横山 仁 よこやま ひとし 先生

来歴等

略歴

1980年 金沢大学医学部医学科 卒業
1984年 金沢大学大学院医学研究科内科学第一 修了（医学博士甲688号）
1986年 金沢大学医療技術短期大学部衛生技術科 講師
1987年 金沢大学医学部附属病院第１内科 助手
1992年 金沢大学医学部 講師・併任
1992年 米国Brigham and Women 病院 Harvard大学医学部講師・兼任 研究員
1993年 金沢大学医学部附属病院血液浄化療法部 助手（医学部講師・併任）
1994年 金沢大学医学部附属病院血液浄化療法部 助教授（副部長）
2002年 金沢大学医学部附属病院血液浄化療法部 助教授（部長）
2006年 金沢医科大学医学部腎機能治療学（腎臓内科） 部門教授（2010年4月に腎臓内科学・主任教授へ名称変更）
2008年 金沢医科大学病院 副院長（総務・教育担当）・併任（2010年9月まで）
2017年 金沢医科大学病院 副院長（診療部長）・併任
2019年 金沢医科大学総合医学研究所 所長・併任
2021年 金沢医科大学病院 嘱託教授

論文

• Changes in double-strand DNA breaks predict delayed graft function (DGF) in Japanese renal allograft recipients. Clin Exp Nephrol. 2019 Dec 7. doi: 10.1007/s10157-019-01793-8. [Epub ahead of print]

  Okada K, Nomura-Nakayama K, Okushi Y, Okino K, Mukai K, Hayashi N, Fujimoto K, Adachi H, Yokoyama H.

• Nonproteinuric Versus Proteinuric Phenotypes in Diabetic Kidney Disease: A Propensity Score-Matched Analysis of a Nationwide, Biopsy-Based Cohort Study. Diabetes Care. 2019 May;42(5):891-902

  Yamanouchi M, Furuichi K, Hoshino J, Toyama T, Hara A, Shimizu M, Kinowaki K, Fujii T, Ohashi K, Yuzawa Y, Kitamura H, Suzuki Y, Sato H, Uesugi N, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Samejima K, Kohagura K, Shibagaki Y, Mise K, Makino H, Matsuo S, Ubara Y, Wada T; Research Group of Diabetic Nephropathy, the Ministry of Health, Labour and Welfare, and the Japan Agency for Medical Research and Development.

• A case of apolipoprotein E Toyonaka and homozygous apolipoprotein E2/2 showing non-immune membranous nephropathy-like glomerular lesions with foamy changes. CEN Case Rep. 2019 May;8(2):106-111.

  Kato T, Ushiogi Y, Yokoyama H, Hara S, Matsunaga A, Muso E, Saito T.

• Amplified Association Between Blood Pressure and Albuminuria in Overweight Patients With Biopsy-Proven Hypertensive Nephrosclerosis. Am J Hypertens. 2019 Apr 22;32(5):486-491.

  Kohagura K, Furuichi K, Kochi M, Shimizu M, Yuzawa Y, Hara A, Toyama T, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ubara Y, Hoshino J, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Ogawa D, Mise K, Shibagaki Y, Kimura K, Haneda M, Makino H, Matsuo S, Wada T; Research Group of Diabetic Nephropathy and Nephrosclerosis, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Research and Development.

• Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type 2 diabetes patients with diabetic nephropathy. J Diabetes Investig. 2019 Jul;10(4):1041-1049.

  Shimizu M, Furuichi K, Toyama T, Funamoto T, Kitajima S, Hara A, Iwata Y, Sakai N, Takamura T, Kitagawa K, Yoshimura M, Kaneko S, Yokoyama H, Wada T; Kanazawa Study Group for Renal Diseases and Hypertension.

• Distribution of nephrologists and regional variation in the clinical severity of IgA nephropathy at biopsy diagnosis in Japan: a cross-sectional study. BMJ Open. 2018;8(10):e024317.

  Okabayashi Y, Tsuboi N, Amano H, Miyazaki Y, Kawamura T, Ogura M, Narita I, Ninomiya T, Yokoyama H, Yokoo T.

• Distinct characteristics and outcomes in elderly-onset IgA vasculitis (Henoch-Schönlein purpura) with nephritis: Nationwide cohort study of data from the Japan Renal Biopsy Registry (J-RBR). PLoS One. 2018;13(5):e0196955. doi: 10.1371/journal.pone.0196955.

  Komatsu H, Fujimoto S, Maruyama S, Mukoyama M, Sugiyama H, Tsuruya K, Sato H, Soma J, Yano J, Itano S, Nishino T, Sato T, Narita I, Yokoyama H.

• High molecular weight adiponectin inhibits vascular calcification in renal allograft recipients. PLoS One. 2018;13(5):e0195066

  Nomura-Nakayama K, Adachi H, Miyatake N, Hayashi N, Fujimoto K, Yamaya H, Yokoyama H.

• Regional variations in immunosuppressive therapy in patients with primary nephrotic syndrome: the Japan nephrotic syndrome cohort study. Clin Exp Nephrol. 2018;22(6):1266-1280.

  Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Fukami K, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Yoshio T, Katafuchi R, Fujimoto S, Okada H, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Shibagaki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Kashihara N, Sato H, Matsuo S, Narita I, Isaka Y.

• Clinical features and pathogenesis of membranoproliferative glomerulonephritis: a nationwide analysis of the Japan renal biopsy registry from 2007 to 2015. Clin Exp Nephrol. 2018;22(4):797-807.

  Nakagawa N, Hasebe N, Hattori M, Nagata M, Yokoyama H, Sato H, Sugiyama H, Shimizu A, Isaka Y, Maruyama S, Narita I.

• Renal response to anaphylaxis in anesthetized rats and isolated perfused rat kidneys: roles of nitric oxide. J Physiol Sci. 2018;68(5):689-697.

  Mukai K, Kuda Y, Shibamoto T, Tanida M, Kurata Y, Yokoyama H.

• Nationwide multicentre kidney biopsy study of Japanese patients with type 2 diabetes. Nephrol Dial Transplant. 2018;33(1):138-148.

  Furuichi K, Yuzawa Y, Shimizu M, Hara A, Toyama T, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ubara Y, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Kohagura K, Ogawa D, Mise K, Shibagaki Y, Kimura K, Haneda M, Makino H, Matsuo S, Wada T.

• Nationwide multicenter kidney biopsy study of Japanese patients with hypertensive nephrosclerosis. Clin Exp Nephrol. 2018;22(3):629-637.

  Furuichi K, Shimizu M, Yuzawa Y, Hara A, Toyama T, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ubara Y, Hoshino J, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Kohagura K, Ogawa D, Mise K, Shibagaki Y, Kimura K, Haneda M, Makino H, Matsuo S, Wada T; Research Group of Diabetic Nephropathy and Nephrosclerosis, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Research and Development.

• Clinicopathological analysis of biopsy-proven diabetic nephropathy based on the Japanese classification of diabetic nephropathy. Clin Exp Nephrol. 2018;22(3):570-582.

  Furuichi K, Shimizu M, Yuzawa Y, Hara A, Toyama T, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ubara Y, Hohino J, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Kohagura K, Ogawa D, Mise K, Shibagaki Y, Makino H, Matsuo S, Wada T; Research Group of Diabetic Nephropathy, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Research and Development.

• Rationale and study design of a clinical trial to assess the effects of LDL apheresis on proteinuria in diabetic patients with severe proteinuria and dyslipidemia. Clin Exp Nephrol. 2018;22(3):591-596.

  Wada T, Muso E, Maruyama S, Hara A, Furuichi K, Yoshimura K, Miyazaki M, Sato E, Abe M, Shibagaki Y, Narita I, Yokoyama H, Mori N, Yuzawa Y, Matsubara T, Tsukamoto T, Wada J, Ito T, Masutani K, Tsuruya K, Fujimoto S, Tsuda A, Suzuki H, Kasuno K, Terada Y, Nakata T, Iino N, Kobayashi S.

• Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS. Clin Exp Nephrol. 2018;22(2):377-387.

  Shimizu M, Furuichi K, Toyama T, Funamoto T, Kitajima S, Hara A, Ogawa D, Koya D, Ikeda K, Koshino Y, Kurokawa Y, Abe H, Mori K, Nakayama M, Konishi Y, Samejima KI, Matsui M, Yamauchi H, Gohda T, Fukami K, Nagata D, Yamazaki H, Yuzawa Y, Suzuki Y, Fujimoto S, Maruyama S, Kato S, Naito T, Yoshimura K, Yokoyama H, Wada T; Research Group of Diabetic Nephropathy, the Ministry of Health, Labour, and Welfare of Japan and Japan Agency for Medical Research and Development.

• Glomerular mannose-binding lectin deposition in intrinsic antigen-related membranous nephropathy. Nephrol Dial Transplant 2018;33(5):832-840.

  Hayashi N, Okada K, Matsui Y, Fujimoto K, Adachi H, Yamaya H, Matsushita M, Yokoyama H.

• The long-term outcomes of hepatitis C virus core antigen-positive Japanese renal allograft recipients. Clin Exp Nephrol. 2017; 21(6):1113-1123. doi: 10.1007/s10157-017-1394-9.

  Okino K, Okushi Y, Mukai K, Matsui Y, Hayashi N, Fujimoto K, Adachi H, Yamaya H, Yokoyama H.

• The clinical and pathological characteristics of nephropathies in connective tissue diseases in the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol. 2017;21(6):1024-1029.

  Ichikawa K, Konta T, Sato H, Ueda Y, Yokoyama H.

• Mizoribine therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome.Clin Exp Nephrol. 2017;21(6):961-970.

  Saito T, Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S, Sasatomi Y, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino Y; Refractory Nephrotic Syndrome Study Group.

• Circulating and renal expression of HLA-G prevented chronic renal allograft dysfunction in Japanese recipients. Clin Exp Nephrol. 2017;21(5):932-940.

  Okushi Y, Okino K, Mukai K, Matsui Y, Hayashi N, Fujimoto K, Adachi H, Yamaya H, Yokoyama H.

• Adiponectin Fractions Influence the Development of Posttransplant Diabetes Mellitus and Cardiovascular Disease in Japanese Renal Transplant Recipients. PLoS One. 2016;11(10):e0163899.

  Adachi H, Nakayama K, Hayashi N, Matsui Y, Fujimoto K, Yamaya H, Tonami H, Yokoyama H.

• Clinical manifestations of Henoch-Schönlein purpura nephritis and IgA nephropathy: comparative analysis of data from the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol. 2016;20(4):552-60.

  Komatsu H, Fujimoto S, Yoshikawa N, Kitamura H, Sugiyama H, Yokoyama H.

• Clinical and histological features of lupus nephritis in Japan: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR). Nephrology (Carlton). 2016 Jul 26. doi: 10.1111/nep.12863.

  Hiromura K, Ikeuchi H, Kayakabe K, Sugiyama H, Nagata M, Sato H, Yokoyama H, Nojima Y.

• A clinical evaluation of renal amyloidosis in the Japan renal biopsy registry: a cross-sectional study. Clin Exp Nephrol. 2016 Aug 25. [Epub ahead of print]

  Nishi S, Muso E, Shimizu A, Sugiyama H, Yokoyama H, Ando Y, Goto S, Fujii H.

• Drug-induced kidney disease: a study of the Japan Renal Biopsy Registry from 2007 to 2015. Clin Exp Nephrol. 2016; 20(5):720-730

  Yokoyama H, Narita I, Sugiyama H, Nagata M, Sato H, Ueda Y, Matsuo S.

• DNA double-strand breaks induced intractable glomerular fibrosis in renal allografts. Clin Exp Nephrol. 2016; 20(3):479-88.

  Matsui Y, Sunatani Y, Hayashi N, Okino K, Okushi Y, Mukai K, Adachi H, Yamaya H, Iwabuchi K, Yokoyama H.

• Different association of cigarette smoking with GFR estimated from serum creatinine and that from serum cystatin C in the general population. Clin Exp Nephrol, 2015; 19(4):669-77.

  Yamada Y, Noborisaka Y, Ishizaki M, Yamazaki M, Honda R, Yokoyama H, Kakuma T.

• Outcomes of primary nephrotic syndrome in elderly Japanese: retrospective analysis of the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol, 2015; 19(3):496-505.

  Yokoyama H, Sugiyama H, Narita I, Saito T, Yamagata K, Nishio S, Fujimoto S, Mori N, Yuzawa Y, Okuda S, Maruyama S, Sato H, Ueda Y, Makino H, Matsuo S.

• Immediate therapeutic efficacy of low-density lipoprotein apheresis for drug-resistant nephrotic syndrome: evidence from the short-term results from the POLARIS Study. Clin Exp Nephrol, 2015; 19(3):379-86.

  Muso E, Mune M, Hirano T, Hattori M, Kimura K, Watanabe T, Yokoyama H, Sato H, Uchida S, Wada T, Shoji T, Yuzawa Y, Takemura T, Sugiyama S, Nishizawa Y, Ogahara S, Yorioka N, Sakai S, Ogura Y, Yukawa S, Iino Y, Imai E, Matsuo S, Saito T.

その他

• 【受賞】厚生労働大臣表彰：移植医療普及推進（平成24年10月13日）

• 【受賞】公益財団法人日本腎臓財団：平成29年度学術賞（平成29年2月24日）

• 【対応可能言語】日本語

• 【対応可能言語】英語