鹿島田 健一 かしまだ けんいち 先生

来歴等

略歴

1994年 東京医科歯科大学医学部 卒業
1994年 東京医科歯科大学医学部附属病院 小児科 研修医
1995年 土浦協同病院 小児科
1996年 取手協同病院 小児科
1999年 東京医科歯科大学大学院医学系研究科 大学院生
2002年 愛仁会太田総合病院 小児科部長
2004年 地域医療振興会東京北社会保険病院 小児科部長
2007年 東京医科歯科大学大学院医学系研究科発生発達病態学 助教
2008年 Queensland大学IMB（Institute for Molecular Bioscience）Peter Koopman研究室 ポストドクトラルフェロー（研究員）
2011年 東京医科歯科大学大学院医学系研究科発生発達病態学 助教授
2013年 同 講師
2022年 同 准教授

論文

• 1. Newborn screening for congenital adrenal hyperplasia in Tokyo, Japan from 1989 to 2013: a retrospective population-based study.BMC Pediatrics (2015) 15:209

  Atsumi Tsuji, Kaoru Konishi, Satomi Hasegawa, Akira Anazawa, Toshikazu Onishi, Makoto Ono, Tomohiro Morio, Teruo Kitagawa and Kenichi Kashimada* (*: contributed as a corresponding author)

• 2. Improved growth velocity of a patient with Noonan-like syndrome with loose anagen hair (NS/LAH) without growth hormone deficiency by low-dose growth hormone therapy.Am J Med Genet A. 2015 Oct;167A(10):2425-9.

  Takasawa K, Takishima S, Morioka C, Nishioka M, Ohashi H, Aoki Y, Shimohira M, Kashimada K*, Morio T. (*: contributed as a corresponding author)

• 3. Similar frequency of paternal uniparental disomy involving chromosome 20q (patUPD20q) in Japanese and Caucasian patients affected by sporadic pseudohypoparathyroidism type Ib (sporPHP1B).Bone. 2015 Oct;79:15-20

  Takatani R, Minagawa M, Molinaro A, Reyes M, Kinoshita K, Takatani T, Kazukawa I, Nagatsuma M, Kashimada K, Sato K, Matsushita K, Nomura F, Shimojo N, J?ppner H.

• 4. Clinical, biochemical, and genetic features of non-classical 21-hydroxylase deficiency in Japanese children.2015;62(3):277-82.

  Kashimada K*, Ishii T* (*: equally contributed), Nagasaki K, Ono M, Tajima T, Yokota I and Hasegawa Y, Endocrine J

• 5. A 45,X/46,XY DSD (Disorder of Sexual Development) case with an extremely uneven distribution of 46,XY cells between lymphocytes and gonads.Clin Pediatr Endocrinol. 2015 Jan;24(1):11-4.

  Nomura R, Miyai K, Okada M, Kajiwara M, Ono M, Ogata T, Onishi I, Sato M, Sekine M, Akashi T, Mizutani S, Kashimada K.

• 6. TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis.Stem Cells Dev. 2015 May 15;24(10):1164-70A

  Matsubara Y, Kato T, Kashimada K, Tanaka H, Zhi Z, Ichinose S, Mizutani S, Morio T, Chiba T, Ito Y, Saga Y, Takada S, Asahara H.

• 7. Urinary calcium to creatinine ratio: a potential marker of secondary hyperparathyroidism in patients with vitamin D-dependent rickets type 1A.Endocr J. 2015;62(1):61-8.

  Miyai K, Onishi T, Kashimada K, Hasegawa Y.

• 8. Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus.Sci Rep. 2014 May 23;4:5043

  Matsubara Y, Chiba T, Kashimada K, Morio T, Takada S, Mizutani S, Asahara H.

• 9. site-specific, single-copy transgenesis strategy to identify 5' regulatory sequences of the mouse testis-determining gene Sry.PLoS One. 2014 Apr 17;9(4):e94813.

  Kashimada K*, Quinn A*, (*: equally contributed), Davidson TL, Ng ET, Chawengsaksophak K, Bowles J, Koopman P.

• 10. FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice.FASEB J. 2014 May;28(5):2020-8.

  Takasawa K, Kashimada K*, Pelosi E, Takagi M, Morio T, Asahara H, Schlessinger D, Mizutani S, Koopman P, (*: contributed as a corresponding author)

• 11. Two novel HSD3B2 missense mutations with diverse residual enzymatic activities for Δ5-steroids.Clin Endocrinol (Oxf). 2014 Jun;80(6):782-9.

  Takasawa K, Ono M, Hijikata A, Matsubara Y, Katsumata N, Takagi M, Morio T, Ohara O, Kashimada K*, Mizutani S. (*: contributed as a corresponding author)

• 12. Longitudinal analysis of growth and body composition of Japanese 21-OHD patients in childhood.Endocrine Journal 2013;60(2):149-54. Epub 2012 Sep 28.

  Matsubara Y, Ono M, Miyai K, Takizawa F, Takasawa K, Onishi T, Kashimada K*, Mizutani S.(*: contributed as a corresponding author)

• 13. Initial high dose hydrocortisone (HDC) treatment for 21-hydroxylase deficiency (21-OHD) does not affect linear growth during the first three years of life. Endocr J. 2012;59(11):1001-6. Epub 2012 Jul 10.

  Takasawa K, Ono M, Miyai K, Matsubara Y, Takizawa F, Onishi T, Kashimada K*, Mizutani S.(*: contributed as a corresponding author)

• 14. Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB J. 2011 Oct;25(10):3561-9.

  Kashimada K, Svingen T, Feng CW, Pelosi E, Bagheri-Fam S, Harley VR, Schlessinger D, Bowles J, Koopman P.

• 15. FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development. Endocrinology. 2011 Jan;152(1):272-80.

  Kashimada K, Pelosi E, Chen H, Schlessinger D, Wilhelm D, Koopman P.

• 16. Sry: the master switch in mammalian sex determination. Development. 2010 Dec;137(23):3921-30. Review.

  Kashimada K, Koopman P.

• 17. Two Preterm Infants with Late Onset Circulatory Collapse Induced by Levothyroxine Sodium. Pediatr Int. 2010 Jun;52(3):e154-7

  Takizawa F, Kashimada K*, Enomoto K, Miyai K, Ono M, Asada G, Shimizu J, Mizutani S. (*: contributed as a corresponding author)

• 18. Identification of suitable normalizing genes for quantitative real-time RT-PCR analysis of gene expression in fetal mouse gonads. Sex Dev. 2009;3(4):194-204. 2009

  Svingen T, Spiller CM, Kashimada K, Harley VR, Koopman P.

• 19. Clinical Course of Patients with Nonclassical 21-Hydroxylase Deficiency (21-OHD) Diagnosed in Infancy and Childhood. Endocr J. 2008 May;55(2):397-404

  Kashimada K, Ono M, Onishi T, Koyama S, Toyoura T, Imai K, Saisho S, Mizutani S.

• 20. Two cases of transient pseudohypoaldosteronism due to group B streptococcus pyelonephritis. Pediatr Nephrol. 2008 Sep;23(9):1569-70.2008 15

  Kashimada K, Omori T, Takizawa F, Mizutani S.

• 21. In Vitro Enzyme Assay of CYP21A2 Mutation (R483Q) by A Novel Method Using Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS/MS). Clin Pediatr Endocrinol. 2008 May;17(2):49-56

  Ono M, Kashimada K, Miyai K, Onishi T, Takagi M, Honma S, Mizutani S.

• 22. Liquid chromatography-tandem mass spectrometric method for determination of salivary 17alpha-hydroxyprogesterone: a noninvasive tool for evaluating efficacy of hormone replacement therapy in congenital adrenal hyperplasia. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 1;867(1):49-56

  Shibayama Y, Higashi T, Shimada K, Kashimada K, Onishi T, Ono M, Miyai K, Mizutani S.

• 23. A boy with "transient" growth hormone deficiency in prepubertal stage despite normal growth hormone secretion in childhood and after puberty. Endocr J. 2007;54(6):1015-9. Epub 2007 Nov 14.

  Kashimada K, Onishi T, Ono M, Miyai K, Ohta M, Mizutani S.

• 24. Identification of a new case of hepatocyte nuclear factor-1beta mutation with highly varied phenotypes. Diabetologia. 2004 ;47 (6):1128-9.

  Shihara N, Horikawa Y, Onishi T, Ono M, Kashimada K, Takeda J.

• 25. RMRP mutations in Japanese patients with cartilage-hair hypoplasia.Am J Med Genet A. 2003;123 (3):253-6.

  Nakashima E, Mabuchi A, Kashimada K, Onishi T, Zhang J, Ohashi H, Nishimura G, Ikegawa S.

• 26. Defects in growth and bone metabolism in klotho mutant mice are resistant to GH treatment. J Endocrinol. 2002;174 (3):403-10.

  Kashimada K, Yamashita T, Tsuji K, Nifuji A, Mizutani S, Nabeshima Y, Noda M.

• 27. A highly specific heterologous enzyme immunoassay for 5 alpha-androstane-3 alpha, 17 beta-diol 17-glucuronide (androstanediol-17G) and developmental patterns of urinary androstanediol-17G excretions. Steroids 2002;67 (3-4):175-83

  Onishi T, Takei H, Kambegawa A, Saisho S, Kashimada K, Koyama S, Mizutani S, Rao PN.

• 28. Klotho-deficient mice are resistant to bone loss induced by unloading due to sciaticneurectomy. J Endocrinol. 2001;168 (2):347-51.

  Yamashita T, Sekiya I, Kawaguchi N, Kashimada K, Nifuji A, Nabeshima YI, Noda M.