油井 史郎 ゆい しろう 先生

中村 哲也, 油井 史郎, 水谷 知裕, 渡辺 守. 【消化器幹細胞研究の可能性】 腸上皮の幹細胞 G.I.Research. 2012.02; 20 (1): 16-20.

油井史郎、中村哲也、渡辺 守. 細胞外基質のリモデリングによりひき起こされるYAP/TAZに依存性の大腸上皮細胞のリプログラミングは大腸上皮組織の修復に不可欠である ライフサイエンス 新着論文レビュー. 2018.01;

油井史郎、中村哲也、渡辺 守. 移植の可能な胎生期の未熟な腸管上皮前駆細胞の体外における培養技術の確立 ライフサイエンス 新着論文レビュー. 2013.11;

油井 史郎, 中村 哲也, 渡辺 守. What's New in SURGERY FRONTIER(第76回) 消化器の幹細胞 下部消化管上皮幹細胞 最新の知見 Surgery Frontier. 2013.03; 20 (1): 66-68.

伊藤 剛、岡本隆一、清水寛路、村野竜朗、水谷知裕、油井史郎、土屋輝一郎、中村哲也、渡辺 守. 腫瘍をめぐるQ&A(Question45) Lgr5とは？ Surgery Frontier. 2012.06; 19 (2): 224-227.

中村 哲也, 油井 史郎, 渡辺 守. 【新しい技術を用いた消化器研究の最前線】 上皮細胞移植は消化管を再生できるか 分子消化器病. 2012.06; 9 (2): 113-118.

岡本 隆一, 清水 寛路, 村野 竜朗, 伊藤 剛, 堀田 伸勝, 鄭 秀, 加納 嘉人, 野崎 賢吾, 福田 将義, 水谷 知裕, 油井 史郎, 土屋 輝一郎, 中村 哲也, 渡辺 守. 【免疫統御からみた新しいIBD治療】 腸管細胞の分化・再生の制御機構からみたIBD治療へのアプローチ IBD Research. 2011.12; 5 (4): 226-231.

水谷 知裕, 中村 哲也, 油井 史郎, 渡辺 守. 【消化管幹細胞】 腸管上皮幹細胞研究の新展開 細胞. 2011.07; 43 (8): 286-289.

岡本 隆一, 秋山 純子, 鄭 秀, 加納 嘉人, 水谷 知裕, 油井 史郎, 岩嵜 美智子, 土屋 輝一郎, 中村 哲也, 渡辺 守. IBDの最新の話題 基礎編(第14回) 炎症粘膜上皮の再生制御機構 IBD Research. 2010.06; 4 (2): 121-126.

岡本 隆一, 秋山 純子, 鄭 秀, 加納 嘉人, 水谷 知裕, 油井 史郎, 岩嵜 美智子, 土屋 輝一郎, 中村 哲也, 渡辺 守. 【幹細胞を用いた消化器再生医療の展望】 クローン病・潰瘍性大腸炎の難治性潰瘍も幹細胞を用いた再生医療で治せるか 分子消化器病. 2009.12; 6 (4): 353-358.

油井 史郎, 中村 哲也, 渡辺 守. 【消化管癌Update 研究・診断・治療・予防の進歩】 消化管癌発生メカニズム 腸管上皮幹細胞と大腸癌幹細胞 研究最前線 医学のあゆみ. 2009.09; 230 (10): 855-860.

酒井 義法, 伊藤 祐子, 油井 史郎, 松本 浩之, 市田 崇, 幾世橋 佳, 望月 奈穂子, 玄 世峰, 草野 史彦, 田沢 潤一, 滝口 典聡, 平沼 進, 堀越 建一, 常盤 英文. 電子クリニカルパスを利用したFOLFOX療法の展開 茨城県農村医学会雑誌. 2007.10; 20 14-18.

油井 史郎, 永山 和宜, 伊藤 祐子, 市田 崇, 松本 浩之, 幾世橋 佳, 望月 奈穂子, 玄 世鋒, 草野 史彦, 酒井 義法, 田沢 潤一, エーカポット・パンナチェート , 渡辺 守. 副腎皮質ステロイドが奏効したCronkhite-Canada症候群の1例 Progress of Digestive Endoscopy. 2007.06; 70 (2): 116-117,10.

久保田 大輔, 金井 隆典, 油井 史郎, 松本 智子, 河村 貴広, 井津井 康浩, 岡田 英理子, 陳 正新, 大岡 真也, 長堀 正和, 土屋 輝一郎, 荒木 昭博, 坂本 直哉, 宮田 達也, 渡辺 守. 高用量ステロイド投与を行わず、シクロスポリンにて緩解導入した潰瘍性大腸炎の1例 日本消化器病学会雑誌. 2007.01; 104 (1): 42-46.

Sho Anzai, Ami Kawamoto, Sayaka Nagata, Junichi Takahashi, Mao Kawai, Reiko Kuno, Sakurako Kobayashi, Satoshi Watanabe, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Shigeru Oshima, Mamoru Watanabe, Ryuichi Okamoto. TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells. Biochem. Biophys. Res. Commun.. 2020.04; 524 (3): 533-541.

Pawel J Schweiger, Marie Le Bouteiller, Shiro Yui, Malte Thodberg, Ditte Clement, Kim B Jensen. Extracellular matrix interactions provide tumor cells with an escape mechanism for commitment to differentiation. Gastroenterology. 2022.08;

Satoshi Watanabe, Sakurako Kobayashi, Nobuhiko Ogasawara, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe, Kim B Jensen, Shiro Yui. Transplantation of intestinal organoids into a mouse model of colitis. Nat Protoc. 2022.02; 17 (3): 649-671.

Jordi Guiu, Edouard Hannezo, Shiro Yui, Samuel Demharter, Svetlana Ulyanchenko, Martti Maimets, Anne Jørgensen, Signe Perlman, Lene Lundvall, Linn Salto Mamsen, Agnete Larsen, Rasmus H Olesen, Claus Yding Andersen, Lea Langhoff Thuesen, Kristine Juul Hare, Tune H Pers, Konstantin Khodosevich, Benjamin D Simons, Kim B Jensen. Tracing the origin of adult intestinal stem cells. Nature. 2019.06; 570 (7759): 107-111.

Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P Fordham, Stine L Hansen, Hjalte L Larsen, Jordi Guiu, Mariana R P Alves, Carsten F Rundsten, Jens V Johansen, Yuan Li, Chris D Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H Nielsen, Pawel J Schweiger, Stefano Piccolo, Kim B Jensen. YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration. Cell Stem Cell. 2018.01; 22 (1): 35-49.e7.

Robert P Fordham, Shiro Yui, Nicholas R F Hannan, Christoffer Soendergaard, Alison Madgwick, Pawel J Schweiger, Ole H Nielsen, Ludovic Vallier, Roger A Pedersen, Tetsuya Nakamura, Mamoru Watanabe, Kim B Jensen. Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell. 2013.12; 13 (6): 734-744.

Shiro Yui, Tetsuya Nakamura, Toshiro Sato, Yasuhiro Nemoto, Tomohiro Mizutani, Xiu Zheng, Shizuko Ichinose, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Hans Clevers, Mamoru Watanabe. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat. Med.. 2012.03; 18 (4): 618-623.

Satoshi Watanabe, Nobuhiko Ogasawara, Sakurako Kobayashi, Sakura Kirino, Masami Inoue, Yui Hiraguri, Sayaka Nagata, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Yasuhiro Nemoto, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Shiro Yui. Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment. J Gastroenterol. 2023.02;

Go Ito, Shiro Yui, Ryuichi Okamoto. A Cellular "Hub" Function to Resolve Colitis. Cell Mol Gastroenterol Hepatol. 2021.05;

Reiko Kuno, Go Ito, Ami Kawamoto, Yui Hiraguri, Hady Yuki Sugihara, Sayaka Takeoka, Sayaka Nagata, Junichi Takahashi, Mao Tsuchiya, Sho Anzai, Tomohiro Mizutani, Hiromichi Shimizu, Shiro Yui, Shigeru Oshima, Kiichiro Tsuchiya, Mamoru Watanabe, Ryuichi Okamoto. Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients. Biochem Biophys Rep. 2021.03; 25 100906.

Tsuchiya M, Ito G, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Sugihara HY, Mizutani T, Yui S, Oshima S, Tsuchiya K, Watanabe M, Okamoto R. Functional analysis of isoflavones using patient-derived human colonic organoids. Biochemical and biophysical research communications. 2021.01; 542 40-47.

Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Shinichi Yamauchi, Yusuke Kinugasa, Yoshihito Kano, Yasuhiro Nemoto, Mamoru Watanabe, Kiichiro Tsuchiya, Hiroshi Nishina, Ryuichi Okamoto, Shiro Yui. Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflamm Regen. 2022.11; 42 (1): 49.

Ryuichi Okamoto, Hiromichi Shimizu, Kohei Suzuki, Ami Kawamoto, Junichi Takahashi, Mao Kawai, Sayaka Nagata, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Mamoru Watanabe. Organoid-based regenerative medicine for inflammatory bowel disease. Regen Ther. 2020.03; 13 1-6.

Ami Kawamoto, Sayaka Nagata, Sho Anzai, Junichi Takahashi, Mao Kawai, Minami Hama, Daichi Nogawa, Kohei Yamamoto, Reiko Kuno, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Shiro Yui, Shigeru Ohshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Masanobu Kitagawa, Ryuichi Okamoto, Mamoru Watanabe. Ubiquitin D is up-regulated by synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients. J Crohns Colitis. 2018.11;

Kohei Suzuki, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Toru Nakata, Satoru Fujii, Fumiaki Ishibashi, Ami Kawamoto, Sho Anzai, Reiko Kuno, Konomi Kuwabara, Junichi Takahashi, Minami Hama, Sayaka Nagata, Yui Hiraguri, Kento Takenaka, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties. J. Gastroenterol.. 2018.09; 53 (9): 1035-1047.

Nobukatsu Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Masayoshi Fukuda, Yoshihito Kano, Tomohiro Mizutani, Yasuhiro Nemoto, Shiro Yui, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt. Biochem Biophys Res Commun. 2014.10; 454 (4): 493-499.

Tatsuro Murano, Ryuichi Okamoto, Go Ito, Toru Nakata, Shuji Hibiya, Hiromichi Shimizu, Satoru Fujii, Yoshihito Kano, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells. Biochem Biophys Res Commun. 2014.01; 443 (3): 840-846.

Go Ito, Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells. PLoS ONE. 2013.11; 8 (11): e79693.

Tomohiro Mizutani, Tetsuya Nakamura, Ryo Morikawa, Masayoshi Fukuda, Wakana Mochizuki, Yuhki Yamauchi, Kengo Nozaki, Shiro Yui, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Mamoru Watanabe. Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro. Biochem. Biophys. Res. Commun.. 2012.03; 419 (2): 238-243.

Junko Akiyama, Ryuichi Okamoto, Michiko Iwasaki, Xiu Zheng, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells. Biochem. Biophys. Res. Commun.. 2010.03; 393 (4): 662-667.

小笠原暢彦、油井史郎、渡辺守. 腸上皮の老化に関わるストレス応答の2方向性 生体の科学. 2021.04;