北原 糺 きたはら ただし 先生

来歴等

略歴

1992年 大阪大学医学部医学科 卒業
1997年 大阪大学大学院医学系研究科博士課程 修了
1997年 大阪労災病院耳鼻咽喉科 医員
2001年 大阪大学医学部耳鼻咽喉科学教室 助手
2002年 米国ピッツバーグ大学医学部耳鼻咽喉科 研究員
2008年 大阪大学医学部耳鼻咽喉科学教室 講師
2010年 大阪労災病院耳鼻咽喉科 部長
2012年 大阪大学医学部耳鼻咽喉科学教室 准教授
2014年 奈良県立医科大学耳鼻咽喉・頭頸部外科学教室 主任教授
2016年 奈良県立医科大学附属病院めまいセンター センター長兼任

論文

• Expression of GABAA receptor gamma subunits in the vestibular periphery system of the rat. Brain Res. 650: 157-160, 1994

  Kitahara-T, Takeda-N, Ohno-K, Kubo-T, Kiyama-H.

• Effects of MK801 on Fos expression in the rat brainstem after unilateral labyrinthectomy. Brain Res. 700: 182-190, 1995

  Kitahara-T, Takeda-N, Saika-T, Kubo-T, Kiyama-H.

• Role of the flocculus in the development of vestibular compensation: immunohistochemical studies with retrograde tracing and flocculectomy using Fos expression as a marker in the rat brainstem. Neurosci. 76: 571-580, 1997

  Kitahara-T, Takeda-N, Saika-T, Kubo-T, Kiyama-H.

• Unilateral labyrinthectomy downregulates glutamate receptor delta-2 expression in the rat vestibulocerebellum. Mol. Brain Res. 61: 170-178, 1998

  Kitahara-T, Takeda-N, Uno-A, Kubo-T, Mishina-M, Kiyama-H.

• Molecular mechanisms of vestibular compensation in the central vestibular system-review. Acta Otolaryngol. 539: 19-27, 1998

  Kitahara-T, Takeda-N, Kiyama-H, Kubo-T.

• Nitric oxide in the flocculus works the inhibitory neural circuits after unilateral labyrinthectomy. Brain Res. 815: 405-409, 1999

  Kitahara-T, Takeda-N, Kubo-T, Kiyama-H.

• Role of cholinergic mossy fibers in medial vestibular and prepositus hypoglossal nuclei in vestibular compensation. Neurosci. 102: 159-166, 2001

  Fukushima-M, Kitahara-T, Takeda-N, Saika-T, Uno-A, Kubo-T.

• Effects of exposing the opened endolymphatic sac to large doses of steroids to treat intractable Meniere's disease. Ann. Otol. Rhinol. Laryngol. 110: 109-112, 2001

  Kitahara-T, Takeda-N, Mishiro-Y, Saika-T, Fukushima-M, Okumura-S, Kubo-T.

• Steroid effects on vestibular compensation in human. Neurol. Res. 25: 287-291, 2003

  Kitahara-T, Kondoh-K, Morihana-T, Okumura-S, Horii-A, Takeda-N, Kubo-T.

• Microarray analysis of gene expression in the rat vestibular nucleus complex following unilateral vestibular deafferentation . J Neurochem. 91: 975-982, 2004

  Horii-A, Masumura-C, Smith-PF, Darlington-CL, Kitahara-T, Uno-A, Mitani-K, Kubo-T.

• Regulation of mitochondrial uncoupling proteins in mouse inner ear ganglion cells in response to systemic kanamycin challenge. Neurosci. 135: 639-653, 2005

  Kitahara-T, Li-HS, Balaban-CD.

• Changes in transient receptor potential cation channel superfamily V (TRPV) mRNA expression in the mouse inner ear after kanamycin challenge. Hear. Res. 201: 132-144, 2005

  Kitahara-T, Li-HS, Balaban-CD.

• Prognosis of inner ear periphery and central vestibular plasticity in sudden deafness with vertigo. Ann. Otol. Rhinol. Laryngol. 114: 786-791, 2005

  Kitahara-T, Takeda-N, Nishiike-S, Okumura-S, Kubo-T.

• Fos-enkephalin signaling in the medial vestibular nucleus facilitates vestibular compensation. J Neurosci. Res. 83: 1573-1583, 2006

  Kitahara-T, Kaneko-T, Horii-A, Fukushima-M, Kizawa-Okumura-K, Takeda-N, Kubo-T.

• Changes in mitochondrial uncoupling protein expression in the rat vestibular nerve after labyrinthectomy. Neurosci. Res. 59: 237-242, 2007

  Kitahara-T, Horii-A, Kizawa-K, Maekawa-C, Kubo-T.

• Meniere's attacks occur in the inner ear with excessive vasopressin type-2 receptors. J Neuroendocrinol. 20: 1295- 1300, 2008

  Kitahara-T, Doi-K, Maekawa-C, Kizawa-K, Horii-A, Kubo-T, Kiyama-H.

• Effects of endolymphatic sac drainage with steroids for intractable Meniere's disease: A long-term follow-up and randomized controlled study. Laryngoscope 118: 854-861, 2008

  Kitahara-T, Kubo-T, Okumura-S, Kitahara-M.

• Plasma vasopressin and V2 receptor in the endolymphatic sac in patients with delayed endolymphatic hydrops. Otol. Neurotol. 30: 812- 819, 2009

  Kitahara-T, Maekawa-C, Kizawa-K, Horii-A, Doi-K.

• Behavioral assessment and identification of a molecular marker in a salicylate- induced tinnitus in rats. Neurosci. 165: 1323-1332, 2010

  Kizawa-K, Kitahara-T, Horii-A, Maekawa-C, Kuramasu-T, Kawashima-T, Nishiike-S, Doi- K, Inohara-H.

• Expression and translocation of aquaporin-2 in the endolymphatic sac in patients with Meniere's disease. J Neuroendocrinol. 22: 1157-1164, 2010

  Maekawa-C, Kitahara-T, Kizawa-K, Okazaki-S, Kamakura-T, Horii-A, Imai-T, Doi-K,Inohara-H, Kiyama-H.

• Tinnitus as a prognostic factor of sudden deafness. Acta Otolaryngol. 130: 79-83, 2010

  Hikita-Watanabe-N, Kitahara-T, Horii-A, Kawashima-T, Doi-K, Okumura-S.

• Endolymphatic sac tumor with overexpression of V2 receptor and inner ear hydrops. Acta Otolaryngol. 131: 951- 957, 2011

  Kitahara-T, Maekawa-C, Kizawa-K, Kamakura-T, Horii-A, Inohara-H.

• Low-tone air- bone gaps after endolymphatic sac surgery. Auris Nasus Larynx 38: 178-184, 2011

  Kitahara-T, Horii-A, Mishiro-Y, Kawashima-T, Imai-T, Nishiike-S, Inohara-H.

• Changes in beta-2 adrenergic receptor and AMP-activated protein kinase alpha-2 subunit in the rat vestibular nerve after labyrinthectomy. Neurosci. Res. 72: 221-226, 2012

  Kitahara-T, Horii-A, Uno-A, Imai-T, Okazaki-S, Kamakura-T, Takimoto-Y, Inohara-H.

• Transient low-tone air-bone gaps during convalescence immediately after canal plugging surgery for BPPV. Auris Nasus Larynx 39: 356-360, 2012

  Uetsuka-S, Kitahara-T, Horii-A, Imai-T, Uno-A, Okazaki-S, Kamakura-T, Takimoto-Y,Inohara-H.

• Functional expression of TRPV1 and TRPA1 in rat vestibular ganglia. Neurosci. Lett. 552: 92-97, 2013

  Kamakura-T, Ishida-Y, Nakamura-Y, Yamada-T, Kitahara-T, Takimoto-Y, Horii-A, Uno-A, Imai-T, Okazaki-S, Inohara-H, Shimada-S.

• Long-term results of endolymphatic sac drainage with local steroids for intractable Meniere’s disease. Auris Nasus Larynx 40: 425-430, 2013

  Kitahara-T, Fukushima-M, Uno-A, Imai-T, Ohta-Y, Morihana-T, Kamakura-T, Horii-A, Inohara-H.

• Constraint-induced music therapy for sudden sensorineural hearing loss – a pilot study. Scientific Reports 4: 3927, 2014

  Okamoto-H, Fukushima-M, Teismann-H, Lagemann-L, Kitahara-T, Inohara-H, Kakigi-R, Pantev-C.

• Does endolymphatic sac decompression surgery prevent bilateral development of unilateral Meniere’s disease? Laryngoscope 124: 1932-1936, 2014

  Kitahara-T, Horii-A, Imai-T, Ohta-Y, Morihana-T, Inohara-H, Sakagami-M.

• Chronic otitis media with cholesteatoma with canal fistula and bone conduction threshold after tympanoplasty with mastoidectomy. Otol. Neurotol. 35: 981-988, 2014

  Kitahara-T, Kamakura-T, Ohta-Y, Morihana-T, Horii-A, Uno-A, Imai-T, Mishiro-Y, Inohara-H.

• Differential diagnosis of vertigo and dizziness at the emergency department. Acta Otolaryngol. 134: 140-145, 2014

  Ozono-Y, Kitahara-T, Tomiyama-Y, Nishiike-S, Morita-H, Inohara-H.

• NKCCs in the fibrocytes of the spiral ligament are silent on the unidirectional K+ transport that controls the electrochemical properties in the mammalian cochlea. Pflugers Arch. 467: 1577-1589, 2015

  Yoshida-T, Nin-F, Ogata-G, Uetsuka-S, Kitahara-T, Inohara-H, Akazawa-K, Komune-S, Kurachi-Y, Hibino-H.

• Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea. Eur. J Neurosci. 42: 1984-2002, 2015

  Uetsuka-S, Ogata-G, Nagamori-S, Isozumi-N, Nin-F, Yoshida-T, Komune-S, Kitahara-T, Kikkawa-Y, Inohara-H, Kanai-Y, Hibino-H.

• Effects of posterior tympanotomy with steroids at round window on hearing recovery after revision surgery for intractable Meniere’s disease. Acta Otolaryngol. 135: 667-672, 2015

  Sakagami-M, Kitahara-T, Ito-T, Ota-I, Nishimura-T, Nishimura-A, Otsuka-S, Yamanaka-T.

• A two-year randomized trial of interventions to decrease stress hormone vasopressin production in patients with Meniere’s disease PLOS ONE 11: e0158309, 2016

  Kitahara-T, Okamoto-H, Fukushima-M, Sakagami-M, Ito-T, Yamashita-A, Ota-I, Yamanaka- T.

• Long-term effects of electrotactile sensory substitution therapy on balance disorders. Neurorep. 27: 744-748, 2016

  Yamanaka-T, Sawai-Y, Murai-T, Nishimura-T, Kitahara-T.

• Functional expression of an osmosensitive cation channel, transient receptor potential vanilloid 4, in rat vestibular ganglia. Audiol. Neurootol. 21: 268-274, 2016

  Kamakura-T, Kondo-M, Koyama-Y, Hanada-Y, Ishida-Y, Nakamura-Y, Yamada-T, Takimoto-Y, Kitahara-T, Ozono-Y, Horii-A, Imai-T, Inohara-H, Shimada-S.

• Endolymphatic space size in patients with Meniere’s disease and healthy controls. Acta Otolaryngol. 136: 879-882, 2016

  Ito-T, Kitahara-T, Inui-H, Miyasaka-T, Kichikawa-K, Ota-I, Nario-K, Matsumura-Y, Yamanaka-T.

• Volumetric measurements of the inner ear in patients with Meniere’s disease using three-dimensional MRI. Acta Otolaryngol. 136: 888-893, 2016

  Inui-H, Ito-T, Sakamoto-T, Ito-T, Kitahara-T.

• Effects of repeated snowboard exercise in virtual reality with time lags of visual feedback behind body rotation on head stability and subjective slalom run performance in healthy young subjects. Acta Otolaryngol. 136: 1121-1124, 2016

  Wada-Y, Nishiike-S, Kitahara-T, Yamanaka-T, Imai-T, Ito-T, Sato-G, Matsuda-K, Kitamura- Y, Takeda-N.

• Negative prognostic factors for psychological condition in patients with audio-vestibular diseases. Auris Nasus Larynx 43: 632-636, 2016

  Sakagami-M, Kitahara-T, Okayasu-T, Yamashita-A, Hasukawa-A, Ota-I, Yamanaka-T.

• Effects of noise exposure to pregnant guinea pigs at gestational periods on neonatal auditory brainstem response thresholds. J Obstet. Gynaecol. Res. 43: 78-86, 2017

  Morimoto-C, Nario-K, Nishimura-T, Shimokura-R, Hosoi-H, Kitahara-T.

• Sound change integration error: an explanatory model of tinnitus. Front. Neurosci. 12: e831, 2018

  Noda-K, Kitahara-T, Doi-K.

• Evidence of surgical treatments for intractable Meniere’s disease – review –. Auris Nasus Larynx 45: 393-398, 2018

  Kitahara-T.

• International consensus (ICON) on treatment of Ménière's disease. Eur. Ann. Otorhinolaryngol. Head Neck Dis. 135(S): S29-S32, 2018

  Nevoux-J, Barbara-M, Dornhoffer-J, Gibson-W, Kitahara-T, Darrouzet-V.

• Three-dimensional magnetic resonance imaging reveals the relationship between the control of vertigo and decreases in endolymphatic hydrops after endolymphatic sac drainage with steroids for Meniere’s disease. Front. Neurol. 10: e46, 2019

  Ito-T, Inui-H, Sakamoto-T, Miyasaka-T, Shiozaki-T, Matsuyama-S, Yamanaka-T, Kichikawa-K, Kitahara-T.

• Differentiation of embryonic stem cells into inner ear vestibular hair cells using vestibular cell derived-conditioned medium. Biochem Biophys Rep 19: e100649, 2019

  Sakagami-M, Ouji-Y, Kawai-N, Misu-M, Yoshikawa-M, Kitahara-T.

• Vestibular compensation after vestibular dysfunction induced by arsanilic acid in mice. Brain Sci 9: e329, 2019

  Ito-T, Tatsumi-K, Takimoto-Y, Imai-T, Yamanaka-T, Takeda-N, Wanaka-A, Kitahara-T.

• Head-up sleep may cure patients with intractable benign paroxysmal positional vertigo: a six-month randomized trial. Laryngoscope Investig. Otolaryngol. 4: 353-358, 2019

  Horinaka-A, Kitahara-T, Shiozaki-T, Ito-T, Wada-Y, Yamanaka-T, Nario-K.

• Endolymphatic space volume in patients with Meniere’s disease and healthy controls: three- dimensional analysis with magnetic resonance imaging. Laryngoscope Investig. Otolaryngol. 4: 653-658, 2019

  Ito-T, Inui-H, Miyasaka-T, Shiozaki-T, Hasukawa-A, Yamanaka-T, Kichikawa-K, Kitahara- T.

• Idiopathic benign paroxysmal positional vertigo with persistent vertigo/dizziness sensation is associated with latent canal paresis, endolymphatic hydrops and osteoporosis. Auris Nasus Larynx 46: 27-33, 2019

  Kitahara-T, Ota-I, Horinaka-A, Ohyama-H, Sakagami-M, Ito-T, Shiozaki-T, Wada-Y, Yamanaka-T.

• Meniere’s disease with unremitting floating sensation is associated with canal paresis, gravity sensitive dysfunction, mental illness, and bilaterality. Auris Nasus Larynx 46: 186-192, 2019

  Kitahara-T, Sakagami-M, Ito-T, Shiozaki-T, Kitano-K, Yamashita-A, Ota-I, Wada-Y, Yamanaka-T.

• Combination of head-up sleep and vertical recognition training may cure intractable motion-evoked dizziness with unknown origin. Acta Otolaryngol., in press

  Kitahara-T, Horinaka-A, Shiozaki-T, Ito-T, Yamanaka-T, Nario-K.

• Retrospective evaluation of secondary effects of hearing aids for tinnitus therapy in patients with hearing loss. Auris Nasus Larynx, in press

  Yokota-Y, Yamashita-A, Koyama-S, Kitano-K, Otsuka-S, Kitahara-T.

著書

• 【著】めまいの待合室 金原出版 2008年

• 【著】めまいを診る 金芳堂 2017年

• 【編集】聴平衡覚と健康長寿・フレイル対策 先端医学社 2019年

• 【著】原因不明のめまいはもう怖くない 金原出版 2020年

• 【著】めまいは頭を高くして寝ると治る マキノ出版 2022年

特許

• 耳石に優しい睡眠頭位調節マットレス／MBT1号商品

• ベスティブルフレイル（vestibular frailty）／MBT登録商標

受賞

• 2006年 6月 国際バラニー学会若手研究奨励賞＠スウェーデン王国ウプサラ市

• 2007年10月 国際ポリッツァー学会賞臨床部門＠米国オハイオ州クリーブランド

• 2018年11月 日本めまい平衡医学会60周年記念理事長賞＠山口県湯田温泉

その他

• 【学会主催】2022年 日本めまい平衡医学会 会長

• 【学会主催】2025年 耳鼻咽喉科臨床学会 会長

• 【学会主催】2026年 日本耳科学会 会長

• 【テレビ出演】2015年11月 たけしの家庭の医学（テレビ朝日）

• 【テレビ出演】2017年 12月 たけしの家庭の医学（テレビ朝日）

• 【テレビ出演】2019年10月 ガッテン！（NHK）

• 【テレビ出演】2019年11月 たけしの家庭の医学（テレビ朝日）

• 【テレビ出演】2019年12月 名医の極み（テレビ朝日）

• 【テレビ出演】2023年1月 石原さとみのトリセツショー（NHK）

• 【テレビ出演】2023年1月 草野 仁のカラダ若返りTV（BS朝日）

• 【テレビ出演】2023年5月 NHK WORLD JAPAN: Medical Frontiers（NHK BS）

SNS・ブログ等

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• その他メディア
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  • http://www.naramed-u.ac.jp/~oto/
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