赤尾 浩慶 あかお ひろのぶ 先生

来歴等

略歴

1994年 金沢医科大学医学部 卒業
1996年 金沢医科大学病院研修医 修了
2000年 金沢医科大学大学院 修了 医学博士取得
2005年 金沢医科大学循環制御学 助教
2008年 金沢医科大学循環制御学 学内講師
2010年 金沢医科大学循環器内科学 講師
2010年 Lipid Metabolism Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (Professor Ernst J. Schaefer) Boston, MA USA Visiting scientist
2012年 金沢医科大学循環器内科学 臨床准教授

論文

• Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients. Drug Metab Pharmacokinet. 2019 Dec;34(6):387-395

  Lee N, Maeda K, Fukizawa S, Ieiri I, Tomaru A, Akao H, Takeda K, Iwadare M, Niwa O, Masauji T, Yamane N, Kajinami K, Kusuhara H, Sugiyama Y

• Circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) as a novel predictor of clinical outcome after endovascular therapy in patients with peripheral artery disease (PAD). Atherosclerosis. 2017 Aug;263:192-197

  Takamura TA, Tsuchiya T, Oda M, Watanabe M, Saito R, Sato-Ishida R, Akao H, Kawai Y, Kitayama M, Kajinami K

• A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients. Drug Metab Pharmacokinet. 2016 Dec;31(6):467-470

  Sai K, Kajinami K, Akao H, Iwadare M, Sato-Ishida R, Kawai Y, Takeda K, Tanimoto T, Yamano T, Akasaka T, Ishida T, Hirata KI, Saku K, Yagi S, Soeki T, Sata M, Ueno M, Miyazaki S, Shiraki A, Oyama JI, Node K, Sugamura K, Ogawa H, Kurose K, Maekawa K, Matsuzawa Y, Imatoh T, Hasegawa R; Japanese Pharmacogenomics Data Science Consortium, Saito Y

• Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products. J Cardiol. 2017 Apr;69(4):625-631

  Watanabe M, Kawai Y, Kitayama M, Akao H, Motoyama A, Wakasa M, Saito R, Aoki H, Fujibayashi K, Tsuchiya T, Nakanishi H, Saito K, Takeuchi M, Kajinami K

• Chronic total occlusions of the right coronary and left anterior descending coronary arteries in a young adult patient with antiphospholipid syndrome. J Cardiol Cases. 2016 Apr 11;14(2):46-48

  Kawai Y, Kitayama M, Motoyama A, Wakasa M, Saito R, Aoki H, Fujibayashi K, Watanabe M, Takamura T, Akao H, Tsuchiya T, Kajinami K

• A case of coronary rupture and pseudoaneurysm formation after fracture of implanted paclitaxel-eluting stents. Cardiovasc Interv Ther. 2016 Jul;31(3):231-7

  Kawai Y, Kitayama M, Akao H, Motoyama A, Tsuchiya T, Kajinami K

• ABCA1 gene variation and heart disease risk reduction in the elderly during pravastatin treatment. PROspective Study of Pravastatin in the Elderly at Risk Investigator. Atherosclerosis. 2014 Jul;235(1):176-81

  Akao H, Polisecki E, Schaefer EJ, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Packard C, Buckley BM, Kajinami K

• Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm.J Cardiol. 2014 Aug;64(2):86-90

  Tanabe K, Kawai Y, Kitayama M, Akao H, Ishida R, Motoyama A, Wakasa M, Saito R, Aoki H, Fujibayashi K, Watanabe M, Tsuchiya T, Kimura H, Yoshida K, Kajinami K

• Nutri-pharmacogenomics of warfarin anticoagulation therapy: VKORC1 genotype-dependent influence of dietary vitamin K intake.J Thromb Thrombolysis. 2014 Jul;38(1):105-14

  Saito R, Takeda K, Yamamoto K, Nakagawa A, Aoki H, Fujibayashi K, Wakasa M, Motoyama A, Iwadare M, Ishida R, Fujioka N, Tsuchiya T, Akao H, Kawai Y, Kitayama M, Kajinami K

• Serum deoxyribonuclease I activity can be a useful diagnostic marker for the early diagnosis of unstable angina pectoris or non-ST-segment elevation myocardial infarction.J Cardiol. 2012 May;59(3):258-65

  Fujibayashi K, Kawai Y, Kitayama M, Akao H, Ishida R, Motoyama A, Wakasa M, Arakawa K, Ueki M, Kajinami K, Yasuda T

• KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.Atherosclerosis. 2012 Feb;220(2):456-62

  Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ

• Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly.Atherosclerosis. 2012 Feb;220(2):413-7

  Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ

• Marked PT-INR prolongation associated with appetite loss due to urinary tract infection in a late elderly case with chronic atrial fibrillation.Nihon Ronen Igakkai Zasshi. 2009;46(6):541-4

  Saito R, Akao H, Kaseno K, Nomura Y, Kitayama M, Tsugawa H, Kajinami K

• Serum deoxyribonuclease I activity can be used as a novel marker of transient myocardial ischaemia: results in vasospastic angina pectoris induced by provocation test. Eur Heart J. 2007 Dec;28(24):2992-7

  Morikawa N, Kawai Y, Arakawa K, Kumamoto T, Miyamori I, Akao H, Kitayama M, Kajinami K, Lee JD, Takeshita H, Kominato Y, Yasuda T

• Pharmacogenomics of statin responsiveness.Am J Cardiol. 2005 Nov 7;96(9A):65K-70K

  Kajinami K, Akao H, Polisecki E, Schaefer EJ

著書

• 【共著】スタチンのファーマコゲノミクス, 赤尾浩慶, 河合康幸, 梶波康二, 臨床検査, 医学書院54:1178-1182, 2010年

• 【共著】脂質異常症　動脈硬化　RADIANCE1, 若狭　稔, 赤尾浩慶, 梶波康二, DATA UPDATE CARDIOVASCULAR 4th EDITION, 先端医学社: 360-361, 2009年

• 【共著】家族性高コレステロール血症（家族性高脂血症）, 赤尾浩慶, 若狭　稔, 佐藤良子, 梶波康二, 腎と透析　臨時増刊号, 東京医学社65:484-489, 2008年

• 【共著】個々の危険因子の疫学、評価法とそのエビデンス　家族性高コレステロール血症, 梶波康二, 赤尾浩慶, 上西博章, 冠動脈疾患プロフェッション5　冠動脈疾患の予防戦略, 中山書店, 2006年

• 【共著】スタチン製剤をどう使うか, 梶波康二, 赤尾浩慶, 河合康幸, 北山道彦, 冠動脈疾患プロフェッション2　慢性冠動脈疾患の臨床, 中山書店:197-202, 2006年