朴木 寛弥 ほおのき かんや 先生

来歴等

略歴

1987年 奈良県立医科大学医学部付属病院 臨床研修医(整形外科）
1994年 Thomas Jefferson University, Philadelphia, U.S.A. Postdoctoral fellow
2001年 奈良県立医科大学 助手（整形外科）
2002年 St. Jude Children’s Research Hospital, Memphis, U.S.A., Visiting fellow
2008年 公立大学法人　奈良県立医科大学 学内講師（整形外科）
2011年 公立大学法人　奈良県立医科大学 講師（整形外科、寄付講座　人工関節・骨軟骨再生医学併任）
2015年 公立大学法人　奈良県立医科大学 准教授（整形外科、寄付講座　人工関節・骨軟骨再生医学併任）
2019年 公立大学法人　奈良県立医科大学　寄付講座　骨軟部腫瘍制御・再建医学 教授

論文

• Miscorrelation of Functional Outcome and Sociooccupational Status of Childhood, Adolescent, and Young Adult Generation With Bone and Soft Tissue Sarcoma Patients. J Pediatr Hematol Oncol. 2019 Mar;41(2):112-117.

  Fujii H, Honoki K, Ishihara T, Shinomiya T, Tsukamoto S, Kido A, Kondoh Y, Kishi S, Shima M, Tanaka Y.

• Preventing aging with stem cell rejuvenation: Feasible or infeasible? World J Stem Cells 9(1):1-8., 2017.

  Honoki K.

• Crossroads of Hallmarks in Aging and Cancer: Anti-aging and anti-cancer target pathways can be shared? Trends in Cancer Research. 2016

  Honoki K, Fujii H, Tsukamoto S, Kishi S, Tsujiuchi T, Tanaka Y.

• The clinical outcome of pazopanib treatment in Japanese patients with relapsed soft tissue sarcoma: A Japanese Musculoskeletal Oncology Group (JMOG) study. Cancer. 2016 122:1408-16

  Nakamura T, Matsumine A, Kawai A, Araki N, Goto T, Yonemoto T, Sugiura H, Nishida Y, Hiraga H, Honoki K, Yasuda T, Boku S, Sudo A, Ueda T.

• Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 2015 Dec;35 Suppl:S276-304. doi: 10.1016/j.semcancer.2015.09.007.

  Block KI, Gyllenhaal C, Lowe L・・・ Honoki K, et al.

• Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of pro-senescence therapy in sarcomas. Expert Rev Anticancer Ther. 13:983-96, 2013

  Honoki K, Tsujiuchi T.

• Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. Oncol. Rep. 24: 501-505, 2010.

  Honoki K, Fujii H, Kubo A, Kido A, Mori T, Tanaka Y, Tsujiuchi T.

• Do stem-like cells play a role in drug resistance of sarcomas? Expert Rev.Anticancer Ther. 10: 261-270, 2010

  Honoki K.

• Epithelioid sarcoma of the forearm arising from perineural sheath of median nerve mimicking carpal tunnel syndrome. Sarcoma. 2009: 595391. Epub 2009 Apr 14.

  Fujii H, Honoki K, Yajima H, Kido A, Kobata Y, Kaji D, Takakura Y.

• Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines. Int J Oncol. 34:1381-6, 2009.

  Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, Takakura Y.

• Epiphyseal preservation and an intercalary vascularized fibular graft with hydroxyapatite composites. Reconstruction in metaphyseal osteosarcoma of the proximal tibia: a case report. Arch Orthop Trauma Surg. 128: 189-193, 2008.

  Honoki K, Kobata Y, Miyauchi Y, Yajima H, Fujii H, Kido A, Kawamura K, Morishita T, Mii Y, Takakura T.

• Reduced expression of INK4a/ARF genes in stem-like sphere cells from rat sarcomas. Biochem Biophys Res Commun. 362: 773-778, 2007.

  Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, Mori T, Takakura Y.

• Prognostic significance of p16INK4a alteration in Ewing’s sarcoma. A meta-analysis. Cancer. 110: 1351-1360, 2007.

  Honoki K, Stojanovski, E, McEvoy M, Fujii H, Tsujiuchi T, Kido A, Takakura Y, Attia J.

• Adamantinoma-like Ewing's sarcoma with EWS-FLI1 fusion gene: a case report. Virchows Arch. 449: 579 – 584, 2006.

  Fujii H, Honoki K, Enomoto Y, Kasai T, Kido A, Amano I, Kumamoto M, Morishita T, Mii Y, Nonomura A, Takakura Y.

• Growth inhibition and induction of apoptosis by Flavopiridol in rat lung adenocarcinoma, osteosarcoma and malignant fibrous histiocytoma cell lines. Oncology Reports. 11: 1025 -1030, 2004.

  Honoki K, Yoshitani K, Tsujiuchi T, Mori T, Tsutsumi M, Morishita T, Takakura Y, Mii Y.

• Expression of p16INK4a Gene Methylation Pattern of CpG Sites in the Promoter region in Rat Tumor Cell Lines. Mol. Carcinogenesis. 39: 10-14, 2004.

  Honoki K, Tsujiuchi T, Mori T, Yoshitani K, Tsutsumi M, Takakura T, Mii Y.

• Differential Expression of Cytokines in Rat Osteosarcoma and Malignant Fibrous Histiocytoma Cell Line Induced by 4-(Hydoxyamino) Quinokine 1-Oxide. Mol. Carcinogenesis. 33: 81-87, 2002.

  Honoki K, Tsujiuchi T, Sasaki Y, Masahiro T, Morishita T, Kido A, Miyauchi Y, Mii Y, Takakura Y, Konishi Y.

• A Primaly Osteogenic Sarcoma in the Finger Phalanx: A Case Report and literature review. J. Hand Surg. 26A: 1151-1156, 2001.

  Honoki K, Miyauchi Y, Yajima H, Takakura Y, Tamai S.

• Possible involvement of bcl-2 suppression in Wild-type p53 gene-dependent cell growth repression in rat osteosarcoma cells. Toxicol. Pathol. 28: 575-579, 2000.

  Honoki K, Tsujiuchi T, Tsutsumi T, Kido A, Morishita T, Yoshimoto M, Miyauchi Y, Mii Y, Tamai S, Konishi Y.

• Heterogeneous pattern of gene expression in cloned cell lines established from a rat transplantable osteosarcoma lung metastatic nodule. Cancer Lett. 127:221-228, 1998

  Honoki K, Mori T, Tsutsumi T, Tsujiuchi T, Kido A, Morishita T, Miyauchi Y, Dohi Y, Mii Y, Tamai S and Konishi Y.

• Increased expression of nucleotide diphosphate kinase/nm23 and c-Ha-ras mRNA is associated with spontaneous lung metastasis in rat-transplantable osteosarcomas. Cancer Res. 53: 5038-5042, 1993. (Thesis for PhD. at Nara Medical University)

  Honoki K, Tsutsumi M, Miyauchi Y, Mii Y, Tsujiuchi T, Morishita T, Miura S, Aoki M, Kobayashi E, Tamai S and Konishi Y.

• Correlation between lack of bone Gla protein mRNA expression in rat transplantable osteosarcomas and expression of both c-fos and c-jun proto-oncogenes. Mol.Carcinogenesis. 7: 111-115, 1993.

  Honoki K, Dohi Y, Tabata S, Mii Y, Miyauchi Y, Tsutsumi T, Tsujiuchi T, Morishita T, Miura S, Moriyama T, Tamai S and Konishi Y.

• Expression of the transin, c-fos and c-jun genes in rat transplantable osteosarcomas and malignant fibrous histiocytomas. Mol.Carcinogenesis. 6: 122-128, 1992.

  Honoki K, Tsutsumi M, Tsujiuchi T, Kondoh S, Shiraiwa K, Miyauchi Y, Mii Y, Tamai S, Konishi K and Bowden GT.

著書

• 【Book Editor】Honoki K. and Weiss KR. Osteosarcoma: Biology, Behavior and Mechanisms. InTech (Croatia). April, 2017.

• 【Book Chapter】Kishi S, Honoki K, Kuniyasu H, Tanaka Y. A Novel Strategy of Dual Inhibition of Distinct Metabolic Features in Osteosarcoma. In Osteosarcoma: Biology, Behavior and Mechanisms. pp 81-96, 2019, InTech (UK)

• 【Book Chapter】Honoki K and Weiss KR. From Chaos to Cosmos: Toward Precision Medicine in Osteosarcoma. In Osteosarcoma: Biology, Behavior and Mechanisms. pp3-10, 2017, InTech (Croatia)　

• 【Book Chapter】Honoki K, Fujii H, Tsujiuchi T. Cancer Stem Cell Niche: The Role of Mesenchymal Stem Cells in Tumor Microenvironment. In: Cancer Stem Cells (ISBN 978-953-307-1454-5), INTECH d.o.o., Rijeka, Croatia, 2011

• 【Book Chapter】Honoki K, Fujii H, Tsujiuchi T. Chapter I: Cancer Stem Cell and Clustering Metastasis Theory; A Hypothesis for Evasion of Apoptosis in Cancer Metastatic Process. Cell Apoptosis and Cancer (Taylor AW ed.), Nova Publishers Inc., New York, pp 9 – 21, 2007.

• 【Book Chapter】Honoki K. and Mii Y. Molecular Genetics of Bone and Soft Tissue Tumors In New Perspectives in Cancer research and Therapy (Kuriyama, S ed.), Research Signpost, India, pp307-323, 2005.

その他

• 【受賞】2004年　第37回　がん振興財団がん研究費助成　

• 【受賞】2012年　第12回　日本抗加齢医学会　優秀演題賞

• 【受賞】2013年度　第46回　日本整形外科学会　骨軟部腫瘍学術集会　優秀ポスター演題賞

• 【受賞】2017年度　(一財)奈良県健康づくり財団がん研究費助成

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