望月 秀樹 もちづき ひでき 先生

来歴等

略歴

1985年　順天堂大学医学部　卒業
1985年　順天堂大学脳神経内科　専攻生
1990年　順天堂大学脳神経内科　助手
1996年　米国, NIH, NINDS留学 (visiting associate)
1999年　順天堂大学脳神経内科　臨床講師
2000年　順天堂老人性疾患病態・治療研究センター講師併任
2005年　順天堂大学脳神経内科助教授、
2009年　北里大学神経内科学　教授
2010年　北里大学再生医療学講座設立
2011年　大阪大学大学院医学研究科　神経内科学　教授
2012年　大阪大学大学附属病院　遺伝子診療部　部長併任
2016年　大阪大学神経難病認知症探索治療学寄附講座設立
2016年　大阪大学大学附属病院　脳卒中センター長併任
2016年　大阪大学大学附属病院　難病医療推進センター副センター長併任

論文

1. Mochizuki H, Schwartz JP, Tanaka K, Brady RO, Reiser J. High-titer HIV-1-based vector systems for gene delivery into nondividing cells. J Virol. 1998 Nov;72(11):8873-83.
2. Mochizuki H, Hayakawa H, Migita M, Shibata M, Tanaka R, Suzuki A, Shimo-Nakanishi Y, Urabe T, Yamada M, Tamayose K, Shimada T, Miura M and Mizuno Y. An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as anti- apoptotic gene therapy for Parkinson’s disease. Proc Natl Acad Sci USA. 2001 Sep 11;98(19):10918-23.
3. Furuya T, Hayakawa H, Yamada M, Yoshimi K, Hisahara S, Miura M, Mizuno Y, Mochizuki H. Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci. 2004 Feb 25;24(8):1865-72.
4. Yoshimi K, Ren YR, Seki T, Yamada M, Oizumi H, Onodera M, Saito Y, Murayama S, Okano H, Mizuno Y, Mochizuki H. Possibility for neurogenesis in substantia nigra of parkinsonian brain. Ann Neurol. 2005 Jul;58(1):31-40.
5. Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T, Sato F, Hirose T, Tanaka Y, Mochizuki H, Kawamori R, Watada H. Amelioration of glucose tolerance by hepatic inhibition of nuclear factor κB in db/db mice. Diabetologia. 2007 Jan;50(1):131-41.
6. Muramatsu R, Kubo T, Mori M, Nakamura Y, Fujita Y, Akutsu T, Okuno T, Taniguchi J, Kumanogoh A, Yoshida M, Mochizuki H, Kuwabara S, Yamashita T. RGMa modulates T cell　responses and is involved in autoimmune encephalomyelitis. Nat Med. 2011 Apr;17(4):488-94.
7. Fujimoto H, Mezaki T, Yokoe M, Mochizuki H. Sonographic guidance provides a low-risk approach to the longus colli muscle. Mov Disord. 2012;27(7):928-9.
8. Nakata Y, Yasuda T, Fukaya M, Yamadori S, Itakura M, Nihira T, Hayakawa H, Kawakami A, Nagai M, Sakagami H, Miyake K, Takahashi M, Mizuno Y, Mochizuki H. Accumulation of α-synuclein triggered by presynaptic dysfunction. J Neurosci. 2012;32(48):17186-96.
9. Miyakawa S, Ogino M, Funabe S, Shimo Y, Hattori N, Ichinose M, Mikami T, Saegusa M, Nishiyama K, Mori H, Mizuno Y, Mochizuki H. Lewy body pathology in a patient with a homozygous parkin deletion. Mov Disord. 2013 Mar;28(3):388-91.
10. Khoo HM, Kishima H, Hosomi K, Maruo T, Tani N, Oshino S, Shimokawa T, Yokoe M, Mochizuki H, Saitoh Y, Yoshimine T. Low-frequency subthalamic nucleus stimulation in Parkinson's disease: a randomized clinical trial. Mov Disord. 2014 Feb;29(2):270-4.
11. Kimura Y, Mihara M, Kawarai T, Kishima H, Sakai N, Takahashi MP, Mochizuki H. Efficacy of deep brain stimulation in an adolescent patient with DYT11 myoclonus-dystonia. Neurology and clinical Neuroscience. 2014 Mar;2(2):57-9.
12. Kimura Y, Oda M, Nakatani T, Sekita Y, Monfort A, Wutz A, Mochizuki H, Nakano T. CRISPR/Cas9-mediated reporter knock-in in mouse haploid embryonic stem cells. Sci Rep. 2015 Jun 3;5:10710.
13. Tada S, Furuta M, Fukada K, Hirozawa D, Matsui M, Aoike F, Okuno T, Sawada JI, Mochizuki H, Hazama T. Severe parkinsonism associated with anti-CRMP5 antibody-positive paraneoplastic neurological syndrome and abnormal signal intensity in the bilateral basal ganglia. J Neurol Neurosurg Psychiatry. 2015 Sep 15. doi:10.1136(Epub ahead of print)
14. Gon Y, Okazaki S, Terasaki Y, Sasaki T, Yoshimine T, Sakaguchi M, Mochizuki H. Characteristics of cryptogenic stroke in cancer patients. Ann Clin Transl Neurol. 2016 Feb 11;3(4):280-7. doi: 10.1002/acn3.291. eCollection 2016 Apr.
15. Hasegawa K, Yasuda T, Shiraishi C, Fujiwara K, Przedborski S, Mochizuki H, Yoshikawa K. Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults. Nat Commun. 2016 Mar 14;7:10943.
16. Freyermuth F, Rau F, Kokunai Y, Linke T, Sellier C, Nakamori M, Kino Y, Arandel L, Jollet A, Thibault C, Philipps M, Vicaire S, Jost B, Udd B, Day JW, Duboc D, Wahbi K, Matsumura T, Fujimura H, Mochizuki H, Deryckere F, Kimura T, Nukina N, Ishiura S, Lacroix V, Campan-Fournier A, Navratil V, Chautard E, Auboeuf D, Horie M, Imoto K, Lee K-Y, Swanson MS, Lopez de Munain A, Inada S, Itoh H, Nakazawa K, Ashihara T, Wang E, Zimmer T, Furling D, Takahashi MP & Charlet-Berguerand N. Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy. Nature Communications 7, Article number:11067 (2016) doi:10.1038/ncomms11067. Published online:11 April 2016
17. Kadowaki A, Miyake S, Saga R, Chiba A, Mochizuki H, Yamamura T. Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3. Nature Communication. Nature Communications 7, Article number: 11639 (2016). doi:10.1038/ncomms11639. Published online:20 May 2016
18. Araki K, Yagi N, Nakatani R, Sekiguchi H, So M, Yagi H, Ohta N, Nagai Y, Goto Y & Mochizuki H. A small-angle X-ray scattering study of alpha-synuclein from human red blood cells. Scientific Report. Scientific Reports 6, Article number: 30473 (2016) doi:10.1038/srep30473. Published online:29 July 2016
19. Kurinami H, Shimamura M, Nakagami H, Shimizu H, Koriyama H, Kawano T, Wakayama K, Mochizuki H, Rakugi H & Morishita R. A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke. Scientific Reports. Published online: 29 November 2016. Scientific Reports 6, Article number: 38062 (2016). doi:10.1038/srep38062
20. Ito K, Eguchi Y, Imagawa Y, Akai S, Mochizuki H & Tsujimoto Y, MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells. Cell Death Discovery. Published online:27 February 2017. doi:10.1038/cddiscovery.2017.13. Cell Death Discovery 3, Article number: 17013
21. Wakayama K, Shimamura M, Suzuki J, Watanabe R, Koriyama H, Akazawa H, Nakagami H, Mochizuki H, Isobe M, Morishita R, Angiotensin II Peptide Vaccine Protects Ischemic Brain Through Reducing Oxidative Stress. Stroke. published March 31, 2017. Stroke. 2017;48:1362-1368
22. Choong C, Mochizuki H. Inappropriate trafficking of damaged mitochondria in Parkinson’s disease. Stem Cell Investigation. 27 February 2017.　doi: 10.21037/sci.2017.02.07
23. Kuroda M, Muramatsu R, Maedera N, Koyama Y, Hamaguchi M, Fujimura H, Yoshida M, Konishi M, Itoh N, Mochizuki H, and Toshihide Yamashita, Peripherally derived FGF21 promotes remyelination in the central nervous system. The Journal of Clinical Investigation. Volume 127, Issue 9 (September 1, 2017) J Clin Invest. 2017;127(9):3496–3509. doi:10.1172/JCI94337.
24. Nakamori M, Hamanaka K, Thomas JD, Wang ET, Hayashi YK, Takahashi MP, Swanson MS, Nishino I, Mochizuki H. Aberrant Myokine Signaling in Congenital Myotonic Dystrophy. Cell Rep. 2017 Oct 31;21(5):1240-1252. doi: 10.1016/j.celrep.2017.10.018.

著書

望月秀樹,　北川一夫,　中辻裕司．神経内科クリニカルスタンダード．（文光堂、東京、2015）

その他

• 【受賞】1994年　財団法人三井生命厚生事業団第26回成人病研究助成、パーキンソン病研究

• 【受賞】2001年　5th International Conference on Progress in Alzheimer’s and Parkinson’s Disease Best Poster賞

• 【受賞】2002年　第２回パーキンソン病フォーラム 　Best Poster賞

• 【受賞】2004年　順天堂大学同窓会学術奨励賞 、1st International Symposium on Dopaminergic and Nondopaminergic Mechanisms in Parkinson’s Disease Best Poster賞

• 【受賞】2007年　Best Research Award、1st Asia & Oceania Parkinson’s disease Movement Disorder Congress、Best Poster Award,3rdInternational Symposium on Dopaminergic and Nondopaminergic Mechanisms in Parkinson’s Disease

• 【受賞】2008年　日本神経学会　楢林賞

• 【受賞】2009年　順天堂医師会賞