小山 隆文 こやま たかふみ 先生

来歴等

略歴

2006年 金沢大学医学部 医学科 卒業
2006年 医療法人 岸和田徳洲会病院 初期臨床研修医
2008年 医療法人鉄蕉会 亀田総合病院 腫瘍内科 後期臨床研修医
2011年 医療法人鉄蕉会 亀田総合病院 腫瘍内科 医員
2012年 医療法人鉄蕉会 亀田総合病院 腫瘍内科 医長
2014年 医療法人鉄蕉会 亀田総合病院 腫瘍内科 部長代理
2016年 国立がん研究センター中央病院 先端医療科 がん専門修練医
2018年 国立がん研究センター中央病院 先端医療科 医員
2018年 千葉大学大学院医学研究院 入学
2022年 千葉大学大学院医学研究院 卒業
2022年 国立がん研究センター中央病院 先端医療科 医長

論文

• 1. Clinical Utility of Comprehensive Genomic Profiling Tests for Advanced or Metastatic Solid Tumor in Clinical Practice. Cancer Sci (Sep 14 2022).https://dx.doi.org/10.1111/cas.15586.

  Ida, H., T. Koyama, T. Mizuno, K. Sunami, T. Kubo, K. Sudo, K. Tao, M. Hirata, K. Yonemori, K. Kato, T. Okusaka, Y. Ohe, Y. Matsui, N. Yamazaki, C. Ogawa, A. Kawai, Y. Narita, M. Esaki, and N. Yamamoto.

• 2. Chronological Improvement in Precision Oncology Implementation in Japan. Cancer Sci (Aug 17 2022). https://dx.doi.org/10.1111/cas.15517.

  Sunami, K., Y. Naito, K. Komine, T. Amano, D. Ennishi, M. Imai, H. Kage, M. Kanai, H. Kenmotsu, T. Koyama, T. Maeda, S. Morita, D. Sakai, S. Kohsaka, K. Tsuchihara, Y. Saigusa, and T. Yoshino.

• 3. Phase I/Iia Trial of Bms-986148, an Anti-Mesothelin Antibody-Drug Conjugate, Alone or in Combination with Nivolumab in Patients with Advanced Solid Tumors.Clin Cancer Res 28, no. 1 (Jan 1 2022): 95-105. https://dx.doi.org/10.1158/1078-0432.Ccr-21-1181.

  Rottey, S., J. Clarke, K. Aung, J. P. Machiels, B. Markman, K. M. Heinhuis, M. Millward, M. Lolkema, S. P. Patel, P. de Souza, M. Duca, G. Curigliano, A. Santoro, T. Koyama, M. Brown, H. Vezina, C. He, and Q. S. Chu.

• 4. Dose Escalation Data from the Phase 1 Study of the Liposomal Formulation of Eribulin (E7389-Lf) in Japanese Patients with Advanced Solid Tumors. Clin Cancer Res 28, no. 9 (May 2 2022): 1783-91. https://dx.doi.org/10.1158/1078-0432.Ccr-21-3518.

  Sato, J., T. Shimizu, T. Koyama, S. Iwasa, A. Shimomura, S. Kondo, S. Kitano, K. Yonemori, Y. Fujiwara, K. Tamura, T. Suzuki, T. Takase, R. Nagai, K. Yamaguchi, T. Semba, Z. M. Zhao, M. Ren, and N. Yamamoto.

• 5. Expert Panel Consensus Recommendations on the Use of Circulating Tumor DNA Assays for Patients with Advanced Solid Tumors.Cancer Sci (Jul 25 2022). https://dx.doi.org/10.1111/cas.15504.

  Imai, M., Y. Nakamura, K. Sunami, H. Kage, K. Komine, T. Koyama, T. Amano, D. Ennishi, M. Kanai, H. Kenmotsu, T. Maeda, S. Morita, D. Sakai, H. Bando, A. Makiyama, T. Suzuki, M. Hirata, S. Kohsaka, K. Tsuchihara, Y. Naito, and T. Yoshino.

• 6. Yamamoto.Practical Consideration for Successful Sequential Tumor Biopsies in First-in-Human Trials. Invest New Drugs 40, no. 4 (Aug 2022): 841-49. https://dx.doi.org/10.1007/s10637-022-01236-4.

  Koyama, T., T. Shimizu, J. Sato, Y. Katsuya, S. Iwasa, S. Kondo, T. Yoshida, K. Sudo, M. Nishino, Y. Takiguchi, K. Yonemori, and N.

• 7. Yamamoto.Study Protocol for Ncch1908 (Upfront-Trial): A Prospective Clinical Trial to Evaluate the Feasibility and Utility of Comprehensive Genomic Profiling Prior to the Initial Systemic Treatment in Advanced Solid Tumour Patients.Jpn J Clin Oncol 51, no. 12 (Dec 1 2021): 1757-60. https://dx.doi.org/10.1093/jjco/hyab159.

  Mizuno, T., T. Yoshida, K. Sunami, T. Koyama, N. Okita, T. Kubo, K. Sudo, T. Shimoi, H. Ueno, E. Saito, K. Katanoda, T. Shibata, K. Yonemori, T. Okusaka, N. Boku, Y. Ohe, Y. Hiroshima, M. Ueno, Y. Kuboki, T. Doi, K. Nakamura, T. Kohno, Y. Yatabe, and N.

• 8. Comprehensive Functional Evaluation of Variants of Fibroblast Growth Factor Receptor Genes in Cancer.NPJ Precis Oncol 5, no. 1 (Jul 16 2021): 66. https://dx.doi.org/10.1038/s41698-021-00204-0.

  Nakamura, I. T., S. Kohsaka, M. Ikegami, H. Ikeuchi, T. Ueno, K. Li, T. S. Beyett, T. Koyama, T. Shimizu, N. Yamamoto, F. Takahashi, K. Takahashi, M. J. Eck, and H. Mano.

• 9. First-in-Human Phase 1 Study of Morab-202, an Antibody-Drug Conjugate Comprising Farletuzumab Linked to Eribulin Mesylate, in Patients with Folate Receptor-Α-Positive Advanced Solid Tumors.Clin Cancer Res 27, no. 14 (Jul 15 2021): 3905-15. https://dx.doi.org/10.1158/1078-0432.Ccr-20-4740.

  Shimizu, T., Y. Fujiwara, K. Yonemori, T. Koyama, J. Sato, K. Tamura, A. Shimomura, H. Ikezawa, M. Nomoto, K. Furuuchi, R. Nakajima, T. Miura, and N. Yamamoto.

• 10. Correction To: The Initial Assessment of Expert Panel Performance in Core Hospitals for Cancer Genomic Medicine in Japan. Int J Clin Oncol 26, no. 5 (May 2021): 1007. https://dx.doi.org/10.1007/s10147-021-01897-w.

  Sunami, K., Y. Naito, E. Aimono, T. Amano, D. Ennishi, H. Kage, M. Kanai, K. Komine, T. Koyama, T. Maeda, S. Morita, D. Sakai, S. Kohsaka, K. Tsuchihara, and T. Yoshino.

• 11. The Initial Assessment of Expert Panel Performance in Core Hospitals for Cancer Genomic Medicine in Japan. Int J Clin Oncol 26, no. 3 (Mar 2021): 443-49. https://dx.doi.org/10.1007/s10147-020-01844-1.

  Sunami, K., Y. Naito, E. Aimono, T. Amano, D. Ennishi, H. Kage, M. Kanai, K. Komine, T. Koyama, T. Maeda, S. Morita, D. Sakai, S. Kohsaka, K. Tsuchihara, and T. Yoshino.

• 12. First-in-Human Phase I Study of E7090, a Novel Selective Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced Solid Tumors. Cancer Sci 111, no. 2 (Feb 2020): 571-79. https://dx.doi.org/10.1111/cas.14265.

  Koyama, T., T. Shimizu, S. Iwasa, Y. Fujiwara, S. Kondo, S. Kitano, K. Yonemori, A. Shimomura, S. Iizumi, T. Sasaki, J. Furuse, and N. Yamamoto.

• 13. Impact of Hepatitis Virus on the Feasibility and Efficacy of Anticancer Agents in Patients with Hepatocellular Carcinoma in Phase I Clinical Trials. Front Oncol 9 (2019): 301. https://dx.doi.org/10.3389/fonc.2019.00301.

  Koyama, T., S. Kondo, T. Shimizu, Y. Fujiwara, C. Morizane, Y. Sakamoto, T. Okusaka, and N. Yamamoto.

• 14. Feasibility and Utility of a Panel Testing for 114 Cancer-Associated Genes in a Clinical Setting: A Hospital-Based Study. Cancer Sci 110, no. 4 (Apr 2019): 1480-90. https://dx.doi.org/10.1111/cas.13969.

  Sunami, K., H. Ichikawa, T. Kubo, M. Kato, Y. Fujiwara, A. Shimomura, T. Koyama, H. Kakishima, M. Kitami, H. Matsushita, E. Furukawa, D. Narushima, M. Nagai, H. Taniguchi, N. Motoi, S. Sekine, A. Maeshima, T. Mori, R. Watanabe, M. Yoshida, A. Yoshida, H. Yoshida, K. Satomi, A. Sukeda, T. Hashimoto, T. Shimizu, S. Iwasa, K. Yonemori, K. Kato, C. Morizane, C. Ogawa, N. Tanabe, K. Sugano, N. Hiraoka, K. Tamura, T. Yoshida, Y. Fujiwara, A. Ochiai, N. Yamamoto, and T. Kohno.

著書

• 1. がんゲノム医療遺伝子パネル検査実践ガイド/医学書院/2020年