三好 正人 みよし まさと 先生

Nagawa F, Kishishita N, Shimizu K, Hirose S, Miyoshi M, Nezu J, Nishimura T, Nishizumi H, Takahashi Y, Hashimoto S, Takeuchi M, Miyajima A, Takemori T, Otsuka AJ, Sakano H. Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice. Nature immunology. 2007.02; 8 (2): 206-13.

三好 正人. 【革新的技術が変える肝疾患診療】iPS細胞培養技術がもたらす肝疾患診療の変革 消化器・肝臓内科. 2022.04; 11 (4): 507-514.

Nitta Sayuri, Takahashi Kazuaki, Kawai-Kitahata Fukiko, Tsuchiya Jun, Sato Ayako, Miyoshi Masato, Murakawa Miyako, Itsui Yasuhiro, Nakagawa Mina, Azuma Seishin, Kakinuma Sei, Watanabe Mamoru, Asahina Yasuhiro. Time course alterations of virus sequences and immunoglobulin titers in a chronic hepatitis E patient HEPATOLOGY RESEARCH. 2020.04; 50 (4): 524-531.

Sato Ayako, Kakinuma Sei, Miyoshi Masato, Kamiya Akihide, Tsunoda Tomoyuki, Kaneko Shun, Tsuchiya Jun, Shimizu Taro, Takeichi Eiko, Nitta Sayuri, Kawai-Kitahata Fukiko, Murakawa Miyako, Itsui Yasuhiro, Nakagawa Mina, Azuma Seishin, Koshikawa Naohiko, Seiki Motoharu, Nakauchi Hiromitsu, Asahina Yasuhiro, Watanabe Mamoru. Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts HEPATOLOGY COMMUNICATIONS. 2020.02; 4 (2): 235-254.

三好 正人, 柿沼 晴. 【肝胆膵の線維化up-to-date】肝臓の線維化 基礎研究 ヒトiPS細胞由来肝星細胞の作製と細胞間相互作用を介した肝細胞の成熟化 肝胆膵. 2019.11; 79 (5): 837-843.

Satoshi Otani, Sei Kakinuma, Akihide Kamiya, Fumio Goto, Shun Kaneko, Masato Miyoshi, Tomoyuki Tsunoda, Yu Asano, Fukiko Kawai-Kitahata, Sayuri Nitta, Toru Nakata, Ryuichi Okamoto, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Yasuhiro Asahina, Tomoyuki Yamaguchi, Naohiko Koshikawa, Motoharu Seiki, Hiromitsu Nakauchi, Mamoru Watanabe. Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells. Biochem. Biophys. Res. Commun. 2016.01; 469 (4): 1062-1068.

Nakano Naoko, Mori Masaaki, Umebayashi Hiroaki, Iwata Naomi, Kobayashi Norimoto, Masunaga Kenji, Imagawa Tomoyuki, Murata Takuji, Kinjo Noriko, Nagai Kazushige, Miyoshi Mari, Takei Syuji, Yokota Shumpei, Ishii Eiichi. Characteristics and outcome of intractable vasculitis syndrome in children: Nation-wide survey in Japan MODERN RHEUMATOLOGY. 2018; 28 (4): 697-702.

Satake Masahiro, Matsubayashi Keiji, Hoshi Yuji, Taira Rikizo, Furui Yasumi, Kokudo Norihiro, Akamatsu Nobuhisa, Yoshizumi Tomoharu, Ohkohchi Nobuhiro, Okamoto Hiroaki, Miyoshi Masato, Tamura Akinori, Fuse Kyoko, Tadokoro Kenji. Unique clinical courses of transfusion-transmitted hepatitis E in patients with immunosuppression TRANSFUSION. 2017.02; 57 (2): 280-288.

小島 直紀, 石井 玲子, 三好 正人, 佐藤 綾子, 松田 浩紀, 野澤 さやか, 山本 奈穂子, 久津川 誠, 幾世橋 佳, 伊田 春菜, 田邊 陽子, 渡邉 秀樹, 新井 勝春, 鈴木 秀明, 小林 史枝, 池田 隆明. 自己免疫性肝疾患診断困難例におけるステロイド治療効果予測指標の検討 末梢血リンパ球CD4/CD8比の有用性 共済医報. 2015.02; 64 (1): 20-26.

山上 洋介, 津浦 幸夫, 疋田 浩之, 大河内 稔, 豊田 茂雄, 池田 隆明, 田村 禎一, 田中 啓之, 青柳 誠, 安藝 昇太, 夏目 一郎, 小松崎 恵子, 小馬瀬 一樹, 田邊 陽子, 矢毛石 眞由美, 水澤 真文, 藤原 高智, 矢野 尚, 三好 正人, 森川 亮, 大坪 加奈, 高橋 直宏, 内田 真梨子, 矢島 優, 鎌倉 栄作, 井上 玲, 木田 達也, 登本 彩子, 高橋 純一, 堤 壮吾, 佐治 龍, 野村 知世, 藤原 俊, 田尻下 紘直, 星野 亜紗子, 杉山 知代. 救命できなかった劇症型心筋炎の一例 共済医報. 2015.02; 64 (1): 73-78.

Onozuka Izumi, Kakinuma Sei, Kamiya Akihide, Miyoshi Masato, Sakamoto Naoya, Kiyohashi Kei, Watanabe Takako, Funaoka Yusuke, Ueyama Mayumi, Nakagawa Mina, Koshikawa Naohiko, Seiki Motoharu, Nakauchi Hiromitsu, Watanabe Mamoru. Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011.03; 406 (1): 134-140.

Seishin Azuma, Yasuhiro Asahina, Sei Kakinuma, Keiko Azuma, Masato Miyoshi, Emi Inoue, Tomoyuki Tsunoda, Ayako Sato, Shun Kaneko, Hiroko Nagata, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Makoto Tomita, Mina Nakagawa, Mamoru Watanabe. Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease. Dig Dis. 2019; 37 (3): 247-254.

Nakagawa Mina, Nawa Nobutoshi, Takeichi Eiko, Shimizu Taro, Tsuchiya Jun, Sato Ayako, Miyoshi Masato, Kawai-Kitahata Fukiko, Murakawa Miyako, Nitta Sayuri, Itsui Yasuhiro, Azuma Seishin, Kakinuma Sei, Fujiwara Takeo, Watanabe Mamoru, Tanaka Yujiro, Asahina Yasuhiro. 直接作用型抗ウイルス薬(DAA)によるC型肝炎ウイルス根絶後の患者の生存に関する新規予測バイオマーカーとしてのMac-2結合タンパク糖鎖修飾異性体(Mac-2 binding protein glycosylation isomer as a novel predictive biomarker for patient survival after hepatitis C virus eradication by DAAs) Journal of Gastroenterology. 2020.10; 55 (10): 990-999.

Mina Nakagawa, Nobutoshi Nawa, Eiko Takeichi, Taro Shimizu, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Takeo Fujiwara, Mamoru Watanabe, Yujiro Tanaka, Yasuhiro Asahina, . Mac-2 binding protein glycosylation isomer as a novel predictive biomarker for patient survival after hepatitis C virus eradication by DAAs. J. Gastroenterol. 2020.08; 55 (10): 990-999.

Nitta Sayuri, Takahashi Kazuaki, Kawai-Kitahata Fukiko, Tsuchiya Jun, Sato Ayako, Miyoshi Masato, Murakawa Miyako, Itsui Yasuhiro, Nakagawa Mina, Azuma Seishin, Kakinuma Sei, Watanabe Mamoru, Asahina Yasuhiro. 慢性E型肝炎患者におけるウイルス配列および免疫グロブリン抗体価の経時変化(Time course alterations of virus sequences and immunoglobulin titers in a chronic hepatitis E patient) Hepatology Research. 2020.04; 50 (4): 524-531.

Kawai-Kitahata Fukiko, Asahina Yasuhiro, Kaneko Shun, Tsuchiya Jun, Sato Ayako, Miyoshi Masato, Tsunoda Tomoyuki, Inoue-Shinomiya Emi, Murakawa Miyako, Nitta Sayuri, Itsui Yasuhiro, Nakagawa Mina, Azuma Seishin, Kakinuma Sei, Tanabe Minoru, Sugawara Emiko, Takemoto Akira, Ojima Hidenori, Sakamoto Michiie, Muraoka Masaru, Takano Shinichi, Maekawa Shinya, Enomoto Nobuyuki, Watanabe Mamoru. 肝細胞癌様領域と異時性肝細胞癌が併存する胆管細胞癌の網羅的遺伝子解析(Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma) Hepatology Research. 2019.12; 49 (12): 1466-1474.

Fukiko Kawai-Kitahata, Yasuhiro Asahina, Shun Kaneko, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Tomoyuki Tsunoda, Emi Inoue-Shinomiya, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Minoru Tanabe, Emiko Sugawara, Akira Takemoto, Hidenori Ojima, Michiie Sakamoto, Masaru Muraoka, Shinichi Takano, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe. Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma. Hepatol. Res.. 2019.07; 49 (12): 1466-1474.

Emi Inoue-Shinomiya, Miyako Murakawa, Yasuhiro Asahina, Mina Nakagawa, Jun Tsuchiya, Ayako Sato, Tomoyuki Tsunoda, Masato Miyoshi, Sayuri Nitta, Fukiko Kawai-Kitahata, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Kazumoto Murata, Masashi Mizokami, Mamoru Watanabe. Association of serum interferon-λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents. Hepatol. Res.. 2019.05; 49 (5): 500-511.

Inoue-Shinomiya Emi, Murakawa Miyako, Asahina Yasuhiro, Nakagawa Mina, Tsuchiya Jun, Sato Ayako, Tsunoda Tomoyuki, Miyoshi Masato, Nitta Sayuri, Kawai-Kitahata Fukiko, Itsui Yasuhiro, Azuma Seishin, Kakinuma Sei, Murata Kazumoto, Mizokami Masashi, Watanabe Mamoru. 直接作用型抗ウイルス薬を投与されたC型慢性肝炎患者における血清インターフェロン-λ3値と肝細胞癌発症との関連性(Association of serum interferon-λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents) Hepatology Research. 2019.05; 49 (5): 500-511.

Sayuri Nitta, Yasuhiro Asahina, Takanobu Kato, Jun Tsuchiya, Emi Inoue-Shinomiya, Ayako Sato, Tomoyuki Tsunoda, Masato Miyoshi, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Hayato Hikita, Tetsuo Takehara, Mamoru Watanabe. Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients. Sci Rep. 2019.04; 9 (1): 5722.

Tomoyuki Tsunoda, Sei Kakinuma, Masato Miyoshi, Akihide Kamiya, Shun Kaneko, Ayako Sato, Jun Tsuchiya, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Tsuyoshi Sogo, Haruki Komatsu, Ryutaro Mukouchi, Ayano Inui, Tomoo Fujisawa, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe. Loss of fibrocystin promotes interleukin-8-dependent proliferation and CTGF production of biliary epithelium. J. Hepatol.. 2019.03; 71 (1): 143-152.

Masato Miyoshi, Sei Kakinuma, Akihide Kamiya, Tomoyuki Tsunoda, Jun Tsuchiya, Ayako Sato, Shun Kaneko, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe. LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. Sci Rep. 2019.02; 9 (1): 2072.

Shun Kaneko, Yasuhiro Asahina, Mina Nakagawa, Miyako Murakawa, Yasunari Miyazaki, Takahiro Asakage, Shohei Fukuda, Takeshi Namiki, Yoshito Kano, Masashi Nagata, Jun Tsuchiya, Masato Miyoshi, Fukiko Kitahata-Kawai, Sayuri Nitta, Yasuhiro Itsui, Sei Kakinuma, Ryuichi Okamoto. Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors. Hepatol Res. 2023.01;

Murakawa Miyako, Asahina Yasuhiro, Nagata Hiroko, Nakagawa Mina, Kakinuma Sei, Nitta Sayuri, Kawai-Kitahata Fukiko, Otani Satoshi, Kaneko Shun, Miyoshi Masato, Tsunoda Tomoyuki, Asano Yu, Sato Ayako, Itsui Yasuhiro, Azuma Seishin, Nouchi Toshihiko, Furumoto Yohei, Asano Tooru, Chuganji Yoshimichi, Tohda Shuji, Watanabe Mamoru. ソホスブビル+リバビリン治療を行ったC型慢性肝炎ジェノタイプ2患者におけるITPA遺伝的変異とリバビリン誘発性貧血(ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin) Hepatology Research. 2017.10; 47 (11): 1212-1218.

Goto Fumio, Kakinuma Sei, Miyoshi Masato, Tsunoda Tomoyuki, Kaneko Shun, Sato Ayako, Asano Yu, Otani Satoshi, Azuma Seishin, Nagata Hiroko, Kawai-Kitahata Fukiko, Murakawa Miyako, Nitta Sayuri, Itsui Yasuhiro, Nakagawa Mina, Asahina Yasuhiro, Watanabe Mamoru. 骨形成因子4は胎児肝幹/前駆細胞の増殖と最終分化を調整する(Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells) Hepatology Research. 2017.08; 47 (9): 941-952.

Hiroko Nagata, Mina Nakagawa, Yasuhiro Asahina, Ayako Sato, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Shun Kaneko, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Toshihiko Nouchi, Hideki Sakai, Makoto Tomita, Mamoru Watanabe, . Effect of interferon-based and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C. J. Hepatol. 2017.06; 67 (5): 933-939.

Miyako Murakawa, Yasuhiro Asahina, Hiroko Nagata, Mina Nakagawa, Sei Kakinuma, Sayuri Nitta, Fukiko Kawai-Kitahata, Satoshi Otani, Shun Kaneko, Masato Miyoshi, Tomoyuki Tsunoda, Yu Asano, Ayako Sato, Yasuhiro Itsui, Seishin Azuma, Toshihiko Nouchi, Yohei Furumoto, Tooru Asano, Yoshimichi Chuganji, Shuji Tohda, Mamoru Watanabe. ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin. Hepatol. Res. 2017.01; 47 (11): 1212-1218.

Miyako Murakawa, Yasuhiro Asahina, Fukiko Kawai-Kitahata, Mina Nakagawa, Sayuri Nitta, Satoshi Otani, Hiroko Nagata, Shun Kaneko, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Yasuhito Tanaka, Sayuki Iijima, Kaoru Tsuchiya, Namiki Izumi, Shuji Tohda, Mamoru Watanabe. Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients. [Epub ahead of print] J. Med. Virol. 2016.12; 89 (7): 1241-1247.

Masato Miyoshi, Sei Kakinuma, Yoko Tanabe, Koji Ishii, Tian-Cheng Li, Takaji Wakita, Yukio Tsuura, Hideki Watanabe, Yasuhiro Asahina, Mamoru Watanabe, Takaaki Ikeda. Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to Be Eliminated after Ribavirin Therapy. Intern. Med. 2016.10; 55 (19): 2811-2817.

Miyoshi Masato, Kakinuma Sei, Tanabe Yoko, Ishii Koji, Li Tian-Cheng, Wakita Takaji, Tsuura Yukio, Watanabe Hideki, Asahina Yasuhiro, Watanabe Mamoru, Ikeda Takaaki. 恒常的免疫抑制患者における慢性E型肝炎感染はリバビリン療法後に排除することができない(Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to Be Eliminated after Ribavirin Therapy) Internal Medicine. 2016.10; 55 (19): 2811-2817.

Fumio Goto, Sei Kakinuma, Masato Miyoshi, Tomoyuki Tsunoda, Shun Kaneko, Ayako Sato, Yu Asano, Satoshi Otani, Seishin Azuma, Hiroko Nagata, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Yasuhiro Asahina, Mamoru Watanabe. Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells. Hepatol. Res. 2016.09; 47 (9): 941-952.

Shun Kaneko, Sei Kakinuma, Yasuhiro Asahina, Akihide Kamiya, Masato Miyoshi, Tomoyuki Tsunoda, Sayuri Nitta, Yu Asano, Hiroko Nagata, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Hiromitsu Nakauchi, Hironori Nishitsuji, Saneyuki Ujino, Kunitada Shimotohno, Masashi Iwamoto, Koichi Watashi, Takaji Wakita, Mamoru Watanabe. Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus. Sci Rep. 2016.07; 6 29358.

Hiroko Nagata, Mina Nakagawa, Yuki Nishimura-Sakurai, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Shun Kaneko, Fumio Goto, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Naoko Tojo, Shuji Tohda, Yasuhiro Asahina, Mamoru Watanabe, . Serial measurement of Wisteria floribunda agglutinin positive Mac-2-binding protein is useful for predicting liver fibrosis and the development of hepatocellular carcinoma in chronic hepatitis C patients treated with IFN-based and IFN-free therapy.[Epub ahead of print] Hepatol Int. 2016.07; 10 (6): 956-964.