might partly break through the P-glycoprotein-mediated drug-resistance of human breast cancer tissues. Breast Cancer. 8(4):333-8,2001.

  Kubota T, Furukawa T, Tanino H, Suto A, Otani Y, Watanabe M, Ikeda T, Kitajima M.

• Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation. Oncol Rep. Jul-Aug;9(4):777-81,2002.

  Egawa T, Kubota T, Suto A, Otani Y, Furukawa T, Watanabe M, Kumai K, Kitajima M.

• Antitumor activity of doxorubicin in combination with docetaxel against human breast cancer xenografts. In Vivo. Jan-Feb;17(1):23-8,2003.

  Egawa T, Kubota T, Suto A, Otani Y, Furukawa T, Saikawa Y, Watanabe M, Kumai K, Kitajima M.

• Fine-needle aspiration cytology of breast lesions: a review of cytological analysis using smooth muscle actin (SMA) immunostaining. Anticancer Res. Sep-Oct;23(5b):4175-9,2003.

  Sato S, Kijima H, Suto A, Yoshida H, Sato T, Shimbori M, Terasaki-Fukuzawa Y, Onoda N, Araki K, Tsuruno K, Takeshita T.

• Antitumor effect of combination of S-1 and docetaxel on the human breast cancer xenograft transplanted into SCID mice. Oncol Rep. June;15(6):1517-22,2006.

  Suto A, Kubota T, Fukushima M, Ikeda T, Takeshita T, Ohmiya H, Kitajima M.

• 周術期管理の実際・乳房温存術。　外科治療　8（104）: 542-548,2011.

  首藤昭彦、池田正

• 乳がんの最新知識　乳がんは今後どうなる？　臨床看護　37（7）:937-941、2011.

  首藤昭彦、池田正

• Gallbladder carcinoma with lymphoid stroma: a case report with immunohistochemical analyses. J Clin Gastroenterol. Apr;28(3):256-8,1999.

  Kijima H, Suto A, Takeshita T, Omiya H, Tsuchida T, Yamazaki H, Nakamura M, Ueyama Y.

• 乳がん診療のトピックス　術前化学療法の効果判定の実際 INNERVISION 29巻８号 P57-60. 2014

  首藤昭彦、印牧義英

• Oncologic outcomes and technical considerations of nipple-sparing mastectomies in breast cancer:experience of 425 cases from a single institution. Breast Cancer, 23(6):851-860,2016.

  Shimo A, Tsugawa K, Tsuchiya S, Yoshie R, Tsuchiya K, Uejima T, Kojima Y, Shimo A, Hayami R, Nishikawa T, Yabuki Y, Kawamoto H, Sudo A, Fukuda M, Kanemaki Y, Maeda I.

• Japanese Research Group for the Development of Breast Cancer Screening Guidelines. The Japanese Guidelines for Breast Cancer Screening. Jpn J Clin Oncol 46(5):482-92, 2016.

  Hamashima C; Japanese Research Group for the Development of Breast Cancer Screening Guidelines, Hamashima C C, Hattori M, Honjo S, Kasahara Y, Katayama T, Nakai M, Nakayama T, Morita T, Ohta K, Ohnuki K, Sagawa M, Saito H, Sasaki S, Shimada T, Sobue T, Suto A

• Spontaneous regression of occult breast cancer with axillary lymph node metastasis: A case report. Int J Surg Case Rep.2019;63:75-79.

  Takayama S1, Satomi K2, Yoshida M2, Watase C2, Murata T2, Shiino S2, Jimbo K2, Suto A

• Towards Circulating-Tumor DNA-Based Precision Medicine. J Clin Med. 2019 Sep 2;8(9).

  Hironaka-Mitsuhashi A, Sanchez Calle A, Ochiya T, Takayama S, Suto A.

• Anthracycline could be essential for triple-negative breast cancer: A randomised phase II study by the Kanagawa Breast Oncology Group (KBOG) 1101. Breast. 2019 Oct;47:1-9.

  Narui K, Ishikawa T, Shimizu D, Yamada A, Tanabe M, Sasaki T, Oba MS, Morita S, Nawata S, Kida K, Mogaki M, Doi T, Tsugawa K, Ogata H, Ota T, Kosaka Y, Sengoku N, Kuranami M, Niikura N, Saito Y, Suzuki Y, Suto A, Arioka H, Chishima T, Ichikawa Y, Endo I, Tokuda Y

• Participants in a randomized controlled trial had longer overall survival than non-participants: a prospective cohort study.Breast Cancer Res Treat. 2019 Aug;176(3):631-635.

  Ohno S, Mukai H, Narui K, Hozumi Y, Miyoshi Y, Yoshino H, Doihara H, Suto A, Tamura M, Morimoto T, Zaha H, Chishima T, Nishimura R, Ishikawa T, Uemura Y, Ohashi Y.

• Clinical usefulness of chemosensitivity testing using the MTT assay. J Surg Oncol. Nov;48(3):188-93,1991.

  Furukawa T, Kubota T, Suto A, Takahara T, Yamaguchi H, Takeuchi T, Kase S, Kodaira S, Ishibiki K, Kitajima M.

• Antitumor activity of 7-N-(2-((2-(gamma-L-glutamylamino) ethyl) dithio) ethyl) mitomycin C (KW2149) against human tumor xenografts serially transplanted into nude mice. Jpn J Clin Oncol. Sep;19(3):216-21,1989.

  Kubota T, Inada T, Inoue S, Kuzuoka M, Arisawa Y, Suto A, Kodaira S, Ishibiki K, Abe O.

• MTT assay with reference to the clinical effect of chemotherapy. J Surg Oncol. Sep;42(1):28-32,1989.

  Suto A, Kubota T, Shimoyama Y, Ishibiki K, Abe O.

• Enhancement of antitumor activity of mitomycin C against human breast carcinoma xenografts by pretreatment with KM 2210. Gan To Kagaku Ryoho. Jan;17(1):109-14.,1990. Japanese.

  Yamamoto T, Kubota T, Oka S, Josui K, Fujita S, Arisawa Y, Suto A, Inoue S, Kuzuoka M, Ishibiki K, et al.

• Nude mouse resists hepatic metastasis of the allogeneic tumor, colon-26. Jpn J Surg. Jul;20(4):487-90,1990

  Arisawa Y, Kubota T, Suto A, Kodaira S, Ishibiki K, Abe O.

• Antitumor activity and pharmacokinetics of a morpholino-anthracycline derivative (KRN8602) against human breast carcinoma xenografts serially transplanted into nude mice. Jpn J Cancer Res. Aug;81(8):827-33,1990.

  Kubota T, Suto A, Josui K, Ishibiki K, Abe O, Yamada Y, Asanuma F, Kawamura E, Koh J, Shiina E, et al.

• MTT assay using fresh surgical specimens with reference to the transfer system and reproducibility in "test center" method. Gan To Kagaku Ryoho. Oct;17(10):2025-30,1990. Japanese.

  Kubota T, Suto A, Ishibiki K, Abe O, Yamada Y, Asanuma F, Kawamura E, Yamada T, Suzuki Y, Suzuki T.

• Antitumor activity of fluoropyrimidines and thymidylate synthetase inhibition. Jpn J Cancer Res. Apr;82(4):476-82,1991.

  Kubota T, Fujita S, Kodaira S, Yamamoto T, Josui K, Arisawa Y, Suto A, Ishibiki K, Abe O, Mabuchi K, et al.

• The influence of stromal cells on the MTT assay (I)--In vitro chemosensitivity of the tumor and stromal cells to mitomycin C. Jpn J Surg. May;21(3):304-7,1991.

  Suto A.

• The influence of stromal cells on the MTT assay (II)--Study on the nude mouse system. Jpn J Surg. May;21(3):308-11,1991.

  Suto A.

• Establishment of transplantable human colon cancer cell lines, chemosensitivity of colon carcinomas and the serially transplantable strains with MTT assay. Gan To Kagaku Ryoho. Oct;18(13):2247-53,1991. Japanese.

  Kase S, Kubota T, Furukawa T, Yamaguchi H, Takeuchi T, Takahara T, Suto A, Kodaira S, Ishibiki K.

• Human breast carcinoma (ZR-75-1) serially transplanted into nude mice--with reference to estradiol dependency and sensitivity to tamoxifen.　Jpn J Surg. Jul;19(4):446-51,1989.

  Kubota T, Oka S, Utsumi T, Inoue S, Kuzuoka M, Suto A, Arisawa Y, Ishibiki K, Abe O.

• Bradlow HL. Induction by estrogen metabolite 16 alpha-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. J Natl Cancer Inst. Apr 15;84(8):634-8,1992.

  Telang NT, Suto A, Wong GY, Osborne MP,

• Telang NT Persistent estrogen responsiveness of ras oncogene-transformed mouse mammary epithelial cells. Steroids. Jun;57(6):262-8,1992.

  Suto A, Bradlow HL, Wong GY, Osborne MP,

• Genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. Recent Prog Horm Res. 48:481-8,1993.

  Telang NT, Suto A, Bradlow HL, Wong GY, Osborne MP.

• Alteration in proliferative and endocrine responsiveness of human mammary carcinoma cells by prototypic tumor-suppressing agents. Steroids. May;58(5):215-9,1993.

  Suto A, Bradlow HL, Kubota T, Kitajima M, Wong GY, Osborne MP, Telang NT.

• Experimental down-regulation of intermediate biomarkers of carcinogenesis in mouse mammary epithelial cells. Breast Cancer Res Treat. Sep;27(3):193-202,1993.

  Suto A, Bradlow HL, Wong GY, Osborne MP, Telang NT.

• Asymptomatic primary mucinous cystadenocarcinoma of the appendix with a large abdominal mass: report of a case. Surg Today. 24(10):915-7,1994.

  Suto A, Tsuyuki A, Hiraoka N, Hosoda Y, Kikuchi K, Fujishiro Y.

• Single-cell suspension assay with an MTT end point is useful for evaluating the optimal adjuvant chemotherapy for advanced gastric cancer. Jpn J Cancer Res. Jul;85(7):762-5,1994.

  Saikawa Y, Kubota T, Furukawa T, Suto A, Watanabe M, Kumai K, Ishibiki K, Kitajima M.

• Asymptomatic pancreatic islet cell tumor (glucagonoma): case report Nippon Geka Gakkai Zasshi. Feb;99(2):124-8,1998. Japanese.

  Suto A, Takayama S, Miki H, Izumika H, Tanahashi T, Suzuki H, Takeshita T, Ohmiya H, Kijima H.

• Invasive lobular breast carcinoma mimicking medullary carcinoma. Acta Cytol. May-Jun;42(3):812-5,1998.

  Terasaki Y, Sato S, Yoshida H, Iezumi K, Suto A, Takeshita T, Omiya H, Kijima H.

• Heterogeneous expression of nm23 gene product as a predictor of lymph nodal status in human breast cancer. Int J Oncol. Dec;13(6):1141-6,1998.

  Yoshida H, Kijima H, Terasaki Y, Suto A, Takeshita T, Omiya H, Shimojima K, Shimbori M, Sato T, Sato S, Onoda N, Yamazaki H, Tamaoki N, Ueyama Y, Nakamura M.

著書

• 【共著】首藤昭彦、池田正 :乳癌薬物療法(オンコロジークリニカルガイド)　 乳癌とホルモン受容体　pp 10-14. 2016

その他

• 【受賞】1994年 6月　慶應義塾大学医学部外科学教室　刀林賞

• 【受賞】2000年 5月　 第1回 Breast Cancer優秀論文賞