桑原 宏哉 くわはら ひろや 先生

西田 陽一郎, 桑原 宏哉, 三條 伸夫, 横田 隆徳. Alzheimer病研究の新しい潮流-4 血液脳関門通過型Aβオリゴマー抗体の開発 神経治療学. 2019.07; 36 (4): 532-536.

Kuwahara Hiroya, Nishina Kazutaka, Yoshida Kie, Nishina Tomoko, Yamamoto Mariko, Saito Yukari, Piao Wenying, Yoshida Masayuki, Mizusawa Hidehiro, Yokota Takanori. Efficient in vivo delivery of siRNA into brain capillary endothelial cells along with endogenous lipoprotein. Mol Ther. 2011.12; 19 (12): 2213-2221.

Kuwahara Hiroya, Nakatsuru Enichi, Ozawa Naoko. Exertional rhabdomyolysis affecting anterior compartment of unilateral lower leg. Intern Med. 2011.04; 50 (7): 793.

Kuwahara Hiroya, Noguchi Yoshimasa, Saito Yukinobu, Inaba Akira. Multiple cavernous angiomas in the brain and spinal cord. Arch Neurol. 2010.11; 67 (11): 1405-1406.

Kuwahara Hiroya, Tsuchiya Kuniaki, Saito Yukinobu, Kobayashi Zen, Miyazaki Hiroshi, Izumiyama Yoko, Akiyama Haruhiko, Arai Tetsuaki, Mizusawa Hidehiro. Frontotemporal lobar degeneration with motor neuron disease showing severe and circumscribed atrophy of anterior temporal lobes. J Neurol Sci. 2010.10; 297 (1-2): 92-96.

Koyama Rikako, Nakanishi Koji, Kato Masako, Yamashita Shigeo, Kuwahara Hiroya, Katori Hideyuki. Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: treatment with double filtration plasmapheresis and prednisolone. Am J Med Sci. 2005.05; 329 (5): 259-264.

Kuwahara Hiroya, Matsunaga Shin-ichi. Central pontine myelinolysis associated with pancreatic diabetes. J Neurol. 2012.02; 259 (2): 353-354.

吉岡耕太郎，桑原宏哉，仁科一隆，永田哲也，横田隆徳.. 核酸医薬研究の現況と展望. 日本臨牀.. 2015.06; 73 (6): 1057-1065.

Kuwahara Hiroya, Nishida Yoichiro, Yokota Takanori. Blood-brain barrier and Alzheimer's disease. Brain Nerve. 2013.02; 65 (2): 145-151.

伊丹亮，三條伸夫，桑原宏哉，山本雅樹，新謙一，横田隆徳，水澤英洋. ほぼ全長にわたる脊髄病変と肺病変を伴った急速進行性HTLV-1-associated myelopathy（HAM）の1例 臨床神経学. 2011.02; 51 (2): 130-134.

桑原宏哉，野口悦正，稲葉彰，水澤英洋. ビタミンB6欠乏により遅発性に持続性部分てんかんを呈したテオフィリン関連痙攣の81歳女性例 臨床神経学. 2008.02; 48 (2): 125-129.

Tomoko Nishina, Junna Numata, Kazutaka Nishina, Kie Yoshida-Tanaka, Keiko Nitta, Wenying Piao, Rintaro Iwata, Shingo Ito, Hiroya Kuwahara, Takeshi Wada, Hidehiro Mizusawa, Takanori Yokota.. Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol. Mol Ther Nucleic Acids.. 2015.01; 4 e220.

Masaki Ohyagi, Takashi Irioka, Takuya Ohkubo, Satoru Ishibashi, Yuko K Takahashi, Eiichiro Amano, Akira Machida, Hiroya Kuwahara, Takanori Yokota. Intrathecal IgG Synthesis and Persistent Inflammation Are Associated with White Matter Lesions in HIV-negative Patients with Cryptococcal Meningoencephalitis. Intern Med. 2019.11; 58 (21): 3077-3082.

Kotaro Yoshioka, Taiki Kunieda, Yutaro Asami, Huijia Guo, Haruka Miyata, Kie Yoshida-Tanaka, Yumiko Sujino, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Rintaro Iwata Hara, Tetsuya Nagata, Takeshi Wada, Satoshi Obika, Takanori Yokota. Highly efficient silencing of microRNA by heteroduplex oligonucleotides. Nucleic Acids Res. 2019.08; 47 (14): 7321-7332.

Satoshi Zeniya, Hiroya Kuwahara, Kaiichi Daizo, Akihiro Watari, Masuo Kondoh, Kie Yoshida-Tanaka, Hidetoshi Kaburagi, Ken Asada, Tetsuya Nagata, Masahiro Nagahama, Kiyohito Yagi, Takanori Yokota. Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system. J Control Release. 2018.05; 283 126-134.

Hiroya Kuwahara, Jindong Song, Takahiro Shimoura, Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Satoshi Zeniya, Fuying Li, Kazutaka Nishina, Tetsuya Nagata, Shingo Ito, Hiroyuki Kusuhara, Takanori Yokota. Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo. Sci Rep. 2018.03; 8 (1): 4377.

Y Anraku, H Kuwahara, Y Fukusato, A Mizoguchi, T Ishii, K Nitta, Y Matsumoto, K Toh, K Miyata, S Uchida, K Nishina, K Osada, K Itaka, N Nishiyama, H Mizusawa, T Yamasoba, T Yokota, K Kataoka. Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain. Nat Commun. 2017.10; 8 (1): 1001.

Koya Ono, Ken Murata, Toshinari Arai, Tomoyuki Kino, Keisuke Onaka, Satoru Takahashi, Hirotaka Sato, Hiroya Kuwahara. Posterior reversible encephalopathy syndrome after iron administration in a patient with chronic severe anemia. Journal of the Neurological Sciences. 2016.08; 367 333-334.

Masahiro Murakami, Kazutaka Nishina, Chie Watanabe, Kie Yoshida-Tanaka, Wenying Piao, Hiroya Kuwahara, Yuji Horikiri, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka, Masayuki Yoshida, Hidehiro Mizusawa, Takanori Yokota.. Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route. Scientific Reports. 2015.11; 5 17035.

Kazutaka Nishina, Wenying Piao, Kie Yoshida-Tanaka, Yumiko Sujino, Tomoko Nishina, Tsuyoshi Yamamoto, Keiko Nitta, Kotaro Yoshioka, Hiroya Kuwahara, Hidenori Yasuhara, Takeshi Baba, Fumiko Ono, Kanjiro Miyata, Koichi Miyake, Punit P Seth, Audrey Low, Masayuki Yoshida, C Frank Bennett, Kazunori Kataoka, Hidehiro Mizusawa, Satoshi Obika, Takanori Yokota.. DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. Nature Communications.. 2015.08; 6 7969.

Hiroya Kuwahara, Kazutaka Nishina, Takanori Yokota.. Blood-brain barrier: a novel therapeutic target in multiple sclerosis. Clinical and Experimental Neuroimmunology.. 2015.05; 6 (2): 129-138.

Su Su Lei Mon, Kotaro Yoshioka, Chunyan Jia, Taiki Kunieda, Yutaro Asami, Kie Yoshida-Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. Highly efficient gene silencing in mouse brain by overhanging-duplex oligonucleotides via intraventricular route. FEBS Lett. 2020.05; 594 (9): 1413-1423.

Kuwahara Hiroya, Tsuchiya Kuniaki, Kobayashi Zen, Inaba Akira, Akiyama Haruhiko, Mizusawa Hidehiro.. Cryptococcal meningitis accompanying lymphocytic inflammation predominantly in cerebral deep white matter: a possible manifestation of immune reconstitution inflammatory syndrome. Neuropathology.. 2014.02; 34 (1): 45-48.

Hirai Takashi, Enomoto Mitsuhiro, Kaburagi Hidetoshi, Sotome Shinichi, Yoshida-Tanaka Kie, Ukegawa Madoka, Kuwahara Hiroya, Yamamoto Mariko, Tajiri Mio, Miyata Haruka, Hirai Yukihiko, Tominaga Makoto, Shinomiya Kenichi, Mizusawa Hidehiro, Okawa Atsushi, Yokota Takanori.. Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injury. Molecular Therapy.. 2014.02; 22 (2): 409-419.

Kuwahara Hiroya, Suzuki Shigeharu, Matsumura Ken, Watanabe Mutsufusa, Yakushiji Fumiatsu, Fujigasaki Hiroto.. Ocular flutter, generalized myoclonus, and truncal ataxia in a patient with Graves' ophthalmopathy. Journal of Neurology.. 2013.11; 260 (11): 2906-2907.

Machida Akira, Kuwahara Hiroya, Mayra Azat, Kubodera Takayuki, Hirai Takashi, Sunaga Fumiko, Tajiri Mio, Hirai Yukihiko, Shimada Takashi, Mizusawa Hidehiro, Yokota Takanori.. Intraperitoneal administration of AAV9-shRNA inhibits target gene expression in the dorsal root ganglia of neonatal mice. Molecular Pain.. 2013.07; 9 36.

Hiroya Kuwahara.. Persistent hemichorea. New England Journal of Medicine. 2013.05; 368 (20): e26.

Piao Wenying, Nishina Kazutaka, Yoshida-Tanaka Kie, Kuwahara Hiroya, Nishina Tomoko, Sakata Mina, Mizusawa Hidehiro, Yokota Takanori. Efficient in vivo delivery of antisense oligonucleotide to choroid plexus. J Med Dent Sci. 2013.03; 60 (1): 9-16.

Kuwahara Hiroya, Matsumura Ken, Watanabe Mutsufusa, Fujigasaki Hiroto. Intravenous t-PA for the occlusion of an accessory MCA. Intern Med. 2013.01; 52 (1): 163.

Hirai Takashi, Enomoto Mitsuhiro, Machida Akira, Yamamoto Mariko, Kuwahara Hiroya, Tajiri Mio, Hirai Yukihiko, Sotome Shinichi, Mizusawa Hidehiro, Shinomiya Kenichi, Okawa Atsushi, Yokota Takanori. Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice. Hum Gene Ther Methods. 2012.04; 23 (2): 119-127.

Kuwahara Hiroya, Yokota Takanori. Delivery of siRNA into the blood-brain barrier: recent advances and future perspective. Ther Deliv. 2012.04; 3 (4): 417-420.