Medical Noteとは

五十嵐 隆

五十嵐 隆先生

国立成育医療研究センター理事長 日本小児科学会前会長

  • 小児科


小児科学一般 小児腎臓病




1978年 東京大学医学部医学科卒業
1978年 東京大学医学部附属病院小児科研修医
1979年 静岡県厚生連遠州総合病院小児科医員
1982年 東京都立清瀬小児病院腎内科医員
1989年 東京大学医学部附属病院小児科助手
1985年 Harvard大学Boston小児病院研究員
1988年 東京大学医学部附属病院小児科助手
1989年 東京大学医学博士
1991年 東京大学医学部附属病院分院小児科講師
2000年 東京大学大学院医学系研究科小児医学講座小児科教授
2003年 東京大学医学部附属病院副院長(平成18年3月まで、平成19年4月から23年3月まで)


1978年 東京大学医学部医学科卒業
1978年 東京大学医学部附属病院小児科研修医
1979年 静岡県厚生連遠州総合病院小児科医員
1982年 東京都立清瀬小児病院腎内科医員
1989年 東京大学医学部附属病院小児科助手
1985年 Harvard大学Boston小児病院研究員
1988年 東京大学医学部附属病院小児科助手
1989年 東京大学医学博士
1991年 東京大学医学部附属病院分院小児科講師
2000年 東京大学大学院医学系研究科小児医学講座小児科教授
2003年 東京大学医学部附属病院副院長(平成18年3月まで、平成19年4月から23年3月まで)
2011年 東京大学教育研究評議員
2012年 独立行政法人国立成育医療研究センター理事長
2014年 東京大学名誉教授


Clinical and Experimental Nephrology Consulting Editor
Current Opinion in Pediatric


Clinical and Experimental Nephrology Consulting Editor
Current Opinion in Pediatrics Editorial Board, Nephrology Editorial Board


1 Miwa S, Fujii H, Tani K, Takahashi K, Takizawa T, Igarashi T: Red cell adenylate kinase deficiency associated with hereditary nonspherocytic anemia: Clinical and biological studies. Am J Hematol 14:325-333, 1983 2 Ohzeki T, Igarashi T, Okamoto A: Familial cases of congenital nephrogenic d


1 Miwa S, Fujii H, Tani K, Takahashi K, Takizawa T, Igarashi T: Red cell adenylate kinase deficiency associated with hereditary nonspherocytic anemia: Clinical and biological studies. Am J Hematol 14:325-333, 1983 2 Ohzeki T, Igarashi T, Okamoto A: Familial cases of congenital nephrogenic diabetes insipidus type II: Remarkable increment of urinary adenosine 3', 5' monophosphate in response to antidiuretic hormone. J Pediatr 104:593-595, 1984 3 Igarashi T, Sakuraba H, Suzuki Y: Activation of platelet function in Fabry's disease. Am J Hematol 22:63-67, 1986 4 Sakuraba H, Yanagawa Y, Igarashi T, Suzuki Y: Cardiovascular manifestations in Fabry's disease. Clin Genet 29:276-283, 1986 5 Sakuraba H, Igarashi T, Suzuki Y: Effect of vitamin E and ticlopidine on platelet aggregation in Fabry's disease. Clin Genet 31:349-354, 1987 6 Igarashi T, Shibata T, Iwata T, Kamoshita S: Congenital nephrotic syndrome with focal segmental glomerular sclerosis, renal insufficiency and tubular dysfunction. Acta Paediatr Jpn 29:614-618, 1987 7 Cicardi M, Igarashi T, Rosen FS, Davis III AE: Molecular basis for the deficiency of complement 1 inhibitor in type I hereditary angioneurotic edema. J Clin Invest 79:698-702, 1987 8 Cicardi M, Igarashi T, Kim M, Frangi D, Agostomi A, Davis III AE: Restriction fragment polymorphism of the C1 inhibitor gene in hereditary angioneurotic edema. J Clin Invest 80:1640-1644, 1987 9 Igarashi T, Minami M, Nishida Y: Molecular analysis of hypoxanthine-guanine phosphoribosyltransferase mutations in five unrelated Japanese patients. Acta Paediatr Jpn 31:303-313, 1989 10 Igarashi T, Higashihara E: Congenital anterior urethral diverticulum and urinary tract infection. Acta Paediatr Jpn 31:493-495, 1989 11 Ariga T, Igarashi T, Ramesh N, Parad R, Cicardi M, Davis III AE: Type I C1 inhibitor deficiency with a small messenger RNA resulting from deletion of one exon. J Clin Invest 83:1883-1893, 1989 12 Igarashi T, Kamoshita S: Carrier detection of partial hypoxanthine-guanine phosphoribosyltransferase deficiency by analysis with Bam HI restriction fragment length polymorphisms and oligonucleotide probes. Pediatr Res 27:417-421, 1990 13 Igarashi T, Ikegami H, Yamazaki H, Minami M: Bam HI restriction fragment length polymorphisms for hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene of carriers and controls of HPRT deficiency in Japan. Acta Paediat Jpn 32:12-15, 1990 14 Igarashi T, Kawato H, Kamoshita S: Reversible low-molecular-weight proteinuria in patients with distal renal tubular acidosis. Pediatr Nephrol 4:593-596, 1990 15 Igarashi T, Shibuya K, Kamoshita S, Higashihara E, Kawato H, Hagishima K, Kosugi T: Renal cyst formation as a complication of primary distal renal tubular acidosis. Nephron 59:75-79, 1990 16 Igarashi T, Kawato H, Kamoshita S, Kosugi T, Hagishima K: Two unknown renal complications in primary distal renal tubular acidosis. Contrib Nephrol 95:178-184, 1991 17 Igarashi T, Sekine Y, Kamoshita S, Kawato H, Saigusa Y: Transient neonatal distal renal tubular acidosis with secondary hyperparathyroidism. Pediatr Nephrol 6:267-269, 1992 18 Mashige F, Igarashi T, Watanabe H, Yamada A, Uchimura H, Ohkubo A: An uncommon peptide band detected in urine of premature babies and newborns. Progress in Clin Biochem 3: 883-885, 1992 19 Igarashi T, Kawato H, Kamoshita S, Nosaka K, Seiya K, Hayakawa H: Acute tubulointerstitial nephritis with uveitis syndrome presenting as multiple tubular dysfunction including Fanconi's syndrome. Pediatr Nephrol 6:547-549, 1992 20 Igarashi T: Normal serum uric acid concentration for age and sex and incidence of renal hypouricemia in Japanese school children. Pediatr Nephrol 7:239-240, 1993 21 Igarashi T, Sekine T, Sugimura H, Hayakawa H, Arayama T: Acute renal failure after exercise in a child with renal hypouricemia. Pediatr Nephrol 7:292-293, 1993 22 Takeda T, Nakao H, Yamanaka T, Igarashi T, Terada Y, Kobayashi N: High prevalence of serum antibodies to verotoxin-1 and verotoxin-2 among healthy adults in Japan. J Infection 27:211-213, 1993 23 Takeda T, Dohi S, Igarashi T, Yamanaka T, Yoshiya K, Kobayashi N: Impairment by verotoxin of tubular function contributes to the renal damage seen in haemolytic uraemic syndrome. J Infection 27: 339-341, 1993 24 Igarashi T, Ishii T, Watanabe K, Hayakawa H, Horio K, Sone Y, Ohga K: Persistent isolated proximal renal tubular acidosis-a systemic disease with a distinct clinical entity. Pediatr Nephrol 8: 70-71, 1994 25 Igarashi T, Kosugi T: The incidence of renal cyst formation in patients with primary distal renal tubular acidosis. Nephron 66: 474, 1994 26 Inatomi J, Watanabe K, Igarashi T, Hayakawa H: Weber Christian disease with benign cytophagic histiocytes in the skin lesion. Acta Pediatr Jpn 37: 105-107, 1995
27 Igarashi T, Hayakawa H, Shiraga H, Kawato H, Yan K, Kawaguchi H, Yamanaka T, Tsuchida S, Akagi K: Hypercalciuria and nephrocalcinosis in patients with idiopathic low molecular weight proteinuria in Japan: Is the disease identical to Dent's disease in United Kingdom? Nephron 69: 242-247, 1995
28 Yoshizawa A, Yokoya S, Igarashi T : A case of juvenile nephronophthisis presenting severe short stature. Clin Pediatr Endocrinol 4 (Supple 6): 95-98, 1995
29 Kohsaka T, Noma S, Takeuchi N, Simizu S, Sekiya T, Igarashi T, Kamoshita S, Kobayashi N : How does the early start of gammaglobulin therapy influence the prognosis of Kawasaki syndrome? Kawasaki Disease, ed. Kato H, et al. pp310-314, Elsevier Science N.Y., 1995
30 Mizuguchi M, Tanaka S, Fujii I, Tanizawa H, Suzuki Y, Igarashi T, Yamanaka T, Takeda T, Miwa M : Neuronal and vascular pathology produced by verocytotoxin 2 in the rabbit central nervous system. Acta Neuropathol 91: 254-262, 1996
31 Kizu J, Watanabe S, Ono H, Inatomi J, Sasaki K, Watanabe K, Igarashi T, Iwata T, Hayakawa H, Imai K : Studies on the latex agglutination inhibition method for assay of plasma theophylline concentration. Jpn J Hosp Pharm 22: 330-341, 1996
32 Lloyd SE, Pearce SHS, Günther W, Kawaguchi H, Igarashi T, Jentsch TJ, Thakker RV: Idiopathic low molecular weight proteinuria associated with hypercalciuric nephrocalcinosis in Japanese children is due to mutations of the renal chloride channel (CLCN5). J Clin Invest 99:561-568, 1997
33 Akuta N, Lloyd SE, Igarashi T, Shiraga H, Matsuyama T, Yokoro S, Cox JPD, Thakker RV: Mutations of CLCN5 in Japanese children with idiopathic low molecular weight proteinuria, hypercalciuria and nephrocalcinosis. Kidney Int 52: 911-916, 1997
34 Sekine T, Cha SH, Hosoyamada M, Kanai Y, Watanabe N, Huruta Y, Hukuda K, Igarashi T, Endou H: Cloning, functional characterization and localization of a rat renal Na+-dicarboxylate transporter. Am J Physiol 275 (Renal Physiol. 44): F298-F305, 1998
35 Igarashi T, Günter W, Sekine T, Inatomi J, Shiraga H, Takahashi S, Suzuki J, Tsuru N, Yanagihara T, Shimazu M, Jentsch TJ, Thakker RV: Functional characterization of renal chloride channel, CLCN5, mutations associated with Dent’s Japan disease. Kidney Int 54: 1850-1856, 1998
36 Igarashi T, Inatomi J, Sekine T, Cha SH, Kanai Y, Kunimi M, Tsukamoto K, Satoh H, Shimadzu M, Tozawa F, Mori T, Shiobara M, Seki G, Endou H: Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. Nature Genet 23:264-266, 1999
37 Igarashi T, Inatomi J, Wake A, Takamizawa M, Katayama H, Iwata T: Failure of pre-diarrheal antibiotics to prevent hemolytic uremic syndrome in serologically-proven Escherichia coli 0157:H7 gastrointestinal infection. J Pediatr 135: 768-769, 1999
38 Igarashi T, Inatomi J, Ohara T, Kuwahara T, Shimadzu M, Thakker RV: Clinical and genetic studies of CLCN5 mutations in Japanese families with Dent’s disease. Kidney Int 58: 520-527, 2000
39 Sugatani J, Igarashi T, Shimura M, Yamanaka T, Takeda T, Miwa M: Disorders in the immune responses of T- and B-cells in mice administered intravenous Verotoxin 2. Life Sci 67: 1059-1072, 2000
40 Sugatani J, Igarashi T, Munakata M, Komiyama Y, Takahashi H, Komiyama N, Maeda T, Takeda T, Miwa M: Activation of coagulation in C57BL/6 mice given verotoxin 2 (VT2) and the effect of co-administration of LPS with VT2. Thromb Res 100: 61-72, 2000
41 Shiohara M, Igarashi T, Mori T, Komiyama A: Genetic and long-term data on a patient with permanent isolated proximal renal tubular acidosis. Eur J Pediatr 159: 892-894, 2000
42 Takemura T, Hino S, Ikeda M, Okada M, Igarashi T, Inatomi J, Yoshioka K: Identification of two novel mutations in the CLCN5 gene in Japanese patients with familial low molecular weight proteinuria (Japanese Dent’s disease). Am J Kidney Dis 37: 138-143, 2001
43 Morimoto T, Chiba A, Kondo Y, Takahashi S, Igarashi T, Inoue CN, Iinuma K: A new approach to mRNA in proximal tubule cells of patients with CLCN5 channelopathy. Pediatr Nephrol 16: 110-112, 2001
44 Igarashi T, Inatomi J, Sekine T, Seki G: Unraveling the molecular basis of hereditary renal tubular acidosis. Clin Exp Nephrol 5: 8-12, 2001
45 Igarashi T, Inatomi J, Sekine T, Seki G, Shimadzu M, Tozawa F, Takeshima Y, Takumi T, Takahashi T, Yoshikawa N, Nakamura H, Endou H: Novel nonsense mutation in the Na+/HCO3- cotransporter gene (SLC4A4) in a patient with permanent isolated proximal renal tubular acidosis and bilateral glaucoma. J Am Soc Nephrol 12: 713-718, 2001
46 Usui T, Hara M, Satoh H, Moriyama N, Kagaya H, Amano S, Oshika T, Ishii Y, Ibaraki N, Hara C, Kunimi M, Noiri E, Tsukamoto K, Inatomi J, Kawakami H, Endou H, Igarashi T, Goto A, Fujita T, Araie M, Seki G: Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis. J Clin Invest 108: 107-115, 2001
47 Kuwahara M, Iwai K, Ooeda T, Igarashi T, Ogawa E, Katsushima Y, Shinbo I, Uchida S, Terada Y, Fujiwara TM, Arthus MF, Lonergan M, Bicher DG, Marumo F: Three families with autosomal dominant nephrogenic diabetes insipidus caused by aquaporin-2 mutations in the C-terminus. Am J Human Genetics 69: 738-748, 2001
48 Basnet NB, Igarashi T: Pediatrician in Nepal. Indian Pediatrics 38: 685-686, 2001
49 Tatsumi K, Saito M, Lin B, Iwamori M, Ichiseki H, Shimozawa N, Kamoshita, Igarashi T: Enhanced expression of a-series gangaliosides in fibroblasts of patients with peroxisome biogenesis disorders. Bioche Biophys Acta 1535: 285-293, 2001
50 Norden AGW, Lapsley M, Christensen EI, Igarashi T, Matsuyama T, Shiraga H, Kelleher CL, Lee P, Scheinman SJ, Thakker RV, Unwin RJ, Verroust P, Wrong O, Moestrup S: Urinary megalin deficiency implicates abnormal tubular endocytic receptor trafficking in the Fanconi syndrome. J Am Soc Nephrol 13: 125-133, 2002
51 Chandler WL, Jelacic S, Boster D, Ciol M, Watkins S, Igarashi T, Tarr PI: Prothrombotic coagulation abnormalities preceding the hemolytic uremic syndrome. New Eng J Med 246: 23-32, 2002
52 Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H: Molecular identification of a renal/urate/anion exchanger that regulates blood urate levels. Nature 417: 447-452, 2002
53 Tsuchida R, Yamada T, Takagi M, Sjimada A, Ishioka C, Katsuki Y, Igarashi T, Chessa L, Delia D, Teraoka H, Mizutani S: Detection of ATM gene mutation in human glioma cell line M059J by a rapid frameshift/stop codon assay in yeast. Radiat Res 158: 195-201, 2002
54 Sugatani J, Komiyama N, Mochizuki T, Hoshino M, Miyamoto D, Igarashi T, Hoshi S, Miwa M: Urinary concentrating defect in rats given Shiga toxin: elevation in urinary AQP2 level associated with polyuria. Life Science 71: 171-189, 2002
55 Igarashi T, Sekine T, Watanabe H: Molecular pathogenesis of proximal renal tubular acidosis. J Nephrol 15 (Suppl 5): S135 – S141, 2002
56 Yoshimura C, Yamaguchi M, Iikura M, Izumi S, Kudo K, Nagase H, Ishii A, Walls AF, Ra C, Iwata T, Igarashi T, Yamamoto K, Hirai K: Activation markers of human basophils: CD69 expression is strongly and preferentially induced by IL-3. J Allergy Clin Immunol 109: 817-823, 2002
57 Ito H, Takeda T, Honda M, Igarashi T, Joh K, Hashizume T, Yamaoka K: Preventive effect of TAK-751S on complications of hemorrhagic colitis (results of clinical study of TAK-751S). Jpn J Antibiot 55: 203-227, 2002
58 Igarashi T, Sekine T, Inatomi J, Seki G: Unrabelling the molecular pathogenesis of isolated proximal renal tubular acidosis. J Am Soc Nephrol 13:2171-2177, 2002
59 Saito M, Fukushima Y, Tatsumi K, Bei L, Fujiki Y, Iwamori M, Igarashi T: Molecular cloning of Chinese hamster ceremide glucosyltransferase and its enhanced expression in peroxisome-defective mutant Z65 cells. Arch Biochem Biophys 403:171-178, 2002
60 Kano H, Mizuta K, Kato H, Miki Y, Shibuya N, Saito M, Narita M, Kawarasaki H, Igarashi T, Hashizume K, Iwata T: Efficacy and safety of immunization for pre- and post-liver transplantation. Transplantation 74: 543-550, 2002
61 Igarashi T: New therapeutic approaches for patients with Fabry’s disease. Inter Med 41: 913-914, 2002
62 Satoh H, Moriyama N, Hara C, Yamada H, Horita S, Kunimi M, Tsukamoto K, Iso-O N, Inatomi J, Kawakami H, Kudo A, Endou H, Igarashi T, Goto A, Fujita T, Seki G: Localization of Na+/HCO3- cotransporter (pNBC-1) variants in rat and human pancreas. Am J Physiol Cell Physiol 284: C729-C737, 2003
63 Nagura M, Nagao Y, Takita J, Igarashi T, LeGuren E, Hayashi Y: The kinesin superfamily protein RabKIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C. Int J Mol Med 11: 45-47, 2003
64 Hirose H, Arayama T, Takita J, Igarashi T, Hayashi Y, Nagao Y: A family of episodic ataxia type 2: No evidence of genetic linkage to the CACNA1A gene. Int J Mol Med 11: 187-189, 2003
65 Ozawa H, Kodama H, Kawaguchi H, Mochizuki T, Kobayashi M, Igarashi T: Renal function in patients with Menkes disease. Eur J Pediatr 162: 51-52, 2003
66 Yoshimura-Uchiyama C, Yamaguchi M, Nagase H, Fujisawa T, Ra C, Matsushima K, Iwata T, Igarashi T, Yamamoto K, Hirai K: Comparative effects of basophil-directed growth factors. Biochem Biophys Res Comm 302: 201-206, 2003
67 Moulin P, Igarashi T, Van der Smissen P, Cosyns JP, Verroust P, Thakker RV, Scheinman SJ, Courtoy PJ, Devuyst O: Altered polarity and expression of H+-ATPase
without ultrastructural changes in kidney of Dent’s disease patients. Kidney Int 63: 1285-1295, 2003
68 Jouret F, Igarashi T, Gafflot F, Wilson PD, Karet FE, Thakker R, Devuyst O: Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5. Kidney Int 65: 198-208, 2004
69 Kitanaka S, Miki Y, Hayashi Y, Igarashi T: Promotor-specific repression of hepatocyte nuclear factor (HNF)-β and HNF-1α transcriptional activity by an HNF-β missense mutant associated with type 5 maturity-onset diabetes of the young with hepatic and biliary manifestations. J Clin End Met 89: 1369-1378, 2004
70 Nagura M, Saito M, Iwamori M, Igarashi T: Alterations of fatty acid metabolism and membrane fluidity in peroxisome-defective mutant ZP102 cells. Lipids 39: 43-50, 2004
71 Basnet NB, Kato H, Nakamura Y, Watanabe H, Igarashi T: Newspaper reporting on child raising in Japan. J Pediatr Nursing 19: 113-120, 2004
72 Matsuyama T, Awazu M, Oikawa T, Inatomi J, Sekine T, Igarashi T: Molecular and clinical studies of Dent’s disease in Japan: biochemical examination and renal ultrasonography do not predict carrier state. Clin Nephrol 61: 231-237, 2004
73 Ohta T, Sakano T, Igarashi T, Itami N, Ogawa T: Exercise-induced acute renal failure associated with renal hypouricemia: results of a questionnaire-based survey in Japan. Nephrol Dial Transplant 19: 1447-1453, 2004
74 Komoda F, Sekine T, Inatomi J, Enomoto A, Endou H, Ota T, Matsuyama T, Ogata T, Ikeda M, Awadzu M, Muroya K, Kamimaki I, Igarashi T: The W258X mutation in SLC22A is the predominant cause of Japanese renal hypouricemia. Pediatr Nephrol 19:728-733, 2004
75 Inatomi J, Horita S, Braverman N, Sekine T, Yamada H, Suzuki Y, Kawahara K, Moriyama N, Kudo A, Kawakami H, Shimadzu M, Endou H, Fujita T, Seki G, Igarashi T: Mutational and functional analysis of SLC4A4 in a patient with proximal renal tubular acidosis. Pfluger Arch – Eur J Physiol 448: 438-444, 2004
76 Basnet NB, Noma S, Basnet SB, Igarashi T: Neonatal intensive care unit hospitalization of very low birth weight Japanese infants with congenital heart disease. J Nepal Med Asso 43: 28-30, 2004
77 Nagao Y, Mazaki-Miyazaki E, Okamura N, Takagi M, Igarashi T: A family of
generalized epilepsy with febrile seizures plus type 2-a new missense mutation of SCN1A found in the pedigree of several patients with complex febrile seizures. Epilepsy Res 63: 151-156, 2005
78 Sato U, Kitanaka S, Sekine T, Takahashi S, Ashida A, Igarashi T: Functional
characterization of LMX1B mutations associated with nail-patella syndrome. Pediatr Res 57: 783-788, 2005
79 Cheong HI, Kang JH, Lee JH, Ha IS, Kim S, Komoda F, Sekine T, Igarashi T, Choi Y: Mutational analysis of idiopathic renal hypouricemia in Korea. Pediatr Nephrol 20:886-890, 2005
80 Horita S, Yamada H, Inatomi J, Moriyama N, Sekine T, Igarashi T, Endo Y, Dasouki M, Ekim M, Al-Gazali L, Shimada M, Seki G, Fujita T: Functional analysis of NBC1 mutants associated with proximal tubular acidosis and ocular abnormalities. J Am Soc Nephrol 16:2270-2278, 2005
81 Chen YY, Takita J, Tanaka K, Ida K, Koh K, Igarashi T, Hanada R, Kikuchi A, Tanaka Y, Toyoda Y, Hayashi Y: Aberration of the CHK2 gene are rare in pediatric solid tumors. Int J Mol Med 16: 85-91, 2005
82 Kanamori Y, Hashizume K, Sugiyama M, Motoi T, Fukuyama M, Ida K, Igarashi T: Intrapulmonary solitary fibrous tumor in an eight-year-old male. Pediatr Pulmonol 40:261-264, 2005
83 Sekine T, Namai Y, Yanagisawa A, Shirahama H, Tashiro Y, Terahara M, Nagata M, Harita Y, Fukuoka U, Inatomi J, Igarashi T: A familial case of muticystic dysplastic kidney. Pediatr Nephrol 20: 1245-1248, 2005
84 Shinjo Y, Kaga K, Igarashi T: Distal renal tubular acidosis associated with large ventricular aqueduct and sensorineural hearing loss. Acta Oto-Laryngo 125: 667-670, 2005
85 Araya K, Fukumoto S, Backenroth R, Takeuchi Y, Kanayama K, Ito N, Yoshii N, Yamazaki Y, Yamashita T, Silver J, Igarashi T, Fujita T: A novel mutation in fibroblast growth factor (FGF) 23 gene as a cause of tumor calcinosis. J Clin Endocrinol Metab 90: 5523- 5527, 2005
86 Anzai N, Jutabha P, Enomoto A, Yokoyama H, Nonoguchi H, Hirata T, Shiraya K, He X, Cha SH, Takeda M, Miyazaki H, Sakata T, Tomita K, Igarashi T, Kanai Y, Endou H: Functional characterization of rat organic anion transporter 5 (SLC22A19) at the apical membrane of renal proximal tubules. J Pharmacol Exp Ther 315: 534-544, 2005
87 Harita Y, Miyauchi N, Karasawa T, Suzuki K, Han GD, Koike H, Igarashi T, Shimizu F, Kawachi H: Altered expression of junctional adhesion molecule 4 (JAM4) in injured podocytes. Am J Physiol Renal Physiol 290:F335-F344,2005
88 Kanamori Y, Hashizume K, Sugiyama M, Tomonaga T, Goishi K, Yokoyama Y, Igarashi T, Kikuchi A, Kawana Y, Kozuma S, Taketani Y: A case of intrapericardial diaphragmatic hernia with a massive pericardial effusion: fetal diagnosis and therapy. J Pediatr Surg 40: e43-45, 2005
89 Kitanaka S, Sato U, Maruyama K, Igarashi T: A compound heterozygous mutation in the BSND gene detected in Bartter syndrome type IV. Pediatr Nephrol 21: 190-193, 2006
90 Kitanaka S, Takeda A, Sato U, Miki Y, Hishimura A, Ieiri T, Igarashi T: A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels. J Hum Genet 51: 379-382, 2006
91 Chen Y, Takita J, Hiwatari M, Igarashi T, Hanada R, Kikuchi A, Hongo T, Taki T, Ogasawara M, Shimada A, Hayashi Y: Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies. Genes, Chrom & Cancer 45: 583-591, 2006
92 Saitoh M, Kubota M, Kimura I, Mizuguchi M, Igarashi T: A case of panayiotopolos syndrome showing an atypical course. Seizure 15: 643-648, 2006
94 Sekine T, Nozu K, Iyengar R, Fu XJ, Matsuo M, Tanaka R, Iijima K, Matsui E, Harita Y, Inatomi J, Igarashi T: OCRL1 mutations in patients with Dent phenotype in Japan. Pediatr Nephrol 22: 975-980, 2007
95 Takahashi K, Saitoh M, Hoshino H, Mimaki M, Takamizawa M, Mizuguchi M, Lin Z-M, Yang Y, Igarashi T: A case of primary erythermalgia, wintry hypothermia and encephalopthy. Neuropediatr 38: 157-159, 2007
95 Saito M, Horikawa M, Iwamori Y, Mizuguchi M, Igarashi T, Fujiki Y, Iwamori M: Alterations in the molecular species of plasmalogen phospholipids and glycolipids due to peroxisomal dysfunction in Chinese hamster ovary-mutant Z65 cells by FABMS method. J Chromato B 852: 367-373, 2007
96 Suzuki M, Vaisbich MH, Yamada H, Horita S, Li Y, Sekine T, Moriyama N, Igarashi T, Endo Y, Cardoso TP, de Sa LC, Koch VH, Seki G, Fujita T: Functional analysis of a novel missense NBC1 mutation and of other mutations causing proximal renal tubular acidosis. Pflugers Arch-Eur J Physiol 455: 583-593, 2008
97 Nozu K, Inagaki T, Fu XJ, Nozu Y, Kanda K, Sekine T, Igarashi T, Nakanishi N, Yoshikawa N, Iijima K, Matsuo M: Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness. J Med Genet 45: 182-186, 2008
98 Yanagisawa A, Namai Y, Sekine T, Igarashi T: Ischemic colitis as a complication in a patient with steroid-dependent nephrotic syndrome. Pediatr Nephrol 23:655-657, 2008
99 Inatomi J, Yokoyama Y, Sekine T, Igarashi T: A case of cerebral salt-wasing syndrome associated with aseptic meningitis in an 8-year-old girl. Pediatr Nephrol 23:659-662, 2008
100 Shimizu N, Yamamoto K, Obi S, Kumagaya S, Masumura T, Shimano Y, Naruse K, Yamashita JK, Igarashi T, Ando J: Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor β. J Appl Physiol 104:766-772, 2008
101 Takanashi S, Okame M, Shiota T, Takagi M, Yagyu F, Tung PG, Nishimura S, Katsumata N, Igarashi T, Okitsu S, Ushijima H: Development of a rapid immunochromtographic test for noroviruses genogroups I and II. J Viral Methods 148:1-8, 2008
102 Seki G, Yamada H, Horita S, Suzuki M, Sekine T, Igarashi T, Fujita T: Activation and inactivation of Na-H-HCO3 cotransporter NBC1. J Epithel Pharm 1:35-39, 2008
103 Toda M, Yamamoto K, Shimizu N, Obi S, Kumagaya S, Igarashi T, Kamiya A, Ando J: Differential gene responses in endothelial cells exposed to a combination of shear stress and cyclic stretch. J Biotechnol 133: 239-244, 2008
104 Amemiya S, Akahane M, Takita J, Igarashi T, Ohtomo K: Imaging findings of upper abdominal involvement by acute megakaryoblastic leukemia. Pediatr Radiol 38: 457-461, 200
105 Saeki H, Watanabe A, Tada Y, Kakinuma T, Komine M, IHN H, Asahina A, Etoh T, Ktanaka S, Sato U, Kano H, Igarashi T, Tamaki K: Juvenile pustular psoriasis associated with steroid withdrawal syndrome due to topical corticosteroid. J Dermatol 35:601-603, 2008
106 Chen Y, Takita J, Choi YM, Kato M, Ohira M, Sanada M, Wang L, Soda M, Kikuchi A, Igarashi T, Nakagawara A, Hayashi Y, Mano H, Ogawa S: Oncogenic mutations of ALK kinase in neuroblastoma. Nature 455: 971-975, 2008
107 Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Hattori S: Neph 1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grbs. J Biol Chem 283: 9177-9186, 2008
108 Saito H, Takahashi S, Nagata M, Tsuchiya T, Mugishima H, Yan K, Kondo Y, Matsuyama T, Sekine T, Igarashi T: Reevaluation of glomerular charge selective protein-sieving function. Pediatr Nephrol 24: 609-612, 2008
109 Kanamori Y, Iwanaka T, Nakahara S, Kawashima H, Komura M, Sugiyama M, Kamei Y, Hyodo H, Yamaguchi SI, Kohzuma S, Taketani Y, Goishi K, Ishiguro S, Takamizawa M, Igarashi T: Survival in a neonate with complete urorectal malformtion sequence after fetal vesico-amniotic shunting for a prominently dilated cloacae. Fetal Diagn Ther 24: 458-461, 2008
110 Komura M, Kanamori Y, Sugiyama M, Nakahara S, Kawashima H, Hatanaka A, Takazawa Y, Goishi K, Igarashi T, Iwanaka T: Antenatally diagnosed giant multicystic dysplastic kidney resected during the neonatal period. J Pediatr Surg 43: 2118-2120, 2008
111 Sato A, Mizuguchi M, Mimaki M, Takahashi K, Jimi H, Oka A, Igarashi T: Cortical gray matter lesions in acute encephalopathy with febrile convulsive status epilepticus. Brain Dev 31: 622-624, 2009
112 Saito T, Fukumoto S, Ito N, Suzuki H, Igarashi T, Fujita T: A novel mutation in the GAT3 gene of a Japanese patient with PTH-deficient hypoparathyroidsm. J Bone Miner Metab 27: 386-389, 2009
113 Takanashi S, Hashira S, Matsunaga T, Yoshida A, Shiota T, Tung PG, Khamrin P, Okitsu S, Mizuguchi M, Igarashi T, Ushijima H: Detection, genetic characterization and quantification of norovirus RNA from sera of children with gastroenteritis. J Clin Virol 44:161-163, 2009
114 Jo A, Tsukimoto I, Ishii E, Asou N, Mitani S, Shimada A, Igarashi T, Hayashi Y, Ichikawa H: Age-associated difference in gene expression of paediatric acute myelomonocytic leukaemia (FAB M4 and M5 subtypes) and its correlation with prognosis. Br J Haematol 144: 917-929, 2009
115 Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Hattori S: Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-γ1. J Biol Chem 284: 8951-8962, 2009
116 Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Miwa A, Cehn Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamaoto K, Tobinai K, Nakagawa H, Nakahra T, Yoshino T, Kobayashi Y, Ogawa S: Frequent inactivation of A20 in B-cell lymphoma. Nature 459: 712-716, 2009
117 Takita J, Motomura A, Koh K, Ida K, Taki T, Hayashi Y, Igarashi T: Acute megakaryoblastic leukemia in a child with the MLL-AF4 fusion gene. Eur J Haematol 83: 149-153, 2009
118 Ide H, Yasunaga H, Koike S, Kodama T, Igarashi T, Imamura T: Shortage of pediatricians in Japan: a longitudinal analysis using physician’s survey data. Pediatr Int 51: 645-649, 2009
119 Ishiguro A, Sekine T, Kakiuchi S, Nishimura R, Goishi K, Tsuchida S, Ohtsu H, Igarashi T: Skin and subcutaneous blood flows of very low birth weight infants during the first 3 postnatal days. J Matern Fetal Neonatal Med 11:1-7, 2009
120 Abe Y, Oka A, Mizuguchi M, Igarashi T, Ishikawa S, Aburatani H, Yokoyama S, Asahara,H, Nagao K, Yamada M, Miyashita T: YA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally. Hum Mutat 30: E946-955, 2009
121 Kato M, Takita J, Takahashi K, Mimaki M, Chen Y, Koh K, Ida K, Oka A, Mizuguchi M, Ogawa S, Igarashi T: Hepatoblastoma in a patient with Sotos syndrome. J Pediatr 155: 937-939, 2009
122 Miura K, Sekine T, Iida A, Takahashi K, Igarashi T: Salt-losing nephrogenic diabetes insipidus caused by fetal exposure to angiotensin receptor blocker. Pediatr Nephrol 24: 1235-1238, 2009
123 Morita T, Ashida A, Fujieda A, Hayashi A, Meda A, Ohta K, Shimizu M, Sekine T, Igarashi T, Tamai H, Wakiguchi H: Four cases of postrenal renal failure induced by renal stone associated with rotavirus infection. Clin Nephrol 73: 398-402, 2010
124 Mizuno Y, Tsuchida S, Kakiuchi S, Ishiguro A, Goishi K, Kamei Y, Kanamori Y, Yamazaki Y, Sekine T, Igarashi T: Prenatal intervention for severe anterior urethral valve. Pediatr Inter 52: e92-e95, 2010
125 Sekine T, Konno M, Sasaki S, Moritani S, Miura T, Wong WS, Nishio H, Nishiguchi T, Ohuchi MY, Tsuchiya S, Matsuyama T, Kanegane H, Ida K, Miura K, Harita Y, Hattori M, Horita S, Igarashi T, Saito H, Kunishima S: Patients with Epstein-Fechtner syndrome owing to MYH9 R702 mutations develop progressive proteinuric renal disease. Kidney Int 78: 207-214, 2010
126 Suzuki M, Paesschen WV, Stalmans I, Horita S, Yamada H, Bergmans BA, Legius E, Riant F, Jonghe PD, Li Y, Sekine T, Igarashi T, Fujimoto I, Mikoshiba K, Shimadzu M, Shohara M, Braverman N, Al-Gazali L, Fujita T, Seki J: Defective membrane expression of the Na+-HCO3- cotransporter NBCe1 is associated with familial migraine. PNAS 107: 15963-15968, 2010
127 Takahashi K, Oka A, Mizuguchi M, Saitoh M, Takita J, Sato A, Mimaki M, Kato M, Ogawa S, Igarashi T: Interstitial deletion of 13q14.13-q32.3 presenting with Arima syndrome and bilateral retinoblastoma. Brain & Develop 33: 353-356, 2010
128 Oki K, Takita J, Hiwatari M, NishimuraR, Sanada M, OkuboJ, Adachi M , Sotomatsu M, Kikuchi A, Igarashi T, HayashiY, Ogawa S: IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies. Leukemia 25: 1-3, 2011
129 Ikeda H, Shiojima I, Oka T, Yoshida M, Maemura K, Walsh K, Igarashi T, Komuro I: Increased Akt-mTOR signaling in lung epithelium is associated with respiratory distress syndrome in mice. Mol Cell Biol 31: 1054-1065, 2011
130 Mizuno Y, Takahashi K, Igarashi T, Saito M, Mizuguchi M: Congenital infection-like syndrome with intaracranial calcification. Brain & Develop 33: 530-533, 2011
131 Takita J, Chen Y, Sanada M, Adachi M, Ohki K, Nishimura R, Hanada R, Igarashi T, Hayashi Y, Ogawa S: Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma. Cancer Science 102: 1645-1650, 2011
132 Miura K, Sekine T, Nishimura R, Kanamori Y, Yanagisawa A, Sakai K, Nagata M, Igarashi T: Morphological and functional analyses of two infants with obstructive renal dysplasia. Clin Exp Nephrol 15: 602-606, 2011
133 Kanda S, Harita Y, Shibagaki Y, Sekine T, Igarashi T, Inoue T, Hattori S. Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-γ1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis. Mol Biol Cell. 22:1824-35, 2011
134 Hirata Y, Soekia T, Yamadaa H, Shiotac A, Shimabukuroc M, Sakaid Y, Nakayamae M, Matsumotoe K, Igarashi T, Sataa M: A synthetic prostacyclin agonist, ONO-1301, ameliorates ventricular remodeling after acute myocardial infarction via upregulation of HGF in rat. Biomedicine & Aging Pathology 1: 90–96, 2011
135 Nakamura Y, Awa S, Kato H, Ito YM, Kamiya A, Igarashi T: Model combining hydrodynamics and fractal theory for analysis of in vivo peropheral pulmonary and systemic resistance of shunt cardiac defects. J Theoret Biology 287: 64-73, 2011
136 Takahashi K, Makita N, Manaka K, Hisano M, Akioka Y, Miura K, Takubo N, Iida A, Ueda N, Hashimoto M, Fujita T, Igarashi T, Sekine T, Iiri T. V2 vasopressin receptor (V2R) mutations in partial nephrogenic diabetes insipidus highlights protean agonism of V2R antagosists. J Biol Chem 287: 2099-2106, 2012
137 Ashida A, Fujieda M, Ohta K, Nakakura H, Matsumura H, Morita T, Igarashi T, Tamai H: Clinical characteristics of obstructive uropthy associated with rotavirus gastroenteritis in Japan. Clin Nephrol 77: 49-54, 2012
138 Miura K, Sekine T, Takamizawa M, Terashima H, Furuya A, Koh K, Takita J, Ida K, Igarashi T: Early occurrence of nephrotic syndrome associated with cord blood stem cell transplantation. Clin Exp Nephrol 16: 180-182, 2012
139 Kajiho Y, Harita Y, Kurihara H, Horita S, Matsunaga A, Tsurumi H, Kanda S, Sugawara N, Miura K, Sekine T, Hattori S, Hattori M, Igarashi T: SIRPα interacts with nephrin at the podocyte slit diaphragm. FEBS J 279: 3010-3021, 2012
140 Kitanaka S, Isojima T, Takaki M, Numakura C, Hayasaka K, Igarashi T: Association of vitamin D-related gene polymorphisms with manifestation of vitamin D deficiency inchildren. Endocrine J 59: 1007-1014, 2012
141 Vaisbich MH, Henriques Ldos S, Igarashi T, Sekine T, Seki G, Koch VH: The long-term use of enalapril and hydrochlorothaiazide in two novel mutations patients with Dent’s disease. J Bras Nefrol 34: 78-81, 2012
142 Okubo J, Takita J, Chen Y, Oki K, Nishimura R, Kato M, Sanada M, Hiwatari M, Hayashi Y, Igarashi T, Ogawa S: Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma. Oncogene 31: 4667-4676, 2012
143 Kim KS, Arima Y, Kitazawa T, Nishiyama K, Asai R, Uchijima Y, Sato T, Levi G, Kitanaka S, Igarashi T, Kurihara Y, Kurihara H: Endothelin regulates neural crest development and fate to form great vessels through Dlx5/Dlx6-independent mechanism. Mech Dev 130:553-66, 2013
144 Kakiuchi S, Nonoyama S, Wakamatssu H, Kogawa K, Wang L, Kinoshita-Yamaguchi H, Takayama-Ito M, Lim CK, Mizuguchi M, Igarashi T, Saijo M: Neonatal herpes encephalitis confirmed acyclovir-resistant herpes simplex virus 1 strain. J Clin Microbio 51: 356-359, 2013
145 Sekine T, Komoda F, Miura K, Takita J, Shimadzu M, Matsuyama T, Ashida A, Igarashi T: Japanese Dent disease has a wider clinical spectrum than Dent disease in Europe/USA: genetic and clinical studies of 86 unrelated patients with low-molecular-weight proteinuria. Nephrol Dial Transplant 29:376-384, 2014
146 Harita Y, Ishizuka K, Tanego A, Sugawara N, Chikamoto H, Akioka Y, Tsurumi H, Miura K, Gotoh Y, Tsujita M, Yamamoto T, Horike K, Takeda A, Oka A, Igarashi T, Hattori M: Decreased glomerular filtration as the primary factor of elevated circulating suPAR levels in focal segmental glomerulosclerosis. Pediatr Nephrol 29: 1553-1560, 2014
147 Tsurumi H., Harita Y, Kurihara H, Kosako H, Hayashi K, Matsunaga A, Kajiho Y, Kanda S, Miura K, Sekine T, Oka A, Ishizuka K, Horita S, Hattori M, Hattori S, Igarashi T: Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells. Kidney Int 86: 548-557, 2014
148 Nakaya T, Morita K, Kurata A, Ushiku T, Igarashi T, Kuroda M, Fukayama M: Multifocal kaposiform hemangioendothelioma in multiple visceral organs: an autopsy of 9-day-old female baby. Human Patho 45: 1773-1777, 2014
149 Ashida A, Yamamoto D, Nakakura H, Shirasu A, Matsumura H, Sekine T, Igarashi T, Tamai H: Molecular effect of a novel missense mutation, L266V, on function of ClC-5 protein in a Japanese patient with Dent’s disease. Clin Nephrol 82: 58-61, 2014
150 Seki M, Yoshida K, Shiraishi Y, Shimamura T, Sato Y, Nishimura R, Okuno Y, Chiba K, Tanaka H, Kato K, Kato M, Hanada R, Nomura Y, Oark Myong-Ja, Ishida T, Oka A, Igarashi T, Miyano S, Hayashi Y, Ogawa S, Takita J: Bialleic DICER1 mutations in sporadic pleuropulmonary blastoma. Cancer Res 74: 2742-2749, 2014
151 Igarashi T, Ito S, Sako M, Saitoh M, Hataya S, Mizuguchi M, Morishima T, Ohnishi K, Kawamura N, Kitayama H, Ashida A, Kaname S, Taneichi H, Tang J, Ohnishi M, Study group for establishing guidelines for the diagnosis and therapy of hemolytic uremic syndrome: Guidelines for the management and investigation of hemolytic uremic syndrome. Clin Exp Nephrol 18: 525-557, 2014
152 Yoshikawa N, Nakanishi K, Sako M, Oba MS, Mori R, Ota E, Ishikura K, Hataya H, Honda M, Ito S, Shima Y, Kaito H,
 Nozu K, Nakamura H, Igarashi T, Ohashi Y and Iijima I; for the Japanese Study Group of Kidney Disease in Children: A multicenter randomized trial indicates initial prednisolone treatment for childhood nephrotic syndrome for two months is not inferior to six-month treatment, Kidney Int 87: 225-232, 2015
153 Hattori M, Sako M, Kaneko T, Ashida A, Matsunaga A, Igarashi T, Itami N, Ohta T, Gotoh Y, Satomura K, Honda M, Igarashi T: End-stage renal disease in Japanese children: a nationwide survey during 2005-2011. Clin Exp Nephrol 2014
154 Terasaka A, Tachibana Y, Okuyama M, Igarashi T: Post-traumatic stress disorder in children following natural disasters: a systematic review of the long-term follow-up studies. Int J Child Youth Family Studies 6: 111-133, 2015

1. Igarashi T: Fanconi syndrome, pp1039-1068, Pediatric Nephrology six edition, vol 1, Edited by Avner ED, Harmon WE, Niaudet P, Yoshikawa N, Springer-Verlag, Berlin, Heidelberg, 2009
2. Igarashi T: Pedatric Nephrology around the world, Japan, pp1951-1954, Pediatric Nephrology, vol 2, Edited by Avner ED, Harmon WE, Niaudet P, Yoshikawa N, Springer-Verlag, Berlin, Heidelberg, 2009
3. Devuyst O, Igarashi T: Renal Fanconi syndrome, Dent’s disease and Bartter’s syndrome. pp 553-568, Genetics of Bone Biology and Skeletal Disease. Edited by Thakker RV, Whyte MP, Eisman JA, Igarashi T, Elsevier, Amsterdam, 2013



子どもに見られる 病気の症状 ー症状を理解して対応しましょうー
子どもに見られる 病気の症状 -このような症状があったら受診しましょう-1
子どもがかかる病気と治療③ ブドウ球菌性熱傷様皮膚症候群/湿疹/じんましん
子どもがかかる病気と治療④ 虫さされ/水いぼ/やけど/日焼け/アトピー性皮膚炎/アレルギー性鼻炎・結膜炎
子どもがかかる病気と治療⑩ うつ病/性器をいじる/自閉症スペクトラム/注意欠陥多動性障害/先天性歯/歯ぎしりなど
子どもがかかる病気と治療⑪ さかさまつげ/気道異物/消化管異物/ねんざ/骨折/中毒など



小田急電鉄小田原線 成城学園前 バス10分

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